MRC Centre for Global Infectious Disease Analysis

Lead Research Organisation: Imperial College London
Department Name: School of Public Health

Abstract

The continuing threat from new infectious diseases has been highlighted in recent years by the emergence of MERS-coronavirus in the Middle East, Ebola in West Africa and Zika in Latin America. Preparing for and responding to such threats is a priority for public health agencies and governments worldwide. Equally importantly, as scientific research delivers new approaches to controlling existing infectious diseases such as malaria, HIV, tuberculosis and polio, there is a need to determine what interventions are likely to work best to limit the disease and illness caused by a specific disease in a particular setting.

In this context, computer modelling of the spread of diseases in populations coupled with scientifically rigorous data analysis have proven themselves as powerful tools for giving insight into how diseases spread and what can be done to limit that control that spread. The Centre for Global Infectious Disease Analysis undertakes research on these scientific methods and applies them to disease threats of concern.

A key feature of the Centre is the close links it has made with with public health agencies - such as the Public Health England, the Centers for Disease Control and Prevention in the US (CDC), and the World Health Organization (WHO) - organisations which have to formulate and implement strategies to control infectious diseases.

Senior scientists in the Centre are world-leaders in infectious disease modelling and analysis. They have broad experience in responding to real epidemics, and undertaking epidemiological research on endemic diseases (such as malaria, HIV, tuberculosis and polio). Their work directly influences disease control policy through the many interactions the Centre has with public health organisations and governments.

Funding provided by MRC and Imperial College has allowed dedicated investment into the development of close collaborative partnerships with PHE, CDC and WHO and governments and research centres in many low and middle income countries (LMICs). We also work closely with other important organisations who work on improving health in LMICs (notably the Bill and Melinda Gates Foundation, The Global Fund and Gavi). With each, our collaborative research has both scientific interest to Centre researchers and contributes to the evidence base for public health decisions. Centre funding supports a core technical capacity available to all projects and pays for dedicated liaison staff who facilitate and enhance our partnerships with major global health organisations and LMICs.

MRC funding has also facilitated a greater focus on collaboration, training and career development within the Centre - training the next generation of quantitative infectious disease epidemiologists. We are also involved in increasing knowledge of advanced modelling methods in public health institutions and the wider infectious disease research community, and so have run a large number of introductory short-courses and workshops (in 13 countries in the last 5 years)

This applied activity depends on more fundamental research undertaken in the Centre on the transmission dynamics of different diseases, how diseases evolve genetically over time, and on analysing new approaches to control or treat diseases. This research is interdisciplinary, with Centre researchers working with leading clinical and experimental scientists around the world.

Continued Centre funding will allow existing partnerships to be sustained and enhanced, and new collaborations with researchers and health agencies in LMICs to be developed. By supporting PhD training and postdoctoral career development, it will also continue to expand the UK skill base in mathematical modelling and advanced analysis applied to health problems. Last, continued MRC support will pump-prime new priority research areas, including work on improving the development of new vaccines and on tackling the global challenge posed by antimicrobial resistance.

Technical Summary

The continued threat posed by emerging infectious diseases has been highlighted in recent years by the emergence of MERS-coronavirus in the Middle East, Ebola in West Africa and Zika in Latin America. Preparedness therefore remains a policy priority for public health agencies and governments worldwide. In addition, as new vaccines, drugs and other interventions are developed for endemic diseases such as malaria, HIV and TB, there is a need to extrapolate from clinical trial results to determine which combination of interventions gives the optimal (or most cost-effective) control strategy for a specific disease in a particular setting.

In this context, modern epidemiological modelling and analysis methods have proven themselves increasingly powerful tools for giving insight into the patterns of emergence of novel outbreaks, the transmission dynamics of endemic diseases and the options available for the control of both. The Centre for Global Infectious Disease Analysis is a world leader in research in this area, and in translating our research into improved public-health decision-making. Since it was founded, MRC funding has supported this translation by facilitating the forging of close partnerships with all major global health organisations (e.g. WHO, PHE, CDC, BMGF, The Global Fund, Gavi) and research centres and public health agencies in many low and middle income countries (LMICs).

Continued funding for the Centre will allow existing partnerships to be sustained and enhanced, and new collaborations with researchers and health agencies in LMICs to be developed. By supporting PhD training and postdoctoral career development, it will also continue to expand the UK skill base in mathematical modelling and advanced analysis applied to health problems. Last, continued MRC support will pump-prime new priority research areas, including work on improving the development of new vaccines and on tackling the global challenge posed by antimicrobial resistance.

Planned Impact

A primary aim of the MRC Centre for Global Infectious Disease Analysis is to have societal as well as academic impact - both in the UK and across the world. Our goal is to improve public and global health decision making in relation to infectious disease control through the use of advanced statistical and mathematical modelling methods, whether in emergencies like the West African Ebola epidemic in 2014, or in improving control of major infectious disease killers like HIV, malaria and Tuberculosis. We believe the only effective way of delivering on this goal is to form long-term collaborative partnerships with the leading public and global health organisations world-wide, providing analytical support and capacity building for those partners.

Since the Centre was founded in 2008, we have worked on dozens of policy-relevant problems with decision-makers around the world. We provided real-time support to the World Health Organization (WHO), the governments of the UK, and many other international partners during the 2001 H1N1 influenza pandemic, in relation to continued outbreaks of MERS coronavirus in the Middle East, during the 2014-15 West African Ebola epidemic, and, most recently, during the Latin American Zika epidemic. In addition, we have worked closely with WHO and the major international organisations (e.g. The Global Fund, Gavi and the Bill and Melinda Gates Foundation [BMGF]) that fund infectious disease control efforts in low income countries on HIV, malaria, tuberculosis, polio, influenza and a wide range of other diseases. Our relationship with BMGF is of particular strategic importance - it is both the largest funder of Centre research, but more importantly is a key stakeholder in global health decision-making.

These interactions, and our consequent impact on policy, is facilitated by staff dedicated to acting as liaisons between the scientists working in the Centre and the staff of the global and public health agencies we work with. Indeed, in times of crisis, we embed our staff in some of those key organisations. Recently, one of our researchers joined a WHO field mission to the Democratic Republic of Congo to help that country respond to an outbreak of Ebola.

In addition to formal research outputs, often the most important value we give to these organisations is advice provided from a dynamical modelling perspective. This analytical advisory role is multifaceted: from improving situational awareness in crises, advising on likely impact of interventions for endemic diseases, undertaking rapid analyses of priority questions, and advising on improving surveillance and data capture systems.

Capacity building within our partners is another priority, through informal skills transfer and formal training. The former occurs as a natural result of the degree of interaction, and for the latter we run short-courses, both in the Centre and at our partners' sites. Increasingly, we have also been undertaking capacity-building in low and middle income countries [LMIC], either by running disease-specific workshops with local ministries of health, or by training able local scientists. This activity will be further emphasised in the future.

In addition to impact on public health, we have also been increasing our collaborations with the pharmaceutical industry, most notably with vaccine manufacturers. In the last 5 years we have worked closely with GSK and Sanofi Pasteur, helping to characterise the effectiveness of their malaria and dengue vaccines, respectively. Our work involved analysing the data those companies collected on their products during clinical trials and advising them, WHO and regulatory agencies on how their vaccines might best be used. We also work with a wide range of public-private product development partnerships developing new vaccines, drugs and vector control measures.

Attached letters of support from UK DoH, GoS, PHE, US CDC, WHO and BMGF highlight the public health impact of the Centre.

Organisations

Publications

10 25 50
 
Description The COVID-19 Response Team at Imperial College London have been at the forefront globally in providing analytical capacity and modelling to support government responses to the COVID-19 pandemic worldwide. During the first quarter of 2020 the team provided regular epidemiological and modelling updates to UK government via its scientific committee SAGE, including key evidence in March 2020 demonstrating the need to move to a suppression strategy to avoid the NHS becoming overwhelmed that led to the first UK national lockdown. Weekly estimates of the reproduction number R, the epidemic growth rate and medium-term projections have been used to support UK government and NHS planning. Analysis of the novel variant in December 2020 demonstrated its increased transmissibility leading directly to the tightening of restrictions. Internationally, the team's work has supported WHO policy development and other country responses to the pandemic.
First Year Of Impact 2020
Sector Education,Healthcare,Government, Democracy and Justice
Impact Types Societal,Economic,Policy & public services

 
Description ASCEND Programme - UK AID programme funded by FCDO
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
Impact Advice to individual governments in Africa and South East Asia on how to manage COVID-19 in the context of other disease programmes.
 
Description Active case finding in South India
Geographic Reach Asia 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Modelling analysis helped local authorities in their decision making for how to implement a highly resource intensive activity (active case finding) in a more efficient way. Guidance allowed a 20% increase in numbers of x-rays being diagnosed for TB. Awaiting further data to assess further impact on patient outcomes. Update 2021: Paper under preparation
 
Description Advice given to UK government on Brazil variant (Nuno Faria)
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Advice given to UK govt on potential for increased transmissibility and/or immune escape of Brazil variant. Advice given led to ban on all flights from South America and Portugal and led to the introduction of mandatory hotel quarantine upon arrival in the UK. Widely discussed in media - policy change had a considerable impact on the UK aerospace industry and has been an effective measure to control the spread of COVID-19 in the UK.
 
Description Advice given to WHO and Public Health England on P1 variant lineage (Nuno Faria)
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Presented evidence to WHO and advice given to Public Health England on P1 variant and how guidelines should be amended to adapt COVID-19 response to changing variants. Advice given and awareness raised will lead to a decrease in COVID-19 transmission globally and will contribute to decreasing case and death rates, and increased control measures within the UK to ensure the success of COVID-19 restrictions
 
Description Advise to Chinese government to set up national procurement
Geographic Reach Asia 
Policy Influence Type Participation in a advisory committee
Impact Centralized national procurement process for pharmaceuticals was established in China based on this advise, launched in 2018.
 
Description Advising on global polio policy to the Global Polio Eradication Initiative
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Guidance on vaccine choice during polio eradication endgame, release of global stockpile, development of a new oral poliovirus vaccine 2009-2020 WHO SAGE polio vaccine working group 2016 onwards - participation in CRTT - modelling committee for polio eradication
 
Description Advisory Board of Parasites & Vectors
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Shaping up the scope of the journal; engagement with contributors; advising the Editor-in-Chief
 
Description Awarded role of Co-convenor for the National Infected Blood Enquiry (Katharina Hauck)
Geographic Reach Europe 
Policy Influence Type Gave evidence to a government review
 
Guideline Title 2018 BASHH UK national guideline for the management of infection with Mycoplasma genitalium
Description British Association for Sexual Health and HIV guidelines on public health management of Mycoplasma genitalium and antimicrobial resistance
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
URL https://www.bashh.org/news/news/bashh-launches-new-nice-accredited-guidelines-to-help-prevent-mycopl...
 
Description Chair of Oriole Global Health Limited
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Chair of OGH Limited which is helping UK Aid and DFID deliver the ASCEND project for the control of NTDs in resource poor settings.
URL https://orioleglobalhealth.com
 
Description Chair of the COVID-19 modelling guidance group for the Global Fund (Tim Hallett)
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Led analytical work of the Global Fund to quantify the impact that COVID-19 has had on the portfolio of countries in 2020 and the following 2 years Analytical work has contributed to acute awareness of potential impact of COVID-19 on other disease (HIV, TB, Malaria) and a recognition of how the impact would extend to post pandemic years.
 
Description Citation in Blackett review
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/computational-modelling-blackett-review
 
Description Citation in GAVI decision to support HBV birth dose
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.gavi.org/our-alliance/strategy/vaccine-investment-strategy
 
Description Citation in WHO consolidated guidelines in HIV testing
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Modelling expertise has contributed to guideline development and publication in WHO guidelines and policy briefs. Guidelines have led to changes in services - diagnosis of HIV. https://www.who.int/publications/i/item/978-92-4-155058-1 https://www.who.int/publications/i/item/WHO-CDS-HIV-19.31 https://www.who.int/publications/i/item/WHO-CDS-HIV-19.34
URL https://www.who.int/publications/i/item/978-92-4-155058-1
 
Description Citation in WHO policy document 'Considerations for implementing and adjusting public health and social measures in the context of COVID-19: interim guidance, 4 November 2020'
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Citation in WHO policy document. Implementation of guidance has resulted in decisions made at country levels to assist in response to COVID-19 pandemic - actions taken by countries include implementation of non-pharmaceutical interventions
URL https://apps.who.int/iris/handle/10665/336374
 
Description Citation in WHO report: Genomic sequencing of SARS-CoV-2 (Erik Volz)
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Has impacted the ways in which nations are responding to COVID-19 (setting up of surveillance systems)
URL https://apps.who.int/iris/bitstream/handle/10665/338480/9789240018440-eng.pdf
 
Description Co-wrote a WHO protocol for assessing non-inferiority of bednets and indoor residual sprays
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact We have devised a protocol to enable novel vector control products that are part of an existing intervention class to be recommended by the WHO (and therefore purchased by the Global Fund) without the need to go through expensive randomised control trials. Update 2020 - The policy was refined and accepted by the Malaria Programme Advisory Comittee at the WHO. New bednets are currently being distributed across Africa which are predicted to have a significant public health benefit to the people using them.
 
Description Collaboration with WHO Global Malaria Programme
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact This publication was cited in new policy guidance for the use of current rapid diagnostic tests for malaria, including guidance on when to switch test type if resistance mutations are present.
URL https://www.who.int/malaria/mpac/en/
 
Description Commonwealth Heads of Government Malaria Committment
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL https://www.malariasummit.com/
 
Description Comparison of different brands of bed nets
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Determine methods to ensure that bed nets procured by governments and charitable organisations are of an efficient standard
 
Description Confidential report to Ministry of Health Singapore regarding number if imported cases from China
Geographic Reach Asia 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Estimates produced were used to support COVID-19 response in Singapore and used to evaluate the decision to impose travel restrictions in Singapore.
 
