Enabling technologies
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
The Enabling Technologies programme consists of a number of core facilities that provide critical technologies and equipment to scientists in the MDU and it is crucial its success. Because metabolic disease affects the entire body, it is vital to study these diseases whole animals. Our model of choice is the mouse. The Disease Model Core provides facilities for the measurement of the amount of fat and muscle in an animal’s body, how much and what type of food is eaten, and how much energy is burnt, through either metabolism, heat production, or exercise. It also provides facilities for examining isolated cells, tissues and organs. At the other end of the size spectrum, the Genomics/Transcriptomics Core enables scientists to study the sub-microscopic world of genes and how they function and are turned into proteins and the Core Biochemistry Assay Lab measures hormones and other molecules in blood.
Technical Summary
This programme provides the core facilities and technologies that act as vital supporting infrastructure, not only for MDU Programmes 1-4 but also for the other investigators across the MRL. At the heart of this programme are the Disease Model Core (DMC), the Genomics and Transcriptomics Core (GTC) and the Biochemistry Assay Lab (CBAL).
The DMC integrates two major platforms, physiology and histology, and provides a full range of support services to maximise scientific output from in vivo model systems. These include Home Office licensing support, cutting-edge in vivo phenotyping techniques, ex vivo tissue analysis, statistical analysis and data interpretation. The GTC provides access to high-throughput sequencing technologies, RNA quantification and ‘Sanger’ DNA sequencing as well as bioinformatics support. CBAL runs alongside the Clinical Biochemistry Lab of the Cambridge NIHR Cambridge Biomedical Research Centre and offers biochemical and immunoassay analyses (mainly rodent plasma and serum) to members of the MDU and IMS-MRL.
While the DMC and GTC are the primary facilities within Programme 5, a number of other key technologies, which receive the majority of their funding from other sources (Wellcome Trust and NIHR BRC), also provide critical support to MDU scientists. These are Microscopy and Imaging, Metabolomics/Lipidomics, Proteomics and the Genome Engineering Core. We seek to build on the success of these cores facilities and strengthen key areas where there is pressing, multi-user need.
The DMC integrates two major platforms, physiology and histology, and provides a full range of support services to maximise scientific output from in vivo model systems. These include Home Office licensing support, cutting-edge in vivo phenotyping techniques, ex vivo tissue analysis, statistical analysis and data interpretation. The GTC provides access to high-throughput sequencing technologies, RNA quantification and ‘Sanger’ DNA sequencing as well as bioinformatics support. CBAL runs alongside the Clinical Biochemistry Lab of the Cambridge NIHR Cambridge Biomedical Research Centre and offers biochemical and immunoassay analyses (mainly rodent plasma and serum) to members of the MDU and IMS-MRL.
While the DMC and GTC are the primary facilities within Programme 5, a number of other key technologies, which receive the majority of their funding from other sources (Wellcome Trust and NIHR BRC), also provide critical support to MDU scientists. These are Microscopy and Imaging, Metabolomics/Lipidomics, Proteomics and the Genome Engineering Core. We seek to build on the success of these cores facilities and strengthen key areas where there is pressing, multi-user need.
Organisations
- University of Cambridge (Lead Research Organisation)
- California Institute of Technology (Collaboration)
- Heidelberg University (Collaboration)
- King Saud University (Collaboration)
- Chiba University (Collaboration)
- Uppsala University (Collaboration)
- Microsoft Research (Collaboration)
- Autonomous University of Madrid (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- AstraZeneca (Collaboration)
- Max Planck Society (Collaboration)
- UNIVERSITY OF ABERDEEN (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- Mayo Clinic (Collaboration)
- Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm, Paris, France (Collaboration)
- Florida State University (Collaboration)
- University of Montreal (Collaboration)
- Mercodia AB (Collaboration)
- Icahn School of Medicine at Mount Sinai (Collaboration)
- LGC Ltd (Collaboration)
- Addenbrooke's Hospital (Collaboration)
- Model Animal Research Center (MARC) Nanjing (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- University of Barcelona (Collaboration)
- Royal Netherlands Academy of Arts and Sciences (Collaboration)
- University of Copenhagen (Collaboration)
- University of Girona (Collaboration)
- Newcastle University (Collaboration)
- Rey Juan Carlos University Hospital (Collaboration)
- Nanjing University (NJU) (Collaboration)
- Centro de Investigacion Principe Felipe (Collaboration)
- British Heart Foundation (BHF) (Collaboration)
- Université Catholique de Louvain (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- University of California, Davis (Collaboration)
- Plasticell Ltd (Collaboration)
- ULSTER UNIVERSITY (Collaboration)
- Eli Lilly & Company Ltd (Collaboration)
- University of Toronto (Collaboration)
- VTT Technical Research Centre of Finland Ltd (Collaboration)
- European Commission (Collaboration)
Publications
Adriaenssens A
(2011)
Comprehensive Physiology
Adriaenssens AE
(2019)
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
in Cell metabolism
Adriaenssens AE
(2020)
The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system.
in Peptides
Aiken CE
(2019)
Early life environment influences the trajectory of post-partum weight loss in adult female rats.
in Reproductive biomedicine online
Ajjaji D
(2019)
Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.
in Molecular biology of the cell
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| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00014/1 | 31/03/2018 | 31/03/2024 | £2,995,583 | ||
| MC_UU_00014/2 | Transfer | MC_UU_00014/1 | 31/03/2018 | 31/03/2024 | £2,871,979 |
| MC_UU_00014/3 | Transfer | MC_UU_00014/2 | 31/03/2018 | 31/03/2024 | £1,667,444 |
| MC_UU_00014/4 | Transfer | MC_UU_00014/3 | 31/03/2018 | 31/03/2024 | £1,743,788 |
| MC_UU_00014/5 | Transfer | MC_UU_00014/4 | 31/03/2018 | 31/03/2024 | £3,355,490 |
| MC_UU_00014/6 | Transfer | MC_UU_00014/5 | 31/03/2018 | 31/03/2024 | £1,325,715 |
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| Sector | Public |
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| End | 04/2021 |
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| Amount | £625,065 (GBP) |
| Funding ID | BB/S017593/1 |
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| Sector | Public |
| Country | United Kingdom |
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| Amount | £15,000 (GBP) |
| Organisation | Mason Medical Research Foundation |
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| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
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| Sector | Public |
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| Sector | Public |
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| Country | United Kingdom |
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| End | 05/2023 |
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| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
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| End | 03/2027 |
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| Country | United Kingdom |
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| End | 12/2021 |
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| Country | United Kingdom |
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| End | 02/2020 |
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| Sector | Charity/Non Profit |
| Country | United Kingdom |
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| End | 07/2021 |
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| Funding ID | RG/18/7/33636 |
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| Sector | Charity/Non Profit |
| Country | United Kingdom |
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| Sector | Charity/Non Profit |
| Country | United Kingdom |
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| End | 07/2025 |
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| Amount | £214,297 (GBP) |
| Funding ID | 100585/Z/12/A |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 10/2019 |
| Description | Understanding and disrupting the link between obesity and metabolic disease |
| Amount | £1,944,579 (GBP) |
| Funding ID | 219417/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2025 |
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| Amount | £76,125 (GBP) |
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| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2020 |
| End | 12/2020 |
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| Amount | £180,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2022 |
| Description | Wellcome PhD studentship to Emily Miedzybrodzka |
| Amount | £180,824 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
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| End | 09/2021 |
| Description | Wellcome Trust Major Award |
| Amount | £5,044,481 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
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| End | 03/2023 |
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| Amount | £11,976 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 07/2018 |
| End | 01/2020 |
| Description | cm, BMA FOUNDATION FOR MEDICAL RESEARCH |
| Amount | £28,000 (GBP) |
| Organisation | British Medical Association (BMA) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 08/2022 |
| Description | cm, NOVO NORDISK FONDEN |
| Amount | £573,325 (GBP) |
| Organisation | Novo Nordisk Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 11/2019 |
| End | 10/2024 |
| Description | fm, NEW YORK STEM CELL FOUNDATION |
| Amount | £1,229,507 (GBP) |
| Organisation | New York Stem Cell Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2020 |
| End | 12/2024 |
| Description | fm, SILICON VALLEY COMMUNITY FOUNDATION 1 |
| Amount | £3,968 (GBP) |
| Organisation | Silicon Valley Community Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2019 |
| End | 10/2020 |
| Description | gy, NOVO NORDISK A/S |
| Amount | £56,700 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 09/2019 |
| End | 09/2023 |
| Description | human cellular models of hypothalamic metabolic sensing... |
| Amount | £1,212,840 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 08/2023 |
| Description | hypoglycaemia: redefining solutions |
| Amount | £565,666 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2018 |
| End | 04/2022 |
| Description | imterventions during obese pregnancy |
| Amount | £200,000 (GBP) |
| Organisation | Nutricia BV |
| Sector | Private |
| Country | Netherlands |
| Start | 04/2018 |
| End | 05/2019 |
| Description | me, NOVO NORDISK A/S |
| Amount | £133,762 (GBP) |
| Organisation | Novo Holdings A/S |
| Sector | Private |
| Country | Denmark |
| Start | 09/2019 |
| End | 09/2022 |
| Description | ns, BRITISH THYROID FOUNDATION |
| Amount | £20,000 (GBP) |
| Organisation | British Thyroid Foundation (BTF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 06/2020 |
| Description | resloving uncertainties in diagnosis and management of thyroid hormone... |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 01/2019 |
| Description | rh, MANCHESTER UNIVERSITY NHS FOUNDATION TRUST (FB NOVO NORDISK LTD) |
| Amount | £20,190 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 05/2019 |
| End | 05/2022 |
| Description | targetting macrophage lipid metabolism |
| Amount | £1,255,413 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 05/2023 |
| Description | tvp, az |
| Amount | £86,956 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 10/2022 |
| Title | Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state |
| Description | Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state This is an improvement in the methodology that allows us to study insulin sensitivity without radioactivity in animals that are not sedated and recapitulate more physiological conditions. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice. Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB. Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. Epub 2018 May 16. |
| URL | https://www.ncbi.nlm.nih.gov/pubmed/29789270 |
| Title | FM, quantitative mass spectoscopy for analysing neuropeptide production |
| Description | We used liquid chromatography tandem mass spectroscopy (LC-MS/MS) to develop quantitative methods to analyse neuropeptide production in cultured human cells and in primary human brain samples. This consists of both standard curved made with sythetic human peptides, and synthetic peptides generated to incorporate stable heavy isotopes, which are spiked into samples during preparation. This enables very accurate and sensitive quantification of peptides, and assessment of relative quantities of different peptides of interests. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This method enabled us to examine the relative production of POMC-derived peptides in both human cellular culture and in the primary brain. We found that alpha-MSH, which is the predominant MSH form studied, is produced at most lower levels than desacetyl alpha-MSH. Furthermore, we confirmed that beta-MSH, whose existence has been controversial, is indeed produced both in vivo and in vitro at similar quantities as desacetyl alpha-MSH. |
| Title | Gipr-Cre transgenic mouse |
| Description | GIPR-Cre mouse enabling identification and manipulation of cells expressing Gipr |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Collaborations and publications. Research collaboration with Eli Lilly, investigating MOA of GLP1/GIP dual agonists (currently in phase 3 clinical trials) |
| Title | Guanylin-Venus transgenic mouse |
| Description | Guanylin-venus mouse, enabling identification and characterisation of cells expressing guanylin |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Publication |
| Title | High-throughput single cell unbiased lipidomics assay in human iPSC-derived dopamine neurons (AK) |
| Description | The development of single cell lipidomics approaches to study the lipid metabolism of dopaminergic neurons in relation to parkinson's disease. Changes in lipid metabolism have been strongly associated with Parkinson's disease (PD). Lipids have the potential to be important biomarkers for PD, but the lack of appropriate tools to measure total lipids (lipidome) in human dopamine neurons has limited advances in this field. we have developed a novel unbiased and high-throughput single cell assay to determine total lipids. This will allow us to identify and validate lipid metabolites in dopamine neurons, which may serve as biomarkers for PD. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | project is ongoing |
| URL | https://www.michaeljfox.org/grant/measuring-lipids-ipsc-derived-dopamine-neurons-identify-parkinsons... |
| Title | Insl5-rtTA mouse |
| Description | transgenic mouse Insl5-rtTA allowing identification and manipulation of INSL5-expressing cells |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | publications |
| Title | Metabolic phenotyping technology |
| Description | Systems of administration of lipids in vivo as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Systems for controlled administration of lipids as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. Both approaches are very useful to investigate the effects and localisation of specific fatty acids in vivo as well as their routes of metabolisation. This allowed dynamic studies of fluxes of lipids. |
| Title | Rxfp4-Cre transgenic mouse |
| Description | Rxfp4-Cre transgenic mouse |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2015 |
| Provided To Others? | No |
| Impact | BBSRC-iCASE studentship joint with AstraZeneca to investigate central signalling involving Rxfp4 |
| Title | Stem cell protocol to differentiate BAT |
| Description | Stem cell protocol to differentiate BAT |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | This is a unique tool to differentiate in vitro human brown fat, overcoming a limited resource and providing a model for therapeutic developmenst |
| URL | https://pubmed.ncbi.nlm.nih.gov/33606988/ |
| Title | Tissue culture with low volume to prevent hypoxia |
| Description | Validation of hypoxia as a key factor preventing optimal tissue culture cell functionality. Use of small amount of volume to improve output |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Improvement quality of tissue culture cellular output |
| Title | bioinformatic pipeline for analysis of sequencing data from gene-edited cell lines (FM) |
| Description | CRISPR is a powerful way to edit stem cell clones, but identifying cell clones carrying desired edits remains challenging. To address this issue we developed GenEditID, a flexible, open-access platform for sample tracking, analysis and integration of multiplexed deep sequencing and proteomic data, and intuitive plate-based data visualisation to facilitate gene edited clone identification. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The impact of this work is not immediately clear, but our hope is that it will facilitate other groups and facilities to establish their own high-throughput gene editing workflows. |
| URL | https://www.biorxiv.org/content/10.1101/657650v1 |
| Title | human GLU-Venus |
| Description | Human ileal organoids expressing the fluorescent reporter Venus driven by the proglucagon promoter |
| Type Of Material | Cell line |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | requests for collaborations |
| Title | Alteration of the plasma peptidome of gastrectomised patients during an OGTT |
| Description | Performing gastric bypass surgery on patients severely changes their gut hormone response to glucose. The plasma concentrations of Insulin and a number of associated incretin peptides are significantly raised shortly after ingestion of glucose. Typically the plasma concentrations of these peptides are monitored using immunoassays. A simple and high throughput plasma peptidomics approach was used to simulatneously monitor a large number of these peptides. Comparison of gastresctomised and control individuals showed significant increases of insulin, glucagon gene products, PYY and neurotensin. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD016690 |
| Title | Characterization of Guca2a expressing cells in the mouse intestine |
| Description | RNA seq of Guca2a expressing cells |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | openly accessible data |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128117 |
| Title | Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells |
| Description | Analysis of vesicular colocalisation by 3D-SIM |
| Type Of Material | Data analysis technique |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open method |
| Title | Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state |
| Description | Background: Gastrointestinal hormones regulate intestinal transit, control digestion, influence appetite and promote satiety. Altered production or action of gut hormones, including glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and peptide YY (PYY), may contribute to the biological basis of obesity and altered glucose homeostasis. However, challenges in analytical methodology and lack of clarity on expected values for healthy individuals has limited progress in this field. The aim of this study was to describe expected concentrations of gastrointestinal and pancreatic hormones in healthy volunteers following a standardised meal test (SMT) or 75g oral glucose tolerance test (OGTT). Methods: 28 healthy volunteers (12 men, 16 women; mean age 31.3 years; mean body mass index 24.9 kg/m2) were recruited to attend a hospital clinic on two occasions. Volunteers had blood sampling in the fasting state and were given, in randomised order, an oral glucose tolerance test (OGTT) and standardised mixed liquid meal test with venepuncture at timed intervals for 4 hours after ingestion. Analytical methods for gut and pancreatic hormones were assessed and optimised. Concentrations of gut and pancreatic hormones were measured and used to compile ranges of expected values. Results: Ranges of expected values were created for glucose, insulin, glucagon, GLP-1, GIP, PYY and free fatty acids in response to a standardised mixed liquid meal or OGTT. Intact Proinsulin and C-peptide levels were also measured following the OGTT. Conclusions: These ranges of expected values can now be used to compare gut hormone concentrations between healthy individuals and patient groups. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Openly accessible dataset |
