Enabling technologies

Lead Research Organisation: University of Cambridge

Abstract

The Enabling Technologies programme consists of a number of core facilities that provide critical technologies and equipment to scientists in the MDU and it is crucial its success. Because metabolic disease affects the entire body, it is vital to study these diseases whole animals. Our model of choice is the mouse. The Disease Model Core provides facilities for the measurement of the amount of fat and muscle in an animal’s body, how much and what type of food is eaten, and how much energy is burnt, through either metabolism, heat production, or exercise. It also provides facilities for examining isolated cells, tissues and organs. At the other end of the size spectrum, the Genomics/Transcriptomics Core enables scientists to study the sub-microscopic world of genes and how they function and are turned into proteins and the Core Biochemistry Assay Lab measures hormones and other molecules in blood.

Technical Summary

This programme provides the core facilities and technologies that act as vital supporting infrastructure, not only for MDU Programmes 1-4 but also for the other investigators across the MRL. At the heart of this programme are the Disease Model Core (DMC), the Genomics and Transcriptomics Core (GTC) and the Biochemistry Assay Lab (CBAL).

The DMC integrates two major platforms, physiology and histology, and provides a full range of support services to maximise scientific output from in vivo model systems. These include Home Office licensing support, cutting-edge in vivo phenotyping techniques, ex vivo tissue analysis, statistical analysis and data interpretation. The GTC provides access to high-throughput sequencing technologies, RNA quantification and ‘Sanger’ DNA sequencing as well as bioinformatics support. CBAL runs alongside the Clinical Biochemistry Lab of the Cambridge NIHR Cambridge Biomedical Research Centre and offers biochemical and immunoassay analyses (mainly rodent plasma and serum) to members of the MDU and IMS-MRL.

While the DMC and GTC are the primary facilities within Programme 5, a number of other key technologies, which receive the majority of their funding from other sources (Wellcome Trust and NIHR BRC), also provide critical support to MDU scientists. These are Microscopy and Imaging, Metabolomics/Lipidomics, Proteomics and the Genome Engineering Core. We seek to build on the success of these cores facilities and strengthen key areas where there is pressing, multi-user need.

Publications

10 25 50
 
Description Barcelona, Spain. 05th -07th June 2019. Cardiovascular and Metabolic diseases Expert Selection Committee - La Caixa Foundation
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Barcelona, Spain. 05th -07th June 2019. Cardiovascular and Metabolic diseases Expert Selection Committee - La Caixa Foundation Interview of candidates awards CAIXA
URL https://obrasociallacaixa.org/en/investigacion-y-becas/convocatorias-de-investigacion/convocatoria-d...
 
Description Barcelona, Spain. 27th November 2019. External Scientific Council meeting, Institut D'investigacions Blomediques Agust PI Sunyer (IDIBAPS)
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Barcelona, Spain. 27th November 2019. External Scientific Council meeting, Institut D'investigacions Blomediques Agust PI Sunyer (IDIBAPS) Defined strategic plan and funding allocation priorities at IDIBAPS research centre
URL https://www.clinicbarcelona.org/en/idibaps/about-us/governing-bodies/idibaps
 
Description Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2.
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact 4. Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. Chair Panel selecting awardees ERC starting grant. Decision of science and work force
 
Description London, UK. 13th November 2019. Medical Research Council Leaders Conference 2019
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact London, UK. 13th November 2019. Medical Research Council Leaders Conference 2019 Meeting for dissemination of MRC strategic plans and advisory
 
Description Madrid, Spain. 20th-21 November 2019 SAB Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact SAB Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) Strategic advice and funding allocation prioritisation
URL https://www.ciberobn.es/
 
Description Valencia, Spain. 28th-29th November 2019. Instituto de Investigacion Sanitaria (INCLIVA)
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact 2. Valencia, Spain. 28th-29th November 2019. Instituto de Investigacion Sanitaria (INCLIVA) Defined strategic plan and budget allocation of activities of INCLIVA research centre
URL https://www.incliva.es/comite-cientifico-externo
 
Description • International Scientific Advisory Board Danish Academy of Diabetes (2018-)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact • International Scientific Advisory Board Danish Academy of Diabetes (2018-) Advice on training and research priorities.
URL https://www.danishdiabetesacademy.dk/news/dda-appoints-strong-new-international-advisory-board
 
Description Academy of Medical Sciences Clinical Lecturer Starter Grant (30,000)
Amount £30,000 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description CM, ASSOCIATION OF PHYSICIANS OF GB & IRELAND
Amount £19,996 (GBP)
Organisation Association of Physicians of Great Britain and Ireland 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 03/2022
 
Description Cellular mechanisms of metabolic sensing by human hypothalamic neurons
Amount £1,212,840 (GBP)
Funding ID 211221/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 08/2023
 
Description Characterisation of oligodendrocyte plasticity in the adult median eminence and its role in the regulation of energy balance
Amount £520,614 (GBP)
Funding ID MR/S011552/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 03/2022
 
Description Chewing the fat: gestational weight gain, getational diabetes
Amount £804,191 (GBP)
Funding ID 17/0005712 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2020 
End 02/2022
 
Description Consequences of targeted SNORD116 deletion...
Amount £46,958 (GBP)
Organisation Foundation for Prader-Willi Research (FPWR) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2019
 
Description Disorders of thyroid hormone action:
Amount £1,601,656 (GBP)
Funding ID 210775/z/18/z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2018 
End 07/2023
 
Description ER, BRITISH SOCIETY FOR NEUROENDOCRINOLOGY
Amount £2,120 (GBP)
Organisation British Society for Neuroendocrinology 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
End 08/2019
 
Description Exploring sex specific programming ...
Amount £43,656 (GBP)
Organisation European Association for the Study of Diabetes (EASD) 
Department European Foundation for the Study of Diabetes (EFSD)
Sector Academic/University
Country Germany
Start 09/2018 
End 04/2019
 
Description Exposure to maternal obesity ...
Amount £27,839 (GBP)
Organisation University of Cambridge 
Department Isaac Newton Trust
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 08/2018
 