Description Confidential reports to Ministry of Health and National Institutes of Health Italy
Geographic Reach Europe 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Confidential advice given to Italian Ministry of Health and Italian National Institute of Health which has led to implementation of non-pharmaceutical interventions and closure of schools and businesses
 
Description Confidential reports to support COVID-19 response in Philippines
Geographic Reach Asia 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Contribution to tracking of reproductive number of COVID-19 in the Philippines
 
Description Consultation on Zimbabwe COVID-19 response
Geographic Reach Africa 
Policy Influence Type Participation in a national consultation
Impact Modelling support to Zimbabwe Ministry of Health led to implementation on national lockdown and introduction of non pharmaceutical interventions to reduce the transmission of COVID-19 in Zimbabwe
 
Description Contribution to Kenya's National Strategic Plan for TB control
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Guideline Title HBV prevention of mother-child transmission
Description Contribution to and citation in WHO guideline for HBV prevention of mother-child transmission
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
 
Description Design and teaching on Global Master in Public Health
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact The Global Master in Public Health attracts postgraduate students across from health care, public and private health organization, etc. I have led the design and taught with fellow academics the policy impact evaluation modules of the master program. In doing so, the knowledge and skills of the students, mostly from the active workforce, will have improved, i.e. an impact is knowledge transfer.
URL https://www.coursera.org/degrees/global-mph-imperial
 
Description Directing London Centre for NTD research - Helping deliver impact in the control of infectious diseases in resource poor settings
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
Impact Creation of an evidence base of how best to control NTDs. Influence on WHO guidelines for disease control and funding by philanthropic organisations, (GATES and CIFF). Guidelines hope to improve health in resource poor settings.
URL https://www.lshtm.ac.uk/newsevents/news/2013/ntd_research_launch.html
 
Description EU policy on banning trade in vector species infected with Batrachochytrium salamandrivorans fungus
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
Impact Biosecurity-relevant policy on banning the import of vector species with a view to stopping the introduction of Batrachochytrium salamandrivorans into the EU
URL https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32018D0320&from=EN
 
Description Elimination Scenario Planning Exercise with Senegal & The Gambia
Geographic Reach Africa 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Supported by The Global Fund, in 2016-2017 we undertook three workshops to support malaria country programme planning with The Gambia and Senegal. The last of these, in March 2017, was a joint workshop between the two programmes in which we coordinated discussions surrounding cross-border collaboration between the two countries. Our role in supporting the establishment of this new collaboration was acknowledged at the Malaria Summit held ahead of the Commonwealth Heads of Government meeting by the President of The Gambia (see URL below - we are mentioned in the film). A formal collaboration between the two countries was signed in January 2019.
URL https://www.malariasummit.com/
 
Description Epidemics Analysis, Modelling and Response Short Course, Bogota, 11-15 December 2017
Geographic Reach South America 
Policy Influence Type Influenced training of practitioners or researchers
Impact This short course has been the first of a series of capacity building activities in Latin America about mathematical modelling for infectious disease analysis. The course was done in collaboration between Imperial College London, R Epidemics Consortium and Universidad Nacional de Colombia. The course received abot 620 applications from which we selected 45 participants. The course provided capacity building and skills improvement for analysing data of infectious diseases.
URL https://epicoursebogota.netlify.app/
 
Description Evidence to UK government to support COVID-19 response (genomics)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact Senior advisory group at MRC-GIDA have presented to UK government on multiple occasions to assist COVID-19 efforts nationally. Evidence provided has included: Modelling of worst case scenarios (led to introduction of national NPIs and lockdown measures) Assessed the effectiveness of COVID-19 interventions internationally Assessed the international research evidence Report submitted: https://www.cogconsortium.uk/wp-content/uploads/2020/05/16th-April-2020-Report-Covid-19-Genomics-Consortium-UK-COG-UK.pdf https://www.cogconsortium.uk/wp-content/uploads/2020/07/25th-June-2020-Report-COVID-19-Genomics-UK-COG-UK-Consortium.pdf
 
Description Evidence to UK government to support Covid-19 response (epidemiology and modelling): UK response December 2020 - Phylodynamic analysis of new variants
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Towards the end of 2020 rapid research was undertaken to evaluate the significance of a new variant of SARS-Cov-2 that had emerged in the UK, with phylodynamic analysis coupled with epidemiological analysis demonstrating significantly increased transmissibility of the new variant of concern. Submitted for publication: Volz et al. (2021) Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking epidemiological and genetic data. medRxiv https://doi.org/10.1101/2020.12.30.20249034. In December 2020, phylodynamic analysis provided the first estimates of increased transmissibility of the new Variant of Concern 202012/01 (VOC) of up to 70%, the figure cited by the Prime Minister in his statement on 19th December that led to the decision to put more regions of the UK into Tier 4 restriction and eventually the 3rd UK national lockdown in January 2021.
URL https://www.gov.uk/government/speeches/prime-ministers-statement-on-coronavirus-covid-19-19-december...
 
Description Evidence to UK government to support Covid-19 response: AMS Report - RWC projections (UK response May - December 2020)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact The Imperial team have developed Reasonable Worst-Case (RWC) outputs for an independent report commissioned by the Chief Scientific Advisor and produced by the Academy of Medical Sciences, highlighting the need to prepare for a challenging winter period.
URL https://acmedsci.ac.uk/more/news/prepare-now-for-a-winter-covid-19-peak-warns-academy-of-medical-sci...
 
Description Evidence to UK government to support Covid-19 response: Reasonable worst case (RWC) projections (UK response May - December 2020)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact The Imperial team have provided medium-term projections of the UK COVID-19 epidemic released by UK government and to support government departments in the form of "Reasonable Worst-Case (RWC)" projections.
URL https://www.gov.uk/government/publications/spi-m-o-covid-19-preparatory-analysis-long-term-scenarios...
 
Description Evidence to UK government to support Covid-19 response: Report 9 (UK early response Jan-Apr 2020)
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Whilst multiple UK teams contributed to the modelling evidence underpinning the UK lockdown that occurred in March 2020, "Report 9" [Ferguson NM et al. (2020) Report 9 - Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. https://doi.org/10.25561/77482] was one of the most globally influential with the highest ever global score for impact in the Altmetric database (63,840 mentions as of January 1st 2021). The policy report summarised scenarios for NPIs developed in close collaboration with SAGE and the Government Office for Science - including case isolation in the home, household quarantine, isolation of the elderly and closure of schools and universities. The results demonstrated that mitigation (slowing but not interrupting epidemic spread) would result in the UK health service being over-whelmed and that to suppress transmission would require social distancing to be implemented across the population alongside isolation of cases and household quarantine. Results contained in this report were shared with SAGE, the CSA, CMO, the NHS executive and Downing Street in the days preceding the first announcement from the UK government of a move to a suppression strategy on 16 March 2020 [D] that subsequently led to the first UK lockdown on 23 March 2020. The widespread global media coverage of Report 9 generated considerable global impact as evidenced by a drop in mobility from 17th March determined using Google mobility data (https://www.google.com/covid19/mobility/).
URL http://www.gov.uk/government/collections/scientific-evidence-supporting-the-government-response-to-c...
 
Description Evidence to UK government to support Covid-19 response: Report 9 - SAGE Meeting 16 (1) (UK early response Jan-Apr 2020)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact "Report 9" [Ferguson NM et al. (2020) Report 9 - Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. https://doi.org/10.25561/77482]. Results contained in this report were shared with SAGE, the CSA, CMO, the NHS executive and Downing Street in the days preceding the first announcement from the UK government of a move to a suppression strategy on 16 March 2020 [D] that subsequently led to the first UK lockdown on 23 March 2020. Key government and SAGE documents informing the move to a suppression strategy, including Meeting 16, 16th March 2020.
URL https://www.gov.uk/government/publications/impact-of-non-pharmaceutical-interventions-npis-to-reduce...
 
Description Evidence to UK government to support Covid-19 response: Report 9 - SAGE Meeting 16 (2) (UK early response Jan-Apr 2020)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact "Report 9" [Ferguson NM et al. (2020) Report 9 - Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. https://doi.org/10.25561/77482]. Results contained in this report were shared with SAGE, the CSA, CMO, the NHS executive and Downing Street in the days preceding the first announcement from the UK government of a move to a suppression strategy on 16 March 2020 [D] that subsequently led to the first UK lockdown on 23 March 2020. Key government and SAGE documents informing the move to a suppression strategy, including Meeting 16, 16th March 2020.
URL https://www.gov.uk/government/publications/coronavirus-disease-2019-covid19-intervention-strategies
 
Description Evidence to UK government to support Covid-19 response: Report 9 - SAGE Meeting 17 (UK early response Jan-Apr 2020)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact "Report 9" [Ferguson NM et al. (2020) Report 9 - Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. https://doi.org/10.25561/77482]. Results contained in this report were shared with SAGE, the CSA, CMO, the NHS executive and Downing Street in the days preceding the first announcement from the UK government of a move to a suppression strategy on 16 March 2020 [D] that subsequently led to the first UK lockdown on 23 March 2020. Key government and SAGE documents informing the move to a suppression strategy, including Meeting 17, 18th March 2020.
URL https://www.gov.uk/government/publications/timing-of-the-introduction-of-school-closure-for-covid-19...
 
Description Evidence to UK government to support Covid-19 response: SAGE Meeting 10 (UK early response Jan-April 2020).
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact During February 2020, several Imperial College COVID-19 reports submitted to SAGE (meetings 9, 10, 12 and 13 directly informed SAGE advice to government. These include evidence of the potential impact of a range of NPIs - including banning of large gatherings, school closures and isolation of the elderly.
URL https://www.gov.uk/government/publications/potential-effect-of-non-pharmaceutical-interventions-on-a...
 
Description Evidence to UK government to support Covid-19 response: SAGE Meeting 12 (UK early response Jan-April 2020).
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact During February 2020, several Imperial College COVID-19 reports submitted to SAGE (meetings 9, 10, 12 and 13 directly informed SAGE advice to government. These include evidence of the potential impact of a range of NPIs - including banning of large gatherings, school closures and isolation of the elderly.
URL https://www.gov.uk/government/publications/adoption-and-impact-of-non-pharmaceutical-interventions-f...
 
Description Evidence to UK government to support Covid-19 response: SAGE Meeting 13 (UK early response Jan-April 2020).
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact During February 2020, several Imperial College COVID-19 reports submitted to SAGE (meetings 9, 10, 12 and 13 directly informed SAGE advice to government. These include evidence of the potential impact of a range of NPIs - including banning of large gatherings, school closures and isolation of the elderly.
URL https://www.gov.uk/government/publications/timing-local-triggering-of-non-pharmaceutical-interventio...
 
Description Evidence to UK government to support Covid-19 response: SAGE Meeting 9 (UK early response Jan-April 2020).
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact During February 2020, several Imperial College COVID-19 reports submitted to SAGE (meetings 9, 10, 12 and 13 directly informed SAGE advice to government. These include evidence of the potential impact of a range of NPIs - including banning of large gatherings, school closures and isolation of the elderly.
URL https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/8917...
 
Description Evidence to UK government to support Covid-19 response: Summary of scientific evidence supporting the UK government response (UK early response Jan-April 2020).
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Imperial College research on the epidemiology of SARS-CoV-2 and modelling of potential mitigation options in a UK context formed a central piece of evidence underpinning the UK government response during the first 4 months of the pandemic. The Imperial team was cited in a summary of scientific evidence supporting the response to coronavirus published on 26th June 2020 which includes a unique section on "Imperial College Reports" [https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/covid-19-reports/] including the first 8 online reports (including estimates of the early-scale of the potential scale of the epidemic in Wuhan, and the first estimates of transmissibility and severity) and reference [Verity R et al. (2020) Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 20(6):669-677. doi: 10.1016/S1473-3099(20)30243-7] which provided the most robust estimates of the infection fatality ratio (IFR). These latter estimates were critical during the early stages of the response in determining, alongside estimates of the reproduction number made in earlier reports, the potential magnitude of an unmitigated epidemic (~500,000 deaths) and therefore the need to act to contain transmission of the virus.
URL http://www.gov.uk/government/collections/scientific-evidence-supporting-the-government-response-to-c...
 
Description Evidence to UK government to support Covid-19 response: UK Government Consensus Statement on Mass Testing (UK response May - December 2020)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact As testing capacity increased in the UK and NHS Test and Trace was established, Imperial research [Grassly NC, Pons-Salort M, Parker EPK et al. (2020) Comparison of molecular testing strategies for COVID-19 control: a mathematical modelling study. Lancet Infect Dis. 2020 20(12):1381-1389. doi: 10.1016/S1473-3099(20)30630-7] directly informed the policy and UK Government Consensus Statement on Mass Testing.
URL https://www.gov.uk/government/publications/tfms-consensus-statement-on-mass-testing-27-august-2020
 
Description Evidence to UK government to support Covid-19 response: UK Government Coronavirus Action Plan (UK early response Jan-April 2020).
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Imperial College research on the epidemiology of SARS-CoV-2 and modelling of potential mitigation options in a UK context formed a central piece of evidence underpinning the UK government response during the first 4 months of the pandemic. The Imperial team was cited in the UK Government Coronavirus Action Plan published on 3 March 2020.
URL http://www.gov.uk/government/publications/coronavirus-action-plan;
 
Description Evidence to UK government to support Covid-19 response: Weekly R estimates to SPI-M-O (UK response May - December 2020)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact From May 2020 onwards, the UK government, via SAGE, has published weekly estimates of the reproduction number, R, and associated growth rates [ https://www.gov.uk/guidance/the-r-number-in-the-uk], of which the Imperial team is one of four contributing modelling groups. These estimates, provided as part of a SPI-M-O "consensus statement", are shared across government departments, the NHS and local resilience forums and are used widely for planning purposes and to support local and national responses, thereby directly impacting the course of the UK epidemic.
URL https://www.gov.uk/government/publications/scientific-advisory-group-for-emergencies-sage-coronaviru...
 
Description GAVI Vaccine Investment Strategy
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Membership of the GAVI Vaccine Investment Strategy Committee which provided the scientific input for the recommendation of new vaccines to be supported by GAVI in the upcoming replenishment. This has a direct impact on worldwide childhood vaccination strategies.
URL https://www.gavi.org/about/strategy/vaccine-investment-strategy/
 
Description HPCs-UNAIDS
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
 
Description HPCs-Zimbabwe
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Health system strategic plan in Malawi
Geographic Reach Africa 
Policy Influence Type Membership of a guideline committee
 
Description Informing strategic priorities for TB elimination in Mumbai, India
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
 
Description Interagency Liaison Group on Biodiversity and Health
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL https://www.cbd.int/health/ilg-health/
 
Description Internaional Response: Country level support
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
Impact The team directly supported control efforts in 10 countries (Columbia, India, Indonesia, Italy, Malawi, Nigeria, Senegal, Sudan, the United States and Zimbabwe) providing local model reports through academic and public health partners to support government responses. Example: Announcement by New York Governor's Office of Research Partnership with Imperial College London.
URL https://www.governor.ny.gov/news/amid-ongoing-covid-19-pandemic-governor-cuomo-announces-state-bring...
 