| URL | https://www.repository.cam.ac.uk/handle/1810/312528 |
| Title | Glucose-dependent Insulinotropic polypeptide receptor-expressing cells in the hypothalamus regulate food intake |
| Description | Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and antagonism are effective strategies for inhibiting weight gain. To enable identification and manipulation of Gipr-expressing (Gipr) cells we created GIPR-Cre knock-in mice. As GIPR-agonists have recently been reported to suppress food intake we aimed to identify central mediators of this effect. Gipr cells were identified in the arcuate, dorsomedial, and paraventricular nuclei of the hypothalamus, as confirmed by RNAscope in mouse and human. Single cell RNAseq identified clusters of hypothalamic Gipr cells exhibiting transcriptomic signatures for mural, glial and neuronal cells, the latter expressing somatostatin, but little proopiomelanocortin or agouti-related peptide. Activation of Gq-DREADDs in hypothalamic Gipr cells suppressed food intake in vivo, which was not obviously additive with concomitant GLP1R activation. These data identify hypothalamic GIPR as a target for the regulation of energy balance. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134726 |
| Title | Human embryonic genome activation initiates at the one-cell stage (Supplementary Tables) |
| Description | Tables showing differentially expressed genes in Human 2PN embryos vs MII Oocytes |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/331269 |
| Title | Human enteroendocrine cell transcriptomic profiling |
| Description | We purified two populations of human jejunal enteroendocrine cells (GLP1+ and GLP1-) by FACS and identified transcripts enriched in endocrine cell lineages. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114853 |
| Title | Human intestinal organoid cell transcriptomic profiling |
| Description | We purified two populations of human ileal enteroendocrine cells (Venus+ and Venus-) from mature differentiated hGLU-Venus organoids by FACS and identified transcripts enriched in endocrine cell lineages. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE148224 |
| Title | Mouse duodenal enteroendocrine transcriptome |
| Description | Using genetically modifed mice to express fluorescent reporter in proglucagon expressing cells (GluVenus) or in all enteroendocrine cells (NeuroD1), we purifed positive and negative cells by FACS from duodenal epithelial cells and identified transcripts enriched in positive populations |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open accessible dateset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114913 |
| Title | Peptidomic analysis of pancreatic neurodendocrine tumours (Glucagonoma) |
| Description | A peptidomic analysis of plasma from patients with well characterised pancreatic neuroendocrine tumours (PNET) was performed. A nano LC-MS analysis identified a number of peptides from the glucagon gene, which were idenfiried in a previous case study using multiple immunoassays. Peptides to other proteins involved in peptide secretion were also identified. Plasma from a second glucagonoma patient was analysed using a high flow approach, and this identified similar peptides to the nano analysis. In order to demonstrate the potential clinical application of LC-MS to characterising neuroendocrine tumours, a large cohort of plasma samples were analysed to demonstrate the ability of this approach to identify glucagonoma patients, and differentiate from a single insulinoma patient |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD008465 |
| Title | Peptidomics of sorted enteroendocrine cells from human organoids |
| Description | A human organoid culture system was set up to grow enteroendocrine cells with a venus labeled on the glucagon gene promoter sequence. This enabled the sorting of glucagon gene positive cells from negative cells, thereby enabling the enrichment of glucagon producing cells for study. Both Venus positive and venus negative cell populations were collected and their peptidome was assessed using nano LC-MS/MS |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | open data |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD017825 |
| Title | Peptidomics profiling of biopsies from the human jejunum before and after gastrectomy |
| Description | Profiling of the human jejunum peptidome before and after total gastrectomy. The study compares the peptidome of jejunum using intact mass spectrometry and database searching. These peptides included most gut hormones including proglucagon derived peptides, PYY, GIP, Motilin somatostatin and neurotensin amongst others. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD011498 |
| Title | Peptidomics profiling of human intestine |
| Description | The aim of the project is to generate a peptidomics map of gut hormone peptides along the gastrointestinal tract, starting with the stomach and including the duodenum, jejunum, ileum, ascending colon, sigmoid colon and rectum. The tissues would be collected after surgery and the peptide fraction extracted and anlysed by nano LC-MS to identify what peptide hormones are present. These data will then be used to compare against the human transcriptome, and also for comparison against equivent peptides from murine intestinal extracts. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD009788 |
| Title | Peptidomics profiling of murine intestine |
| Description | The aim of the project is to generate a peptidomics map of gut hormone peptides along the gastrointestinal tract, starting with the stomach and including the duodenum, jejunum, ileum, colon and rectum. The tissues would be collected after surgery and the peptide fraction extracted and anlysed by nano LC-MS to identify what peptide hormones are present. These data will then be used to compare against the murine transcriptome, and also for comparison against equivent peptides from human intestinal extracts. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD009796 |
| Title | Peptidomics profiling of the murine gut after vertical sleeve gastrectomy |
| Description | Profiling of the murine peptidome along the gastrointestinal tract and pancreas in vertical sleeve gastrectomy and sham operated mice. The study compares the peptidome of various portions of the GI tract using intact mass spectrometry and database searching. These peptides included most gut hormones including proglucagon derived peptides, PYY, GIP, somatostatin, neurotensin amongst others. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD011455 |
| Title | Research data supporting "Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty" |
| Description | Supplementary data supporting "Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty" |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/352960 |
| Title | Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice |
| Description | We report the different enteroendocrine populations in the large intestine in mice based on their transcriptomics profile. Hormone, receptor and transcription factors are analysed for differential expression between the different cell clusters to give a comprehensive view of the different characterisitcs of the distal entereondocrine cells |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137572 |
| Title | The effect on the transcriptome by inhibition of mitochondrial function by metformin in intestinal cells |
| Description | We purified mouse duodenal cells from organoids derived from two different transgenic mouse lines (GIP-Cre tdRFP, SST-Cre tdRFP), and identified transcripts enriched in metformin-treated cells. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE165122 |
| Title | Transcriptomics analysis of enteroendocrine cells after vertical sleeve gastrectomy |
| Description | We report here the transcriptome of sorted enteroendocrine cells from duodenum, ileum and colon from mice after vertical sleeve gastrectomy or sham operation, weight matched or not. We analyze the effect of region of origin and surgery and gene expression and found that only region of origin had an impact on EEC transcriptome |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121489 |
| Title | Transcriptomics analysis of human jejunal enteroendocrine cells after vertical sleeve gastrectomy |
| Description | We report here the transcriptome of a population enriched in enteroendocrine cells from human jejunum from patients before or after gastrectomy. We analyze the effect of surgery on gene expression and found very little effect on EEC transcriptome |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121486 |
| Title | fm, database of neuropeptides in the human brain and in human stem cell-derived neurons |
| Description | We performed mass spectrometry on both human stem cell-derived hypothalamic neurons and on primary human brain samples. The resulting datasets, which are the first description of the peptides of the human hypothalamus, are freely available to the public via the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD008795 and 10.6019/PXD008795 (http://proteomecentral.proteomexchange.org). Is this research database or model published or available to others? * |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | These data describe the sequence and relative abundance of human hypothalamic peptides, and revealed that beta-MSH is likely an important peptide for human appetite regulation. |
| URL | http://proteomecentral.proteomexchange.org |
| Description | Acosta |
| Organisation | Mayo Clinic |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Training provided to Acosta's group |
| Collaborator Contribution | Analysis of patient samples |
| Impact | None |
| Start Year | 2018 |
| Description | Ana Garcia nanoparticles |
| Organisation | Catholic University of Louvain |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | We are hosting a post doc in our group |
| Collaborator Contribution | Our partners are funding the project and provided the initial study design |
| Impact | Extension of the partnership from 1 year to 2 years |
| Start Year | 2020 |
| Description | BAT analysis |
| Organisation | Centro de Investigacion Principe Felipe |
| Country | Spain |
| Sector | Public |
| PI Contribution | Our group has developed the protocol fr human born fat development |
| Collaborator Contribution | Prof. Kathryn Lilley (Univ of Cambridge): Collaboration and use of the Proteomics Centre facilities to perform LOPT proteomic analyses on differentiating stem cell-derived brown adipocytes at different stages. Prof. Julio Saez-Rodriguez (Univ of Heidelberg): Development and use of integration methods (mainly COSMOSR) for the combined analysis of omic data. Dr. Maria Chondronikola (UC Davis): Contribution to prioritisation/validation of targets using transcriptomic and clinical data from obese women exposed to cold. Dr Stefania Carobbio (CIPF) experiments with White and brown differentiation Dr Francesco Napolitano, KAUST, Saudi Arabia, bioinformatic analysis for repositioning. Dr Davide Chiarugi, Max Plnk. Bioinformatics |
| Impact | This is a multidisciplinary collaboration combining cell biology and proteomics, bioinformatics |
| Start Year | 2021 |
| Description | BAT analysis |
| Organisation | Heidelberg University |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Our group has developed the protocol fr human born fat development |
| Collaborator Contribution | Prof. Kathryn Lilley (Univ of Cambridge): Collaboration and use of the Proteomics Centre facilities to perform LOPT proteomic analyses on differentiating stem cell-derived brown adipocytes at different stages. Prof. Julio Saez-Rodriguez (Univ of Heidelberg): Development and use of integration methods (mainly COSMOSR) for the combined analysis of omic data. Dr. Maria Chondronikola (UC Davis): Contribution to prioritisation/validation of targets using transcriptomic and clinical data from obese women exposed to cold. Dr Stefania Carobbio (CIPF) experiments with White and brown differentiation Dr Francesco Napolitano, KAUST, Saudi Arabia, bioinformatic analysis for repositioning. Dr Davide Chiarugi, Max Plnk. Bioinformatics |
| Impact | This is a multidisciplinary collaboration combining cell biology and proteomics, bioinformatics |
| Start Year | 2021 |
| Description | BAT analysis |
| Organisation | King Saud University |
| Country | Saudi Arabia |
| Sector | Academic/University |
| PI Contribution | Our group has developed the protocol fr human born fat development |
| Collaborator Contribution | Prof. Kathryn Lilley (Univ of Cambridge): Collaboration and use of the Proteomics Centre facilities to perform LOPT proteomic analyses on differentiating stem cell-derived brown adipocytes at different stages. Prof. Julio Saez-Rodriguez (Univ of Heidelberg): Development and use of integration methods (mainly COSMOSR) for the combined analysis of omic data. Dr. Maria Chondronikola (UC Davis): Contribution to prioritisation/validation of targets using transcriptomic and clinical data from obese women exposed to cold. Dr Stefania Carobbio (CIPF) experiments with White and brown differentiation Dr Francesco Napolitano, KAUST, Saudi Arabia, bioinformatic analysis for repositioning. Dr Davide Chiarugi, Max Plnk. Bioinformatics |
| Impact | This is a multidisciplinary collaboration combining cell biology and proteomics, bioinformatics |
| Start Year | 2021 |
| Description | BAT analysis |
| Organisation | Max Planck Society |
| Department | Max Planck Society Leipzig |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Our group has developed the protocol fr human born fat development |
| Collaborator Contribution | Prof. Kathryn Lilley (Univ of Cambridge): Collaboration and use of the Proteomics Centre facilities to perform LOPT proteomic analyses on differentiating stem cell-derived brown adipocytes at different stages. Prof. Julio Saez-Rodriguez (Univ of Heidelberg): Development and use of integration methods (mainly COSMOSR) for the combined analysis of omic data. Dr. Maria Chondronikola (UC Davis): Contribution to prioritisation/validation of targets using transcriptomic and clinical data from obese women exposed to cold. Dr Stefania Carobbio (CIPF) experiments with White and brown differentiation Dr Francesco Napolitano, KAUST, Saudi Arabia, bioinformatic analysis for repositioning. Dr Davide Chiarugi, Max Plnk. Bioinformatics |
| Impact | This is a multidisciplinary collaboration combining cell biology and proteomics, bioinformatics |
| Start Year | 2021 |
| Description | BAT analysis |
| Organisation | University of California, Davis |
| Department | UC Davis Genome Cente |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Our group has developed the protocol fr human born fat development |
| Collaborator Contribution | Prof. Kathryn Lilley (Univ of Cambridge): Collaboration and use of the Proteomics Centre facilities to perform LOPT proteomic analyses on differentiating stem cell-derived brown adipocytes at different stages. Prof. Julio Saez-Rodriguez (Univ of Heidelberg): Development and use of integration methods (mainly COSMOSR) for the combined analysis of omic data. Dr. Maria Chondronikola (UC Davis): Contribution to prioritisation/validation of targets using transcriptomic and clinical data from obese women exposed to cold. Dr Stefania Carobbio (CIPF) experiments with White and brown differentiation Dr Francesco Napolitano, KAUST, Saudi Arabia, bioinformatic analysis for repositioning. Dr Davide Chiarugi, Max Plnk. Bioinformatics |
| Impact | This is a multidisciplinary collaboration combining cell biology and proteomics, bioinformatics |
| Start Year | 2021 |
| Description | BAT analysis |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Our group has developed the protocol fr human born fat development |
| Collaborator Contribution | Prof. Kathryn Lilley (Univ of Cambridge): Collaboration and use of the Proteomics Centre facilities to perform LOPT proteomic analyses on differentiating stem cell-derived brown adipocytes at different stages. Prof. Julio Saez-Rodriguez (Univ of Heidelberg): Development and use of integration methods (mainly COSMOSR) for the combined analysis of omic data. Dr. Maria Chondronikola (UC Davis): Contribution to prioritisation/validation of targets using transcriptomic and clinical data from obese women exposed to cold. Dr Stefania Carobbio (CIPF) experiments with White and brown differentiation Dr Francesco Napolitano, KAUST, Saudi Arabia, bioinformatic analysis for repositioning. Dr Davide Chiarugi, Max Plnk. Bioinformatics |
| Impact | This is a multidisciplinary collaboration combining cell biology and proteomics, bioinformatics |
| Start Year | 2021 |
| Description | Brubaker lab |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Mouse models and discussion |
| Collaborator Contribution | Experimentation and project design |
| Impact | Publication |
| Start Year | 2015 |
| Description | Chiba University |
| Organisation | Chiba University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Technology and animal models |
| Collaborator Contribution | Salary support for postdoctoral fellow |
| Impact | 1. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448. PMID: 31509948 Free PMC Article Similar articles Select item 26615883 2.Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. PMID: 26615883 Free PMC Article Similar articles Select item 26584636 3.Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. Lee E, Korf H, Vidal-Puig A. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. |
| Start Year | 2018 |
| Description | Clinical Research |
| Organisation | University of Girona |
| Department | Faculty of Medicine |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Provision of candidate genes for subsequent validation in human studies |
| Collaborator Contribution | Access of adipose tissue bank |
| Impact | Lagathu, C., C. Christodoulides, C.Y. Tan, S. Virtue, M. Laudes, M. (7 authors) A. Vidal-Puig, Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond), 2010. 34(12): p. 1695-705. Rodriguez-Cuenca, S., S. Carobbio, V.R. Velagapudi, N. Barbarroja, J.M. Moreno-Navarrete,( 5 authors) A. Vidal-Puig, Peroxisome proliferator-activated receptor gamma-dependent regulation of lipolytic nodes and metabolic flexibility. Mol Cell Biol, 2012. 32(8): p. 1555-65 Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. Moreno-Navarrete JM, Escoté X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Frühbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernández-Real JM. A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia 2013 Nov;56(11):2524-37 Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] Napolitano A, Miller SR, Murgatroyd PR, Delafont B, Brooke A, Elkhawad M, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ. Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention. Clin Pharmacol Ther. 2012 Feb 15 Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6. Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM.Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. Diabetologia. 2015 Oct;58(10):2424-34. doi: 10.1007/s00125-015-3692-7. Epub 2015 Jul 23.PMID: 26201685 Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM. Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPAR? gene expression. J Mol Med (Berl). 2015 Jan;93(1):83-92. doi: 10.1007/s00109-014-1207-5. Epub 2014 Sep 25. PMID: 25249007 Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Select item 31918923 Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function. Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM.FASEB J. 2019 Aug;33(8):9656-9671. doi: 10.1096/fj.201900479R. Epub 2019 May 30. PMID: 31145872 Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis. Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Mol Metab. 2020 Jan;31:67-84. doi: 10.1016/j.molmet.2019.10.006. Epub 2019 Oct 31. PMID: 31918923 Free PMC Article Peroxisome Proliferator-Activated Receptor ?2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A. Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. Erratum in: Nat Med. 2018 Apr 10;24(4):525. PMID: 27270587 Free PMC Article Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Mol Metab. 2020 Jan;31:67-84. doi: 10.1016/j.molmet.2019.10.006. Epub 2019 Oct 31. PMID: 3191892 Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y.Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Nov;28(11):3022-3035. doi: 10.1038/s41418-021-00798-9. Epub 2021 Jun 5. PMID: 34091599 |
| Start Year | 2011 |
| Description | Collaboration with University Rey Juan carlos Madrid. |