Description FM, SILICON VALLEY COMMUNITY FOUNDATION
Amount £1,937,983 (GBP)
Organisation Silicon Valley Community Foundation 
Sector Charity/Non Profit
Country United States
Start 12/2018 
End 11/2023
 
Description FR, Medimmune
Amount £60,000 (GBP)
Organisation MedImmune Ltd 
Sector Private
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Insights into metabolic health and disease from human genetic variants with major functional impact
Amount £1,894,039 (GBP)
Funding ID 214274/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2019 
End 02/2024
 
Description Jo Lewis, BSN symposium support for Physiology 2019, Aberdeen, UK
Amount £2,000 (GBP)
Organisation British Society for Neuroendocrinology 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2019
 
Description Jo Lewis, BSN symposium support for the ECR day at the BSN's annual conference, Glasgow, UK
Amount £5,000 (GBP)
Organisation British Society for Neuroendocrinology 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2019
 
Description Jo Lewis, The Physiological Society satellite support for Physiology 2019, Aberdeen, UK
Amount £20,000 (GBP)
Organisation Physiological Society 
Sector Charity/Non Profit
Country Global
Start 08/2019 
End 08/2019
 
Description Jo Lewis, The Physiological Society symposium support for Experimental Biology, Orlando,
Amount £2,000 (GBP)
Organisation Physiological Society 
Sector Charity/Non Profit
Country Global
Start 06/2019 
End 06/2019
 
Description Litmus IMI
Amount € 16,000,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2018 
End 12/2022
 
Description Mapping the human hypothalamic functional architecture underlying food intake control
Amount £625,065 (GBP)
Funding ID BB/S017593/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2019 
End 06/2022
 
Description Mason Medical Research Grant (15,000)
Amount £15,000 (GBP)
Organisation Mason Medical Research Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description Molecular characterization in human neurons of genes associated with severe obesity identified from consanguineous pedigrees.
Amount £1,014,003 (GBP)
Funding ID MR/S026193/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2022
 
Description Molecular mechanisms of impaired glucose transport in insulin resistance
Amount £1,252,723 (GBP)
Funding ID MR/S007091/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2019 
End 05/2024
 
Description NOVO NORDISK UK RESEARCH FOUNDATION
Amount £12,000 (GBP)
Organisation Novo Nordisk Foundation 
Sector Charity/Non Profit
Country Denmark
Start 08/2018 
End 01/2020
 
Description NS, wellcome senior fellowship
Amount £1,758,388 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2020 
End 03/2025
 
Description RH, UNIVERSITY OF EAST ANGLIA (FB NIHR)
Amount £53,253 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2021
 
Description Role of monocyte metabolism and signaling in NASH
Amount £30,000 (GBP)
Funding ID SGL018\1039 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2018 
End 02/2020
 
Description SF, Evelyn trust
Amount £10,000 (GBP)
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2019 
End 07/2021
 
Description Targeting macrophage lipid metabolism to dissociate obesity from cardiovascular risk (renewal)
Amount £1,245,413 (GBP)
Funding ID RG/18/7/33636 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2018 
End 05/2023
 
Description The Genetic Basis of Congenital Hypothyroidism
Amount £214,297 (GBP)
Funding ID 100585/Z/12/A 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2018 
End 10/2019
 
Description Wellcome PhD studentship to Elisabeth O'Flaherty
Amount £180,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2019 
End 09/2022
 
Description Wellcome PhD studentship to Emily Miedzybrodzka
Amount £180,824 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Wellcome Trust Major Award
Amount £5,044,481 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2023
 
Description closed loop insulin delivery in adults with type 2 diabetes
Amount £11,976 (GBP)
Organisation Novo Nordisk 
Sector Private
Country Denmark
Start 08/2018 
End 01/2020
 
Description cm, BMA FOUNDATION FOR MEDICAL RESEARCH
Amount £28,000 (GBP)
Organisation British Medical Association (BMA) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2019 
End 08/2022
 
Description cm, NOVO NORDISK FONDEN
Amount £573,325 (GBP)
Organisation Novo Nordisk Foundation 
Sector Charity/Non Profit
Country Denmark
Start 11/2019 
End 10/2024
 
Description fm, SILICON VALLEY COMMUNITY FOUNDATION 1
Amount £3,968 (GBP)
Organisation Silicon Valley Community Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2019 
End 10/2020
 
Description gy, NOVO NORDISK A/S
Amount £56,700 (GBP)
Organisation Novo Nordisk 
Sector Private
Country Denmark
Start 10/2019 
End 09/2023
 
Description human cellular models of hypothalamic metabolic sensing...
Amount £1,212,840 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 08/2023
 
Description hypoglycaemia: redefining solutions
Amount £565,666 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2018 
End 04/2022
 
Description me, NOVO NORDISK A/S
Amount £133,762 (GBP)
Organisation Novo Holdings A/S 
Sector Private
Country Denmark
Start 10/2019 
End 09/2022
 
Description ns, BRITISH THYROID FOUNDATION
Amount £20,000 (GBP)
Organisation British Thyroid Foundation (BTF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
End 06/2020
 
Description resloving uncertainties in diagnosis and management of thyroid hormone...
Amount £10,000 (GBP)
Organisation Society for Endocrinology 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2018 
End 01/2019
 
Description rh, MANCHESTER UNIVERSITY NHS FOUNDATION TRUST (FB NOVO NORDISK LTD)
Amount £20,190 (GBP)
Organisation Novo Nordisk 
Sector Private
Country Denmark
Start 06/2019 
End 05/2022
 
Description targetting macrophage lipid metabolism
Amount £1,255,413 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2018 
End 05/2023
 
Description tvp, az
Amount £86,956 (GBP)
Organisation AstraZeneca 
Sector Private
Country United Kingdom
Start 06/2019 
End 10/2022
 
Title Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state 
Description Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state This is an improvement in the methodology that allows us to study insulin sensitivity without radioactivity in animals that are not sedated and recapitulate more physiological conditions. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2018 
Provided To Others? Yes  
Impact Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice. Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB. Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. Epub 2018 May 16. 
URL https://www.ncbi.nlm.nih.gov/pubmed/29789270
 