Description International Course - Outbreak Analysis and Modelling for Public Health June 2019
Geographic Reach South America 
Policy Influence Type Influenced training of practitioners or researchers
Impact This was the second version of a course on mathematical modelling applied to infectious diseases in Latin America. The course reached 498 person interested from wich we selected 45 participants from 4 countries in Latin America: Colombia, Panamá, Peru, and Venezuela. The course was co-organised by Imperial College London, R Epidemics Consortium, Universidad Javeriana and National Institute of Health in Colombia. The course provided capacity building and skills improvement for analysing data of infectious diseases.
URL https://www.ins.gov.co/modelamiento/modelamiento.html
 
Description International response: Vaccine modelling
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact The team has developed models to explore the impact of vaccination in the UK and globally, demonstrating that even partially effective vaccines can have a significant public health impact and that global allocation of limited vaccine supply according to population size is near-optimal to equitably reduce the impact of the pandemic. Research has contributed to the WHO SAGE Roadmap for Prioritizing Uses of COVID-19 vaccines in the context of limited supply. Submitted for publication: Hogan et al. (2020) Report 33 - Modelling the allocation and impact of a COVID-19 vaccine. doi: https://doi.org/10.25561/82822 [https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-33-vaccine/].
URL https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-33-vaccine/
 
Description Malaria Policy Advisory Committee
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact This committee provides advice directly to the WHO Global Malaria Programme on all topics relevant to malaria control and elimination. WHO guidance has direct impact on the policies adopted by national government, which over the past year has included amendment of treatment protocols, advice on current and new prevention interventions, allocation of global donor funding and certification of malaria elimination.
URL https://www.who.int/malaria/mpac/en/
 
Description Member of Executive Management of Neglected Tropical Disease Modelling Consortium
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Member of Global Polio Eradication Initiative - Environmental Surveillance Implementation working group
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Member of Global Polio Eradication Initiative - Environmental Surveillance Implementation working group Contributed analysis of surveillance data Recommendations were made by the group based on results of analysis of data. Recommendations led to changes in best practice for environmental surveillance
 
Description Member of Global Polio Eradication Initiative - nOPV2 genetic characterisation sub-group
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Member of Global Polio Eradication Initiative - nOPV2 genetic characterisation sub-group Contributed analysis of data to inform surveillance during vaccine roll out
 
Description Member of Global Polio Eradication Initiative cessation risk task team
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Member of Global Polio Eradication Initiative cessation risk task team Contributed analysis of surveillance data Recommendations made based on results of data analysis to improve best practice of outbreak response
 
Description Member of Influenza Incidence Analytics Group
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Member of Scientific Advisory Group for Emergencies (SAGE), COVID-19
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Presented multiple reports on modelling COVID-19 to SAGE. Reports have led to implementation of social distancing, changes to NHS services and business operations nationally and have averted COVID cases and death numbers. Reports available: https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/
URL https://www.gov.uk/government/organisations/scientific-advisory-group-for-emergencies
 
Description Member of Scientific Pandemic Influenza Group on Modelling (SPI-M), COVID-19
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Membership of SPI-M ( Professors Peter White, Neil Ferguson, Steven Riley, Nick Grassly and Drs Samir Bhatt and Marc Baguelin) Presented multiple reports on modelling COVID-19 to SPI-M. Reports have contributed to implementation of social distancing, changes to NHS services and business operations nationally and have averted COVID cases and death numbers. Reports have aldo contributed to the planning and successful roll out of the COVID-19 vaccination programme. Reports available: https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/
URL https://www.gov.uk/government/groups/scientific-pandemic-influenza-subgroup-on-modelling
 
Description Member of WHO Strategic and Technical Advisory Group for Tuberculosis
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Membership of guidance committee - have contributed mathematical modelling expertise Recommendations have informed WHO policy on mitigating COVID disruptions on TB and on strategies for 'building back stronger'.
URL https://www.who.int/publications/m/item/report-of-the-20th-meetingwho-strategic-and-technical-adviso...
 
Description Member of WHO committee for recommendation for screening and treatment for cervical cancer
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Involvement in WHO committee. Have informed WHO guidelines on cervical cancer screening. Publications ongoing.
 
Description Member of WHO-SAGE COVID-19 vaccines working group
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Professor Nick Grassly is a member of the WHO SAGE COVID-19 vaccine working group. The group approves and make recommendations for COVID-19 vaccines. These recommendations are used by countries to support their immunisation policies
 
Description Member of expert group for MoD (Confidential) - ongoing as of 2021
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Membership of Pandemic Preparedness Committee of the National Science Foundation USA - Professor Sir Roy Anderson
Geographic Reach North America 
Policy Influence Type Membership of a guideline committee
Impact Membership of committee which advises USA government on pandemic preparedness and lessons learnt from COVID-19. Advise given in confidence
 
Description Membership of SET-C committee - guidance to Chief Scientist Officer (Professor Sir Roy Anderson)
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Membership of Royal Society SET-C committee which provides advice in confidence to the Chief Scientists Office continuously throughout the COVID-19 pandemic. Professor Anderson has contributed extensively to multiple reports and has been lead author on multiple papers: 14 December 2020: SARS-CoV-2: Where do people acquire infection and 'who infects whom'? (PDF) - 30 November 2020: Appendix (PDF) 24 August 2020: Reproduction number (R) and growth rate (r) of the COVID-19 epidemic in the UK (PDF)
URL https://royalsociety.org/topics-policy/projects/set-c-science-in-emergencies-tasking-covid/
 
Description Membership of WHO SE Asian regional green light committee for TB
Geographic Reach Asia 
Policy Influence Type Membership of a guideline committee
Impact Membership of WHO guidance committee. Provided 11 countries of SE Asian region with technical assistance in management of drug resistant TB. Activities have already influence strategic planning for several countries within the region.
 
Description Membership of WHO Technical Advisory Group on Health benefit packages
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Issue WHO guidance on how to design healthcare packages eg Universal Healthcare Coverage
 
Description Membership of regional WHO advisory committee on multi-drug-resistant TB in South East Asian Region
Geographic Reach Asia 
Policy Influence Type Participation in a advisory committee
 
Description Methods development for global HIV estimates and projections
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact We developed new mathematical models used to estimate and project trends in the global HIV epidemic. These models are used by all countries in sub-Saharan Africa and over 150 countries globally to develop official national estimates of their HIV epidemic and plan, budget, and allocate resources to the HIV response. Estimates are reported by UNAIDS as official global HIV estimates and projection, and they form consensus estimates underpinning resource allocation by the US President's Emergency Plan for AIDS Relief (PEPFAR) and the Global Fund to fight HIV, TB, and Malaria. 2021 - still ongoing
URL http://aidsinfo.unaids.org
 
Description Modelling impact of COVID disruptions on TB
Geographic Reach Asia 
Policy Influence Type Citation in other policy documents
Impact Modelling paper was used to influence in country discussions regarding domestic financing for TB control. Contribution was especially important in the Phillipines where public finances were under severe strain and in Tajekistan where modelling shaped strategy for international donors (USAID).
 
Description NERVTAG (New and Emerging Respiratory Virus Threats Advisory Group) - Since 2015
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
URL https://www.gov.uk/government/groups/new-and-emerging-respiratory-virus-threats-advisory-group
 
Description Pandemic influenza preparedness - advice to government
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Effective preparedness and response to pandemics, which are the highest category of risk identified on the National Risk Register of Civil Emergencies. This is an ongoing activity, supported by multiple relevant grants spanning different time-periods. Updated 2020: Involvement in coronavirus real time analysis and advice
 
Description Participation in International Best Practice Advisory Group to Cabinet Office UK (Katharina Hauck)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Involvement led to greater awareness of looking at the combined economic/health impacts of the COVID-19 pandemic to UK policy makers
 
Description Participation in NHRDP - national health research and development programme - committee to decide on grant allocations for COVID-19 networks
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Participation in WHO consultation process for setting the 2030 Roadmap on Neglected Tropical Diseases
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Report of the consultation meeting by the WHO - Neglected Tropical Disease Modelling Consortium Report Open Letter for Gates Open Research on Onchocerciasis, Chagas Disease and Taeniasis/Cysticercosis - contribution by ICL by highlighting insights from mathematical modelling in these 3 disciplines for the achievement of the 2030 NTD goals. Will result in increases in survival. improved quality of life for patients, decrease in disease burden and infection. This modelling can be used with economic modelling to assess the cost effectiveness of the interventions modelled.
URL https://www.who.int/neglected_diseases/news/WHO-launches-global-consultations-for-new-NTD-Roadmap/en...
 
Description Participation in expert scientific advisory committee (New Paradigms in Vector Control)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Investment in most appropriate tools for killing mosquitoes
URL http://www.ivcc.com
 
Description PhD Co-supervision
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Co-supervision of a PhD student. Providing inputs on a weekly basis. Inputs are reading material, help with shaping the analysis, interpretation of findings, writing up of the final results and overall progress of the PhD. The PhD focuses on HIV and economic productivity in Sub-Saharan Africa, a topic closely related to my funded research. My support helped the student to improve the output and to progress in her PhD.
 
Description Population wide mass testing campaign conducted in Vo, Italy
Geographic Reach Europe 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Support to population testing campaign in Vo, Italy in early stages of COVID-19 pandemic led to increased testing in the region. Early testing identified asymptomatic infection and led to a lower number of cases in the region compared to other regions in Italy.
 
Description Presentation and participation in WHO Technical Consultation in Research priorities for the use of more highly sensitive diagnostics during pregnancy
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL https://www.who.int/malaria/mpac/mpac-april2018-hi-sensitive-tests-session5.pdf?ua=1
 
Description Production of estimates of travel data to/from China globally for Office for National Statistics and Department for International Development
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Provided evidence to government reviews on phylogenetics of COVID-19 (Erik Volz)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact Provided evidence to govt to inform policies relating to transmission of COVID-19 in UK
 
Description Publication of work about Evidence Synthesis for Policy
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL https://royalsociety.org/topics-policy/projects/evidence-synthesis/
 
Description Published estimates of Impact of President's Malaria Initiative used in 12th annual report to congress
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Our estimates, published in PLoS Medicine, of the impact of the PMI since it's conception were used by PMI in it's report to congress. This report is used to advocate for resources for malaria prevention across 19 focus countries, amid a time when the US' contribution to foreign aid was being questioned.
URL https://www.pmi.gov/docs/default-source/default-document-library/pmi-reports/2018-pmi-twelfth-annual...
 
Description RDTs-WHO
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
Impact Evidence generated on the cost-effectiveness of repeat HIV testing prior to initiation on antiretroviral treatment contributed to a decision in Zimbabwe (and possibly elsewhere) to adopt a World Health Organisation recommendation to implement repeat HIV testing prior to initiating people onto antiretroviral treatment. This change in policy will reduce the numbers of HIV-negative people put on potentially life-long treatment, will reduce the occurrence of unnecessary side effects, and will reduce unnecessary expenditure.
 
Description REACT study - national study led by Professor Steven Riley
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact REACT (REal-time Assessment of Community Transmission) is a series studies that are using home testing to improve our understanding of how the COVID-19 pandemic is progressing across England. This major research programme was commissioned by the Department of Health and Social Care (DHSC) and is being carried out by Imperial College London in partnership with Ipsos MORI and Imperial College Healthcare NHS Trust. Here's our announcement from when the study first launched in April 2020. Results from the REACT study have been reported extensively in the media and have shaped public attitudes to non-pharmaceutical interventions, whilst providing both public and government with high level estimates of community transmission. Results from REACT have been used to shape public policy decisions regarding interventions and have been used to directly inform the Secretary of State Matt Hancock: Results from the REACT study have contributed to the implementation of the 'Rule of 6' to assist with the COVI-19 response https://www.imperial.ac.uk/medicine/research-and-impact/groups/react-study/ Multiple reports have been published
URL https://www.gov.uk/government/news/february-interim-findings-from-covid-19-react-1-study-published
 
Description Recommendation of second dose of inactivated polio vaccine into routine immunisation
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Recommendations made have contributed to decision to include second dose of inactivated polio vaccine into routine immunisation Policy decision will lead to decrease number of polio cases
URL https://www.who.int/immunization/sage/meetings/2020/october/SAGE_eYB_Oct2020final.pdf?ua=1
 
Description Scientific Advisory Group for Emergencies (SAGE) - Covid-19
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Report submitted to SAGE: https://www.cogconsortium.uk/wp-content/uploads/2020/05/16th-April-2020-Report-Covid-19-Genomics-Consortium-UK-COG-UK.pdf
 
Description Scientific Pandemic Influenza Group on Modelling (SPI-M-O) (since 2009)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL https://www.gov.uk/government/publications/spi-m-publish-updated-modelling-summary
 
Description Scientific committee for Pandemic Influenza - Modelling (SPI-M)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Evidence given to SPI_M committee directly influenced early messaging about the severity of COVID-19.
URL https://www.gov.uk/government/groups/scientific-pandemic-influenza-subgroup-on-modelling
 
Description Special Adviser to Governor of New York State Andrew Cuomo
Geographic Reach North America 
Policy Influence Type Participation in a advisory committee
Impact Special adviser to NY state government to provide modelling and information regarding easing of control measures. Advice given has led to reduction in number of COVID cases and deaths and led to slowing of reopening of retail and hospitality sectors. Quoted in Andrew Cuomo's book 'American crisis'
 
Description Strategic Technical Advisory Group for Infectious Hazards at WHO
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Influence on continued operational response for Ebola outbreak in DRC - has led to increased situational awareness of epidemiological trends. HAs led to improved service provision from international organisations.
URL https://www.who.int/emergencies/diseases/strategic-and-technical-advisory-group-for-infectious-hazar...
 
Description Support MSF surveillance of malaria policy
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Provided evidence to allow MSF to monitor malaria severity using antinatal clinic data
URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114784
 
Description Support the development of guidelines for malaria surveillance in near-elimination settings. We have outlined a set of questions that should be asked to estimate whether an identified case of malaria was acquired locally or imported from abroad. These include statements on the time and location of travel, duration of stay and date of arrival of symptoms. Questions trailed in regions of South Africa.
Geographic Reach Africa 
Policy Influence Type Influenced training of practitioners or researchers
 
Description TB control priorities in India
Geographic Reach Asia 
Policy Influence Type Gave evidence to a government review
 
Description Talk given to All Party PArliamentary Group on Biosecurity re COVID-19
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://www.parliament.uk/mps-lords-and-offices/offices/bicameral/post/post-events/future-biosecurit...
 