| Organisation | Rey Juan Carlos University Hospital |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | Provided animal models to study Kidney lipotoxicity |
| Collaborator Contribution | Provided expertise in murine characterisation of kidney phenotypes. Provide expertise in murine metabolic phenotyping |
| Impact | 1 Obesity and pregnancy, the perfect metabolic storm. Corrales P, Vidal-Puig A, Medina-Gómez G. Eur J Clin Nutr. 2021 Dec;75(12):1723-1734. doi: 10.1038/s41430-021-00914-5. Epub 2021 Apr 28. PMID: 33911209 Review. 2. Autocrine IGF2 programmes ß-cell plasticity under conditions of increased metabolic demand. Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M. Sci Rep. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID: 33833312 Free PMC article. 3. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. PLoS Genet. 2020 Oct 15;16(10):e1009069. doi: 10.1371/journal.pgen.1009069. eCollection 2020 Oct. PMID: 33057429 Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article 4.PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity. Corrales P, Vidal-Puig A, Medina-Gómez G. Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review. PMID: 30037087 Free PMC Article 5. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 F |
| Start Year | 2019 |
| Description | FAtty Liver |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP.Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 23. doi: 10.1097/HEP.0000000000000341. Online ahead of print. PMID: 36811413 Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešic M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. eCollection 2022 Sep 16. PMID: 36065182 Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | FAtty Liver |
| Organisation | European Commission |
| Department | Innovative Medicines Initiative (IMI) |
| Country | Belgium |
| Sector | Public |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP.Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 23. doi: 10.1097/HEP.0000000000000341. Online ahead of print. PMID: 36811413 Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešic M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. eCollection 2022 Sep 16. PMID: 36065182 Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | FAtty Liver |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP.Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 23. doi: 10.1097/HEP.0000000000000341. Online ahead of print. PMID: 36811413 Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešic M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. eCollection 2022 Sep 16. PMID: 36065182 Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | G/R Bertie Goettgens, Single Cell RNAseq |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments |
| Collaborator Contribution | Experiments |
| Impact | none yet |
| Start Year | 2015 |
| Description | GIP receptor localisation and function |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We generated a gipr knockin mouse, which has been shipped to Toronto |
| Collaborator Contribution | Analysis of the genetically modified mouse in Toronto |
| Impact | None to date |
| Start Year | 2016 |
| Description | Gastrectomy clinicians |
| Organisation | Addenbrooke's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Physiological studies on humans after gastrectomy plus in vitro analysis of tissue samples |
| Collaborator Contribution | Identification of suitable patients |
| Impact | Publications |
| Start Year | 2015 |
| Description | Generation of organoids from transgenic models |
| Organisation | Royal Netherlands Academy of Arts and Sciences |
| Department | Hubrecht Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We provided tissue from transgenic mouse models |
| Collaborator Contribution | Collaborators will generate organoids for use in their research programme |
| Impact | None to date |
| Start Year | 2016 |
| Description | Heisler. CNS appetite circuitry |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Transgenic mouse models |
| Collaborator Contribution | Data analysis |
| Impact | Publication |
| Start Year | 2019 |
| Description | Holst perfused pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Ideas for experiments |
| Collaborator Contribution | Perfused pancreas to test ideas developed in Cambridge |
| Impact | Publication |
| Start Year | 2015 |
| Description | Joint Unit CIPF-CAMBRIDGE Obesity and Metabolic Regulation |
| Organisation | Microsoft Research |
| Department | Microsoft Research Cambridge |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Genetic engineering of human pluripotent stem cells |
| Collaborator Contribution | Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Cite s |
| Impact | Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S.Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free article. 2 Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Honig F, Kamzolas I, Samuelson I, Long K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A.Unraveling the developmental roadmap toward human brown adipose tissue. Stem Cell Reports. 2021 Feb 6:S2213-6711(21)00043-6. doi: 10.1016/j.stemcr.2021.01.013. Online ahead of print. PMID: 33606988 Free article.enetic engineering of Cell |
| Start Year | 2017 |
| Description | LGC peptidomics |
| Organisation | LGC Ltd |
| Country | Global |
| Sector | Private |
| PI Contribution | Supporting a BBSRC iCASE studentship |
| Collaborator Contribution | Analysis and training |
| Impact | One publication to date |
| Start Year | 2017 |
| Description | Larraufie Paris lab |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Experimentation |
| Collaborator Contribution | Experimentation and project planning |
| Impact | Publications |
| Start Year | 2016 |
| Description | Lilly GIPR |
| Organisation | Eli Lilly & Company Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Research in the field of central GIPR signalling |
| Collaborator Contribution | Tool compounds and unpublished data |
| Impact | None yet |
| Start Year | 2018 |
| Description | Lipidomic analysis in the context of lipotoxicity |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have provided biological samples for lipidomic analysis and the intellectual background to justify this programme of research. |
| Collaborator Contribution | The lab of Prof Matej Oresic has performed lipidomic analysis in murine tissues from our genetically modified models. Our models have provided biological material for analytical platform development. Funding forthis experiments has been provided through collaborative FP6 Hepadip and FP7 Etherpath grants. Continued collaboration with Horizon 2020 Epoos and IMI Litmus |
| Impact | Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QMTranscriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi: 10.1126/scitranslmed.aba4448. PMID: 33268509 Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Elife. 2019 Aug 16;8:e47990. doi: 10.7554/eLife.47990. PMID: 31418690 Free PMC article. 2 Cite Share Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC article. 3 Cite Share Peroxisome Proliferator-Activated Receptor ?2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A. Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063. PMID: 30134163 Free PMC article. 4 Cite Share Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption. Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL. Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8. PMID: 29925420 Free PMC article. 5 Cite Share Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R. PMID: 3348419 Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article << First< PrevPage of 2Next >Last >> Select item 28683288 1.Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 Free PMC Article Similar articles Select item 28104532 2.Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases. Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review. PMID: 28104532 Similar articles Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. PMID: 23919961 Free PMC Article Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-PuigLipocalin prostaglandin D synthase and PPAR?2 coordinate to regulate carbohydrate and lipid metabolism in vivo.A.PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5. PMID: 22792179 Free PMC Article1. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice. Diabetes Jan 24, 2011. Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešic M. Association of lipidome remodelling in the adipocyte membrane with acquired obesity in humans. PLoS Biol June 7, 2011. 1.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 3. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE]Related citations Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešic M, Sethi JK, Vidal-Puig A.4.Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond). 2010 Jun 1. PMID: 20514047 [PubMed - as supplied by publisher] 5.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig .Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 [PubMed - in process]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 [PubMed - indexed for MEDLINE] . Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.8.Informatics and computational strategies for the study of lipids Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. PMID: 18213405 [PubMed - indexed for MEDLINE] Related citations 9.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 10.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M. BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 11.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PLoS Biol. 2006 Nov;4(11):e369. PMID: 17090215 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 12.Metabolomic approaches to phenotype characterization and applications to complex diseases. Oresic M, Vidal-Puig A, Hänninen V. Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 [PubMed - indexed for MEDLINE] Related citations 13.Pathways to the analysis of microarray data. Curtis RK, Oresic M, Vidal-Puig A. Trends Biotechnol. 2005 Aug;23(8):429-35. Review. PMID: 15950303 [PubMed - indexed for MEDLINE] Related citations 14.The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. 15.Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Diabetes. 2005 Jun;54(6):1706-16. PMID: 15919792 [PubMed - indexed for MEDLINE]Free Article Related citations |
| Description | Lipidomic analysis in the context of lipotoxicity |
| Organisation | VTT Technical Research Centre of Finland Ltd |
| Department | QBIX Group |
| Country | Finland |
| Sector | Private |
| PI Contribution | We have provided biological samples for lipidomic analysis and the intellectual background to justify this programme of research. |
| Collaborator Contribution | The lab of Prof Matej Oresic has performed lipidomic analysis in murine tissues from our genetically modified models. Our models have provided biological material for analytical platform development. Funding forthis experiments has been provided through collaborative FP6 Hepadip and FP7 Etherpath grants. Continued collaboration with Horizon 2020 Epoos and IMI Litmus |
| Impact | Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QMTranscriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi: 10.1126/scitranslmed.aba4448. PMID: 33268509 Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Elife. 2019 Aug 16;8:e47990. doi: 10.7554/eLife.47990. PMID: 31418690 Free PMC article. 2 Cite Share Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC article. 3 Cite Share Peroxisome Proliferator-Activated Receptor ?2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A. Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063. PMID: 30134163 Free PMC article. 4 Cite Share Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption. Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL. Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8. PMID: 29925420 Free PMC article. 5 Cite Share Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R. PMID: 3348419 Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article << First< PrevPage of 2Next >Last >> Select item 28683288 1.Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 Free PMC Article Similar articles Select item 28104532 2.Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases. Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review. PMID: 28104532 Similar articles Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. PMID: 23919961 Free PMC Article Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-PuigLipocalin prostaglandin D synthase and PPAR?2 coordinate to regulate carbohydrate and lipid metabolism in vivo.A.PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5. PMID: 22792179 Free PMC Article1. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice. Diabetes Jan 24, 2011. Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešic M. Association of lipidome remodelling in the adipocyte membrane with acquired obesity in humans. PLoS Biol June 7, 2011. 1.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 3. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE]Related citations Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešic M, Sethi JK, Vidal-Puig A.4.Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond). 2010 Jun 1. PMID: 20514047 [PubMed - as supplied by publisher] 5.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig .Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 [PubMed - in process]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 [PubMed - indexed for MEDLINE] . Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.8.Informatics and computational strategies for the study of lipids Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. PMID: 18213405 [PubMed - indexed for MEDLINE] Related citations 9.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 10.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M. BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 11.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PLoS Biol. 2006 Nov;4(11):e369. PMID: 17090215 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 12.Metabolomic approaches to phenotype characterization and applications to complex diseases. Oresic M, Vidal-Puig A, Hänninen V. Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 [PubMed - indexed for MEDLINE] Related citations 13.Pathways to the analysis of microarray data. Curtis RK, Oresic M, Vidal-Puig A. Trends Biotechnol. 2005 Aug;23(8):429-35. Review. PMID: 15950303 [PubMed - indexed for MEDLINE] Related citations 14.The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. 15.Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Diabetes. 2005 Jun;54(6):1706-16. PMID: 15919792 [PubMed - indexed for MEDLINE]Free Article Related citations |
| Description | Macrophage |
| Organisation | British Heart Foundation (BHF) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Financial support for experiments and research expertise |
| Collaborator Contribution | Research Expertise in worm models of immune disease |
| Impact | Publication under review 1. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575 2. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432 3. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599 4. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223 5. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266.doi: 10.1096/fj.202001101R. PMID:33484195 |
| Start Year | 2018 |
| Description | Macrophage |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Financial support for experiments and research expertise |
| Collaborator Contribution | Research Expertise in worm models of immune disease |
| Impact | Publication under review 1. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575 2. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432 3. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599 4. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223 5. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266.doi: 10.1096/fj.202001101R. PMID:33484195 |
| Start Year | 2018 |
| Description | Medimmune BBSRC iCASE (Galvin) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Supervision of PhD student |
| Collaborator Contribution | Joint supervision of student, training, peptide synthesis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Mercodia assay validation |
| Organisation | Mercodia AB |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Mass spec analysis to validate Mercodia's glucagon assay. Measurement of patient samples using glucagon and glicentin assays to establish the cause of assay cross reactivity |
| Collaborator Contribution | Provision of assays and suggestions for protocol changes to remove cross-reactivity |
| Impact | Mercodia published a white paper outlining the collaboration and how it has impacted on the use of the glucagon assay |
| Start Year | 2018 |
| Description | Moffett. Trophoblast physiology |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of LC-MS/MS peptidomics to analysis of trophoblast organoids |
| Collaborator Contribution | Development of trophoblast organoids |
| Impact | Publication |
| Start Year | 2018 |
| Description | NANJING/SUZHOU |
| Organisation | Model Animal Research Center (MARC) Nanjing |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | NANJING/SUZHOU |
| Organisation | Nanjing University (NJU) |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | New Tissue Culture system |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Establishment of a physiological culture system to improve translation in metabolic research |
| Collaborator Contribution | Daniel Fazakerley: Expertise in signalling Sam virtue: Expertise in Tissue culture Christian Frezza: Expertise in Metabolomics Research Interests |
| Impact | This is a multi collaborative collaboration to improve tissue culture and contributes to 3R |
| Start Year | 2021 |
| Description | Obesity uncoupling |
| Organisation | Icahn School of Medicine at Mount Sinai |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Stem cell work modelling human mutations |
| Collaborator Contribution | Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information. |
| Impact | Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for a postdoctoral fellowship 4) Publication: Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22. PMID: 33619380 |
| Start Year | 2016 |
| Description | Obesity uncoupling |
| Organisation | Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm, Paris, France |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Stem cell work modelling human mutations |
| Collaborator Contribution | Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information. |
| Impact | Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for a postdoctoral fellowship 4) Publication: Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22. PMID: 33619380 |
| Start Year | 2016 |
| Description | Obesity uncoupling |
| Organisation | Uppsala University |
| Department | Department of Medical Sciences |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Stem cell work modelling human mutations |
| Collaborator Contribution | Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information. |
| Impact | Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for a postdoctoral fellowship 4) Publication: Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22. PMID: 33619380 |
| Start Year | 2016 |
| Description | Plasticell: "In vivo activation of brown adipose tissue by plant-derived natural extracts", Innovation |
| Organisation | Plasticell Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Knowledge on mouse murine phenotyping |
| Collaborator Contribution | Technology in conbinatorial optimisation of Stem cell differentiation. |
| Impact | Multidisciplinary combining our unique expertise |
| Start Year | 2017 |
| Description | Rinaman, Fadool, Williams. Central GLP-1 signalling |
| Organisation | Florida State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mouse models |
| Collaborator Contribution | Dissection of CNS appetite circuitry |
| Impact | multiple publications |
| Start Year | 2013 |
| Description | SF, GPCR biology |
| Organisation | University of Montreal |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | identifying human variants in MC4R associated with obesity and creating constructs to characterise the effects of human mutations in trafficking |
| Collaborator Contribution | characterise the effects of human mutations in trafficking |
| Impact | manuscript being prepared for submission |
| Start Year | 2018 |
| Description | Ulster, transgenic mice |
| Organisation | Ulster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration involving transgenic mouse models generated in Cambridge, and shipped to Ulster |
| Collaborator Contribution | Collaborators will work with the transgenic model |
| Impact | None to date |
| Start Year | 2016 |
| Description | Univerisdad de Barcelona- |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Provide genetically modified murine models and technological support for phenotyping |