Title FM, quantitative mass spectoscopy for analysing neuropeptide production 
Description We used liquid chromatography tandem mass spectroscopy (LC-MS/MS) to develop quantitative methods to analyse neuropeptide production in cultured human cells and in primary human brain samples. This consists of both standard curved made with sythetic human peptides, and synthetic peptides generated to incorporate stable heavy isotopes, which are spiked into samples during preparation. This enables very accurate and sensitive quantification of peptides, and assessment of relative quantities of different peptides of interests. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2018 
Provided To Others? Yes  
Impact This method enabled us to examine the relative production of POMC-derived peptides in both human cellular culture and in the primary brain. We found that alpha-MSH, which is the predominant MSH form studied, is produced at most lower levels than desacetyl alpha-MSH. Furthermore, we confirmed that beta-MSH, whose existence has been controversial, is indeed produced both in vivo and in vitro at similar quantities as desacetyl alpha-MSH. 
 
Title Gipr-Cre transgenic mouse 
Description GIPR-Cre mouse enabling identification and manipulation of cells expressing Gipr 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2016 
Provided To Others? Yes  
Impact Collaborations and publications. Research collaboration with Eli Lilly, investigating MOA of GLP1/GIP dual agonists (currently in phase 3 clinical trials) 
 
Title Guanylin-Venus transgenic mouse 
Description Guanylin-venus mouse, enabling identification and characterisation of cells expressing guanylin 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2019 
Provided To Others? Yes  
Impact Publication 
 
Title Insl5-rtTA mouse 
Description transgenic mouse Insl5-rtTA allowing identification and manipulation of INSL5-expressing cells 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? Yes  
Impact publications 
 
Title Metabolic phenotyping technology 
Description Systems of administration of lipids in vivo as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2019 
Provided To Others? Yes  
Impact Systems for controlled administration of lipids as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. Both approaches are very useful to investigate the effects and localisation of specific fatty acids in vivo as well as their routes of metabolisation. This allowed dynamic studies of fluxes of lipids. 
 
Title Rxfp4-Cre transgenic mouse 
Description Rxfp4-Cre transgenic mouse 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2015 
Provided To Others? No  
Impact BBSRC-iCASE studentship joint with AstraZeneca to investigate central signalling involving Rxfp4 
 
Title fm, database of neuropeptides in the human brain and in human stem cell-derived neurons 
Description We performed mass spectrometry on both human stem cell-derived hypothalamic neurons and on primary human brain samples. The resulting datasets, which are the first description of the peptides of the human hypothalamus, are freely available to the public via the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD008795 and 10.6019/PXD008795 (http://proteomecentral.proteomexchange.org). Is this research database or model published or available to others? * 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact These data describe the sequence and relative abundance of human hypothalamic peptides, and revealed that beta-MSH is likely an important peptide for human appetite regulation. 
URL http://proteomecentral.proteomexchange.org
 
Description Acosta 
Organisation Mayo Clinic
Country United States 
Sector Charity/Non Profit 
PI Contribution Training provided to Acosta's group
Collaborator Contribution Analysis of patient samples
Impact None
Start Year 2018
 
Description Brubaker lab 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Mouse models and discussion
Collaborator Contribution Experimentation and project design
Impact Publication
Start Year 2015
 
Description Chiba University 
Organisation Chiba University
Country Japan 
Sector Academic/University 
PI Contribution Technology and animal models
Collaborator Contribution Salary support for postdoctoral fellow
Impact 1. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448. PMID: 31509948 Free PMC Article Similar articles Select item 26615883 2.Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. PMID: 26615883 Free PMC Article Similar articles Select item 26584636 3.Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.
Start Year 2018
 
Description G/R Bertie Goettgens, Single Cell RNAseq 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Experiments
Collaborator Contribution Experiments
Impact none yet
Start Year 2015
 
Description GIP receptor localisation and function 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution We generated a gipr knockin mouse, which has been shipped to Toronto
Collaborator Contribution Analysis of the genetically modified mouse in Toronto
Impact None to date
Start Year 2016
 
Description Gastrectomy clinicians 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Physiological studies on humans after gastrectomy plus in vitro analysis of tissue samples
Collaborator Contribution Identification of suitable patients
Impact Publications
Start Year 2015
 
Description Generation of organoids from transgenic models 
Organisation Royal Netherlands Academy of Arts and Sciences
Department Hubrecht Institute
Country Netherlands 
Sector Academic/University 
PI Contribution We provided tissue from transgenic mouse models
Collaborator Contribution Collaborators will generate organoids for use in their research programme
Impact None to date
Start Year 2016
 
Description Heisler. CNS appetite circuitry 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Transgenic mouse models
Collaborator Contribution Data analysis
Impact Publication
Start Year 2019
 
Description Holst perfused pancreas 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Ideas for experiments
Collaborator Contribution Perfused pancreas to test ideas developed in Cambridge
Impact Publication
Start Year 2015
 
Description LGC peptidomics 
Organisation LGC Ltd
Country Global 
Sector Private 
PI Contribution Supporting a BBSRC iCASE studentship
Collaborator Contribution Analysis and training
Impact One publication to date
Start Year 2017
 
Description Larraufie Paris lab 
Organisation French National Institute of Agricultural Research
Country France 
Sector Academic/University 
PI Contribution Experimentation
Collaborator Contribution Experimentation and project planning
Impact Publications
Start Year 2016
 
Description Lilly GIPR 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution Research in the field of central GIPR signalling
Collaborator Contribution Tool compounds and unpublished data
Impact None yet
Start Year 2018
 
Description Macrophage 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Academic/University 
PI Contribution Financial support for experiments and research expertise
Collaborator Contribution Research Expertise in worm models of immune disease
Impact Publciation under submission.
Start Year 2018
 
Description Medimmune BBSRC iCASE (Galvin) 
Organisation MedImmune
Department MedImmune Cambridge
Country United Kingdom 
Sector Private 
PI Contribution Supervision of PhD student
Collaborator Contribution Joint supervision of student, training, peptide synthesis
Impact None yet
Start Year 2016
 