Description Talk given to Zimbabwe MoH on 'Misclassification errors in routine HIV testing'
Geographic Reach Africa 
Policy Influence Type Gave evidence to a government review
Impact Led to changes in decisions to the national HIV testing algorithm.
 
Description Technical advisory committee for the development of GOData2 - WHO Software for contact tracing
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Development of software used in contact tracing for various diseases including Ebola and COVID-19
URL https://www.who.int/godata
 
Description Typhoid environmental surveillance advisory group for the Gates Foundation
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description UNAIDS reference group
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact From 2015 to 2018, I co-chaired the UNAIDS Reference Group on Estimates, Modelling and Projections. This group advises UNAIDS and WHO on the methods used to generate international estimates of HIV infection and it's demographic impact. During this period, significant progress was made in improving these estimates - for example, for children infected with HIV, by incorporating age-structure into the models, and in producing local estimates of levels of HIV infection - that can be used to strengthen national HIV control programmes and, thereby, to further reduce levels of new infections and mortality.
URL http://www.epidem.org/
 
Guideline Title WHO Dengue Vaccination recommendation
Description WHO Dengue Vaccination recommendation
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Recommendations on optimal vaccine use has led to changes in the delivery of vaccines in relevant populations
URL https://www.who.int/wer/2016/wer9130.pdf?ua=1
 
Description WHO Flu Burden
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description WHO Technical Consultation on the Validation of elimination of HBV mother-to-child transmission.
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description WHO guidelines for prevention of mother to child transmission of HBV
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Contribution to the goal of elimination of HBV for new technologies for mother to child transmission
 
Description WHO policy of recommending the use of second-in-class bednets against malaria
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Impacts not yet recognised
 
Description WHO spread of pyrethroid resistant mosquitoes across Africa.
Geographic Reach Africa 
Policy Influence Type Participation in a advisory committee
Impact Collaboration with the World Health Organisation (WHO) Global Malaria Programme to understand the spread of pyrethroid resistant mosquitoes across Africa and how this influences the effectiveness of insecticide treated bednets used to control malaria. Though this has not led to any specific policy recommendations the work was presented in a WHO document (World Malaria Report 2019, Global report on insecticide resistance in malaria vectors: 2010-2016, accessed https://www.who.int/malaria/publications/atoz/9789241514057/en/ ) and on a live WHO webinar (https://apps.who.int/iris/bitstream/handle/10665/274556/WHO-CDS-GMP-2018.17-eng.pdf?ua=1). This work has supported the development of online threat maps for insecticide resistance status (https://www.who.int/malaria/maps/threats-about/en/).
URL https://www.who.int/malaria/publications/atoz/9789241514057/en/
 
Description WHO world malaria report
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
Impact Tracking of ITN numbers and use and inefficiencies
 
Description World Malaria Report 2019
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Published estimates of exposure and burden of malaria during pregnancy and associated Low birthweight were incorporated into official WHO estimates underpinning the World Malaria Report estimates of malaria burden and progress.
URL https://www.who.int/publications-detail/world-malaria-report-2019
 
Description Zimbabwe national AIDs council - workshop on HIV prevention cascade
Geographic Reach Africa 
Policy Influence Type Participation in a national consultation
 
Description (CoroNAb) - Nanobodies and antibodies against 2019-nCoV
Amount € 2,771,658 (EUR)
Funding ID 101003653 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2020 
End 03/2022
 
Description A genealogical approach to tracking bacterial transmission (Xavier Didelot)
Amount £403,170 (GBP)
Funding ID MR/N010760/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2016 
End 05/2019
 
Description A global registry of women affected by COVID-19 in pregnancy, understanding natural history to guide treatment and prevention
Amount £253,257 (GBP)
Funding ID MC_PC 19066 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 10/2021
 
Description A search-engine inspired platform enabling open sharing and access of both data and results from all genomic studies
Amount £38,832 (GBP)
Funding ID 219699/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2020 
End 07/2021
 
Description ALPHA network: HIV incidence trends and risk factors to describe patterns and risks for HIV incidence in selected communities in Southern and Eastern Africa
Amount £180,208 (GBP)
Funding ID EPPHZM5513/Imperial 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2018 
End 08/2021
 
Description APW WHO Global Malaria Programme
Amount £17,932 (GBP)
Funding ID 202011200 
Organisation World Health Organization (WHO) 
Sector Public
Country Global
Start 06/2018 
End 03/2019
 
Description Alessandra Lochen - PhD project support June2017 - Dec2020
Amount £58,818 (GBP)
Funding ID PO 480075829 
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 07/2019 
End 06/2021
 
Description Analysis of ALPHA Network
Amount £37,490 (GBP)
Funding ID PR2017/724002 EPPHZL91/IMPERIAL 
Organisation Joint United Nations Programme on HIV/AIDS (UNAIDS) 
Sector Public
Country Global
Start 12/2017 
End 11/2018
 
Description Analytic and sequencing tools for poliovirus environmental surveillance
Amount £876,522 (GBP)
Funding ID OPP1171890 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 05/2017 
End 12/2020
 
Description Anti-tuberculosis drug hepatotoxicity and treatment introduction - Stage 2
Amount £277,695 (GBP)
Funding ID 19GRM013/HTA/Lim 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2020 
End 12/2026
 
Description Antibiotic Resistance: Mathematical modelling simulating the evolutionary response of genococcus within human populations to gepotidacin use
Amount £151,716 (GBP)
Funding ID 3000862100 
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 06/2017 
End 12/2020
 
Description Assessing the impact of waning vaccine efficacy on malarial elimination using a population transmission model
Amount £61,597 (GBP)
Funding ID GAT.0888-30-01320457-COL 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2016 
End 11/2018
 
Description Assessing the risk that chytridiomycosis poses to the megadiverse amphibian community of Madagascar
Amount £119,900 (GBP)
Funding ID D16ZO-022 
Organisation Morris Animal Foundation 
Sector Private
Country United States
Start 09/2016 
End 04/2020
 
Description BMGF Project Grant: Vaccine Modelling Initiative (VMI) 2
Amount £970,053 (GBP)
Funding ID OPP1092240 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 06/2013 
End 06/2020
 
Description Better decisions for Better 1
Amount £132,748 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 12/2021
 
Description Beyond 90-90-90: Phylodynamic analysis to guide HIV surveillance, control & elimination
Amount £293,580 (GBP)
Organisation Imperial College London 
Department School of Public Health
Sector Academic/University
Country United Kingdom
Start 11/2018 
End 11/2021
 
Description Building International Collaborations on the Mathematical Modelling of Emerging Infectious Disease Threats (Neil Ferguson)
Amount £49,657 (GBP)
Funding ID P11329/DF118 
Organisation Imperial College London 
Department Imperial College Trust
Sector Charity/Non Profit
Country United Kingdom
Start 04/2008 
End 12/2023
 
Description Building TRUST
Amount £143,306 (GBP)
Funding ID Sub Award No. 1800014 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 07/2015 
End 06/2020
 
Description COVID 19 - Improving COVID-19 forecasts by accounting for seasonality and environmental responses
Amount £287,120 (GBP)
Funding ID NE/V009710/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 06/2020 
End 11/2021
 
Description COVID-19 Genomics UK (COG-UK) Consortium
Amount £20,790,000 (GBP)
Funding ID G106266 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 09/2021
 
Description COVID-19 UKRI Website
Amount £64,125 (GBP)
Funding ID 4020019245 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2020 
End 09/2020
 
Description Capturing the full public health value of RSV vaccines: using mathematical modelling to inform target product profiles
Amount £200,359 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 01/2020 
End 12/2023
 
Description Combination prevention and strategies for HIV control: In-depth analysis of data from the HPTN 071 (PopART) trial
Amount £127,927 (GBP)
Funding ID EPIDZS7011 / INPUTT 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 02/2020 
End 01/2022
 
Description Contributing quantitative analysis towards accelerating declines in TB burden in India and South Africa
Amount £564,674 (GBP)
Funding ID INV-025664 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 12/2020 
End 01/2024
 
Description Control of TB in India: developing analytical tools
Amount £387,267 (GBP)
Funding ID OPP1095710 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2013 
End 03/2020
 
Description Cost-effectiveness of testing and treating latent TB infection (LTBI) and active TB disease in the UK using different strategies of patient targeting and different test technologies: a multidisciplinary transmission-dynamic health-economic
Amount £483,406 (GBP)
Funding ID NIHR HTA 127459 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2019 
End 09/2021
 
Description Defining disease importation and target interventions from routine surveillance data
Amount $100,000 (USD)
Funding ID OPP1161898 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2016 
End 04/2018
 
Description Develop a novel, cost-effective, surveillance approach for malaria elimination through existing antenatal care platform
Amount £56,255 (GBP)
Organisation PATH 
Sector Charity/Non Profit
Country Global
Start 02/2018 
End 08/2018
 
Description Developing entomological indicators to assess the public health value of next generation LLINs and IRS chemistries
Amount £176,348 (GBP)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2019 
End 07/2022
 
Description Developing modelling approaches for influenza control in the USA
Amount £210,020 (GBP)
Funding ID BAA 75D301-19-R-67835 
Organisation Centers for Disease Control and Prevention (CDC) 
Sector Public
Country United States
Start 08/2019 
End 01/2021
 
Description Developing reliable epidemic forecasting using branching processes: Ebola as a case study
Amount £99,998 (GBP)
Funding ID SBF005\1044 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2020 
End 09/2022
 
Description Development and implementation of the Naomi model for second administrative level HIV estimates in Sub-Saharan Africa
Amount £351,155 (GBP)
Funding ID 2019/974072 
Organisation Joint United Nations Programme on HIV/AIDS (UNAIDS) 
Sector Public
Country Global
Start 12/2019 
End 12/2021
 
Description Development and pilot implementation of rapid poliovirus detection and sequencing from stool samples using nanopore technology
Amount £200,458 (GBP)
Funding ID OPP1207299 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2018 
End 06/2021
 
Description Development evaluation and impact of RT-LAMP diagnostics and sequence surveillance on SARS-CoV-2 transmission in South Africa (RADIATES)
Amount £41,889 (GBP)
Funding ID RIA2020EF-3030 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2020 
End 09/2022
 
Description Development of Methods to Measure and Interpret HIV Prevention Cascades in Population-Based Surveys
Amount £773,529 (GBP)
Funding ID OPP1161471 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2016 
End 07/2021
 
Description Deworm3 unit for transmission dynamics, trial simulation and data analysis
Amount £1,205,330 (GBP)
Funding ID SON15004 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 04/2016 
End 03/2021
 
Description Dynamic Modelling of HSV-2 and HIV Infections to Estimate the Burden of HSV-associated HIV Infections and the Predicted Impact of HSV Vaccines
Amount £118,543 (GBP)
Funding ID 202002015 
Organisation World Health Organization (WHO) 
Sector Public
Country Global
Start 05/2018 
End 12/2019
 
Description Early antiretroviral therapy and pre-exposure prophylaxis for HIV prevention among emale sex workers in Benin, West Africa
Amount £121,857 (GBP)
Funding ID OPP1098973 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 08/2014 
End 12/2018
 
Description Ed Parker: The effect of maternal and neonatal viral exposure on innate and adaptive immune function
Amount £34,726 (GBP)
Funding ID 204834/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 08/2019
 
Description Emergence and global epidemiology of non-polio enteroviruses
Amount £909,233 (GBP)
Funding ID 216427/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2020 
End 01/2025
 
Description Epidemiological analysis and mathematical modelling of poliovirus elimination and endgame vaccination strategies
Amount £236,130 (GBP)
Funding ID 2017/769688-0 
Organisation World Health Organization (WHO) 
Sector Public
Country Global
Start 11/2017 
End 08/2019
 
Description Epidemiological analysis and mathematical modelling of serotype 2 vaccine-derived poliovirus
Amount £122,044 (GBP)
Funding ID 2020/1014353-0 
Organisation World Health Organization (WHO) 
Sector Public
Country Global
Start 04/2020 
End 12/2021
 
Description Epidemiological modelling to support the global COVID-19 response: How to mitigate impact in low-income and crisis-affected settings
Amount £96,664 (GBP)
Funding ID 221350/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2020 
End 10/2020
 
Description Evaluation of the potential for rapid diagnostic testing (RDTs) for malaria within antenatal care to provide sustainable, dynamic and scalable malaria surveillance
Amount £802,854 (GBP)
Funding ID INV-005289 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2020 
End 09/2023
 
Description Evaluation of the potential for rapid diagnostic testing for malaria within antenatal care to provide sustainable, dynamic and scalable malaria surveillance.
Amount £99,998 (GBP)
Funding ID SBF005\1107 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2020 
End 02/2022
 
Description Evaluation work by LCNTDR for the Geshiaro project in support of EPHI
Amount £1,359,171 (GBP)
Funding ID R-1701-01771 
Organisation Children's Investment Fund Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2018 
End 06/2023
 
Description Evaluations to Inform Decisions using Economics and Epidemiology (EVIDENCE)
Amount £88,510 (GBP)
Organisation United States Agency for International Development 
Sector Public
Country United States
Start 07/2019 
End 11/2020
 
Description Evidence for and against selection of specific pyrethroids for programmatic purposes
Amount £36,768 (GBP)
Funding ID Collab_TA5_RBPS04426_ICL 
Organisation Global Fund to Fight AIDS, Tuberculosis and Malaria 
Sector Charity/Non Profit
Country Switzerland
Start 12/2020 
End 12/2020
 
Description Evolutionary dynamics underlying pneumococcal genomic diversity
Amount £640,778 (GBP)
Funding ID 104169/Z/14/A 
Organisation Sir Henry Dale Fellowships 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2019 
End 09/2022
 
Description Evolutionary dynamics underlying pneumococcal genomic diversity.
Amount £708,513 (GBP)
Funding ID 104169/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2014 
End 09/2019
 
Description Explore the Pathway of China NICE-like Mechanism by Piloting Three Suggested Projects
Amount £172,623 (GBP)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 12/2017 
End 05/2019
 
Description Geospatial modelling for malaria risk stratification and intervention targeting
Amount £219,507 (GBP)
Funding ID 1606H5002/JH6 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2016 
End 08/2020
 
Description Global systematic review of the immunogenicity, safety, efficacy, and durability of HPV vaccines among HIV positive individuals
Amount £70,643 (GBP)
Funding ID 2020/997664-0 
Organisation World Health Organization (WHO) 
Sector Public
Country Global
Start 03/2020 
End 06/2021
 
Description HC-HIV modeling activity
Amount £156,940 (GBP)
Funding ID 48345 
Organisation United States Agency for International Development 
Sector Public
Country United States
Start 06/2017 
End 08/2018
 
