UK Biobank (core renewal)
Lead Research Organisation:
UK Biobank
Department Name: UNLISTED
Abstract
UK Biobank is supported by The Wellcome Trust, The National Institute of Health Research, The Medical Research Council, The British Heart Foundation and Cancer Research UK. The figures presented on this record represent the Medical Research Council funding contribution only with some additional UKRI Infrastructure funds in addition.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
Technical Summary
The UK Biobank resource has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. There are now sufficient numbers of incident cases of the commoner conditions to support extensive and powerful research into their determinants.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
Organisations
People |
ORCID iD |
Rory Collins (Principal Investigator) |
Publications
Van De Vegte YJ
(2018)
Heart Rate Recovery 10 Seconds After Cessation of Exercise Predicts Death.
in Journal of the American Heart Association
Johnson EC
(2018)
Relationships between estimated autozygosity and complex traits in the UK Biobank.
in PLoS genetics
Gazal S
(2018)
Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations.
in Nature genetics
Gallacher KI
(2018)
Risk factors and mortality associated with multimorbidity in people with stroke or transient ischaemic attack: a study of 8,751 UK Biobank participants.
in Journal of comorbidity
Hamer M
(2018)
Association of objectively measured physical activity with brain structure: UK Biobank study.
in Journal of internal medicine
Cullen B
(2018)
Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank
in Scientific Reports
Bonfiglio F
(2018)
Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome.
in Gastroenterology
Day FR
(2018)
Elucidating the genetic basis of social interaction and isolation.
in Nature communications
Carreras-Torres R
(2018)
Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank.
in BMJ (Clinical research ed.)
Davies NM
(2018)
The Causal Effects of Education on Health Outcomes in the UK Biobank.
in Nature human behaviour
Roselli C
(2018)
Multi-ethnic genome-wide association study for atrial fibrillation.
in Nature genetics
Mountjoy E
(2018)
Education and myopia: assessing the direction of causality by mendelian randomisation.
in BMJ (Clinical research ed.)
Hoffmann TJ
(2018)
A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
in Genetics
Jorgenson E
(2018)
Genetic variation in the SIM1 locus is associated with erectile dysfunction.
in Proceedings of the National Academy of Sciences of the United States of America
Taylor M
(2018)
Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts.
in International journal of epidemiology
Gill D
(2018)
Age at menarche and adult body mass index: a Mendelian randomization study.
in International journal of obesity (2005)
Zhu Z
(2018)
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
in Nature genetics
Pilling LC
(2018)
Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years.
in PloS one
Guo W
(2018)
Adiposity and breast cancer risk in postmenopausal women: Results from the UK Biobank prospective cohort.
in International journal of cancer
Hanlon P
(2018)
Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants.
in The Lancet. Public health
Thériault S
(2018)
A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis
in Nature Communications
McKibbin M
(2018)
Monocular and binocular visual impairment in the UK Biobank study: prevalence, associations and diagnoses.
in BMJ open ophthalmology
Stein MB
(2018)
Genome-wide analysis of insomnia disorder.
in Molecular psychiatry
Du Rietz E
(2018)
Association of Polygenic Risk for Attention-Deficit/Hyperactivity Disorder With Co-occurring Traits and Disorders.
in Biological psychiatry. Cognitive neuroscience and neuroimaging
Fukaya E
(2018)
Clinical and Genetic Determinants of Varicose Veins.
in Circulation
Ong JS
(2018)
Height and overall cancer risk and mortality: evidence from a Mendelian randomisation study on 310,000 UK Biobank participants.
in British journal of cancer
Verweij N
(2018)
Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.
in Nature communications
Harvey NC
(2018)
Calcium and Vitamin D Supplementation Are Not Associated With Risk of Incident Ischemic Cardiac Events or Death: Findings From the UK Biobank Cohort.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Colodro-Conde L
(2018)
Association Between Population Density and Genetic Risk for Schizophrenia.
in JAMA psychiatry
Minelli C
(2018)
Age at puberty and risk of asthma: A Mendelian randomisation study.
in PLoS medicine
Thériault S
(2018)
Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease.
in Circulation. Genomic and precision medicine
Warrington NM
(2018)
Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank.
in International journal of epidemiology
Fall T
(2018)
Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank.
in Diabetologia
Cook MJ
(2018)
The prevalence of co-morbidities and their impact on physical activity in people with inflammatory rheumatic diseases compared with the general population: results from the UK Biobank.
in Rheumatology (Oxford, England)
Paccou J
(2018)
Prior fragility fracture and risk of incident ischaemic cardiovascular events: results from UK Biobank.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Khawaja A
(2018)
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma
in Nature Genetics
Zhang L
(2018)
Automatic Assessment of Full Left Ventricular Coverage in Cardiac Cine Magnetic Resonance Imaging with Fisher Discriminative 3D CNN.
in IEEE transactions on bio-medical engineering
Winchester LM
(2018)
Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease.
in Genome medicine
MacGregor S
(2018)
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.
in Nature genetics
Zhou W
(2018)
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
in Nature genetics
Maguire LH
(2018)
Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.
in Nature genetics
Gai L
(2018)
Finding associated variants in genome-wide association studies on multiple traits.
in Bioinformatics (Oxford, England)
Hagenaars S
(2018)
Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function
in PLOS ONE
Hill W
(2018)
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
in Molecular Psychiatry
Magnus MC
(2018)
Independent and combined associations of maternal and own smoking with adult lung function and COPD.
in International journal of epidemiology
Description | Impact of clinically silent atrial fibrillation on cerebrovascular disease and cognitive decline in the UK Biobank Imaging Cohort |
Amount | £2,474,260 (GBP) |
Funding ID | RG/18/6/33576 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2019 |
End | 06/2024 |
Description | UK Biobank - The Repeat Imaging Project |
Amount | £2,500,000 (GBP) |
Funding ID | R39738/CN039 |
Organisation | MRC Dementias Platform UK |
Sector | Academic/University |
Country | United Kingdom |
Start | 04/2019 |
End | 01/2023 |
Description | UK Biobank - Whole genome sequencing of 50,000 UKB participants |
Amount | £30,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2020 |
Description | UK Biobank- Expansion of the UKB imaging to a 4th centre and repeat imaging assessment of 10,000 participants |
Amount | £8,500,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 12/2022 |
Description | UK Biobank Scientific Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The UK Biobank Scientific Symposium included presentations about the successes and future plans of the UK Biobank. It took place on 21 June 2018 in London |
Year(s) Of Engagement Activity | 2018 |
Description | UK Biobank participant imaging event |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UK Biobank for participants of the imaging work |
Year(s) Of Engagement Activity | 2021 |
Description | UKBiobank participant events - 2014 - 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UKB Biobank participants regularly attend events aimed at informing them about the work being undertaken with their data. Usually, the events last a few hours and include an overview from the chief scientist and two talks from scientists that have used UKB data. From 2014 - 2020 over 4,000 participants have taken part in events in Edinburgh (4), Manchester (4), Nottingham, Leeds, Cardiff (2), Newcastle (5), Glasgow (2), Bristol (2) and Reading(4). They are often over-subscribed and participants leave these events wishing to seek more information and support he programme in new ways (EG in imaging, genome sequencing) |
Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018,2019 |
URL | http://www.ukbiobank.ac.uk |