Description Mercodia assay validation 
Organisation Mercodia AB
Country Sweden 
Sector Private 
PI Contribution Mass spec analysis to validate Mercodia's glucagon assay. Measurement of patient samples using glucagon and glicentin assays to establish the cause of assay cross reactivity
Collaborator Contribution Provision of assays and suggestions for protocol changes to remove cross-reactivity
Impact Mercodia published a white paper outlining the collaboration and how it has impacted on the use of the glucagon assay
Start Year 2018
 
Description Moffett. Trophoblast physiology 
Organisation University of Cambridge
Department Department of Pathology
Country United Kingdom 
Sector Academic/University 
PI Contribution Application of LC-MS/MS peptidomics to analysis of trophoblast organoids
Collaborator Contribution Development of trophoblast organoids
Impact Publication
Start Year 2018
 
Description NANJING/SUZHOU 
Organisation Model Animal Research Center (MARC) Nanjing
Country China 
Sector Academic/University 
PI Contribution Provide expertise in murine metabolic phenotyping
Collaborator Contribution Phenotyping of mice and PhD studentship
Impact N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing.
Start Year 2018
 
Description Rinaman, Fadool, Williams. Central GLP-1 signalling 
Organisation Florida State University
Country United States 
Sector Academic/University 
PI Contribution Provision of transgenic mouse models
Collaborator Contribution Dissection of CNS appetite circuitry
Impact multiple publications
Start Year 2013
 
Description SF, GPCR biology 
Organisation University of Montreal
Country Canada 
Sector Academic/University 
PI Contribution identifying human variants in MC4R associated with obesity and creating constructs to characterise the effects of human mutations in trafficking
Collaborator Contribution characterise the effects of human mutations in trafficking
Impact manuscript being prepared for submission
Start Year 2018
 
Description Ulster, transgenic mice 
Organisation Ulster University
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration involving transgenic mouse models generated in Cambridge, and shipped to Ulster
Collaborator Contribution Collaborators will work with the transgenic model
Impact None to date
Start Year 2016
 
Description Univerisdad de Barcelona- 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution Provide genetically modified murine models and technological support for phenotyping
Collaborator Contribution Specific knowledge in the analysis of CPT1 mutants. This is a very specific type of specialised knowledge that provides us with competitive advantage
Impact 1. P465L-PPAR? mutation confers partial resistance to the hypolipidaemic action of fibrates. Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. Epub 2018 Jun 27. PMID: 29790245 Free PMC Article Similar articles Select item 26584636 Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. PMID: 26584636 Free PMC Article Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article Trends Pharmacol Sci. 2013 Jun;34(6):347-55. doi: 10.1016/j.tips.2013.04.004. Epub 2013 May 3. Pharmacological strategies for targeting BAT thermogenesis. Whittle A1, Relat-Pardo J, Vidal-Puig A.
Start Year 2018
 
Description Valverde. PTP1B in GLP-1 secretion 
Organisation Autonomous University of Madrid
Country Spain 
Sector Academic/University 
PI Contribution Hosted visiting student and provided training
Collaborator Contribution Visiting student brought project
Impact Publication
Start Year 2017
 
Description Yuki Oka 
Organisation California Institute of Technology
Department Division of Biology and Biological Engineering (BBE)
Country United States 
Sector Academic/University 
PI Contribution Provision of mouse models
Collaborator Contribution Research contribution
Impact Nature publication
Start Year 2017
 
Description kidney Lipotoxicity 
Organisation Rey Juan Carlos University Hospital
Country Spain 
Sector Hospitals 
PI Contribution Provided animal models to study Kidney lipotoxicity
Collaborator Contribution Provided expertise in murine characterisation of kidney phenotypes.
Impact Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article 2.PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity. Corrales P, Vidal-Puig A, Medina-Gómez G. Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review. PMID: 30037087 Free PMC Article 3. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 F
Start Year 2019
 
Description Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming.

PhD programme related to the German Centre of Cancer where I serve as SAAB
Year(s) Of Engagement Activity 2019
URL https://ampro.helmholtz-muenchen.de/news-events/past-events/ampro-summer-school-2019/index.html
 
Description Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2.
This was an event where we selected the awardees of ERC starting grants
Year(s) Of Engagement Activity 2019
URL https://erc.europa.eu/document-category/evaluation-panels
 
Description 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London.

Key meeting to engage with industry.
Year(s) Of Engagement Activity 2020
URL http://www.global-engage.com/event/nash/
 
Description 2. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing.

Meeting and networking event with colleagues from Cambridge and Nanjing to develop collaborative network
Year(s) Of Engagement Activity 2019
 
Description 24th European Congress on Obesity (ECO 2017) Miguel Constancia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact https://www.ncbi.nlm.nih.gov/pubmed/28528328
Year(s) Of Engagement Activity 2017
URL https://easo.org/congress-proceedings/eco2017-porto-portugal/
 
Description 3x work experience students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 3 year 9 students from local schools each spent 1 week at the institute, shadowing scientists and other staff to gain understanding of lab work and the scientific process and various career options related to scientific research.
Year(s) Of Engagement Activity 2019
 
Description 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research"

Global forum related to Ageing from a socio scientific and multicultural perspective. Open to lay public and highly advertised.
Year(s) Of Engagement Activity 2019
URL https://www.longevityworldforum.com/tag/aging-2/
 
Description 6. Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease.