Description HIV Modelling Consortium Renewal
Amount £3,527,347 (GBP)
Funding ID OPP1084364 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 06/2013 
End 01/2019
 
Description Health in a changing climate: the dynamic challenge of snake bite in South Asia
Amount £179,625 (GBP)
Funding ID MR/P024513/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 02/2020
 
Description Human Infectious Challenge Vaccine (HIC vac) network
Amount £2,041,189 (GBP)
Funding ID MR/R005982/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 02/2020
 
Description Human challenge with live-attenuated rotavirus to assess next-generation rotavirus vaccines in Africa
Amount £776,687 (GBP)
Funding ID MR/T030321/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2020 
End 08/2023
 
Description IDC Genomics Lab refurb
Amount £125,000 (GBP)
Organisation St. Mary's Development Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2018 
End 06/2020
 
Description IImpact of COVID 19 on sexual risk behavior for HIV infection in SSA
Amount £1,117,944 (GBP)
Funding ID INV-023210 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2020 
End 10/2022
 
Description ISID/ESCMID Fellowship - Using seroprevalence age profiles to identify changes in incidence and interruption of transmission of filarial infections in Mali
Amount £6,125 (GBP)
Organisation International Society for Infectious Diseases (ISID) 
Sector Charity/Non Profit
Country United States
Start 04/2019 
End 06/2020
 
Description Immunological investigation for the implenatation of Live Attenuated Influenza Vaccination
Amount £811,303 (GBP)
Funding ID MR/R021643/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2018 
End 12/2021
 
Description Impact of maternally derived antibodies and microbiota on the immunogenicity of rotavirus vaccines in African, Indian and European infants
Amount £255,266 (GBP)
Funding ID JXR11990 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 12/2018
 
Description Improving HIV phylodynamic research capacity in Botswana
Amount £13,580 (GBP)
Organisation United Kingdom Research and Innovation 
Department Global Challenges Research Fund
Sector Public
Country United Kingdom
Start 10/2019 
End 07/2021
 
Description Improving the efficacy of malaria prevention in an insecticide resistant Africa
Amount £162,798 (GBP)
Funding ID 200222/B/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2016 
End 10/2019
 
Description Innovations to improve the speed and sensitivity of poloio surveillance
Amount £1,341,964 (GBP)
Funding ID INV-024477 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2020 
End 12/2021
 
Description Integrating Ethics and Equity into Priority Setting for Universal Health Coverage: A Proof-of-Concept Study in South Africa
Amount £128,944 (GBP)
Funding ID 208045/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description Integrating genomic surveillance and ecological modelling to maximise pneumococcal vaccine efficacy
Amount £558,204 (GBP)
Funding ID MR/T016434/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2020 
End 06/2023
 
Description Joint estimation of HIV and adult mortality trends in sub-Saharan Africa
Amount £67,680 (GBP)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 08/2018 
End 12/2019
 
Description Key populations and HIV epidemics in Sub-Saharan Africa: Developing better epidemiologic tools to inform priorities and programs
Amount £179,258 (GBP)
Funding ID PO: 2003388501 
Organisation Family Health International 
Sector Charity/Non Profit
Country United States
Start 06/2016 
End 03/2019
 
Description London Centre for NTD Research
Amount £555,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 06/2015 
End 05/2019
 
Description London Centre for NTD Research (renewal 3)
Amount £785,649 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 06/2018 
End 05/2021
 
Description MIDAS 2: Models for synthesising molecular, clinical and epidemiological data, and translation to public health response (NIH)
Amount £1,246,328 (GBP)
Funding ID 1U01GM110721-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2014 
End 05/2019
 
Description MIDAS: Modeling Epidemic Infectious Diseases Using Sequence Analysis
Amount £300,028 (GBP)
Funding ID 258162IMP 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 01/2016 
End 05/2020
 
Description Malaria Eradication Metrics
Amount £222,688 (GBP)
Funding ID OPP1197730 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 03/2019 
End 09/2021
 
Description Malaria Evaluation and Research Consortium
Amount £5,057 (GBP)
Funding ID AID.574718-01706929-SUB_PAL 
Organisation United States Agency for International Development 
Sector Public
Country United States
Start 10/2020 
End 12/2020
 
Description Management of chronic hepatitis B in Africa: is a one-stop assessment of liver disease enough? The MATCH-B study
Amount £882,167 (GBP)
Funding ID MR/R011117/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2018 
End 12/2020
 
Description Mapping the Risk of International Infectious Disease Spread (MRIIDS)
Amount £204,244 (GBP)
Funding ID SBFF-2019-37324 
Organisation International Society for Infectious Diseases (ISID) 
Sector Charity/Non Profit
Country United States
Start 07/2020 
End 06/2022
 
Description Mapping the risk of international infectious disease spread
Amount £120,202 (GBP)
Funding ID AID-OAA-F-16-00115 
Organisation United States Agency for International Development 
Sector Public
Country United States
Start 10/2016 
End 04/2019
 
Description Mathematical Modelling of Microfilaricidal Drugs for River Blindness: from Patients to Populations
Amount £50,870 (GBP)
Organisation Drugs for Neglected Diseases initiative (DNDi) 
Sector Charity/Non Profit
Country Switzerland
Start 06/2016 
End 05/2019
 
Description Mathematical modeling in the HPTN Renewal
Amount £1,008,218 (GBP)
Funding ID 2UMIAI068617 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 01/2014 
End 11/2020
 
Description Mathematical modelling of poliovirus transmission to support the endgame
Amount £487,817 (GBP)
Funding ID OPP1099374 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2013 
End 07/2018
 
Description Maximising the public health impact of new approaches to control malaria in pregnancy through the translation of evidence-based global policies to country level policies and plans.
Amount £42,075 (GBP)
Funding ID CSA-2014-276 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2016 
End 12/2018
 
Description Minimum Models for Optimal Epidemic Monitoring and Control
Amount £288,432 (GBP)
Funding ID MR/S019693/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2021
 
Description Model development for the draft WHO global report on insecticide resistance in malaria vectors
Amount £13,901 (GBP)
Funding ID 2018/797131-0 
Organisation World Health Organization (WHO) 
Sector Public
Country Global
Start 03/2018 
End 12/2018
 
Description Model development for the draft WHO global report on insecticide resistance in malaria vectors
Amount £258,706 (GBP)
Organisation IVCC 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 02/2020
 
Description Modeling Anorectal HIV Transmission in Women
Amount £288,589 (GBP)
Funding ID 5R01AI057020 Sub#201224310-05 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 11/2014 
End 05/2019
 
Description Modelling Alternative Treatment Strategies for Onchocerciasis: Moxidectin for Control and Elimination
Amount £30,000 (GBP)
Funding ID MDL50 6-9010 
Organisation Medicines Development for Global Health 
Sector Private
Country Australia
Start 02/2017 
End 12/2019
 
Description Modelling To Inform The Planning Of Affordable And Sustainable Programmes To Reduce HIV Incidence In Sub-Saharan Africa. HIV Consortium.
Amount £451,613 (GBP)
Funding ID WT PC 245878 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2019 
End 09/2023
 
Description Modelling antimalarial target product profiles for reducing P. falciparum malaria transmission
Amount £316,782 (GBP)
Funding ID PO14/00561 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2013 
End 02/2019
 
Description Modelling critical characteristics of a future universal influenza vaccine
Amount £293,230 (GBP)
Organisation National Philanthropic Trust 
Sector Charity/Non Profit
Country United States
Start 10/2020 
End 10/2021
 
Description Modelling in support of India program , development and use of new tools and programmatic prioritization
Amount £257,508 (GBP)
Funding ID OPP1205227 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2018 
End 11/2020
 
Description Modelling infectious disease outbreaks using the Hawkes Process
Amount £184,875 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 08/2019 
End 07/2023
 
Description Modelling the Elimination of Onchocerciasis in Cameroon (International Exchanges)
Amount £11,999 (GBP)
Funding ID IES/R2/181017 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2018 
End 12/2021
 
Description Modelling the Value of Vaccines in Reducing the Burden of Antimicrobial Resistance
Amount £54,560 (GBP)
Funding ID OPP1190803 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 06/2019 
End 04/2020
 
Description Modelling the control of artemisinin-based antimalarial drug resistance
Amount £355,171 (GBP)
Funding ID DH140134 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 02/2023
 
Description Modelling the dynamics of viral load to reveal mechanisms of protection in COVID-19
Amount £196,129 (GBP)
Funding ID MR/V027409/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2020 
End 07/2021
 
Description Modelling the efficacy and cost effectiveness of community health workers for the control of malaria, pneumonia and diarrhoea.
Amount £197,958 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Modelling the impact of Seasonal Malaria Chemoprevention in East Africa
Amount £34,150 (GBP)
Funding ID PO18/01036 
Organisation Medicines for Malaria Venture (MMV) 
Sector Charity/Non Profit
Country Switzerland
Start 06/2019 
End 10/2019
 
Description Modelling the potential impact of intermittent preventive treatment of malaria in pregnancy on antimalarial drug resistance
Amount £99,998 (GBP)
Funding ID ch160084 
Organisation Royal Society of Medicine 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2016 
End 08/2018
 
Description Modelling the spatiotemporal dynamics of arbovirus transmission: implications for disease control and elimination
Amount £969,469 (GBP)
Funding ID 213494/Z/18/Z 
Organisation Sir Henry Dale Fellowships 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2019 
End 08/2024
 
Description MoxiMultiDosePedMod
Amount £51,125 (GBP)
Funding ID RIA2017NCT-1843 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 08/2019 
End 07/2024
 
Description Multi-Level Behavioral Economics and Community Psychology Approaches to Strengthen HIV Prevention Cascades in Adolescent Girls and Young Women in East Zimbabwe
Amount £1,980,618 (GBP)
Funding ID 1R01MH114562-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2017 
End 07/2021
 
Description Multidisciplinary Studies of HIV/AIDS and Aging (R21)
Amount £205,531 (GBP)
Funding ID 1R21AG053093 - 01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2016 
End 07/2019
 
Description Multiresolution predictive dynamics of COVID-19 risk and intervention effects
Amount £556,661 (GBP)
Funding ID MR/V038109/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2020 
End 05/2022
 
Description NIHR Health Protection Research Unit in Modelling and Health Economics
Amount £3,999,970 (GBP)
Funding ID NIHR200908 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2020 
End 03/2025
 
Description NIHR Senior Investigator Award
Amount £120,000 (GBP)
Funding ID P/O 427921 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2009 
End 04/2021
 
Description NIHR-HPRU Resp - Arinaminpathy
Amount £5,840 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2020 
End 03/2025
 
Description NIHR-HPRU Respiratory - Riley
Amount £148,903 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2020 
End 03/2025
 
Description NIHR: NIHR HPRU in Modelling Methodology
Amount £4,234,300 (GBP)
Funding ID HPRU-2012-10080 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2020
 
Description NTD Consortium - CIFF Project
Amount £184,212 (GBP)
Funding ID MA4501202974 
Organisation Children's Investment Fund Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 04/2018
 
Description NTD Consortium Renewal (STH, Schisto, Oncho)
Amount £770,936 (GBP)
Funding ID 1708CR001/VP1 (OPP1184344) 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2017 
End 02/2021
 
Description Near-Infrared Spectroscopy: A One-Stop-Shop for Mosquito Epidemiological Monitoring?
Amount £643,683 (GBP)
Funding ID MR/P01111X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 02/2020
 
Description New Data and Models to Track Progress Towards Reducing New HIV Infections
Amount £911,493 (GBP)
Funding ID OPP1190661 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 05/2018 
End 03/2022
 
Description Newton Fund Researcher Links Grant
Amount £34,450 (GBP)
Funding ID 2016-RLWK7-10289 
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2017 
End 01/2018
 
Description Next-generation vector control for malaria: product profiling to implementation
Amount £1,059,509 (GBP)
Funding ID MR/T041986/1 
Organisation United Kingdom Research and Innovation 
Sector Public
Country United Kingdom
Start 01/2021 
End 12/2025
 
Description Optimal spatial scales for deployment of multiple first line therapies for malaria
Amount £105,750 (GBP)
Funding ID RGF\EA180225 
Organisation Royal Society of Medicine 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2017 
End 07/2022
 
Description Pete Winskill Fellowship
Amount £197,958 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Phase variable epigenetic regulation in Firmicutes
Amount £298,700 (GBP)
Funding ID RM33G0360 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Population Effects of Antretroviral Therapy to Reduce HIV Transmission (PopART) - Health Economics
Amount £502,745 (GBP)
Funding ID PO15001410 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 06/2015 
End 01/2020
 
Description Population Effects of Antretroviral Therapy to Reduce HIV Transmission (PopART) - Health Economics
Amount £12,709 (GBP)
Organisation UK Department for International Development 
Sector Public
Country United Kingdom
Start 11/2015 
End 03/2018
 
Description Population genomic analysis of HIV transmission fitness (Wellcome Investigator Award)
Amount £654,391 (GBP)
Funding ID 220885/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2020 
End 10/2023
 
Description Predicting the impact of insecticide resistance and new paradigms of vector control
Amount £161,331 (GBP)
Organisation IVCC 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2015 
End 05/2018
 
Description Predicting the impact of novel vector control interventions
Amount £735,630 (GBP)
Organisation IVCC 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 12/2022
 
Description Predicting the impact of novel vector control interventions against malaria in selected areas of the Asia Pacific region
Amount £294,243 (GBP)
Funding ID DF1 RBPS 108195 
Organisation IVCC 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2020 
End 04/2022
 
Description Predicting the impact of seasonal respiratory infection on temporal dynamics and characteristics of admission rates and time spent in hospital
Amount £115,260 (GBP)
Funding ID RDA02 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2018 
End 03/2022
 
Description Predicting the public health impact of SSM-VIMT Phase III and IV trials
Amount £19,617,788 (GBP)
Organisation Malaria GIA Reference Center - PATH MVI 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description Priority Setting for UHC (transfer from NICE)
Amount £222,478 (GBP)
Funding ID 2017 AVH 
Organisation Rockefeller Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2016 
End 12/2018
 
Description Progestin-based contraceptive modeling in high DMPA-IM use and high HIV incidence settings
Amount £378,999 (GBP)
Funding ID OPP1194416 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2018 
End 07/2020
 
Description Projections on eliminating NTDs (integrating mapping with modelling)
Amount £73,998 (GBP)
Funding ID OPP1156227 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2016 
End 10/2018
 
