UK Biobank (core renewal)
Lead Research Organisation:
UK Biobank
Department Name: UNLISTED
Abstract
UK Biobank is supported by The Wellcome Trust, The National Institute of Health Research, The Medical Research Council, The British Heart Foundation and Cancer Research UK. The figures presented on this record represent the Medical Research Council funding contribution only with some additional UKRI Infrastructure funds in addition.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
Technical Summary
The UK Biobank resource has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. There are now sufficient numbers of incident cases of the commoner conditions to support extensive and powerful research into their determinants.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
Organisations
People |
ORCID iD |
Rory Collins (Principal Investigator) |
Publications
Eales JM
(2019)
Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis.
in Arteriosclerosis, thrombosis, and vascular biology
Smith L
(2019)
Characteristics of the environment and physical activity in midlife: Findings from UK Biobank.
in Preventive medicine
Loftfield E
(2019)
Mosaic Y Loss Is Moderately Associated with Solid Tumor Risk.
in Cancer research
Wilkinson T
(2019)
Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data.
in European journal of epidemiology
McInnes G
(2019)
Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics.
in Bioinformatics (Oxford, England)
Machado-Fragua MD
(2019)
Habitual coffee consumption and risk of falls in 2 European cohorts of older adults.
in The American journal of clinical nutrition
Deng WQ
(2019)
Analytical strategies to include the X-chromosome in variance heterogeneity analyses: Evidence for trait-specific polygenic variance structure.
in Genetic epidemiology
Tikkanen E
(2019)
Body composition and atrial fibrillation: a Mendelian randomization study.
in European heart journal
Gale CR
(2019)
Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank.
in Scientific reports
Jansen IE
(2019)
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
in Nature genetics
Zhang B
(2019)
Associations with Corneal Hysteresis in a Population Cohort
in Ophthalmology
Dekkers IA
(2019)
Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study.
in Radiology
Casanova F
(2019)
A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio.
in Human molecular genetics
Avinun R
(2019)
A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation.
in Journal of psychiatric research
Sarkar C
(2019)
Environmental correlates of chronic obstructive pulmonary disease in 96 779 participants from the UK Biobank: a cross-sectional, observational study.
in The Lancet. Planetary health
Sakornsakolpat P
(2019)
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
in Nature genetics
Han X
(2019)
Genome-wide association analysis of 95 549 individuals identifies novel loci and genes influencing optic disc morphology
in Human Molecular Genetics
Sarnowski C
(2019)
Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program.
in American journal of human genetics
Meisner A
(2019)
Case-Only Analysis of Gene-Environment Interactions Using Polygenic Risk Scores.
in American journal of epidemiology
Kunzmann AT
(2019)
Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors.
in Gastroenterology
Nave G
(2019)
Are Bigger Brains Smarter? Evidence From a Large-Scale Preregistered Study.
in Psychological science
Pan F
(2019)
Association between musculoskeletal pain at multiple sites and objectively measured physical activity and work capacity: Results from UK Biobank study.
in Journal of science and medicine in sport
Rayner C
(2019)
Genetic influences on treatment-seeking for common mental health problems in the UK biobank.
in Behaviour research and therapy
Zhao B
(2019)
Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies.
in Cerebral cortex (New York, N.Y. : 1991)
Barbu MC
(2019)
Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.
in Biological psychiatry. Cognitive neuroscience and neuroimaging
Ramírez J
(2019)
Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics.
in Circulation. Arrhythmia and electrophysiology
Howard DM
(2019)
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
in Nature neuroscience
Ong JS
(2019)
Association between coffee consumption and overall risk of being diagnosed with or dying from cancer among >300 000 UK Biobank participants in a large-scale Mendelian randomization study.
in International journal of epidemiology
Freidin M
(2019)
Genome-wide meta-analysis identifies genetic locus on chromosome 9 associated with Modic changes.
in Journal of medical genetics
Jonsson BA
(2019)
Brain age prediction using deep learning uncovers associated sequence variants.
in Nature communications
Georgakis MK
(2019)
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.
in Circulation
Ferreira MAR
(2019)
Eleven loci with new reproducible genetic associations with allergic disease risk.
in The Journal of allergy and clinical immunology
De Lange AG
(2019)
Population-based neuroimaging reveals traces of childbirth in the maternal brain.
in Proceedings of the National Academy of Sciences of the United States of America
Jordão HW
(2019)
The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study.
in United European gastroenterology journal
Legge SE
(2019)
Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits.
in JAMA psychiatry
Huang Y
(2019)
A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia
in Investigative Opthalmology & Visual Science
Mackay A
(2019)
The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants.
in Journal of public health (Oxford, England)
Havdahl A
(2019)
Investigating causality in the association between vitamin D status and self-reported tiredness.
in Scientific reports
Lind L
(2019)
Genome-Wide Association Study of the Metabolic Syndrome in UK Biobank.
in Metabolic syndrome and related disorders
Clynes MA
(2019)
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank.
in Frontiers in endocrinology
Shen X
(2019)
White Matter Microstructure and Its Relation to Longitudinal Measures of Depressive Symptoms in Mid- and Late Life.
in Biological psychiatry
Muilwijk M
(2019)
Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study.
in BMJ open diabetes research & care
Choi SW
(2019)
PRSice-2: Polygenic Risk Score software for biobank-scale data.
in GigaScience
Mojtahed A
(2019)
Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases.
in Abdominal radiology (New York)
Rawlik K
(2019)
Indirect assortative mating for human disease and longevity.
in Heredity
Description | Impact of clinically silent atrial fibrillation on cerebrovascular disease and cognitive decline in the UK Biobank Imaging Cohort |
Amount | £2,474,260 (GBP) |
Funding ID | RG/18/6/33576 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2019 |
End | 06/2024 |
Description | UK Biobank - The Repeat Imaging Project |
Amount | £2,500,000 (GBP) |
Funding ID | R39738/CN039 |
Organisation | MRC Dementias Platform UK |
Sector | Academic/University |
Country | United Kingdom |
Start | 04/2019 |
End | 01/2023 |
Description | UK Biobank - Whole genome sequencing of 50,000 UKB participants |
Amount | £30,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2020 |
Description | UK Biobank- Expansion of the UKB imaging to a 4th centre and repeat imaging assessment of 10,000 participants |
Amount | £8,500,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 12/2022 |
Description | UK Biobank Scientific Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The UK Biobank Scientific Symposium included presentations about the successes and future plans of the UK Biobank. It took place on 21 June 2018 in London |
Year(s) Of Engagement Activity | 2018 |
Description | UK Biobank participant imaging event |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UK Biobank for participants of the imaging work |
Year(s) Of Engagement Activity | 2021 |
Description | UKBiobank participant events - 2014 - 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UKB Biobank participants regularly attend events aimed at informing them about the work being undertaken with their data. Usually, the events last a few hours and include an overview from the chief scientist and two talks from scientists that have used UKB data. From 2014 - 2020 over 4,000 participants have taken part in events in Edinburgh (4), Manchester (4), Nottingham, Leeds, Cardiff (2), Newcastle (5), Glasgow (2), Bristol (2) and Reading(4). They are often over-subscribed and participants leave these events wishing to seek more information and support he programme in new ways (EG in imaging, genome sequencing) |
Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018,2019 |
URL | http://www.ukbiobank.ac.uk |