| Collaborator Contribution | Specific knowledge in the analysis of CPT1 mutants. This is a very specific type of specialised knowledge that provides us with competitive advantage |
| Impact | 1. Allostatic hypermetabolic response in PGC1a/ß heterozygote mouse despite mitochondrial defects. Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orešic M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puig A. FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR. PMID: 34369602 2. P465L-PPAR? mutation confers partial resistance to the hypolipidaemic action of fibrates. Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. Epub 2018 Jun 27. PMID: 29790245 Free PMC Article Similar articles Select item 26584636 Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. PMID: 26584636 Free PMC Article Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article Trends Pharmacol Sci. 2013 Jun;34(6):347-55. doi: 10.1016/j.tips.2013.04.004. Epub 2013 May 3. Pharmacological strategies for targeting BAT thermogenesis. Whittle A1, Relat-Pardo J, Vidal-Puig A. |
| Start Year | 2018 |
| Description | Valverde. PTP1B in GLP-1 secretion |
| Organisation | Autonomous University of Madrid |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Hosted visiting student and provided training |
| Collaborator Contribution | Visiting student brought project |
| Impact | Publication |
| Start Year | 2017 |
| Description | Yuki Oka |
| Organisation | California Institute of Technology |
| Department | Division of Biology and Biological Engineering (BBE) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of mouse models |
| Collaborator Contribution | Research contribution |
| Impact | Nature publication |
| Start Year | 2017 |
| Description | 'Battle of the sexes' begins in womb as father and mother's genes tussle over nutrition |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | December 2021 - article on Cambridge University Research website about research from the Constancia group (Developmental Cell - The Imprinted Igf2-Igf2r Axis is Critical for Matching Placental Microvasculature Expansion to Fetal Growth) |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.cam.ac.uk/research/news/battle-of-the-sexes-begins-in-womb-as-father-and-mothers-genes-t... |
| Description | 1. Abu Dhabi, United Arab Emirates. 17th November 2022. External Seminar at Department of Biomedical Engineering, Khalifa University. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 1. Abu Dhabi, United Arab Emirates. 17th November 2022. External Seminar at Department of Biomedical Engineering, Khalifa University. |
| Year(s) Of Engagement Activity | 2022 |
| Description | 1. Belgium. Virtual BMP lecture series. 4th November 2020. BMP signally in cancer session. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Webinar to experts on the BMP field. This was a very specialised meeting with experts is this very specific field. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bcp.fu-berlin.de/en/chemie/biochemie/research-groups/knaus-group/news/BMP-Forum-2020.htm... |
| Description | 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. Key meeting to engage with industry. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.global-engage.com/event/nash/ |
| Description | 1. Madrid, Spain (virtual). 11th November 2021. MOIR2 III Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 1. Madrid, Spain (virtual). 11th November 2021. MOIR2 III Symposium ( Mechanisms of obesity and INsulin resistance) |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.moir2.urjc.es/en/programa-cientifico-moir2.php |
| Description | 1. Toronto, Canada (virtual). 25th January 2022. University of Toronto - Adipose Biology Seminar Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 1. Toronto, Canada (virtual). 25th January 2022. University of Toronto - Adipose Biology Seminar Series |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://twitter.com/VeraPieters_/status/1485789669837230082/photo/1 |
| Description | 2. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Meeting and networking event with colleagues from Cambridge and Nanjing to develop collaborative network |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2. Helsingborg, Sweden. 5th September 2022. Keynote speaker at Lund University Diabetes Centre retreat 2022. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2. Helsingborg, Sweden. 5th September 2022. Keynote speaker at Lund University Diabetes Centre retreat 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | 2019: An educational video on diabetes from Senior Research Associate Sam Virtue |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2 019: An educational video on diabetes from Senior Research Associate Sam Virtue https://www.youtube.com/watch?v=YmgYhDHl55c&t=2s. https://www.youtube.com/watch?v=bYSXqTAJBOo&t=8s |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2019: An interview with PhD student Jennie Leggat on CBBC - |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 2019: An interview with PhD student Jennie Leggat on CBBC - https://www.bbc.co.uk/iplayer/episode/m000cgln/operation-ouch-series-8-15-food-poo-and-you |
| Year(s) Of Engagement Activity | 2019 |
| Description | 3. Colorado, USA. 7th-10th August 2022. Keystone Symposia on Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH)/ Adipose Tissue and Metabolic Health. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 3. Colorado, USA. 7th-10th August 2022. Keystone Symposia on Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH)/ Adipose Tissue and Metabolic Health. Advanced international meeting focused Adipose tissue biology and fatty liver. |
| Year(s) Of Engagement Activity | 2022 |
| Description | 3. Monterrey, Mexico. 8th-9th May 2023. Institute for Obesity Research, Tecnológico de Monterrey, annual congress. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Monterrey, Mexico. 8th-9th May 2023. Institute for Obesity Research, Tecnológico de Monterrey, annual congress. Talk about Healthy obesity |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://tecscience.tec.mx/en/health/an-obese-person-is-not-always-sick/ |
| Description | 3. Stockholm, Sweden. 19th-23rd September 2022. 58th EASD Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 3. Stockholm, Sweden. 19th-23rd September 2022. 58th EASD Annual Meeting TAlk about obesity-associated cardiometabolic complications. |
| Year(s) Of Engagement Activity | 2022 |
| Description | 3x work experience students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 3 year 9 students from local schools each spent 1 week at the institute, shadowing scientists and other staff to gain understanding of lab work and the scientific process and various career options related to scientific research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 4. Mexico (virtual). 27th July 2022. Online seminar - Alimentacion para la Salud" (www.alimentacionysalud.unam.mx) in conjunction with UNAM and Tec de Monterrey |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 4. Mexico (virtual). 27th July 2022. Online seminar - Alimentacion para la Salud" (www.alimentacionysalud.unam.mx) in conjunction with UNAM and Tec de Monterrey |
| Year(s) Of Engagement Activity | 2022 |
| Description | 4. Valencia, Spain. 14th-16th December 2022. Web-based Omics Data Analysis course in Cardiometabolic Diseases (WODA-CMD) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | 4. Valencia, Spain. 14th-16th December 2022. Web-based Omics Data Analysis course in Cardiometabolic Diseases (WODA-CMD) THis is a bioinformatics course sponsored by the European Atherosclerosis Society |
| Year(s) Of Engagement Activity | 2022 |
| Description | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-... |
| Description | 5. Cambridge (virtual), United Kingdom. 6th July 2021. Innovations for phenotyping for Obesity, Diabetes and Co-morbidities (supported by GemPharmatech) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 5. Cambridge (virtual), United Kingdom. 6th July 2021. Innovations for phenotyping for Obesity, Diabetes and Co-morbidities (supported by GemPharmatech |
| Year(s) Of Engagement Activity | 2021 |
| Description | 5. Kobe, Japan. 12th-14th May 2022. 65th Japanese Diabetes Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 5. Kobe, Japan. 12th-14th May 2022. 65th Japanese Diabetes Meeting |
| Year(s) Of Engagement Activity | 2022 |
| Description | 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" Global forum related to Ageing from a socio scientific and multicultural perspective. Open to lay public and highly advertised. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.longevityworldforum.com/tag/aging-2/ |
| Description | 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bighospitality.co.uk/News/Promotional-Features/California-Walnut-Culinary-Institute-of-A... |
| Description | 6. Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. Conference at Keystone related to lipidomic analysis in the context of lipotoxicity |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1595 |
| Description | 6. Singapore (virtual), 8th-10th March 2022. 10th international Singapore Lipid Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 6. Singapore (virtual), 8th-10th March 2022. 10th international Singapore Lipid Symposium. |
| Year(s) Of Engagement Activity | 2022 |
| Description | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bscr.org/event/bscr-autumn-meeting-2018-inflammation-and-repair/ |
| Description | 66th Annual Scientific Meeting Society for Reproductive Investigation, Paris 2019 - Miguel Constancia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Session on Fetal signals regulating placental function (Placental Satellite Meeting) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.sri-online.org/UserFiles/2019%20AM/Program/AM19FinalProgram.pdf |
| Description | 7th-10th June 2021. British Cardiovascular Society Annual Conference. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 7th-10th June 2021. British Cardiovascular Society Annual Conference. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.manchestercentral.co.uk/case-studies/BCS-virtual-conference |
| Description | AEA ADA talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Alice Adriaenssens ADA 2021: invited talk for 'New turf for the other incretin' Diabetes journal symposium Follow up = invitation to contribute opinion piece in Diabetes, Feature article in 'ADA Meeting News' |
| Year(s) Of Engagement Activity | 2021 |
| Description | AEA Ascona Gut-Brain Axis Meeting, Switzerland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ascona Gut-Brain Axis Meeting, Switzerland. Collaborations and networking |
| Year(s) Of Engagement Activity | 2022 |
| Description | AEA Helmholtz Diabetes Meeting, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Helmholtz Diabetes Meeting, Germany. Networking and prize |
| Year(s) Of Engagement Activity | 2022 |
| Description | AEA Incretin 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Good presentation. Interest in collaborations. Networking |
| Year(s) Of Engagement Activity | 2022 |
| Description | AEA Poster Presentation, Society for the Study of Ingestive Behaviour Annual Meeting, Portugal/Hybrid format |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster Presentation, Society for the Study of Ingestive Behaviour Annual Meeting, Portugal/Hybrid format. Networking and collaboration |
| Year(s) Of Engagement Activity | 2022 |
| Description | AEA SSIB talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | SSIB 2021: accepted talk Follow up = won Harry Kissileff prize for best talk, invitation to contribute to Appetite journal |
| Year(s) Of Engagement Activity | 2021 |
| Description | AEA. Oral presentation at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research talk at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation at BSN Neuroendocrinology Celebrate Symposium for ECRs; Glasgow, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at BSN Neuroendocrinology Celebrate Symposium for Early Career Researchers; Glasgow, UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation at Experimental Biology conference; Orlando, US. 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Experimental Biology conference; Orlando, US. Networking |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation to Eli Lilly; Indianapolis, US, 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Research presentation to Eli Lilly. |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Poster at EASD Incretin Study Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | AEA Poster at Incretin Study Group "The role of glucose-dependent insulinotropic polypeptide receptor-expressing neurons in the hypothalamus" |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Poster at NovoNordisk Foundation Metabolism in Action conference; Copenhagen, Denmark 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation at Novonordisk Foundation Metabolism in Action conference; Copenhagen, Denmark. Sparked debate. |
| Year(s) Of Engagement Activity | 2019 |
| Description | AK, Einstein's Garden at the Green Man Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Took part in Einsteins Garden at the Green Man Festival. Developed an hands-on activity showing the power of nutritional biomarkers and, over 4 days of the festival, spoke to hundreds of people ab. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.greenman.net/news/discover-whats-landing-in-einsteins-garden/ |
| Description | AK, LifeLab Peterborough |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Took part in organised public engagement event invilving using the 'Fortune telling molecules' activity to explain nutritional biomarkers. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.camlifelab.co.uk/peterborough |
| Description | Activities stall at the Suffolk Science Festival 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Four post-docs and students ran a family activities stall at the 2022 Suffolk Science Festival at the Ipswich Town Hall. |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://suffolksciencefestival.co.uk/whats-on/ |
| Description | Activity stalls at Community event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 7 staff and students ran 2 activity stalls with games based on our research as part of an outdoor family fun day run by the North Cambridge Community Partnership, a Community Group operating in the most deprived area of Cambridge. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.nccp.org.uk/events/?event_id1=2188 |
| Description | Advances at the interface between Metabolism and Epigenetics, Cambridge UK, 2019 (Miguel Constancia -co-organiser) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The intended purpose was to gather a number of world-leaders to discuss the latest developments in metabolism and epigenetics, from cellular metabolism, to normal physiology and disease |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.metabolism.cam.ac.uk/advances-at-the-interface-between-metabolism-and-epigenetics/ |
| Description | Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia. This was a conference organised by Biochemical Society where I gave the closing lecture as part of being awardee of the Sir Philip Randle Lecture, Biochemical Society |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://biochemistry.org/grants-and-awards/awards/the-sir-philip-randle-lecture/ |
| Description | Appearance on BBC1 Morning Live - GY |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | June 2021 appearance on BBC1s Morning Live show - Giles Yeo |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://twitter.com/bbcmorninglive/status/1404719504484151307 |
| Description | Are your genes to blame when your jeans don't fit? For Cam Alumni Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Giles Yeo gave this talk to around 250 university alumni and members of the public |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://sms.cam.ac.uk/collection/2851871 |
| Description | BAT in Granada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Interested in Brown Adipose Tissue? Can't miss this Symposium! https://finut-en.congressus.es/symposiumbat/index @ibsGRANADA @CIBER_OBN @TVPLab @FIBAO @CanalUGR @finutibero |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/ruizruizjonatan/status/1024216467729010688?s=12 |
| Description | BBC World Service CrowdScience |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | June 2021 - Giles Yeo was an expert on a programme called Why do I have such a sweet tooth? |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/sounds/play/w3ct1pqh |
| Description | BBSRC symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | RF poster: Mass spectrometry vs immunoassay SG poster: Identification and in vivo characterisation of novel gut-derived peptides |
| Year(s) Of Engagement Activity | 2020 |
| Description | Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.basellife.org/basel-life-2018.html |
| Description | Battle of the sexes begins in the womb - article in The Times |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dec 28 2021 - article in the Times based on Developmental Cell paper - The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth (Miguel Constancia group) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. PhD programme related to the German Centre of Cancer where I serve as SAAB |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://ampro.helmholtz-muenchen.de/news-events/past-events/ampro-summer-school-2019/index.html |
| Description | Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/CICbioGUNE |
| Description | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. Lecture related to the role of Brown fat in metabolism. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.evensi.us/adventures-metabolism-symposium-celebrate-jeffrey-flier-70th-birthday/25406324... |
| Description | Bradford Literarature Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo was in a panel discussion and audience Q+A on the topic of his book 'Calories Don't Count' |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bradfordlitfest.co.uk/event/giles-yeo-calories-dont-count/ |
| Description | Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. This was an event where we selected the awardees of ERC starting grants |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://erc.europa.eu/document-category/evaluation-panels |
| Description | CAA Incretin 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation. Networking |
| Year(s) Of Engagement Activity | 2022 |
| Description | CAS. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | CAS. Poster at EASD incretin study group: "Tracking the development and release of hormone-containing vesicles in murine L-cells" |
| Year(s) Of Engagement Activity | 2019 |
| Description | CM, Association of Clinical Biochemistry NICE guideline advisory group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | aimed to increase awareness of the need for appropriate biochemistry input into clinical care guidelines |
| Year(s) Of Engagement Activity | 2018 |
| Description | CM, Association of Clinical Pathologists Vice chair biochemistry panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Encouraged increased biochemistry input into curricula |
| Year(s) Of Engagement Activity | 2018 |
| Description | CM, Experiences of a chief investigator in CRN Eastern |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | presentation +Q&A session at regional meeting |
| Year(s) Of Engagement Activity | 2018 |
| Description | CM, Gestational diabetes - update at CRN Eastern Reproductive Health symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Increase awareness of clinical studies in reproductive health and metabolism |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 10. Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". 3 day conference organised by EMBO to discuss interorgan communication and its relevance in metabolic disease. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://meetings.embo.org/event/19-organ-crosstalk |
| Description | Cambridge (virtual), United Kingdom. 6th July 2021. Innovations for phenotyping for Obesity, Diabetes and Co-morbidities (supported by GemPharmatech Co.,Ltd). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 3. Cambridge (virtual), United Kingdom. 6th July 2021. Innovations for phenotyping for Obesity, Diabetes and Co-morbidities (supported by GemPharmatech Co.,Ltd). |
| Year(s) Of Engagement Activity | 2015,2021 |
| URL | https://www.mrl.ims.cam.ac.uk/innovations-in-phenotyping-for-obesity-diabetes-and-co-morbidities-pro... |
| Description | Cambridge AD HE+ Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | lecture by RF |