Description Projections on eliminating NTDs (integrating mapping with modelling).
Amount £20,392 (GBP)
Funding ID CRR00140 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2017 
End 12/2019
 
Description Providing academic leadership through a Secretariat for the UNAIDS reference group on estimates modelling & projections (2018-2019)
Amount £480,563 (GBP)
Funding ID 2017/778519 
Organisation Joint United Nations Programme on HIV/AIDS (UNAIDS) 
Sector Public
Country Global
Start 01/2018 
End 12/2019
 
Description Providing academic leadership through a Secretariat for the UNAIDS reference group on estimates modelling & projections (2018-2019)
Amount £1,010,757 (GBP)
Funding ID 2017/778519 
Organisation Joint United Nations Programme on HIV/AIDS (UNAIDS) 
Sector Public
Country Global
Start 01/2018 
End 12/2021
 
Description Quantifying Contact Rates and Mixing Patterns in Workers in Non-healthcare Work Settings in the United States and Modeling the Effect of Workplace Social Distancing Measures in Reducing Influenza Transmission
Amount £26,610 (GBP)
Funding ID GR110431 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2019 
End 12/2021
 
Description Quantifying Spatial Representativeness and Uncertainty in Antenatal Care Sentinel Surveillance for HIV in Sub-Saharan Africa.
Amount $53,375 (USD)
Funding ID 1R03AI125001-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 12/2016 
End 11/2018
 
Description Quantifying and preparing for the non-communicable disease burden in the ageing HIV-positive population in Kenya
Amount £134,891 (GBP)
Funding ID OISE-17-62962-1 
Organisation United States President's Emergency Plan for AIDS Relief 
Sector Public
Country United States
Start 08/2017 
End 02/2020
 
Description R01 Statistical Models for Estimating and Projecting HIV/AIDS Epidemics
Amount £39,706 (GBP)
Funding ID 5776-ICS-DHHS-6664 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2017 
End 08/2020
 
Description Research and Development of Reconstructing HIV Epidemics from HIV Phylogenetics
Amount £72,683 (GBP)
Funding ID Ref: 340798 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 06/2018 
End 02/2019
 
Description Research for Health in Conflict (R4HC): multi-sectorial capacity strengthening, partnership building and research across the MENA region
Amount £432,399 (GBP)
Funding ID MOTEAAR 
Organisation Kings BRC 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 12/2021
 
Description Respiratory Infection Health Protection Research Unit
Amount £93,377 (GBP)
Funding ID IS-HPU-1112-10064 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2020
 
Description RooPfs (Can improved housing provide additional protection against clinical malaria over current best practice? A household-randomised controlled trial)
Amount £179,101 (GBP)
Funding ID RF020305 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2014 
End 10/2019
 
Description Royal Society Laboratory Refurbishment Award
Amount £188,326 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 08/2017
 
Description STH Diagnostics Development
Amount £149,121 (GBP)
Funding ID 1902-03568 
Organisation Children's Investment Fund Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2020 
End 03/2021
 
Description Schisto Vaccine project extn via NTD Modelling Consortium, Warwick
Amount £121,248 (GBP)
Funding ID OPP1176780 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2017 
End 03/2019
 
Description Sources and Impact of Misclassification Errors in HIV Rapid Testing Algorithms in a Hyper-Endemic HIV Setting in sub-Saharan Africa
Amount £886,781 (GBP)
Funding ID OPP1131208 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 07/2015 
End 09/2019
 
Description Spatiotemporal regression analysis of Wolbachia releases in Brazil
Amount £32,000 (GBP)
Organisation Monash University 
Sector Academic/University
Country Australia
Start 05/2019 
End 11/2021
 
Description Spread of antimicrobial resistance in Guyana: A pilot study of private supply and demand side factors
Amount £26,570 (GBP)
Organisation United Kingdom Research and Innovation 
Department Global Challenges Research Fund
Sector Public
Country United Kingdom
Start 07/2019 
End 07/2021
 
Description TB Modelling and Analysis Consortium
Amount £37,133 (GBP)
Funding ID EPIDZJ6210/Imperial 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2018 
End 06/2019
 
Description TaqMan Array Card method for polio environmental surveillance
Amount £37,729 (GBP)
Funding ID GF13847.159399 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 07/2018 
End 06/2021
 
Description Target Malaria Phase II grant - Epimodelling sub
Amount £410,788 (GBP)
Funding ID OPP1210755 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 03/2020 
End 12/2025
 
Description Thanzi La Onse -Frameworks and analysis to ensure value-for-money health care: developing theory, changing practices in low- and middle-income settings.
Amount £772,329 (GBP)
Funding ID R18664 
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 10/2017 
End 12/2021
 
Description The delay-care cascade and its implications for TB transmission: a study in three country settings
Amount £125,031 (GBP)
Organisation Stop TB Partnership 
Sector Charity/Non Profit
Country Switzerland
Start 08/2017 
End 12/2018
 
Description The development of an Alzheimer's disease clinical trial simulator, parameter estimation from international patient cohorts and standardizing epidemiological measurement platforms for cohort studies
Amount £775,501 (GBP)
Funding ID HQR00720 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2019 
End 12/2020
 
Description The evolution of influenza virus: studies of within host and between host evolution to improve pandemic risk assessment and vaccine
Amount £1,269,464 (GBP)
Funding ID 200187/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 06/2021
 
Description The evolutionary dynamics of multiazole resistance in pathogenic Aspergillus fungi
Amount £427,006 (GBP)
Funding ID NE/P001165/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 11/2016 
End 04/2020
 
Description The farm environment: an overlooked reservoir of Mycobacterium bovis?
Amount £21,364 (GBP)
Funding ID RLFEW3022 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2016 
End 12/2020
 
Description The life course of human immune responses to influenza infection and vaccination
Amount £1,928,979 (GBP)
Funding ID 200861/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2016 
End 10/2021
 
Description Tracking the flow of malaria parasites and drug resistance within the DRC and across its borders
Amount £264,838 (GBP)
Funding ID 00001346 
Organisation National Institute of Allergy and Infectious Diseases (NIAID) 
Sector Public
Country United States
Start 11/2018 
End 05/2023
 
Description Trial Modelling Collaboration - renewal
Amount £1,701,830 (GBP)
Funding ID P22539540R 
Organisation Johnson & Johnson 
Department Janssen Vaccines & Prevention bv
Sector Private
Country Netherlands
Start 05/2017 
End 05/2020
 
Description Typhoid ES site selection characteristics
Amount £737,345 (GBP)
Funding ID INV_002381 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2019 
End 11/2021
 
Description Understanding acquisition and evolution of antifungal resistance in Cystic Fibrosis (FREAL)
Amount £38,000 (GBP)
Funding ID VIA 081 
Organisation Cystic Fibrosis Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2020 
End 06/2022
 
Description Understanding acquisition and evolution of antifungal resistance in chronic respiratory disease
Amount £201,103 (GBP)
Funding ID MR/T005572/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2020 
End 12/2022
 
Description Understanding and mitigating the impact of emerging antifungal resistance
Amount £2,200,879 (GBP)
Funding ID 219551/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2020 
End 03/2024
 
Description Understanding host heterogeneity to vector-borne disease exposure: Implications for modelling disease transmission and improving the design of control intervention
Amount £8,778 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 09/2020
 
Description Understanding links between microbial communities and emerging fungal pathogens in complex ecosystems
Amount £394,290 (GBP)
Funding ID NE/S000844/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2021
 
Description Understanding the potential impact of new vector control tools
Amount £165,000 (GBP)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 06/2020 
End 05/2023
 
Description Unravelling and predicting the spatiotemporal structure of infectious disease outbreaks
Amount £99,995 (GBP)
Funding ID SBF004/1080 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 06/2021
 
Description Vaccine Efficacy Evaluation for Priority Emerging Diseases
Amount £679,937 (GBP)
Funding ID EPIDZO34 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2021
 
Description Vaccine Impact Modelling Consortium (VIMC) - Secretariat
Amount £4,282,400 (GBP)
Funding ID OPP1157270 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 12/2016 
End 03/2022
 
Description Vaccine Impact Modelling Consortium (VIMC) - Sub-contracts
Amount £4,875,959 (GBP)
Funding ID PO008511 
Organisation Bill and Melinda Gates Foundation 
Department Global Alliance for Vaccination and Immunisation (GAVI)
Sector Charity/Non Profit
Country Switzerland
Start 01/2017 
End 03/2022
 
Description Validation of New Technologies for Diagnostic Evaluation of Tuberculosis (VANTDET)
Amount £1,212,037 (GBP)
Funding ID 12/65/27 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2014 
End 12/2017
 
Description Wellcome Trust Joint Senior Investiogator Award - Informing strategies for malaria eradication: a combined epidemiological and economics approach
Amount £1,409,484 (GBP)
Funding ID 220900/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2021 
End 12/2025
 
Description What's the cost of poor quality medicine? Estimating the prevalence, health impact and economic cost of substandard and falsified medicines in Indonesia in the age of UHC
Amount £1,982,131 (GBP)
Funding ID NIHR131145 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2020 
End 10/2023
 
Description Widening real-time genomic infectious disease epidemiology in response to a global pandemic
Amount £19,338 (GBP)
Funding ID C16F2E7C-5912-4ADE-A7C8-67BE6C 
Organisation Mozilla 
Sector Charity/Non Profit
Country Global
Start 08/2020 
End 12/2020
 
Description Work productivity effects of HIV prevention and treatment interventions on populations from endemic settings
Amount £286,454 (GBP)
Funding ID MR/T025409/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2022
 
Description Zika: A fast new intervention and an innovative method of evaluation
Amount £34,518 (GBP)
Funding ID AID-OAA-F-16-00094 
Organisation United States Agency for International Development 
Sector Public
Country United States
Start 10/2016 
End 09/2019
 
Description iDSI 2
Amount £6,063,871 (GBP)
Funding ID OPP1134345 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 05/2018 
End 09/2021
 
Description iDSI 2 (DFID Supplement)
Amount £1,506,767 (GBP)
Funding ID OPP1134345 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 04/2017 
End 03/2021
 
Description iDSI 2 (DFID Supplement)
Amount £1,982,131 (GBP)
Funding ID NIHR131145 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2020 
End 10/2023
 
Title Development of an individual based model for stochastic simulations of onchocerciasis 
Description Individual host model incorporating complex life cycle in humans and vectors to investigate interventions against human onchocerciasis that may require targeting of individuals and/or age sex groups 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2019 
Provided To Others? Yes  
Impact This research tool is now being used for; business case for macrofilaricides, development of clinical trial simulators, epidemiological impact of moxidectin, assessment of anti-Wolbachia drugs for the treatment of filariases. 
URL https://www.ncbi.nlm.nih.gov/pubmed/?term=hamley%2C+basanez
 
Title Development of clinical trial simulators to guide clinical development of macrofilaricides 
Description Collaboration with Drugs for Neglected Diseases Initiative (Geneva) Adaptation of a stochastic simulation model of transmission to mimic characteristics of clinical trials to help assess; optimal sample sizes, optimal interim and end points, demonstrate superiority or non-inferiority of novel drugs in comparison with current therapies 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2019 
Provided To Others? No  
Impact Not known yet Paper under review in Nature Communications 
 
Title HPCs-integrated formulations 
Description Generic core and expanded formulations of HIV prevention cascades for use in tracking progress with implementation of efficacious methods of HIV prevention including combination HIV prevention. The core cascade is applied to a population at a given risk of HIV infection and comprises three steps - motivation to use the method(s), accessibility of the method(s), and effective use of the method(s). The core cascade can be used for high-level monitoring and advocacy. The expanded formulation adds factors that can contribute to drop-offs between the main steps in the core cascade which can aid identification of time- and place-specifically appropriate interventions to increase the level of effective use. These cascades can be used in mathematical models to measure the impact of current levels of use of HIV prevention methods on on HIV incidence and evaluate the potential impact of alternative interventions targeted at the different steps in the cascade (i.e. to improve motivation, accessibility and/or effective use). 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2019 
Provided To Others? Yes  
Impact This work contributed to a decision by UNAIDS to adopt HIV prevention cascades as an international framework for tracking progress with implementing primary methods of HIV prevention and to produce international guidelines for countries on formulations to use and methods of measurement. 
 
Title HPCs-questionnaire 
Description Questionnaire comprising questions to measure and interpret HIV prevention cascades for male and female condoms, pre-exposure prophylaxis, voluntary medical male circumcision, sexual partner reduction and combination HIV prevention in general population surveys. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2018 
Provided To Others? No  
Impact None as yet - the tool is currently being piloted in a large population survey in east Zimbabwe 
 
Title New method to detect and sequence poliovirus 
Description Direct molecular detection and nanopore sequencing of poliovirus 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact Awarded new grant to evaluate wider use and implementation of new method globally 
 
Title RDTs-smartphone camera app 
Description Smartphone camera application developed by our collaborators on the study on HIV misclassification errors (Global Solutions for Infectious Diseases) to collect and transmit images of the outputs from HIV rapid tests used in routine health services - thereby enabling evaluation by external experts of the quality of outputs from these tests and the accuracy of interpretation of these outputs by local clinic staff. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? No  
Impact The tool has enabled us to establish that approximately 50% of false-negative HIV test results occurring in routine health services in Zimbabwe could be due to errors by local clinic staff in reading or recording the outputs from HIV rapid tests. 
 
Title YZ-UHP! survey management portal 
Description Portal showing progress with conducting general population surveys on use of HIV prevention methods. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact Improvements in tracking progress against targets and errors/inconsistencies in the data requiring investigation and correction resulting in improved data completeness and quality. 
 