Conference at Keystone related to lipidomic analysis in the context of lipotoxicity
Year(s) Of Engagement Activity 2019
URL https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1595
 
Description 66th Annual Scientific Meeting Society for Reproductive Investigation, Paris 2019 - Miguel Constancia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Session on Fetal signals regulating placental function (Placental Satellite Meeting)
Year(s) Of Engagement Activity 2019
URL https://www.sri-online.org/UserFiles/2019%20AM/Program/AM19FinalProgram.pdf
 
Description AEA. Oral presentation at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research talk at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands.
Year(s) Of Engagement Activity 2019
 
Description AEA. Oral presentation at BSN Neuroendocrinology Celebrate Symposium for ECRs; Glasgow, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk at BSN Neuroendocrinology Celebrate Symposium for Early Career Researchers; Glasgow, UK
Year(s) Of Engagement Activity 2019
 
Description AEA. Oral presentation at Experimental Biology conference; Orlando, US. 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker at Experimental Biology conference; Orlando, US. Networking
Year(s) Of Engagement Activity 2019
 
Description AEA. Oral presentation to Eli Lilly; Indianapolis, US, 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Research presentation to Eli Lilly.
Year(s) Of Engagement Activity 2019
 
Description AEA. Poster at EASD Incretin Study Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact AEA Poster at Incretin Study Group "The role of glucose-dependent insulinotropic polypeptide receptor-expressing neurons in the hypothalamus"
Year(s) Of Engagement Activity 2019
 
Description AEA. Poster at NovoNordisk Foundation Metabolism in Action conference; Copenhagen, Denmark 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation at Novonordisk Foundation Metabolism in Action conference; Copenhagen, Denmark. Sparked debate.
Year(s) Of Engagement Activity 2019
 
Description AK, Einstein's Garden at the Green Man Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Took part in Einsteins Garden at the Green Man Festival. Developed an hands-on activity showing the power of nutritional biomarkers and, over 4 days of the festival, spoke to hundreds of people ab.
Year(s) Of Engagement Activity 2018
URL https://www.greenman.net/news/discover-whats-landing-in-einsteins-garden/
 
Description AK, LifeLab Peterborough 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Took part in organised public engagement event invilving using the 'Fortune telling molecules' activity to explain nutritional biomarkers.
Year(s) Of Engagement Activity 2018
URL https://www.camlifelab.co.uk/peterborough
 
Description Advances at the interface between Metabolism and Epigenetics, Cambridge UK, 2019 (Miguel Constancia -co-organiser) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The intended purpose was to gather a number of world-leaders to discuss the latest developments in metabolism and epigenetics, from cellular metabolism, to normal physiology and disease
Year(s) Of Engagement Activity 2019
URL http://www.metabolism.cam.ac.uk/advances-at-the-interface-between-metabolism-and-epigenetics/
 
Description Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia. This was a conference organised by Biochemical Society where I gave the closing lecture as part of being awardee of the Sir Philip Randle Lecture, Biochemical Society
Year(s) Of Engagement Activity 2019
URL https://biochemistry.org/grants-and-awards/awards/the-sir-philip-randle-lecture/
 
Description CAS. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact CAS. Poster at EASD incretin study group: "Tracking the development and release of hormone-containing vesicles in murine L-cells"
Year(s) Of Engagement Activity 2019
 
Description CM, Association of Clinical Biochemistry NICE guideline advisory group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact aimed to increase awareness of the need for appropriate biochemistry input into clinical care guidelines
Year(s) Of Engagement Activity 2018
 
Description CM, Association of Clinical Pathologists Vice chair biochemistry panel 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Encouraged increased biochemistry input into curricula
Year(s) Of Engagement Activity 2018
 
Description CM, Experiences of a chief investigator in CRN Eastern 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact presentation +Q&A session at regional meeting
Year(s) Of Engagement Activity 2018
 
Description CM, Gestational diabetes - update at CRN Eastern Reproductive Health symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Increase awareness of clinical studies in reproductive health and metabolism
Year(s) Of Engagement Activity 2018
 
Description Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 10. Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease".

3 day conference organised by EMBO to discuss interorgan communication and its relevance in metabolic disease.
Year(s) Of Engagement Activity 2019
URL https://meetings.embo.org/event/19-organ-crosstalk
 
Description Cambridge Big Biology Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact participated in the 2019 Cambridge Big Biology Day at hills Rd 6th Form College. Ran hands on events based on unit research areas.
Also advised student on career choices related to life science
Year(s) Of Engagement Activity 2019
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Developed and staged display related to metabolism at the 'Family Weekend' sessions for the Cambridge Science Festival (4 days in total, 1 weekend in the Centre of Cambridge + following weekend at the Cambridge Biomedical Campus). ~ 25 members of the institute volunteered their time.
Year(s) Of Engagement Activity 2018
 
Description Cambridge big weekend 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The institute ran a display at the Cambridge Big Weekend as part of the University 'Fun Lab' Tent. Involved 7 volunteers from the institute. The audience/participants were mainly local families and adults. The impression was that the event attracted a visitors with broader demographic profile that at the Cambridge Science Festival.
Year(s) Of Engagement Activity 2018
 
Description Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping

Training hands on to develop expertise in cardiometabolic phenotyping
Year(s) Of Engagement Activity 2019
URL https://www.eas-society.org/events/EventDetails.aspx?id=1211946
 
Description Cambridgeshire Girlguiding Girls in STEM event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Cambridgeshire Girlguiding Girls in STEM event
Year(s) Of Engagement Activity 2020
 
Description DG Poster at EASD study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact DG. Poster at Incretin Study Group: "Modelling human enteroendocrine cells using adult intestinal organoids"
Year(s) Of Engagement Activity 2019
 
Description DG. Poster at Copenhagen Biosciences Conference on Intestinal Organoids 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "Modelling hormone secretion in human enteroendocrine cells using adult intestinal organoids"
Year(s) Of Engagement Activity 2019
 
Description DS, Helmholtz Diabetes meeting, invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact invited speaker at prestigious international conference
Year(s) Of Engagement Activity 2019
 
Description DS, Keystone presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact invited speaker at influential scientific meeting
Year(s) Of Engagement Activity 2019
 
Description DS, NHS England review of Severe Insulin Resistance Service 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact VISIT BY POLYCYMAKERS TO secure ongoing support for specialist clinic
Year(s) Of Engagement Activity 2019
 
Description Doha, Qatar. 4th-6th December 2019 Anti-Doping Laboratory Qatar for the 7th Junior Symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact This activity was related to a PhD annual conference ree=lated to the course for women in Qatar as part of the programme coordinated by Univeristy College of London, Bristol and Groningen.
Year(s) Of Engagement Activity 2019
 