| Year(s) Of Engagement Activity | 2020 |
| Description | Cambridge Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | participated in the 2019 Cambridge Big Biology Day at hills Rd 6th Form College. Ran hands on events based on unit research areas. Also advised student on career choices related to life science |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge City Council holiday club EM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Science activities at Cambridge City Council drop-in holiday club for families |
| Year(s) Of Engagement Activity | 2021 |
| Description | Cambridge Festival 29th March 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk title: "How nutrition and growth in the womb influences our risk of type 2 diabetes" |
| Year(s) Of Engagement Activity | 2021 |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Cambridge Science Festival - covering all aspects of the world-leading research happening at Cambridge |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.tvplab-cambridge.com/post/diana-cambridge_festival-2021 |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Developed and staged display related to metabolism at the 'Family Weekend' sessions for the Cambridge Science Festival (4 days in total, 1 weekend in the Centre of Cambridge + following weekend at the Cambridge Biomedical Campus). ~ 25 members of the institute volunteered their time. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Science Festival - Ionel Sandovici |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Escape room: Research breakthrough! (9 April 2022, Nuns Way Pavillion, Cambridge) |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.festival.cam.ac.uk/ |
| Description | Cambridge University in Nanjing. Cambridge UNiversity Anjing Centre for innovation and technology |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Cambridge University in Nanjing. At the entrance of the Cambridge University Nanjing Centre of Technology and Innovation, with my colleague from Cambridge Prof Daping Chu, the Director of the Centre |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge alumni festival 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | September 2021 - GY talk for the Annual Cambridge Alumni Festival on Why Calories Don't Count |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=aJQxadvsmEQ |
| Description | Cambridge big weekend 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The institute ran a display at the Cambridge Big Weekend as part of the University 'Fun Lab' Tent. Involved 7 volunteers from the institute. The audience/participants were mainly local families and adults. The impression was that the event attracted a visitors with broader demographic profile that at the Cambridge Science Festival. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge, UK (virtual). 29th April 2021. Cambridge Cardiovascular Annual Research Symposium. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 4. Cambridge, UK (virtual). 29th April 2021. Cambridge Cardiovascular Annual Research Symposium. Organisation |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.cardiovascular.cam.ac.uk/research/cambridgecre/bhf-cambridge-cre-annual-meetings |
| Description | Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping Training hands on to develop expertise in cardiometabolic phenotyping |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.eas-society.org/events/EventDetails.aspx?id=1211946 |
| Description | Cambridgeshire Girlguiding Girls in STEM event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Cambridgeshire Girlguiding Girls in STEM event |
| Year(s) Of Engagement Activity | 2020 |
| Description | Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Deborah Goldspink attended the North Norfolk School Federation Careers Fair to talk to year 6 pupils about careers in science |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cell Symposia: Molecular mechanisms and integrative physiology of obesity October 13-15, 2023, Shanghai, China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Cell Symposia: Molecular mechanisms and integrative physiology of obesity October 13-15, 2023, Shanghai, China |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cell-symposia.com/obesity-2023/index.html |
| Description | Centre on AI technology for Humankind NUS Business school |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The development of Artificial Intelligence (AI) promises amazing opportunities for transforming our lives and the way we work. It will help elevate our human potential in ways we cannot yet see or even imagine. But what are the challenges that lie ahead? Amid the hype and excitement, there is a risk that allowing technology alone to dictate the course of development may bring with it as yet unknown threats to our human condition. At AiTH, we believe that the development of AI technologies must be understood and examined in the context of collaboration and co-creation with humans. Our aim is to study, explore and develop deep insights into how AI technologies should be advanced with human-centred choices, promoting creativity and happiness whilst serving and enhancing human identity. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://bschool.nus.edu.sg/aith/people/international-research-affiliate/ |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | GY gave talk on why calories don't count as part of the 2021 Cheltenham Science Festival |
| Year(s) Of Engagement Activity | 2021 |
| Description | Children's activity stalls at ChYPps lunch club run by Cambridge City Council |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 6 staff and students ran outdoor children's activity stalls at a Council-run holiday lunch club in August 2021. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.cambridge.gov.uk/chypps-activities |
| Description | China Medical University Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | China Medical University Conference - "The First International Conference on the Comprehensive Life Course Prevention and Treatment of Obesity and Related Chronic Diseases" |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://en.chinacdc.cn/news/latest/202201/t20220105_255718.html |
| Description | Contribution to 100 Kilo Kids, Channel 4 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Sadaf Farooqi was filmed talking to a mother and daughter in the Institute's Translational Research Facility for this Channel 4 documentary |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=N-ciIB9-4KM&t=2s |
| Description | Contribution to Genomics England video |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Krishna Chatterjee contributed to a film, partly made int he Institute, by Genomics England as part of a series on the 100K Genomes Project. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=OONvM0CX03I |
| Description | Contribution to Operation Ouch, Food, poo and you |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | IMS-MRL PhD student Jennie Leggat was filmed speaking to presenter Chris Van Tulleken in the Institute for this CBBC programme. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/iplayer/episode/m000cgln/operation-ouch-series-8-15-food-poo-and-you |
| Description | DG Poster at EASD study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DG. Poster at Incretin Study Group: "Modelling human enteroendocrine cells using adult intestinal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | DG. Poster at Copenhagen Biosciences Conference on Intestinal Organoids 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Modelling hormone secretion in human enteroendocrine cells using adult intestinal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | DS, Helmholtz Diabetes meeting, invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | invited speaker at prestigious international conference |
| Year(s) Of Engagement Activity | 2019 |
| Description | DS, Keystone presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | invited speaker at influential scientific meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | DS, NHS England review of Severe Insulin Resistance Service |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | VISIT BY POLYCYMAKERS TO secure ongoing support for specialist clinic |
| Year(s) Of Engagement Activity | 2019 |
| Description | Daily Mail article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Nov 2021 article: Scientists have discovered the receptor in the human brain that is responsible for people growing taller and reaching puberty earlier than ever. Based on Lam et al Nature paper (MC3R links nutritional state to childhood growth and the timing of puberty) |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dailymail.co.uk/sciencetech/article-10162351/Scientists-brain-receptor-responsible-peopl... |
| Description | Daily Mail article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | May 2021 - article (based on Nature Medicine 'Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort' from SOR group) 'Fat gene' carried by one in 340 people makes children pile on an extra 37 POUNDS by the time they reach 18, study finds in discovery that could pave the way for an anti-obesity pill |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dailymail.co.uk/sciencetech/article-9625915/Fat-gene-carried-one-340-makes-children-pile... |
| Description | Danish Diabetes Academy Summer School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Ebberup, Denmark (virtual). 30th August - 2nd September 2021. Summer school od Danish Diabetes Association 50 studnets |
| Year(s) Of Engagement Activity | 2021 |
| Description | Davidson Nichol film for black History Month |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | IMS-MRL PhD student Tendai Chisowa made this film as part of the Cambridge University Black History Month activities |
| Year(s) Of Engagement Activity | 2018 |
| Description | Deep history of obesity, Cambridge 26th May 2021 (Virtual) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Session chair and meeting organising committee. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Doha, Qatar. 4th-6th December 2019 Anti-Doping Laboratory Qatar for the 7th Junior Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | This activity was related to a PhD annual conference ree=lated to the course for women in Qatar as part of the programme coordinated by Univeristy College of London, Bristol and Groningen. |
| Year(s) Of Engagement Activity | 2019 |
| Description | EASD virtual meeting. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a meeting at the EASD Virtual Symposium, 29th September 2021. "What's the matter with adipose tissue and insulin resistance?" |
| Year(s) Of Engagement Activity | 2016,2021 |
| URL | https://www.easd.org/virtualmeeting/home.html%20#!resources/adipose-tissue-as-a-major-determinant-of... |
| Description | EB. Poster at Academic Foundation Programme and NIHR BRC and BTRU Trainee's Annual Research Day 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Localisation and characterisation of glucose-dependent insulinotropic polypeptide receptor (GIPR) expressing cells" |
| Year(s) Of Engagement Activity | 2018 |
| Description | EM Talk at Society for Endocrinology conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at Society for Endocrinology conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | EM. Poster at Copenhagen Bioscience Conference on Intestinal Organoids 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM Poster. "Using human duodenal organoids to study motilin production and secretion" |
| Year(s) Of Engagement Activity | 2019 |
| Description | EM. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM. Poster at EASD incretin study group. "The contribution of TRP channels to L-cell signalling" |
| Year(s) Of Engagement Activity | 2019 |
| Description | EM: Danish Diabetes Academy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation at Danish Diabetes academy - "Characterising stimulus-secretion coupling of the gut hormone motilin in human duodenal organoids" |
| Year(s) Of Engagement Activity | 2020 |
| Description | EM: Physiology of Obesity: From Mechanisms to Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Hormonal Regulation of Gut and Pancreas Physiology" - online webinar as part of Journal of Physiology 'Physiology of Obesity: From Mechanisms to Medicine' series |
| Year(s) Of Engagement Activity | 2020 |
| Description | EM: Virtual Q&A at the Cambridge Rare Disease Network RAREfest 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Virtual Q&A at the Cambridge Rare Disease Network RAREfest 2020 |
| Year(s) Of Engagement Activity | 2020 |
| Description | EMBO/EMBL Symposia - Ionel Sandovici |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation on 'IGF2 is a key feto-placental communication signal that maintains normal growth and development' |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.embl.org/about/info/course-and-conference-office/events/ees22-02/ |
| Description | EPOS2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wehosted the 2020 Horizon EPoS project Steering commitee meeting at St Catherine College in Cambridge to discuss the latest results on the pathogenesis, diagnostic and treatment of fatty liver and NASH. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | ER appeared on Countryfile Diaries |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In May 2019, Eleanor Raffan spoke to Countryfile Diaries reporters about her obesity research with labrador dogs. |
| Year(s) Of Engagement Activity | 2019 |
| Description | ER, presentation to scientists from a different field |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Researcher invited talk at a conference on peptide processing, which gave the opportunity to present work in our canine model of obesity and stimulated discussion on how using non-laboratory model organisms has value in research. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.grc.org/protein-processing-trafficking-and-secretion-conference/2018/ |
| Description | ER, BBC Futures article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A widely read 'long read' article on BBC Futures which sparked interest in how our and other work studying pets and production animals can inform the science of the human obesity epidemic. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bbc.com/future/story/20190109-what-we-can-learn-from-overweight-pets-about-human-obesity |
| Description | ER, Continuing education to practicing vets |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to medicine specialist vets and general practitioners at a leading US clinical veterinary conference on my research and how the findings impact on clinical management of overweight dogs. |
| Year(s) Of Engagement Activity | 2018 |
| Description | ER, Dog obesity roadshows |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Taking our sample collection and recruitment drive to local and national dog shows generated not just samples but discussion about the importance of genetics in obesity with the dog owners attending. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://nefra.co.uk/nefra-shows/ |
| Description | ER, Engagement with GOdogs study participants |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | 800 dog owning members of the public have signed up to participate in our study and receive quarterly electronic newsletters detailing our findings and updates on new canine science. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.GOdogs.org.uk |
| Description | ER, Interview on BBC Radio Cambridgeshire about dogs, obesity and genetics |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Following an interview on local radio about research into dog obesity genetics, callers responded with tales of their dogs' eating (mis)adventures and how this might be genetically related. |
| Year(s) Of Engagement Activity | 2018 |
| Description | ER, Talk on obesity genetics to Kennel Club breeders' forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenting our work on the genetics of obesity in dogs to Breed Health Coordinators at a Kennel Club Forum; attendees were particularly interested in how studying dogs can inform human focussed research. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.thekennelclub.org.uk/events/ |
| Description | ER, careers talk at local school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | During this workshop for 16-18 year olds interested in becoming a vet we discussed the diverse careers that veterinary science can lead to and the practicalities of working as a vet. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.hillsroad.ac.uk/ |
| Description | ER, public talk + Q&A at the Cambridge Science Festival by Eleanor Raffan |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk on how dog breeding makes dog genetics special and feeds into their value for models of human disease prompted questions about obesity genetics, canine breeding ethics, brain development and other wide ranging topics. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.sciencefestival.cam.ac.uk/woofing-it-do |
| Description | EU Science event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | took part in an EU H2020-funded event at Ely Cathedral. Ran several activities based on unit research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Eclip Lipodystrophy Annual Meeting (DS) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Host annual European Consortium for Lipodystrophy (Eclip) meeting in Cambridge |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.aelip.co.uk/european-consortium-of-lipodystrophies-eclip.asp#:~:text=European%20Consortiu... |
| Description | Epigenetics of metabolism, panel discusssion |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Panel discussion and Q&A session for members of the general public associated with an international conference entitled 'Epigenetics of metabolism' organised in Jan 2019. Panel members were speakers at the conference plus others with a non-typical approach. The event was compered by Giles Yeo and took place in a local café. The event was very popular with tickets oversubscribed in advance and a queue of hopeful people waiting for returns. Questions from the audience prompted several interesting discussions. |
| Year(s) Of Engagement Activity | 2019 |
| Description | European Brain & Behaviour Society (EBBS) symposium, Lausanne, Switzerland 4th - 7th September 2021.(virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Programming of metabolic health by maternal obesity- are effects sex-specific? |
| Year(s) Of Engagement Activity | 2021 |
| Description | European Congress of Endocrinology 2021, 22-26th May 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Programming of cardio-metabolic health: the role of maternal and fetal hyperinsulinaemia. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Experimental Biology 2021, 27-30th April 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Maternal diet regulates insulin action by epigenetic mechanisms. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FG Foster talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | FG gave invited lecture in the Department of Physiology, Development and Neuroscience at University of Cambridge. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FG invited speaker at Keystone conference: Interconnection between the Gut, Brain and Microbiome for Metabolic Disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered questions, collaborations and discussion with industry |
| Year(s) Of Engagement Activity | 2022 |
| Description | FG invited speaker at Metabolism in Action conference in Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered questions and potential collaborations |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://cbmr.ku.dk/metabolism-in-action/ |
| Description | FG invited speaker at symposium on 100 years of Glucagon |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at this symposium |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://glucagonconference.com/ |
| Description | FG invited talk at 7th International Conference on Food Digestion, Cork |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at this conference on food digestion. |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://www.icfd2022.com |
| Description | FG invited talk at International scientific symposium - Gut / brain axis and regulation of food intake, organized by SFNCM/INRAE |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at this symposium. Delivered virtually due to travel difficulties. Inspired questions from the audience |
| Year(s) Of Engagement Activity | 2022 |