Title A dynamic power-law sexual network model of gonorrhoea outbreaks 
Description Generates a dynamic power-law sexual network 
Type Of Material Computer model/algorithm 
Year Produced 2019 
Provided To Others? Yes  
Impact Impacts not yet recognised 
URL https://github.com/lwhittles/simdynet
 
Title AIDS data repository 
Description Data repository for national HIV programmes to store AIDS data. Supported by UNAIDs 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Used by multiple countries to support collation and analysis of HIV data 
URL https://adr.unaids.org/
 
Title All-India TB Model 
Description Model developed in collaboration with India National TB Programme, combining the best available epidemiological and surveillance data to capture India's TB epidemic on a national level. The model now forms the basis for different modelling analyses, conducted by the group, relating to TB in India. 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? Yes  
Impact Model is currently being used to help inform India Government on strategic priorities for TB control in the country Updated 2020: model is applied by Indian government for their updated national strategic plan 
 
Title COVID-19 Austria 
Description This site gives estimates of the reproduction number of COVID-19 and projections of cases for districts in Austria based on testing data and mortality data. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact No impacts yet 
URL https://www.covid19model.at/
 
Title COVID-19 LMIC Reports 
Description The LMIC reports are generated using an age-structured SEIR model. The developed model is an extension of the model used in our previous report (see Report 12) and the source code for the model can be found at https://github.com/mrc-ide/squire. In this model, the infectious class is divided into different stages reflecting progression through different disease severity pathways. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact The global fits from this model were used to directly inform WHO estimates of global financial need. The team also directly supported control efforts in 10 countries (Columbia, India, Indonesia, Italy, Malawi, Nigeria, Senegal, Sudan, the United States and Zimbabwe) providing local model reports through academic and public health partners to support government responses. Ongoing. Example: Announcement by New York Governor's Office of Research Partnership with Imperial College London https://www.governor.ny.gov/news/amid-ongoing-covid-19-pandemic-governor-cuomo-announces-state-bringing-international-experts 
URL http://mrc-ide.github.io/global-lmic-reports/
 
Title COVID/TB disruption model 
Description Model developed to simulate the adverse impact of COVID related disruptions on TB control in different countries 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact Model was used by WHO South East Asia region to inform regional TB strategies at country level Publication in E Clinical Medicine 
URL https://beta.avstaging.org/tbcovidapp/
 
Title Case Surveillance and Vital Registration (CSAVR) tool 
Description Model for the estimation of HIV incidence from case surveillance and AIDS deaths 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? Yes  
Impact Used by 40-60 countries to produce official HIV national statistics 
 
Title Covid 19 elective care scheduling: 
Description Covid 19 elective care scheduling: this tool models optimal weekly scheduling of patient admissions to all hosptials across england 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact No impacts recognised yet 
URL http://github.com/ImperialCollegeLondon/OptimalScheduling4COVID
 
Title Creation and analysis of clinical trial databases 
Description DW3, Gates funded clinical trail for control of soil transmitted helminths. Tumikia - Gates funder clinical trial for control of soil transmitted helminths Geshiyaro - CIFF funded clinical trial for control of schistosomiasis and soil transmitted helminths 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Sophisticated analysis of data and scientific publications 
 
Title Data from: Adaptive estimation for epidemic renewal and phylogenetic skyline models 
Description Estimating temporal changes in a target population from phylogenetic or count data is an important problem in ecology and epidemiology. Reliable estimates can provide key insights into the climatic and biological drivers influencing the diversity or structure of that population and evidence hypotheses concerning its future growth or decline. In infectious disease applications, the individuals infected across an epidemic form the target population. The renewal model estimates the effective reproduction number, R, of the epidemic from counts of observed incident cases. The skyline model infers the effective population size, N, underlying a phylogeny of sequences sampled from that epidemic. Practically, R measures ongoing epidemic growth while N informs on historical caseload. While both models solve distinct problems, the reliability of their estimates depends on p-dimensional piecewise-constant functions. If p is misspecified, the model might underfit significant changes or overfit noise and promote a spurious understanding of the epidemic, which might misguide intervention policies or misinform forecasts. Surprisingly, no transparent yet principled approach for optimising p exists. Usually, p is heuristically set, or obscurely controlled via complex algorithms. We present a computable and interpretable p-selection method based on the minimum description length (MDL) formalism of information theory. Unlike many standard model selection techniques, MDL accounts for the additional statistical complexity induced by how parameters interact. As a result, our method optimises p so that R and N estimates properly and meaningfully adapt to available data. It also outperforms comparable Akaike and Bayesian information criteria on several classification problems, given minimal knowledge of the parameter space, and exposes statistical similarities among renewal, skyline and other models in biology. Rigorous and interpretable model selection is necessary if trustworthy and justifiable conclusions are to be drawn from piecewise models. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
URL http://datadryad.org/stash/dataset/doi:10.5061/dryad.mpg4f4qv6
 
Title Data from: Are skyline plot-based demographic estimates overly dependent on smoothing prior assumptions? 
Description In Bayesian phylogenetics, the coalescent process provides an informative framework for inferring changes in the effective size of a population from a phylogeny (or tree) of sequences sampled from that population. Popular coalescent inference approaches such as the Bayesian Skyline Plot, Skyride and Skygrid all model these population size changes with a discontinuous, piecewise-constant function but then apply a smoothing prior to ensure that their posterior population size estimates transition gradually with time. These prior distributions implicitly encode extra population size information that is not available from the observed coalescent data i.e. the tree. Here we present a novel statistic, O, to quantify and disaggregate the relative contributions of the coalescent data and prior assumptions to the resulting posterior estimate precision. Our statistic also measures the additional mutual information introduced by such priors. Using O we show that, because it is surprisingly easy to over-parametrise piecewise-constant population models, common smoothing priors can lead to overconfident and potentially misleading inference, even under robust experimental designs. We propose O as a useful tool for detecting when posterior estimate precision is overly reliant on prior choices. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL http://datadryad.org/stash/dataset/doi:10.5061/dryad.1jwstqjs2
 
Title Data from: Effect of culling on individual badger Meles meles behaviour: potential implications for bovine tuberculosis transmission 
Description 1. Culling wildlife as a form of disease management can have unexpected and sometimes counterproductive outcomes. In the UK, badgers (Meles meles) are culled in efforts to reduce badger-to-cattle transmission of Mycobacterium bovis, the causative agent of bovine tuberculosis (TB). However, culling has previously been associated with both increased and decreased incidence of M. bovis infection in cattle. 2. The adverse effects of culling have been linked to cull-induced changes in badger ranging, but such changes are not well documented at the individual level. Using GPS-collars, we characterised individual badger behaviour within an area subjected to widespread industry-led culling, comparing it with the same area before culling and with three unculled areas. 3. Culling was associated with a 61% increase (95% CI 27-103%) in monthly home range size, a 39% increase (95% CI 28-51%) in nightly maximum distance from the sett, and a 17% increase (95% CI 11-24%) in displacement between successive GPS-collar locations recorded at 20-minute intervals. Despite travelling further, we found a 91.2 minute (95% CI 67.1-115.3 minute) reduction in the nightly activity time of individual badgers associated with culling. These changes became apparent while culls were ongoing and persisted after culling ended. 4. Expanded ranging in culled areas was associated with individual badgers visiting 45% (95% CI 15-80%) more fields each month, suggesting that surviving individuals had the opportunity to contact more cattle. Moreover, surviving badgers showed a 19.9-fold increase (95% CI 10.8-36.4 increase) in the odds of trespassing into neighbouring group territories, increasing opportunities for intergroup contact. 5. Synthesis and Applications: Badger culling was associated with behavioural changes among surviving badgers which potentially increased opportunities for both badger-to-badger and badger-to-cattle transmission of M. bovis. Furthermore, by reducing the time badgers spent active, culling may have reduced badgers' accessibility to shooters, potentially undermining subsequent population control efforts. Our results specifically illustrate the challenges posed by badger behaviour to cull-based TB control strategies and furthermore, they highlight the negative impacts culling can have on integrated disease control strategies. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
 
Title Develop statistical methods for determining whether a cases of malaria was acquired in the country of detection or imported from abroad. 
Description Develop a Bayesian method of taking a persons travel history, details of malaria endemicity and seasonality of transmission and determining the percentage likelihood that the case of malaria was: (1) acquired at home, (2) imported from abroad, (3) imported from another region of the country (4) was of unknown origin. 
Type Of Material Data analysis technique 
Year Produced 2018 
Provided To Others? No  
Impact None as yet 
 
Title EPP-ASM model for estimation HIV epidemic trends 
Description The EPP-ASM model is a new demographic-structured model for estimating HIV epidemic trends in sub-Saharan Africa. Compared to previously existing tools, the new model better captures the demographic impacts of the HIV epidemic and improves estimates of recent HIV incidence trends in generalised epidemic settings. 
Type Of Material Computer model/algorithm 
Year Produced 2019 
Provided To Others? Yes  
Impact - Model implemented in 2019 version of Spectrum software (v5.73) supported by UNAIDS for global HIV estimates and projections in developed in 2019 (to be published June 2019). - Model and software code utilised for HIV estimation by the Global Burden of Disease study by the Institute for Health Metrics and Evaluation 
URL https://github.com/mrc-ide/eppasm
 
Title Estimating duration of protection provided by antimalarials 
Description This analysis code in R software is freely available and can be used to estimate the duration of protection provided after treatment with an antimalarial. The analysis uses Bayesian techniques and adjusts for common confounders. 
Type Of Material Data analysis technique 
Year Produced 2020 
Provided To Others? Yes  
Impact Unknown 
URL https://github.com/lucyokell/duration_protection_AL_ASAQ
 
Title Experiments for detection of Plasmodium berghei infected Anopheles stephensi mosquitoes using near-infrared spectroscopy 
Description Spectra from uninfected, indected and infectious mosquitoes 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact None currently 
URL https://doi.org/10.5281/zenodo.1001720
 
Title Fluscape project dataset 
Description Serological data from a study in China 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact None yet 
URL http://www.fluscape.org
 
Title Gubbins phylogenetic software 
Description Gubbins (Genealogies Unbiased By recomBinations In Nucleotide Sequences) is an algorithm that iteratively identifies loci containing elevated densities of base substitutions while concurrently constructing a phylogeny based on the putative point mutations outside of these regions. Simulations demonstrate the algorithm generates highly accurate reconstructions under realistic models of short-term bacterial evolution, and can be run in only a few hours on alignments of hundreds of bacterial genome sequences. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact [14:52] Croucher, Nicholas J Impact: new version updates the algorithm to use the latest phylogenetic software, to allow for the continuing use of this software, which has already been cited >800 times. 
URL https://github.com/sanger-pathogens/gubbins
 
Title HPV and HIV vaccination model 
Description Mathematical model of HIV and HPV transmission to assess HPV vaccination and screening programme for cervical cancer elimination in South Africa. 
Type Of Material Computer model/algorithm 
Year Produced 2019 
Provided To Others? No  
Impact Development is still ongoing. As a result of development, funding was received from WHO to carry out further modelling analysis to provide guidance for the vaccination and screening programmes to reach cervical cancer elimination in countries with high HIV prevalence. 
 
Title HSV2 - HIV Model 
Description Mathematical model designed to estimate the contribution of HSV2 to HIV transmission and impact of HSV2 vaccination globally 
Type Of Material Computer model/algorithm 
Year Produced 2019 
Provided To Others? No  
Impact Resulted in publications that will inform WHO business investment case for development of HSV2 vaccine 
 
Title Harvard Consortium for the creation of an international Alzheimer's database 
Description Drawing together of multiple longitudinal cohort databases 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact Publications in 'Brain', 'Neuroscience' and 'Lancet' 
 
Title Household survey in Eastern Zimbawe 
Description Conducting a household survey in Eastern Zimbawe to determine HIV risks as part of a 20 year old study. See Manicaland HIV project (.org) 
Type Of Material Database/Collection of data 
Year Produced 2007 
Provided To Others? No  
Impact This has been going on since 2007 and it is on-going 
 
Title International risk of disease spread due to air travel 
Description Model to establish the number of exported cases due to air travel during an outbreak. This has been applied to Zika, Yellow Fever and COVID-19. 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? Yes  
Impact Model has been used to inform US CDC on the risk of importation of Yellow Fever from Brazil Model is used to advise on the need of travel restrictions and role of travellers vaccinations. Paper published in 2019 in Scientific Reports. 
URL https://www.nature.com/articles/s41598-019-56521-9
 
Title MARDY - Antifiungal Resistance Database 
Description Online database of anti fungal resistance alleles for multiple fungal pathogens 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Published in 2018 
URL http://mardy.dide.ic.ac.uk
 
Title Malaria socio-economic data 
Description qualitative and quantitative data from several West African countries on perceptions of quality, risk, costs and cost effectiveness 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact Too early to identify impacts 
 
Title Manicaland - HPCs 
Description SQL database comprising data from the baseline general population survey for a study to measure and interpret HIV prevention cascades and to evaluate the impact of novel behavioural economics and community psychology interventions to strengthen these cascades in adolescent girls and young women and their male partners. The database includes HIV infection data obtained from provider-initiated HIV testing and counselling (PITC) and, for those who decline PITC, from laboratory tests conducted using dried blood spots collected in the survey. UPDATE 2021 - data from 2 follow up surveys completed in 2020 and now being added to the database. These data will be used to measure the impact of the interventions. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact None as yet - data collection still in progress 
 
Title Manicaland - cohort 
Description SQL database comprising data from 6 rounds of a general population cohort survey in Manicaland, east Zimbabwe, with linked HIV test results 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Data describing and interpreting declines in HIV prevalence, HIV incidence and AIDS mortality within the general population over the period 1998 to 2013. Results have been published in more than 200 scientific papers including Science and The Lancet. The findings from the study led to our being requested by UNAIDS to conduct in-depth investigations into the existence and causes of national HIV decline in Zimbabwe. 
 
Title Manicaland - test & treat 
Description Database containing data extracted from routine programme records at health centres in three districts of Manicaland province for the periods 6 months prior to and 6 months following the introduction of the 'treat all' policy for people living with HIV infection. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact None as yet. This database was compiled by a PhD student. Papers are currently being drafted for publication. UPDATE 2021 - papers submitted for publication. 
 
Title Mathematical model of HIV prevention cascades 
Description Mathematical model of HIV prevention cascades - adaptation of previous model developed at Imperial for the POPART study to incorporate an HIV prevention cascade structure into the model 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? No  
Impact Not yet recognised 
 
Title Methodology for spatial mapping 
Description Developed two new statistical approaches. One now underpins the local burden of disease project at IHME 
Type Of Material Computer model/algorithm 
Year Produced 2017 
Provided To Others? Yes  
Impact Model results used widely for policy. 
 