Description EB. Poster at Academic Foundation Programme and NIHR BRC and BTRU Trainee's Annual Research Day 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact "Localisation and characterisation of glucose-dependent insulinotropic polypeptide receptor (GIPR) expressing cells"
Year(s) Of Engagement Activity 2018
 
Description EM. Poster at Copenhagen Bioscience Conference on Intestinal Organoids 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EM Poster. "Using human duodenal organoids to study motilin production and secretion"
Year(s) Of Engagement Activity 2019
 
Description EM. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EM. Poster at EASD incretin study group. "The contribution of TRP channels to L-cell signalling"
Year(s) Of Engagement Activity 2019
 
Description ER, presentation to scientists from a different field 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Researcher invited talk at a conference on peptide processing, which gave the opportunity to present work in our canine model of obesity and stimulated discussion on how using non-laboratory model organisms has value in research.
Year(s) Of Engagement Activity 2018
URL https://www.grc.org/protein-processing-trafficking-and-secretion-conference/2018/
 
Description ER, BBC Futures article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A widely read 'long read' article on BBC Futures which sparked interest in how our and other work studying pets and production animals can inform the science of the human obesity epidemic.
Year(s) Of Engagement Activity 2019
URL http://www.bbc.com/future/story/20190109-what-we-can-learn-from-overweight-pets-about-human-obesity
 
Description ER, Continuing education to practicing vets 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk to medicine specialist vets and general practitioners at a leading US clinical veterinary conference on my research and how the findings impact on clinical management of overweight dogs.
Year(s) Of Engagement Activity 2018
 
Description ER, Dog obesity roadshows 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Taking our sample collection and recruitment drive to local and national dog shows generated not just samples but discussion about the importance of genetics in obesity with the dog owners attending.
Year(s) Of Engagement Activity 2018
URL http://nefra.co.uk/nefra-shows/
 
Description ER, Engagement with GOdogs study participants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact 800 dog owning members of the public have signed up to participate in our study and receive quarterly electronic newsletters detailing our findings and updates on new canine science.
Year(s) Of Engagement Activity 2018
URL http://www.GOdogs.org.uk
 
Description ER, Interview on BBC Radio Cambridgeshire about dogs, obesity and genetics  
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Following an interview on local radio about research into dog obesity genetics, callers responded with tales of their dogs' eating (mis)adventures and how this might be genetically related.
Year(s) Of Engagement Activity 2018
 
Description ER, Talk on obesity genetics to Kennel Club breeders' forum 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presenting our work on the genetics of obesity in dogs to Breed Health Coordinators at a Kennel Club Forum; attendees were particularly interested in how studying dogs can inform human focussed research.
Year(s) Of Engagement Activity 2018
URL https://www.thekennelclub.org.uk/events/
 
Description ER, careers talk at local school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact During this workshop for 16-18 year olds interested in becoming a vet we discussed the diverse careers that veterinary science can lead to and the practicalities of working as a vet.
Year(s) Of Engagement Activity 2019
URL http://www.hillsroad.ac.uk/
 
Description ER, public talk + Q&A at the Cambridge Science Festival by Eleanor Raffan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A talk on how dog breeding makes dog genetics special and feeds into their value for models of human disease prompted questions about obesity genetics, canine breeding ethics, brain development and other wide ranging topics.
Year(s) Of Engagement Activity 2018
URL http://www.sciencefestival.cam.ac.uk/woofing-it-do
 
Description EU Science event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact took part in an EU H2020-funded event at Ely Cathedral. Ran several activities based on unit research.
Year(s) Of Engagement Activity 2019
 
Description Epigenetics of metabolism, panel discusssion 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Panel discussion and Q&A session for members of the general public associated with an international conference entitled 'Epigenetics of metabolism' organised in Jan 2019. Panel members were speakers at the conference plus others with a non-typical approach. The event was compered by Giles Yeo and took place in a local café. The event was very popular with tickets oversubscribed in advance and a queue of hopeful people waiting for returns.
Questions from the audience prompted several interesting discussions.
Year(s) Of Engagement Activity 2019
 
Description FM, Participant in Roundtable discussion hosted by Nature magazine 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact A round-table discussion in front of an audience of over 100 professors, postdocs, editors, and policy makers debated the issues surrounding the safety and genetic stability of human stem cell-based research. The results will be published and disseminated via the web to reach a much larger audience.
Year(s) Of Engagement Activity 2018
 
Description FM, Primary school outreach activity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Visit to a local elementary school to discuss the neuroscience of hunger
Year(s) Of Engagement Activity 2019
 
Description FM, hosted student in the laboratory 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact the individual who visited the laboratory gained appreciation of a career in biology
Year(s) Of Engagement Activity 2019
 
Description FR. Poster at EASD incretin study group. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact FR poster at EASD study group: "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis"
Year(s) Of Engagement Activity 2019
 
Description FR. presentation at Danish Diabetes Academy Winter School for postdoctoral researchers, at Higuerõn Hotel in Malaga/Spain 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "Incretins along the gut-pancreas-brain axis".
Year(s) Of Engagement Activity 2019
 
Description FR: Mercodia Diagnostics, Uppsala. Invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Invited to talk to Mercodia about how our mass spec analysis methods complement their immunoassay development
Year(s) Of Engagement Activity 2019
 
Description GPR. Cambridge UGI cancer symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact "The post-gastrectomy patient, metabolic considerations"
Year(s) Of Engagement Activity 2018
 
Description Genetics Society 2019 JBS Haldane Award Lecture 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This lecture 'Is Obesity A Choice?' took place at the Royal Institution in London on November 1, 2019. There were 300 people in the audience. The lecture was recorded and uploaded onto the Royal Institution YouTube Channel, where it has (as of Feb 27, 2020) been viewed 26,088 times.
Year(s) Of Engagement Activity 2019
URL https://www.youtube.com/watch?v=88tWJ1p5d4o
 