| Description | FG talk at MRC-DTP symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | FG gave invited lecture at the annual symposium of the MRC-DTP students in Cambridge. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FG talk at Milner Therapeutics Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | FG gave invited lecture to the Milner Institute, which includes industrial audiences from around the world. The talk triggered many interesting questions. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FM, Participant in Roundtable discussion hosted by Nature magazine |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A round-table discussion in front of an audience of over 100 professors, postdocs, editors, and policy makers debated the issues surrounding the safety and genetic stability of human stem cell-based research. The results will be published and disseminated via the web to reach a much larger audience. |
| Year(s) Of Engagement Activity | 2018 |
| Description | FM, Primary school outreach activity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Visit to a local elementary school to discuss the neuroscience of hunger |
| Year(s) Of Engagement Activity | 2019 |
| Description | FM, hosted student in the laboratory |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | the individual who visited the laboratory gained appreciation of a career in biology |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR. Poster at EASD incretin study group. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FR poster at EASD study group: "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR. presentation at Danish Diabetes Academy Winter School for postdoctoral researchers, at Higuerõn Hotel in Malaga/Spain 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Incretins along the gut-pancreas-brain axis". |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR: Mercodia Diagnostics, Uppsala. Invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited to talk to Mercodia about how our mass spec analysis methods complement their immunoassay development |
| Year(s) Of Engagement Activity | 2019 |
| Description | Farooqi group Cell paper press activity |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press activity around the Cell paper Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity (Sadaf Farooqi corresponding author) received substantial coverage in National press (6 UK papers, at least 4 International) plus 11 pieces in popular science/health press |
| Year(s) Of Engagement Activity | 2019 |
| Description | GCSE Science Live, London. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Giles Yeo was one of several science experts speaking at this large event at the Dominium Theatre. The primary objective of the event is to generate greater enthusiasm for science amongst GCSE pupils. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://gcsesciencelive.net/event_categories/london2/ |
| Description | GPR. Cambridge UGI cancer symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | "The post-gastrectomy patient, metabolic considerations" |
| Year(s) Of Engagement Activity | 2018 |
| Description | GY Inside Health for BBC R4 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Broadcast on 4th and 5th Jan 2022. GY took part in a programme called New Year Resolutions |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bbc.co.uk/programmes/m001325v |
| Description | GY spoke for Table Talk podcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | January 2022. Podcast for Food Matters Live on plant-based foods within a healthy sustainable diet . |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://foodmatterslive.com/discover/podcast/plant-based-sustainable-diets-kelloggs/ |
| Description | Genetics Society 2019 JBS Haldane Award Lecture |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This lecture 'Is Obesity A Choice?' took place at the Royal Institution in London on November 1, 2019. There were 300 people in the audience. The lecture was recorded and uploaded onto the Royal Institution YouTube Channel, where it has (as of Feb 27, 2020) been viewed 26,088 times. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=88tWJ1p5d4o |
| Description | Girlguiding Norfolk STEM event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | PhD student Rachel Foreman gave a talk about her research and career in science to Girl Guides as part of a bigger county-wide event in Norwich |
| Year(s) Of Engagement Activity | 2019 |
| Description | Giveaway activity kits for children |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 150 activity kits based on two research-based games we had previously developed for use at Science Festivals were posted out to UK addresses during the Cambridge festival, with information leaflets. Families were invited to share images of their creations. A further 50 kits were sent to a Norfolk school for children on the autistic spectrum and a further 50+ were given out at children's summer events in Cambridge. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Gordon Research Conference - Miguel Constancia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker on the topic of Inter-organ communication and IGFs |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.grc.org/igf-and-insulin-system-in-physiology-and-disease-conference/2023/ |
| Description | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Gothenburg, Sweden. 8th -10th October 2020. 3rd Annual Internal Clinical Science Symposium. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gothenburg, Sweden. 8th -10th October 2020. 3rd Annual Internal Clinical Science Symposium. This was a meeting focused on innovation and pharma approaches organised by Astra Zeneca |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.c2d3.cam.ac.uk/events/astrazeneca-and-university-cambridge-virtual-symposium |
| Description | I'm a Scientist - Get Me Out of Here! |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | I'm a Scientist - Get Me Out of Here! During the lockdown, two members of the TVP Lab - Sonia & Jennie - took part in the MRC initiative 'I'm a Scientist - Stay at Home!'. This programme was established to allow school children to talk to real scientists during their virtual science lessons in the summer term, to find out more about the subjects they were interested in! Sonia was in the 'Disease Detectives Zone', while Jennie was in the 'Medical Research Zone'. They both had a lot of fun, and were amazed by how insightful the questions they received were! |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://imascientist.org.uk/ |
| Description | IMS online academy EM CAS OW |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | developed work experience programme for ~12 Y10 students from underrepresented schools in Cambridge |
| Year(s) Of Engagement Activity | 2021 |
| Description | ITV short film on genetics of thinness |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Sadaf Farooqi took part in a short film, made partly at the Institute, for ITV News. The topic was based around her recent paper Genetic architecture of human thinness compared to severe obesity (PLOS Genetics, Jan 2019) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.itv.com/news/2019-01-24/thin-people-its-down-to-your-genes-not-because-youre-morally-sup... |
| Description | Inspirational Scientists |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Post doc Sam Virtue made 2 films with Cambridge University Press in their Inspirational Scientists YouTube series. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/playlist?list=PL2HgNIO5uPKBNLLCY9lhV8HwUY3OOMeq2 |
| Description | Interview on BBC Radio 4's Life Scientific |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviewed by Jim Al-Khalili about the powerful influence our genes have on how we put on weight, and why many of us struggle to lose it. This sparked a big response, including being contacted by Cambridge MP and shadow food minister Daniel Zeichner. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/programmes/m000rmp5 |
| Description | Interview on Scandinavian Talk Show 'Skavlan' |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This was an interview on Scandinavia's largest talkshow 'Skavlan', which broadcasts to Sweden, Norway and Finland. Each episode has more than 2 million live viewers. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=tqXccq2jLkc |
| Description | Invited Symposium Speaker, British Endocrine Society Annual Meeting, Edinburgh, Scotland November 8, 2021. Title 'Single-cell analysis and heterogeneity of hypothalamic neurons' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Symposium Speaker, British Endocrine Society Annual Meeting, Edinburgh, Scotland November 8, 2021. Title 'Single-cell analysis and heterogeneity of hypothalamic neurons' |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited Symposium Speaker, German Diabetes Association Annual Meeting May 14, 2021. Title 'Heterogeneity of hypothalamic POMC neurons' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Symposium Speaker, German Diabetes Association Annual Meeting May 14, 2021. Title 'Heterogeneity of hypothalamic POMC neurons' |
| Year(s) Of Engagement Activity | 2021 |
| Description | Is obesity a choice talk at Cam Big Biology Day 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo gave this talk at the Cambridge Hills Road Sixth Form College as part of the annual Big Biology Day event in Cambridge - mostly aimed at older children and teens thinking about a future career |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.hillsroad.ac.uk/about-us/news-and-events/2019/09/27/big-biology-day#:~:text=Saturday%205... |
| Description | JL Choosing your first postdoc. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Lewis JE and Joanisse D (2021) Choosing your first postdoc. Career Progression Workshop, Future Physiology, online. |
| Year(s) Of Engagement Activity | 2021 |
| Description | JL Oral presentation at BSN/SFE, online |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lewis JE, Woodward ORM, Phillips BU, Tripodi M, Hornigold D, Baker D, Gribble FM, Reimann F (2021) Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice. |
| Year(s) Of Engagement Activity | 2021 |
| Description | JL. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | JL. Poster at EASD study group. "RXFP4, the cognate receptor for insulin-like peptide 5, alters food preference in mice" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Jiangsu Industrial Technology Research Institute (JITRI), |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Our Cambridge University Nanjing Centre of Technology and Innovation is connected with Jiangsu Industrial Technology Research Institute (JITRI), (http://jitri.cn/en/home) a top application-oriented research organization and a high-tech investor in China, which was founded in 2013 by Jiangsu Province to promote industrial technology research and the commercialization of advanced scientific results. JITRI has established 59+ specialized research institutes in the fields of advanced materials, energy & environment, manufacturing & equipment, biology & medicine, and ICT snd represents one of the most innovative ecosystems for innovation un China and looking for globalisation. |
| Year(s) Of Engagement Activity | 2024 |
| URL | http://www.jitri.cn/ |
| Description | Korea. 3rd-5th September 2020. Symposium special lecture at ICOMES (scientific committee of KSSO (Korean Society for the Study of Obesity). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 4. Korea. 3rd-5th September 2020. Symposium special lecture at ICOMES (scientific committee of KSSO (Korean Society for the Study of Obesity). |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.kongreuzmani.com/international-congress-on-obesity-and-metabolic-syndrome-icomes-2020.ht... |
| Description | Lab Leadership in a Crisis |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Lab Leadership in a Crisis The Covid-19 pandemic has resulted in more people working from home, fewer people working in the laboratory, changes in the pattern of scientific interactions, physical barriers to direct communication, all in a context of anxiety and uncertainty about the present and the future. These difficulties are causing mental health problems, frustration, anger, and disengagement. However, this turbulent time has also enabled new, unexpected leaders to emerge, performing more autonomously and making insightful decisions. This period has provided them with opportunities to show their character, determination and resilience when confronted with challenges. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://alumni.bhf.org.uk/news/390927 |
| Description | Leading with Empathy |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | oni Vidal-Puig - Leading with Empathy Through the Covid-19 Pandemic. Interview for BHF Alumnii |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://alumni.bhf.org.uk/news/286709 |
| Description | Linkedin Social media |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity/shares/ This is my most powerful social media communication channel with 5300 selected followers coming from science, business, academia. Communications include science-related communication and management of research-intensive institutions |
| Year(s) Of Engagement Activity | 2016,2017,2018,2019,2020,2021,2022 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | Live from the lab - a series of four films for children |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A series of four short films produced over four days by 11 students and post-docs. The films were made for children aged 7-10 and were shared with Cambridge Festival participants who signed up in advance to receive the daily links and included answers to questions submitted by children. The videos were posted on our YouTube channel after the event. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/playlist?list=PLetI6tUdcINajvaiyx7DbTU8TPcgA0T1C |
| Description | London International Youth Science Forum visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | 8 six formers came to the IMS-MRL for a lab tour and careers Q+A. Hosted by 6 staff/graduate students |
| Year(s) Of Engagement Activity | 2019 |
| Description | ME radio interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In October 2020, Mark Evans spoke on the Phil Williams show on Times Radio about glucose sensors and diabetes. |
| Year(s) Of Engagement Activity | 2020 |
| Description | MIddle EaSt obesity |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professors Toni Vidal-Puig MD PhD FRCP FMedSci EMBA and Meis Moukayed have honoured us by writing the fascinating article, People with obesity: Their heroic battle to defeat their genes in a hostile hypercaloric sedentary environment. The professors explain why more than 50 human genes, the environment and lifestyle culture all contribute to why it is not so easy as the doctor telling the patient to lose weight. In addition to looking at the 'why' of obesity, |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.middleeastmedicalportal.com/product/november-december-2018/ |
| Description | MRC Festival Science Bus |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | IMS staff and students worked with a local secondary school teacher and a communications trainer to develop 1 existing and 2 new activities for use with Year 9 pupils. We ran a whole day of activities on a bus with each of 2 schools considered to have 'under-served' intake - North Cambridge Academy and Ely College - meeting the complete Year groups in each case. We reached over 300 teenagers with the activities. Feedback from our researcher volunteers: - [Teachers] were also very complimentary and engaged with our activity as it touched on their lessons or personal lives - I was surprised at just how smoothly it went, and by how engaged the pupils were Several teachers commented that they really liked the fact that we had three different activities that looked at different areas of research, but also themselves appealed to different personalities - I was surprised how children very suddenly came up with very interesting and smart questionsit definitely makes you think about the scientific content in a different way! - I learnt that secondary school children are being taught more complex science than I expected Post-event responses from 62 year 9 pupils at North Cambridge Academy showed that - 87% learned something new - 79% did not have any relative or friend who worked in science or for a university - just 11% (7 students) remembered ever going to the Cambridge Science Festival. - 25% said that after the session they were more likely to consider a career in science. Feedback on leaving the Institute from a staff member involved in development and delivery of this activity: - Taking part in PE helped me to decide about the job change. I got the new job partly because of the skills and experience from being involved |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRL Science Slam |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The presenters (a post doc and student together) won a prize for their presentation |
| Year(s) Of Engagement Activity | 2018 |
| Description | MY Poster at Incretin Study Group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | MY poster at Incretin Study Group: "Amino acid sensing in K and L cells from mouse duodenal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | MY. Oral presentation at Diabetes UK Annual Professional Conference 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Metformin alters glucose uptake and metabolism in intestinal cells |
| Year(s) Of Engagement Activity | 2019 |
| Description | Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) This meeting brings all teh community of investigators on the field of obesity in Spain. It is an excellent place to identify talent. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ciberobn.es/en |
| Description | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ciberobn.es/en |
| Description | Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | 9. Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" This was a high level scientific event organised by CSIC in Madrid attended predominantly by experts in endocrinology |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://eventos.uam.es/28633/detail/6th-symposium-on-biomedical-reserch-advances-and-perspectives-in... |
| Description | Mannheim, Germany. 21st-24th May 2023. 91st EAS Congress. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | -----2. Mannheim, Germany. 21st-24th May 2023. 91st EAS Congress.--------------------------------- |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ipccs.org/2023/06/26/relevance-of-adipose-tissue-in-cardio-metabolic-complications/ |
| Description | Meet the Scientist |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Five members of IMS-MRL staff held short 1:1 or small group meetings with members of the public over 2 days as part of the Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2018 |
| Description | Meet the Scientists 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Two members of IMS-MRL staff met members of the public attending Cambridge Science Festival events for short 1:1 or small group conversations |
| Year(s) Of Engagement Activity | 2019 |
| Description | Men's Health Magazine (UK) article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | August 2021 article by Giles Yeo on 'Does calorie counting really add up?' |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.menshealth.com/uk/nutrition/a37289507/calorie-counting/ |
| Description | Metabolism Month, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 16th March 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | "Programming of Cardio-Metabolic Health by Maternal Obesity: a developing crisis" |
| Year(s) Of Engagement Activity | 2021 |
| Description | Mexico Instituto Zubiran de Nutricion |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Seminar evaluation PhD students projects |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | NCA work experience interviews |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In January 2020 3 year 10 pupils from North Cambridge Academy visited the IMS-MRL to see the labs and to be interviewed for summer work experience placements. Unfortunately these were unable to progress due to the COVID pandemic |
| Year(s) Of Engagement Activity | 2020 |
| Description | NCA work experience students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Two Year 10 work experience students spent a week at the IMS-MRL. The students were from North Cambridge Academy, the 'under-served intake' school we started workign with this year. Ten of our staff and students were involved in hosting them. |
| Year(s) Of Engagement Activity | 2019 |
| Description | NS, British Endocrine Society invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A clinical presentation on central hypothyroidism attended by clinical thyroidologists |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS, British thyroid association research presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 75 thyroidologists attended a research presentation which sparked discussion and further collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS, European thyroid association research presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Thyroidologists attended a research presentation which sparked discussion |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS, European thyroid association research presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Thyroidologists attended a late breaking research presentation which sparked discussion and further collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | NS. European thyroid association invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | thyroidologists attended an invited lecture on whole exome sequencing which sparked discussion about uses and interpretation of this technology |
| Year(s) Of Engagement Activity | 2018 |
| Description | Naked scientist podcad |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Senior Research Associate of pour laboratory Sam Virtue on the Naked Scientist podcast - https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/qa-soy-slingshots-and-cyanide & https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/qa-atoms-avalanches-armpits |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/qa-soy-slingshots-and-cyanide. |
| Description | Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 5. Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Meeting in Nanjing with faculty from Nanjing Medical School for collaborative research and networking |
| Year(s) Of Engagement Activity | 2019 |
| Description | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). Lecture on the Adipose tissue expandability, lipotoxicity and metabolic syndrome. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Neuronal Control of Metabolism symposium, 12th February 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | outline of role of GDF15 in control of food intake and how this knowledge may affect drug design in the future |
| Year(s) Of Engagement Activity | 2020 |
| Description | New Scientist Live 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo gave 2 talks: Why don't calories count and Britain's favourite diet expert |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://live.newscientist.com/speakers/giles-yeo |
| Description | New Scientist article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | GY article June 2021: Calories on food packets are wrong - it's time to change that |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.newscientist.com/article/mg25033392-800-calories-on-food-packets-are-wrong-its-time-to-c... |
| Description | OW STEM for BRITAIN |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | STEM for BRITAIN is a major scientific poster competition and exhibition which has been held in Parliament since 1997, and is organised by the Parliamentary & Scientific Committee. Its aim is to give members of both Houses of Parliament an insight into the outstanding research work being undertaken in UK universities by early-career researchers. Prizes are awarded for the posters presented in each discipline which best communicated high level science, engineering or mathematics to a lay audience. The audience was made up of MPs, senior scientists, industry representatives and early career researchers. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://stemforbritain.org.uk/ |
| Description | OW. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | OW poster at EASD incretin study group: "Distribution of G protein coupled relaxin/insulin-like family peptide receptor-4 (RXFP4) expressing cells in the mouse brain" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Online Academy after school 'work experience' sessions for year 10s |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | During April-May 2021 we ran 5, weekly after school sessions with a local partner secondary school - North Cambridge Academy - chosen for Widening Participation potential. The sessions were developed by a group of 11 students and post-docs and delivered by them on a 'hybrid' basis as an alternative to our usual offer of work experience places which we were unable to offer because of COVID19 rules. The sessions included practical, theoretical and careers elements and in agreement with the school are to be developed into a one-day visit to the Institute model for 2022. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Oregon Health & Science University, Center for Developmental Health Developmental Origins of Health and Disease (DOHaD) Summer Course, Oregon, USA, 5th August 2021 (virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Programming and type 2 diabetes: role of epigenetics. |
| Year(s) Of Engagement Activity | 2021 |
| Description | PL. Talk at Incretin Study Group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | PL. Talk at Incretin Study Group. "Peptidomics to study enteroendocrine cells after bariatric surgery" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Paris, France. 11th-15th April 2018. EASL International Liver Congress. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the Paris, France. 11th-15th April 2018. EASL International Liver Congress focused on the pathogenesis of fatty liver and the effect of Lipotoxicty |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://easl.eu/discover/events/detail/2018/the-international-liver-congress-2018 |
| Description | Pint of Science 2022 - Miguel Constancia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk about rare genomic diseases, with a focus on imprinting human disorders |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.facebook.com/pintofscience/ |
| Description | Pint of Science: how to communicate science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk given by Giles Yeo |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to local Brownies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | RF: Girls in STEM "Why I'm a scientist" |
| Year(s) Of Engagement Activity | 2020 |
| Description | Press Release University of Cambridge |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release by the University of Cambridge regarding a paper published in Developmental Cell. This paper received wide-spread media attention after the press-release (over 90 media outlets, with an altmetric score >790) |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.communications.cam.ac.uk |
| Description | Public engagement at the Suffolk Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | On Monday February 17th 2020, a team of PhD students from the Institute of Metabolic Science went to the Suffolk Science Festival in Bury St. Edmunds to teach local children about neurons, the anatomy of the gastrointestinal system and the importance of insulin sensitivity. Among the team was TVP lab PhD student Jennie Leggat. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.tvplab-cambridge.com/post/public-engagement-at-the-suffolk-science-festival |
| Description | Public stand at LifeLab |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 4 IMS staff/ graduate students ran a stand at Ely Cathedral as part of the Cambridge LifeLab events for European Researchers' Night. We ran our Labrador Laboratory activity. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.camlifelab.co.uk/ely |
| Description | Public web section |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | We launched a new public-facing section to our website in summer 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.mrl.ims.cam.ac.uk/find-out-more-2/ |
| Description | RAREfest 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Giles Yeo gave a talk and Claire Adams gave a poster at this event run by Cambridge Rare Disease Network that had national reach and over 900 participants. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.camraredisease.org/rarefest-review/ |
| Description | RAREfest stand |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | In December 2020 we contributed a virtual stand to RAREfest 2020, a biennial event for a broad audience. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.camraredisease.org/rarefest20/ |
| Description | REF Poster at SymBLS 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at DMDG open meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | "Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients" |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | REF poster at EASD study group "A multiplex method for quantifying gut hormone peptides using Mass Spectrometry" |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at REID Bioanalytical Forum 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Immunoassay vs Mass Spectrometry -Measuring insulin and insulin analogues in human plasma |
| Year(s) Of Engagement Activity | 2019 |
| Description | RF: Murray Edwards Graduate Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | RF: Measuring insulin and insulin analogues in human plasma |
| Year(s) Of Engagement Activity | 2021 |
| Description | RGK Incretin 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | poster presentation at Incretin 2022. Lots of interest |
| Year(s) Of Engagement Activity | 2022 |
| Description | RGK Invited lecture on Mass Spectrometric analysis of Insulin at Anglian Ruskin University. Cambridge, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | 1st March 2023. Invited lecture on Mass Spectrometric analysis of Insulin at Anglian Ruskin University. Cambridge, UK Audience: Staff and students Size: ~100 participants |
| Year(s) Of Engagement Activity | 2022 |
| Description | RGK Invited speaker at Reid Bioanalytical Forum. Cambourne, Cambridgeshire, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | 5Th September 2022. Invited speaker at Reid Bioanalytical Forum. Cambourne, Cambridgeshire, UK Audience: Mainly bioanalytical scientists from industry Size: ~100 participants |
| Year(s) Of Engagement Activity | 2022 |
| Description | RGK Invited speaker at the Peptidomics Symposium. University of Copenhagen, Denmark |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 23rd August 2022. Invited speaker at the Peptidomics Symposium. University of Copenhagen, Denmark Audience: Academics and Clinicians Size: ~150 participants Outcome: Was invited to talk at the 2023 Danish Diabetes and Endocrine Academy conference |
| Year(s) Of Engagement Activity | 2022 |
| Description | RGK London Proteomics Discussion Group. London, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Audience: Academic and industry researchers in the proteomics field Size: ~50 participants Outcome: Was invited to talk at the 2022 Reid Bioanalytical Forum |
| Year(s) Of Engagement Activity | 2022 |
| Description | RGK Proteomics Method Forum 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Peptidomics: bridging the space between large and small molecule mass spectrometry |
| Year(s) Of Engagement Activity | 2020 |
| Description | RGK. American Society for Mass Spectrometry (ASMS) 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Waters user group meeting, presentation: "LC-MS analysis of plasma from patients with insulin autoimmune syndrome" Waters MS focused user meeting (Pharmaceutical track) Outcome: Video of talk available on Waters website, video interview on Select Science website, as well as an in-lab video interview. |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster at EASD incretin study group: "Proglucagon peptide analysis - will the real peptide please stand up!" |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Reid Bioanalytical Forum 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | "LC-MS analysis of plasma from patients with insulin autoimmune syndrome" Meeting focussing on broad bioanalytical approaches for wide range of analytes Outcome: Video interview by Bionalaysis zone, available on their website |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Waters UK and Ireland Clinical User Meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Waters UK and Ireland Clinical User Meeting 2019 "LCMS Analysis of Proinsulin Derived Peptides" Waters meeting for users of MS systems in clinical environments |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK: Select Science Clinical Science Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plasma peptidomics - an untapped resource for biomarker analysis." |
| Year(s) Of Engagement Activity | 2020 |
| Description | RSPCA AWERB Lay Members' Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | In December 2019 Tiny Coll gave a talk to the RSPCA AWERB Lay Members' Forum on the ethics of animal research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Institution lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | June 2021: How we got the science of weight loss wrong. GY |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=GQJ0Z0DRumg |
| Description | SF, genetics of thinness |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A press release related to a research publication concerning the genetics of thinness resulted in numerous TV, radio and newspaper articles at national and international level. press conference or response to a media enquiry/interview. Media coverage was used as a platform to start a widespread discussion around the genetic basis of thinness and, through this, a discussion into the genetic contribution to obesity |
| Year(s) Of Engagement Activity | 2018 |
| Description | SG. Poster at EASD incretin study group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | SG. Poster at EASD study group. "Characterisation of novel gut-derived peptides in vivo and in vitro" |
| Year(s) Of Engagement Activity | 2019 |
| Description | SO, British Heart Foundation supporters event and laboratory tour |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Briefly describe the activity, please include the intended purpose and any outcomes or impacts that have arisen from it if known. For example, "60 pupils attended for a school visit to the research organisation, which sparked questions and discussion afterwards, and the school reported increased interest in related subject areas." * Event was for British Heart Foundation volunteers to observe what research is currently happening at the University of Cambridge Biomedical Campus. They were given lab tours from multiple labs (including ours) where we presented data from our research and engaged in hands-on activities. |
| Year(s) Of Engagement Activity | 2018 |
| Description | SOR - BBC News Health interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interviewed by Sophie Hutchinson, BBC News Health Correspondent about the impact of COVID-19 on obesity. She was reporting on the World Obesity Federation's study for the BBC TV 6 o'clock news which found almost 90% of covid deaths are in countries with high obesity rates. |
| Year(s) Of Engagement Activity | 2021 |
| Description | SOR - BBC Radio 4 interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Recorded interview for BBC Radio 4's Inside Science re Nature Medicine paper 'Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort' (arranged by Deborah Cohen, Editor BBC Radio Science Unit (June 2021) |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.endocrinology.org/news/article/16218/professor-stephen-o-rahilly-talks-about-obesity-gen... |
| Description | SOR - BBC Radio 5 live |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | BBC Radio 5 Live interview with Adrian Chiles regarding Nature paper "MC3R links nutritional state to childhood growth and the timing of puberty" |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/news/health-59140359 |
| Description | SOR - BBC Radio Cambridge interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interviewed live on BBC Radio Cambridgeshire by Chris Mann regarding obesity and COVID and to promote forthcoming University of Cambridge Science Festival talk on 31.3.21. |
| Year(s) Of Engagement Activity | 2021 |
| Description | SOR - BBC interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Phone interview with Katherine Roberts, Producer for TV/Radio/Online/Digital BBC News who was researching on the effectiveness of the coronavirus vaccination on people who are classed as obese. |
| Year(s) Of Engagement Activity | 2021 |
| Description | SOR - BBCs |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Telephone interview with BBC (Philippa Roxby, Health Reporter) ahead of Nature paper being released 3.11.21 "MC3R links nutritional state to childhood growth and the timing of puberty" which led to BBC Radio 4 broadcast https://www.bbc.co.uk/sounds/play/m001154h (28 mins in). Also interviewed next day by Christian Frazer for BBC News Channel live regarding Nature paper. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/news/health-59140359 |
| Description | SOR - Brainbody interactions, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker at virtual seminar series on Brain-Body Interactions organised by Beth Israel Deaconess Medical Center, Boston, USA run by brainbodyinteractions.org under the umbrella of worldwideneuro.com. Talk title 'Some new insights into the central sensing of nutritional state and somatic stress'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.brainbodyinteractions.org/ |
| Description | SOR - CU Endo Soci |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited by Cambridge University Endocrine Society to give a lecture for medical students at their annual conference, lecture title "Adventures at the interface of endocrinology, metabolism and behaviour". |
| Year(s) Of Engagement Activity | 2022 |
| Description | SOR - Cambridge Independent interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interviewed by Alex Spencer, Culture Editor and Senior Reporter, from Cambridge Independent for forthcoming University of Cambridge Science Festival talk on 31.3.21. Article published March 2021. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.cambridgeindependent.co.uk/whats-on/why-obesity-makes-covid-19-more-dangerous-and-what-y... |
| Description | SOR - Cambridge Metabolic Network event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at Cambridge Metabolic Network event 'Deep history of obesity, Cambridge University (talk title 'Obesity and COVID19') |
| Year(s) Of Engagement Activity | 2021 |
| Description | SOR - Illinois talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited guest speaker at the Molecular and Integrative Physiology seminar series at the University of Illinois, USA (held virtually), talk title "The central control of energy balance and nutrient disposition and its response to endocrine signals" |
| Year(s) Of Engagement Activity | 2022 |
| Description | SOR - NBC news interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Request was: I am currently researching for a TV report about the links between obesity and COVID-19. This is prompted by a recent study from Italy in the European Society of Endocrinology, suggesting that people with a BMI of over 30 are at a greater risk of severe COVID-19 infection. There seems to be a renewed discussion for a "weight-loss drive" in anticipation of second wave of coronavirus later in the year, and we are keen to delve further into this. The report itself will be for our U.S. output. I was wondering if you might be available to speak to us about your understanding of the links between obesity and COVID-19, initially for a research call, but with the view of arranging a video interview? We are keen to learn more from your expertise on this subject. Talk did not go live but was used for research purposes. |
| Year(s) Of Engagement Activity | 2020 |
| Description | SOR - RTE radio interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | RTE Radio 1 Drivetime live interview regarding Nature paper 'MC3R links nutritional state to childhood growth and the timing of puberty' |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.rte.ie/radio/radio1/drivetime/programmes/2021/1104/1257981-drivetime-thursday-4-november... |
| Description | SOR - RTE radio interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | RTE Radio 1 Interview and quoted in various media outlets including BBC on the trial of drug semaglutide suppressing appetite |
| Year(s) Of Engagement Activity | 2021 |
| Description | SOR - Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave a talk at University of Cambridge Science Festival talk (virtual) on "Why does obesity make Covid-19 more dangerous?" followed by live Q&A session |
| Year(s) Of Engagement Activity | 2021 |