Description II International Symposium on Biological Sciences, Ouro Preto, Brasil, 2017 (Miguel Constancia) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Simposium
Year(s) Of Engagement Activity 2017
URL https://ufop.br/eventos/ii-simposio-internacional-de-ciencias-biologicas
 
Description Interview on Scandinavian Talk Show 'Skavlan' 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was an interview on Scandinavia's largest talkshow 'Skavlan', which broadcasts to Sweden, Norway and Finland. Each episode has more than 2 million live viewers.
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=tqXccq2jLkc
 
Description JL. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact JL. Poster at EASD study group. "RXFP4, the cognate receptor for insulin-like peptide 5, alters food preference in mice"
Year(s) Of Engagement Activity 2019
 
Description MRL Science Slam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The presenters (a post doc and student together) won a prize for their presentation
Year(s) Of Engagement Activity 2018
 
Description MY Poster at Incretin Study Group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact MY poster at Incretin Study Group: "Amino acid sensing in K and L cells from mouse duodenal organoids"
Year(s) Of Engagement Activity 2019
 
Description MY. Oral presentation at Diabetes UK Annual Professional Conference 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Metformin alters glucose uptake and metabolism in intestinal cells
Year(s) Of Engagement Activity 2019
 
Description Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN)

This meeting brings all teh community of investigators on the field of obesity in Spain. It is an excellent place to identify talent.
Year(s) Of Engagement Activity 2019
URL https://www.ciberobn.es/en
 
Description Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact 9. Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology"

This was a high level scientific event organised by CSIC in Madrid attended predominantly by experts in endocrinology
Year(s) Of Engagement Activity 2019
URL https://eventos.uam.es/28633/detail/6th-symposium-on-biomedical-reserch-advances-and-perspectives-in...
 
Description Metabolism in Action Conference (Denmark) - Ionel Sandovici 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Type 2 diabetes and obesity are life threatening metabolic diseases reaching epidemic proportions. The molecular basis for these diseases is incompletely understood, but genetic and environmental variables, synergistically interact throughout our lifespan to modulate metabolism. Today, there is growing appreciation that aging-related alterations in metabolism can be attenuated by lifestyle intervention strategies. Thus, insight into specific genetic, epigenetic, and cellular mechanisms that modulate metabolism throughout the aging continuum may uncover novel therapeutic entry points to manage type 2 diabetes and prevent obesity.
Year(s) Of Engagement Activity 2017
URL https://cph-bioscience.com/en/events/metabolism-action-lifetime-influence-genes-environment
 
Description NS, British Endocrine Society invited lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A clinical presentation on central hypothyroidism attended by clinical thyroidologists
Year(s) Of Engagement Activity 2018
 
Description NS, British thyroid association research presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 75 thyroidologists attended a research presentation which sparked discussion and further collaborations
Year(s) Of Engagement Activity 2018
 
Description NS, European thyroid association research presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Thyroidologists attended a late breaking research presentation which sparked discussion and further collaborations
Year(s) Of Engagement Activity 2018
 
Description NS, European thyroid association research presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Thyroidologists attended a research presentation which sparked discussion
Year(s) Of Engagement Activity 2018
 
Description NS. European thyroid association invited lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact thyroidologists attended an invited lecture on whole exome sequencing which sparked discussion about uses and interpretation of this technology
Year(s) Of Engagement Activity 2018
 
Description Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 5. Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Meeting in Nanjing with faculty from Nanjing Medical School for collaborative research and networking
Year(s) Of Engagement Activity 2019
 
Description Neuronal Control of Metabolism symposium, 12th February 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact outline of role of GDF15 in control of food intake and how this knowledge may affect drug design in the future
Year(s) Of Engagement Activity 2020
 
Description OW. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact OW poster at EASD incretin study group: "Distribution of G protein coupled relaxin/insulin-like family peptide receptor-4 (RXFP4) expressing cells in the mouse brain"
Year(s) Of Engagement Activity 2019
 
Description PL. Talk at Incretin Study Group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact PL. Talk at Incretin Study Group. "Peptidomics to study enteroendocrine cells after bariatric surgery"
Year(s) Of Engagement Activity 2019
 
Description REF Poster at SymBLS 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients
Year(s) Of Engagement Activity 2019
 
Description REF. Poster at DMDG open meeting 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact "Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients"
Year(s) Of Engagement Activity 2019
 
Description REF. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact REF poster at EASD study group "A multiplex method for quantifying gut hormone peptides using Mass Spectrometry"
Year(s) Of Engagement Activity 2019
 
Description REF. Poster at REID Bioanalytical Forum 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Immunoassay vs Mass Spectrometry -Measuring insulin and insulin analogues in human plasma
Year(s) Of Engagement Activity 2019
 
Description RGK. American Society for Mass Spectrometry (ASMS) 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Waters user group meeting, presentation:
"LC-MS analysis of plasma from patients with insulin autoimmune syndrome"
Waters MS focused user meeting (Pharmaceutical track)
Outcome: Video of talk available on Waters website, video interview on Select Science website, as well as an in-lab video interview.
Year(s) Of Engagement Activity 2019
 
Description RGK. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster at EASD incretin study group: "Proglucagon peptide analysis - will the real peptide please stand up!"
Year(s) Of Engagement Activity 2019
 
Description RGK. Reid Bioanalytical Forum 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact "LC-MS analysis of plasma from patients with insulin autoimmune syndrome"
Meeting focussing on broad bioanalytical approaches for wide range of analytes
Outcome: Video interview by Bionalaysis zone, available on their website
Year(s) Of Engagement Activity 2019
 
Description RGK. Waters UK and Ireland Clinical User Meeting 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Waters UK and Ireland Clinical User Meeting 2019
"LCMS Analysis of Proinsulin Derived Peptides"
Waters meeting for users of MS systems in clinical environments
Year(s) Of Engagement Activity 2019
 
Description SF, genetics of thinness 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A press release related to a research publication concerning the genetics of thinness resulted in numerous TV, radio and newspaper articles at national and international level. press conference or response to a media enquiry/interview. Media coverage was used as a platform to start a widespread discussion around the genetic basis of thinness and, through this, a discussion into the genetic contribution to obesity
Year(s) Of Engagement Activity 2018
 
Description SG. Poster at EASD incretin study group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact SG. Poster at EASD study group. "Characterisation of novel gut-derived peptides in vivo and in vitro"
Year(s) Of Engagement Activity 2019
 
Description SO, British Heart Foundation supporters event and laboratory tour 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Briefly describe the activity, please include the intended purpose and any outcomes or impacts that have arisen from it if known. For example, "60 pupils attended for a school visit to the research organisation, which sparked questions and discussion afterwards, and the school reported increased interest in related subject areas." *
Event was for British Heart Foundation volunteers to observe what research is currently happening at the University of Cambridge Biomedical Campus. They were given lab tours from multiple labs (including ours) where we presented data from our research and engaged in hands-on activities.
Year(s) Of Engagement Activity 2018
 
Description SOR, Cambridge SCienec Festival talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Evening talk followed by a Q+A session as part of the Cambridge Science Festival. The event was ilmed and is available on our youtube channel.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=hiCE1FBbsv4&list=PLetI6tUdcINbTF8N3_5NGQnaglrK12RJg
 
Description SS, Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Researchre met with individual school students to talk about career opportunities in research
Year(s) Of Engagement Activity 2018
 
Description SV, Naked Scientist podcast, Aug 2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Naked Scientist podcast based on a press release/recent publication describing conversion of white to brown fat in mice.
Year(s) Of Engagement Activity 2018
 
Description SV, Reddit Ask me anything 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Researcher started a Reddit 'Ask me anything' thread based on a recent publication involving brown fat. The thread had 22K views in one week, answering 'good quality questions' for a couple of days and being, at one point the 3rd most popular topic
Year(s) Of Engagement Activity 2018
URL https://www.reddit.com/r/IAmA/comments/99c2w4/we_are_cambridge_university_scientists/
 
Description SV, Science News article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Study in mice suggests drug to turn fat 'brown' could help fight obesity
Article published by Science Daily based on a press release following publication of an study.
Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/11/181126123416.htm
 
Description SV, school visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Researcher visitited a local school to talk about his research as well as more generally about careers in scientific research
Year(s) Of Engagement Activity 2018
 
Description Science Slam 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Event associated with MRC Festival of Medical Research. An evening of lightening talks aimed at local adults was held in a room at a local pub. Scientists form the institute talked about their research in short (3-minute) presentations. Encouraged to use interesting props to help demonstrate ideas. Included a lively Q+A session.
Year(s) Of Engagement Activity 2018
 
Description Suffolk Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Suffolk Science Festival
Year(s) Of Engagement Activity 2020
 
Description TD. Poster at EASD study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact TD. Poster at EASD incretin study group. "Neutral amino acid transporter: SLC6a19- linking amino acid sensing to gut hormone secretion?"
Year(s) Of Engagement Activity 2019
 
Description VBL talk at Incretin 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact VBL talk at EASD Incretin Study group, "Adenosine triphosphate (ATP) is released from glucagon-like peptide 1 (GLP-1) secreting cells and signals to vagal afferent neurons"
Year(s) Of Engagement Activity 2019
 
Description VBL. Poster at Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact VBL presented a poster at a local Cambridge Neuroscience Association meeting at Robinson College on March 14th, 2019. It was called "Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience" and the poster title was "ATP is released from GLP-1 secreting enteroendocrine cells and signals to vagal afferent neruones". It was a valuable experience sharing our work on gut-brain signalling to the larger Cambridge neuroscience community.
Year(s) Of Engagement Activity 2019
 
Description Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly.

This was the annual meeting of the IMI Litmus where we are aiming to identify biomarkers of NASH. My group leads the preclinical programme and presented advances in cross species validation of biomarkers
Year(s) Of Engagement Activity 2019
URL https://litmus-project.eu/
 
Description brownies, 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact took activities based on unit research to a local brownie group. activities demonstrated by postdocs and PhD students
Year(s) Of Engagement Activity 2019
 
Description bury st edmunds sci fest 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact ran activities and events based on unit research at the Bury St Edmunds Science Festival
Year(s) Of Engagement Activity 2020
 
Description cambridge science festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact participation in Cambridge science festival family weekend events in central Cambridge and on the Addenbrookes campus (3 days in total). events aimed at 8-15 year olds.
Year(s) Of Engagement Activity 2019
 
Description fm, Participant in Neurodegeneration Challenge Network 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact As a award recipient, I interacted with about 150 students, postdocs, clinicians, funders, and patients interested in new paradigms in neurodegenerative disease research and open science.
Year(s) Of Engagement Activity 2019
 
Description fm, Participant in New York Stem Cell Investigator Programme  
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact As a award recipient, I interacted with about 150 students, postdocs, clinicians, funders, and patients interested in new paradigms in neurodegenerative disease research and open science.
Year(s) Of Engagement Activity 2019
 
Description https://en.wikipedia.org/wiki/Antonio_Vidal-Puig 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://en.wikipedia.org/wiki/Antonio_Vidal-Puig
Year(s) Of Engagement Activity 2020
URL https://en.wikipedia.org/wiki/Antonio_Vidal-Puig
 
Description ims schools visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact two full day visits to a local school with activities based on unit research designed for year 9 pupils. Students and postdocs volunteered to lead the activities.
Year(s) Of Engagement Activity 2019
 
Description innvited talk to Diabetes UK annual professional conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact able to share our data with colleagues and clinicians from across the UK
Year(s) Of Engagement Activity 2019
 
Description seminar to Institute of Metabolic Science in Aberdeen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact engaged with scientists in another centre of metabolic excellence to share ideas around common research interests
Year(s) Of Engagement Activity 2018
 
Description visit from Jersey school students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact hosted a 1-day visit from students and teachers from a school in Jersey. students and teachers attended lectures and spent time with our PhD students to learn about life as a PhD student in Cambridge
Year(s) Of Engagement Activity 2020