| Description | SOR - Science Media Centre |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Science Media Centre briefing by experts on COVID19 to ~30 journalists including BBC, Channel 4 News, Guardian, BMJ. SOR participated with 5 other experts. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bbc.co.uk/news/health-54648684 |
| Description | SOR - Science interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Science interview by Reporter from Science Magazine, Washington DC working on a news article exploring why obese people are more likely to develop severe COVID-19 (contacted following Perspective in CellPress/Med) |
| Year(s) Of Engagement Activity | 2020 |
| Description | SOR - Scientific American magazine |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Science journal interview by email by Egyptian journalist writing an article for the Arabic edition of Scientific American magazine https://www.scientificamerican.com/arabic/ on COVID19 and obesity. |
| Year(s) Of Engagement Activity | 2020 |
| Description | SOR - Times interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Rhys Blakely, Times Science Correspondent re Nature Medicine paper 'Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort' (May 2021) |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.thetimes.co.uk/article/200-000-britons-have-appetite-gene-that-adds-two-stone-28z5hpmn3 |
| Description | SOR - US MedPage Today |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Telephone interview with MedPage Today, a US news site that covers health and medicine, regarding Nature paper 'MC3R links nutritional state to childhood growth and the timing of puberty' |
| Year(s) Of Engagement Activity | 2021 |
| Description | SOR - Washington Post interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Email interview/media enquiry by freelance reporter for Washington Post, published online on 24.8.20 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.washingtonpost.com/health/obesity-coronavirus-risk-lose-weight/2020/08/21/1de03bbc-e187-... |
| Description | SOR, Cambridge SCienec Festival talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Evening talk followed by a Q+A session as part of the Cambridge Science Festival. The event was ilmed and is available on our youtube channel. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=hiCE1FBbsv4&list=PLetI6tUdcINbTF8N3_5NGQnaglrK12RJg |
| Description | SS, Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Researchre met with individual school students to talk about career opportunities in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | SV, Naked Scientist podcast, Aug 2018 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Naked Scientist podcast based on a press release/recent publication describing conversion of white to brown fat in mice. |
| Year(s) Of Engagement Activity | 2018 |
| Description | SV, Reddit Ask me anything |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Researcher started a Reddit 'Ask me anything' thread based on a recent publication involving brown fat. The thread had 22K views in one week, answering 'good quality questions' for a couple of days and being, at one point the 3rd most popular topic |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.reddit.com/r/IAmA/comments/99c2w4/we_are_cambridge_university_scientists/ |
| Description | SV, Science News article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Study in mice suggests drug to turn fat 'brown' could help fight obesity Article published by Science Daily based on a press release following publication of an study. Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/11/181126123416.htm |
| Description | SV, school visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Researcher visitited a local school to talk about his research as well as more generally about careers in scientific research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Science News Study inMice suggests drug to turn fat brown could help fight obesity |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | https://www.sciencedaily.com/releases/2018/11/181126123416.htm Study in mice suggests drug to turn fat 'brown' could help fight obesity Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/11/181126123416.htm |
| Description | Science Slam |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Event associated with MRC Festival of Medical Research. An evening of lightening talks aimed at local adults was held in a room at a local pub. Scientists form the institute talked about their research in short (3-minute) presentations. Encouraged to use interesting props to help demonstrate ideas. Included a lively Q+A session. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Seminar at The Diabetes Research Center, University of Iowa |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Iowa, USA (virtual). 4th October 2021. Seminar at The Diabetes Research Center, University of Iowa |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://medicine.uiowa.edu/diabetes/event/76651 |
| Description | Seminar at the Center for Diabetes and Metabolic Diseases, Medical Faculty, Indiana University. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2. Indiana, USA (virtual). 13th December 2021. Seminar at the Center for Diabetes and Metabolic Diseases, Medical Faculty, Indiana University. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://medicine.iu.edu/research-centers/diabetes/enrichment/seminar-series |
| Description | Serendipity Fair |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A series of new web pages aimed at children and young people were designed and promoted for the Cambridge Festival 2021. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.mrl.ims.cam.ac.uk/find-out-more-2/serendipity-fair/ |
| Description | Singapore2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | University of Cambridge meets with our colleagues from the National University of Singapore to strenght our collaborative cardiovascular research network. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Skavlan Norwegian-Swedish TV chat show appearance |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo appeared on Skavlan chat show in November 2021 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=zTRSSOsUizE |
| Description | Skinny Genes - Talk given by Prof Sadaf Farooqi for the Cambridge Festival 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Live online talk with live graphic illustration and audience Q+A as part of the Cambridge Festival |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=Zibd_ifESOg |
| Description | Special lecture at Fudan University, |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Some news from Fudan University in Shanghai and their strategy working close with the local Government to promote the competitiveness of their technological ecosystem Shanghai Friendship Association 2024-02-29 17:19 On February 28, Professor Antonio Vidal-Puig of Cambridge University was invited to visit Yangpu District to give a special lecture at Fudan University, and to participate in exchanges and discussions on industry-University-research cooperation in the field of life and health at Xueyuefeng Book House, a member unit of Yangpu District Association for Friendship with Foreign Countries. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://lnkd.in/eQMzNMy7 |
| Description | Suffolk Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Suffolk Science Festival |
| Year(s) Of Engagement Activity | 2020 |
| Description | Sustainable Future Acacemy |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Online event |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.cam.ac.uk/public-engagement/information-for-staff-and-students/the-sustainable-futures-a... |
| Description | TD. Poster at EASD study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | TD. Poster at EASD incretin study group. "Neutral amino acid transporter: SLC6a19- linking amino acid sensing to gut hormone secretion?" |
| Year(s) Of Engagement Activity | 2019 |
| Description | TEDx Cambridge YouTube - Starch, milk and alcohol |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Uploaded to ted.com as well as YouTube |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=RgClxvQeXc0 |
| Description | TEDx talk -Starch, milk and alcohol |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo gave this talk as part of the Cambridge TEDx series to an audience of about 100. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Taking part in the artificial pancreas study |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Janet Allen and Gianluca Musolino took part in this video about a child study participant as part for the NIHR Innovative technology series |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=d2CHRlBcFAo |
| Description | The Observer - Let's consider the type of food we eat not fixate on calories |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Giles Yeo was interviewed for this article, June 2021 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.theguardian.com/science/2021/jun/20/giles-yeo-why-calories-dont-count-diet-interview |
| Description | The artificial pancreas |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Roman Hovorka made this video with NIHR to explain the artificial pancreas and how it was developed |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=CsUmyA0z6vA |
| Description | The truth about diets for Cam Sci Fest 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public talk given by Giles Yeo as part of the Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2019 |
| Description | Tiktok campaign for Cambridge Festival 2021 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A campaign of Tiktok videos on a theme of #LabLife shared fun insights into life as a PhD student for members of the public. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.tiktok.com/@ims_mrl?lang=en |
| Description | Times Weekend Supplement |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | June 2021 - GY was interviewed for an article in the Times Weekend Supplement: Do calories really count? The scientist who says no |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.thetimes.co.uk/article/do-calories-really-count-the-scientist-who-says-no-d6bt5twvd |
| Description | Twitter campaign for World Obesity Day 2021 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A week-long campaign of Tweets for World Obesity Day, developed with a PhD student mentee from Leicester University, increased our average monthly impressions more than ten-fold. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://twitter.com/IMS_MRL |
| Description | Twitter campaign for World Obesity Day 2022 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A one-day campaign of tweets for World Obesity Day 2022 increased monthly impressions for our Twitter account by threefold compared to the average. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://twitter.com/IMS_MRL |
| Description | Tye 2 Diabetes; Atherapeutic avenue is emerging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Date:December 5, 2018 Source:INSERM (Institut national de la santé et de la recherche médicale) Summary:Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/12/181205134014.htm |
| Description | UNIFESP graduate training course, Brazil June 9th 2021 (virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture title: Mechanisms of intrauterine programming of obesity and type 2 diabetes: are they preventable? |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Cambridge & AZ science symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | SG Presentation: Utilising LC/MS to identify novel bioactive gut-derived peptides and peptidomic differences in type 2 diabetic human islets FG Panel discussion |
| Year(s) Of Engagement Activity | 2020 |
| Description | University of Nottingham Division of Medical Sciences External Seminar Series Event (Virtual), Nottingham, UK 29th January 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Programming by maternal obesity: a developing problem. (virtual) |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Toronto, City-wide Grand Rounds April 23, 2021. Title 'The brain control of food intake: Can an old dog teach us new tricks?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | University of Toronto, City-wide Grand Rounds April 23, 2021. Title 'The brain control of food intake: Can an old dog teach us new tricks?' |
| Year(s) Of Engagement Activity | 2021 |
| Description | VBL talk at Incretin 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | VBL talk at EASD Incretin Study group, "Adenosine triphosphate (ATP) is released from glucagon-like peptide 1 (GLP-1) secreting cells and signals to vagal afferent neurons" |
| Year(s) Of Engagement Activity | 2019 |
| Description | VBL. Poster at Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | VBL presented a poster at a local Cambridge Neuroscience Association meeting at Robinson College on March 14th, 2019. It was called "Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience" and the poster title was "ATP is released from GLP-1 secreting enteroendocrine cells and signals to vagal afferent neruones". It was a valuable experience sharing our work on gut-brain signalling to the larger Cambridge neuroscience community. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. This was the annual meeting of the IMI Litmus where we are aiming to identify biomarkers of NASH. My group leads the preclinical programme and presented advances in cross species validation of biomarkers |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://litmus-project.eu/ |
| Description | Venice Maternal, Neonatal & Childhood Health Forum, Venice, Italy, 22nd March 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: "How does evidence on children's fat and muscle development contribute to the case for investment in MNCH after COVID-19?" |
| Year(s) Of Engagement Activity | 2021 |
| Description | What does it matter? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | In August 2019, Sue Ozanne was one of 4 experts on a panel discussion on food and health organised by BBSRC DTP PhD students. The discussion was preceded by a public film screening. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Why do I put on weight? |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | March 2021 - Channel 5 TV programme with Giles Yeo |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.channel5.com/show/why-do-i-put-on-weight |
| Description | World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Highlights from the World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | YouTube playlist of recorded talks from the Cambridge Festival 2021 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Recordings of live public talks with Q+A and graphic illustration given by Prof Sadaf Farooqi and Prof Stephen O'Rahilly for the 2021 Cambridge Festival were made into a YouTube playlist accessible through our channel. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/playlist?list=PLetI6tUdcINZmh2y_Q6pjLjffxTpmLLO_ |
| Description | brownies, 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | took activities based on unit research to a local brownie group. activities demonstrated by postdocs and PhD students |
| Year(s) Of Engagement Activity | 2019 |
| Description | bury st edmunds sci fest |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | ran activities and events based on unit research at the Bury St Edmunds Science Festival |
| Year(s) Of Engagement Activity | 2020 |
| Description | cambridge science festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | participation in Cambridge science festival family weekend events in central Cambridge and on the Addenbrookes campus (3 days in total). events aimed at 8-15 year olds. |
| Year(s) Of Engagement Activity | 2019 |
| Description | fm, Participant in Neurodegeneration Challenge Network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | As a award recipient, I interacted with about 150 students, postdocs, clinicians, funders, and patients interested in new paradigms in neurodegenerative disease research and open science. |
| Year(s) Of Engagement Activity | 2019 |
| Description | fm, Participant in New York Stem Cell Investigator Programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | As a award recipient, I interacted with about 150 students, postdocs, clinicians, funders, and patients interested in new paradigms in neurodegenerative disease research and open science. |
| Year(s) Of Engagement Activity | 2019 |
| Description | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Description | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 November 27, 2018 Could this be a solution for the obesity crisis? Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity? |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Description | https://www.news-medical.net/news/20210122/Pancreatic-ceb2-cell-derived-exosomal-miR-29s-manipulate-glucose-homeostasis.aspx |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | News Medical Sciences https://www.news-medical.net/news/20210122/Pancreatic-ceb2-cell-derived-exosomal-miR-29s-manipulate-glucose-homeostasis.aspx |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.news-medical.net/news/20210122/Pancreatic-ceb2-cell-derived-exosomal-miR-29s-manipulate-... |
| Description | iPlacenta Symposium on Novel perspectives in maternal and fetal health, 7th May 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Exploring the consequences of obesity during pregnancy for mother and child: a window of opportunity. |
| Year(s) Of Engagement Activity | 2021 |
| Description | ims schools visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | two full day visits to a local school with activities based on unit research designed for year 9 pupils. Students and postdocs volunteered to lead the activities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | innvited talk to Diabetes UK annual professional conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | able to share our data with colleagues and clinicians from across the UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | presentation to a primary school (FM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | FM gave a talk about the brain and the neuroscience of appetite regulation at a local primary school to all grade levels (approximately 210 students). This sparked over 1 hour of questions and the school reported increased interest in the brain and many questions in class in this area. |
| Year(s) Of Engagement Activity | 2019 |
| Description | scars-of-fat? |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | This presentation aims to describe the unique role of one of the less studied members of the superfamily, the Bone Morphogenetic Protein 8b (BMP8B), in the pathophysiology of Non-Alcoholic Steatohepatitis (NASH). Watch this webinar to learn: Discover how a high degree of transability of the 3D NASH microtissues to model human/murine NASH is achieved. Learn about the potential of the 3D NASH microtissues as in vitro tools to study mechanistically TGFß signalling. Hear how the NASH Assay can be used to reveal key mechanistic data underlying the human disease state to help develop new and better medicines. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://webinars.cn-bio.com/the-scars-of-fat?utm_campaign=TechNet%20Webinar&utm_content=137313508&ut... |
| Description | seminar to Institute of Metabolic Science in Aberdeen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | engaged with scientists in another centre of metabolic excellence to share ideas around common research interests |
| Year(s) Of Engagement Activity | 2018 |
| Description | two iBiology talks filmed |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Stephen O'Rahilly filmed 2 talks on obesity (causes and consequences) for the iBiology series (116K subscribers) |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.ibiology.org/human-disease/obesity/ |
| Description | visit from Jersey school students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | hosted a 1-day visit from students and teachers from a school in Jersey. students and teachers attended lectures and spent time with our PhD students to learn about life as a PhD student in Cambridge |
| Year(s) Of Engagement Activity | 2020 |
| Description | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. Role of lipidomics in metabolic research Opening keynote lecture Antonio Vidal-Puig (University of Cambridge, UK) "Adipose tissue expandability, lipotoxicity and the metabolic syndrome" |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oru.se/english/about-us/conferences/nordic-metabolomics-conference/program/ |