Title Molecular Markers of Anti-malaria Partner Drug Resistence 
Description Systematic review of mutations in Pfmdr1 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact None yet 
URL https://gh.bmj.com/content/3/5/e000999
 
Title Multi-locus negative frequency dependent selection model 
Description This model describes the multi-locus negative frequency dependent selection model of bacterial population evolution. 
Type Of Material Computer model/algorithm 
Year Produced 2017 
Provided To Others? Yes  
Impact This model was described in the original publication (Corander et al 2017 Nat. Ecol. Evol. 1:1950-1960), and has subsequently been used to optimise vaccine designs as a part of current work-in-progress. 
URL https://github.com/nickjcroucher/multilocusNFDS/
 
Title ONS Excessive Deaths from non COVID-19 
Description ONS excess deaths: This tool provides weekly updates of deaths in England and Wales using publicly available data on the provisional number of deaths registered in the past week from the ONS 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Tool has been used by advisors to UK cabinet office to understand and report on excess deaths 
URL http://j-idea.github.io/ONSdeaths/
 
Title Outbreaker2 
Description Tool for reconstructing transmission chains using genomic and epidemiological data 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? Yes  
Impact Tool has been used frequently to support response to epidemics Tool has served as a basis for further refinement from others 
URL http://www.repidemicsconsortium.org/outbreaker2/
 
Title Pandemic Hospital planning tool 
Description Hospital planning tool: this tool calculates how much capacity in terms of beds, staff and ventilators is obtained by implementing healthcare provision interventions affecting the management of patient care in hospitals 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact This tool has been developed to assist hospitals in dealing with surges in demands due to the COVID pandemic and to understand which interventions can increase capacity most effectively. This tool has been used by hospitals globally to support treatment of patients during the pandemic. 
URL http://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2020-04-17-COVID19-Report-15-hosp...
 
Title PopPUNK 
Description PopPUNK is software for bacterial genomic epidemiology. It can rapidly calculate core and accessory distances between genomes, use these distances to cluster genomes, assign clusters to new genomes using an existing database, and produce visualisations of these outputs. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact Impact: release of a new version that extends the application of this algorithm to larger bacterial datasets, and to datasets of non-bacterial pathogens. 
URL https://github.com/johnlees/PopPUNK
 
Title Re-parameterisedindividual-based simulation model developed for influenza pandemic planning 
Description To support the UK response to the pandemic, an individual-based simulation model developed for influenza pandemic planning was re-parameterised to enable specific policy scenarios to be explored, including home isolation of suspect cases, home quarantine of household members, social distancing and school closures. Working closely with the NHS executive, the model parameter assumptions were aligned with emerging UK data to explicitly output demand on hospital beds and intensive care facilities in the UK. The outputs from this work - summarised in "Report 9" - demonstrated that under even the most stringent mitigation scenarios (whereby transmission is reduced but not interrupted), the UK health service would quickly become overwhelmed. In contrast, suppression strategies, whilst enabling the epidemic to be brought quickly under control, would need to be intermittently sustained until other therapeutic options became available. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact Ongoing. Ferguson NM, Cummings DAT, Fraser C, Cajka JC, Cooley PC, Burke DS (2006) Strategies for mitigating an influenza pandemic. Nature 442(7101):448-452. doi:10.1038/nature04795 Ferguson NM et al. (2020) Report 9 - Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. https://doi.org/10.25561/77482 
 
Title Research database on schistosomiasis and soil-transmitted helminthiases  
Description The schistosomiasis and soil-transmitted helminthiases (STHs) research theme aims to pool and make available Individual Patient Data (IPD) from all available studies to address knowledge gaps and improve treatment outcomes for people affected by these diseases. By amalgamating and standardising available individual patient data, the utility of existing resources can be maximised to address priority questions on the treatment of schistosomiasis and STHs, to create a framework to prospectively assemble future studies, to guide the design of future studies, and to make research progress more efficient. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact No impacts known yet 
URL https://www.iddo.org/research-themes/schistosomiasis-sths
 
Title Review of the effectiveness of indoor spraying of insecticide for control of malaria 
Description Systematic review of experimental hut trial data 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Not known yet 
 
Title SARS Coronavirus 2 Phylodynamics 
Description Our mission is to advance epidemiological surveillance of COVID19 by studying the evolution of SARS Coronavirus 2. By using publicly available virus genomic data, phylogenetic analysis and advanced population genetic modeling, we aim to shed light on Growth and decline of COVID19 in various populations Epidemic origins The impact of public health interventions Future epidemic trends 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact Not yet recognised 
URL http://sarscov2phylodynamics.org/
 
Title SEIR stochastic compartmental model 
Description Developed to enable real-time estimates of the state of the epidemic to be evaluated and to provide short-term projections of hospital care demand. This has been fitted to sub-national data from the UK epidemic with updates provided at least weekly to the SPI-M modelling subgroup, SAGE and other government departments. These include estimate of the reproduction number and epidemic growth rate, and medium-term projections number of infections, cases, hospitalisations and deaths in different sub-populations, including care homes. Model-based analyses have also been performed in support of the test- and trace strategy, quantifying the impact of PCR-testing of symptomatic cases (and self-isolation of positive cases), weekly screening of health-care workers and contact tracing on the rate of transmission. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? No  
Impact Ongoing. 
 
Title Serosolver R package 
Description This R package allows other scientists to investigate the life course of infection of an individual with influenza strains by using serological data from different historical strains gathered at different time points. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact It is being used by other members of the scientific community to support research 
URL https://github.com/seroanalytics/serosolver
 
Title Short-term forecasts of COVID-19 deaths in multiple countries 
Description This weekly report presents forecasts of the reported number of deaths in the week ahead and analysis of case reporting trends (case ascertainment) for countries with active transmission. 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact No impacts yet 
URL http://mrc-ide.github.io/covid19-short-term-forecasts/index.html#content
 
Title Systematic collation of coronavirus cases Internationally and in mainland China 
Description Collation fo publically available data from government sources ad media to reconstruct linelist of cases for cases detected outside of China Daily updated case numbers across 33 provinces in China 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? No  
Impact Used in COVID-19 response and publciation in MRC reports. 
 
Title Systematic review of key parameters for the WHO R&D priority pathogens 
Description Systematic review of key parameters required for mathematical modelling and outbreak analytics for the 9 pathogens identified by WHO as high potential to cause epidemics. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? No  
Impact Not yet recognised, though used to support COVID-19 analysis. 
 
Title Timing of treatment in severe malaria versus uncomplicated malaria patients: individual patient meta-analysis dataset 
Description We did a systematic review and requested data from original studies in order to do a individual patient analysis examining the relationship between different types of severe malaria and delayed treatment. This included 3,989 severe malaria cases and 5780 uncomplicated malaria cases. The data were all shared publicly with permission of our co-authors and collaborators. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Discussion with Malaria Consortium about interventions to increase the speed of treatment in their Community Health Worker programmes in countries in Africa. 
URL https://doi.org/10.1371/journal.pmed.1003359.s032
 
Title VIMES - Visualisation and monitoring of epidemics 
Description A graph-based evidence synthesis approach to detecting outbreak clusters 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? Yes  
Impact Used by PHE to detect outbreak clusters 
URL https://github.com/reconhub/vimes
 
Title Website for snakebite research (VenBank) 
Description Interactive web portal for global snakebite epidemiological study 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact none yet (beta testing) 
URL https://venbank.info/
 
Title Within-host evolution model 
Description Compartmental model of within-host recombination between bacteria. 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? Yes  
Impact This model was the basis of the publication Croucher et al. (2016) PLoS Biol. 14(3):e1002394. 
URL https://github.com/nickjcroucher/mgeTransformation
 
Title covid19model Europe 
Description covid19model Europe 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact No impacts yet 
 
Title covid19model USA 
Description covid19model USA 
Type Of Material Computer model/algorithm 
Year Produced 2020 
Provided To Others? Yes  
Impact No impacts yet 
 
Description ALPHA Network 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data from Manicaland, Zimbabwe for use in pooled and comparative analyses of trends and determinants of HIV incidence in sub-Saharan African countries with generalised epidemics in the post-antiretroviral treatment era. Contributions to analyses of the pooled and site-specific data.
Collaborator Contribution The ALPHA Network coordinated by researchers at the LSHTM sourced funding from BMGF for the project, are designing the data analyses to be conducted in the project, and will be organising data analysis workshops and results dissemination activities for the project.
Impact No outputs as yet UPDATE 2021 - publications currently under review. Application submitted to Wellcome Trust for funding support
Start Year 2019
 
Description Access to COVID-19 tools accelerator 
Organisation Foundation for Innovative New Diagnostics (FIND)
Country Switzerland 
Sector Charity/Non Profit 
PI Contribution Informing the investment case for diagnostics for COVID-19 in LMICs Mathematical modelling
Collaborator Contribution Result dissemination
Impact Not yet recognised
Start Year 2020
 
Description Access to COVID-19 tools accelerator 
Organisation Global Fund to Fight AIDS, Tuberculosis and Malaria
Country Switzerland 
Sector Charity/Non Profit 
PI Contribution Informing the investment case for diagnostics for COVID-19 in LMICs Mathematical modelling
Collaborator Contribution Result dissemination
Impact Not yet recognised
Start Year 2020
 
Description Alzheimers Disease Epidemiology Research Group (ADERG) 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution expertise, intellectual input and the training of staff
Collaborator Contribution expertise, intellectual input and the training of staff, access to data, equipment and facilities.
Impact Scientific publucations
Start Year 2017
 
Description Alzheimers Disease Epidemiology Research Group (ADERG) 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Academic/University 
PI Contribution expertise, intellectual input and the training of staff
Collaborator Contribution expertise, intellectual input and the training of staff, access to data, equipment and facilities.
Impact Scientific publucations
Start Year 2017
 
Description Alzheimers Disease Epidemiology Research Group (ADERG) 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution expertise, intellectual input and the training of staff
Collaborator Contribution expertise, intellectual input and the training of staff, access to data, equipment and facilities.
Impact Scientific publucations
Start Year 2017
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation Africa Health Research Institute
Country South Africa 
Sector Charity/Non Profit 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation Biomedical Research and Training Institute (BRTI)
Country Zimbabwe 
Sector Charity/Non Profit 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya 
Sector Public 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Department Alpha Network
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Department Department of Population Health
Country United Kingdom 
Sector Academic/University 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda 
Sector Public 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation Rakai Health Sciences Program
Country Uganda 
Sector Public 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysing Longitudinal Population cohort data on HIV/AIDS in Africa (ALPHA) Network 
Organisation University of the Witwatersrand
Country South Africa 
Sector Academic/University 
PI Contribution - Mathematical modelling, demographic analysis, and epidemiological analysis of general population HIV cohort studies in southern and eastern Africa.
Collaborator Contribution - Collection, curation, and analysis of general population HIV cohort studies in southern and eastern Africa - Organization of workshops and support for research dissemination from population cohort study research partners - Methodological training and skills development for scientists based at partner research sites
Impact - Multiple publications in peer reviewed journals: http://alpha.lshtm.ac.uk/publications/ - Inputs to global HIV epidemic estimates and HIV policy at UNAIDS and WHO
Start Year 2013
 
Description Analysis of SARS-COV2 data 
Organisation New York University
Country United States 
Sector Academic/University 
PI Contribution Phylogenetic analysis
Collaborator Contribution Data provision Writing of manuscript Dissemination of results
Impact Publication in Genome Research Publication under review
Start Year 2020
 
Description Assessing the potential impact of disruptions due to COVID-19 on HIV among key and lower-risk populations in the largest cities of Cameroon and Benin 
Organisation Fred Hutchinson Cancer Research Center (FHCRC)
Country United States 
Sector Charity/Non Profit 
PI Contribution Conception Data analysis Mathematical modelling expertise Writing of paper
Collaborator Contribution Writing of paper Interpretation of results and implication
Impact Paper has been accepted for publication in Journal of AIDS
Start Year 2020
 
Description Assessing the potential impact of disruptions due to COVID-19 on HIV among key and lower-risk populations in the largest cities of Cameroon and Benin 
Organisation National Institutes of Health (NIH)
Department HIV Prevention Trials Network HPTN
Country United States 
Sector Charity/Non Profit 
PI Contribution Conception Data analysis Mathematical modelling expertise Writing of paper
Collaborator Contribution Writing of paper Interpretation of results and implication
Impact Paper has been accepted for publication in Journal of AIDS
Start Year 2020
 
Description Avian influenza in wild african penguins 
Organisation University of Pretoria
Department Faculty of Veterinary Science
Country South Africa 
Sector Academic/University 
PI Contribution Statistical and epidemiological design, analysis and interpretation
Collaborator Contribution Provide veterinary expertise Data collection Diagnostic analysis Provide ecological expertise
Impact None reported yet
Start Year 2019
 
Description Baylor School of Medicine (Sasirekha Ramani) 
Organisation Baylor School
Country United States 
Sector Academic/University 
PI Contribution Lead coordinator on a study and design of clinical study design
Collaborator Contribution Rotavirus virology
Impact Not yet
Start Year 2016
 
Description Behaviour and bovine TB 
Organisation Cardiff University
Department School of Geography and Planning
Country United Kingdom 
Sector Academic/University 
PI Contribution Statistical analysis
Collaborator Contribution Behavioural science expertise
Impact Publication in Vaccine
Start Year 2019
 
Description Biomedical Research and Training Institute, Zimbawe 
Organisation Biomedical Research and Training Institute (BRTI)
Country Zimbabwe 
Sector Charity/Non Profit 
PI Contribution Provide Analysis
Collaborator Contribution They provide fieldwork
Impact Awarded a grant with Simon Gregson: Multi-Level Behavioral Economics and Community Psychology Approaches to Strengthen HIV Prevention Cascades in Adolescent Girls and Young Women in East Zimbabwe.
Start Year 2017
 
Description Blantyre HIV prevention strategy 
Organisation Georgetown University
Country United States 
Sector Academic/University 
PI Contribution Modelling expertise Data analysis
Collaborator Contribution Project coordination Secretariat support Data infrastructure and tools Development of strategy documents
Impact Not yet recognised
Start Year 2020
 
Description Blantyre HIV prevention strategy 
Organisation Government of Malawi
Country Malawi 
Sector Public 
PI Contribution Modelling expertise Data analysis
Collaborator Contribution Project coordination Secretariat support Data infrastructure and tools Development of strategy documents
Impact Not yet recognised
Start Year 2020
 
Description Blantyre HIV prevention strategy 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Modelling expertise Data analysis
Collaborator Contribution Project coordination Secretariat support Data infrastructure and tools Development of strategy documents
Impact Not yet recognised
Start Year 2020
 
Description Blantyre HIV prevention strategy 
Organisation Population Services International
Country United States 
Sector Charity/Non Profit 
PI Contribution Modelling expertise Data analysis
Collaborator Contribution Project coordination Secretariat support Data infrastructure and tools Development of strategy documents
Impact Not yet recognised
Start Year 2020
 
Description Bristol University 
Organisation University of Bristol
Department Proteomics Facility
Country United Kingdom 
Sector Academic/University 
PI Contribution Modelling, data analysis
Collaborator Contribution Economic analysis and modelling. Supervision of researchers.
Impact Publications on the impact of the Avahan intervention in India. On-going HIV projects funded by linkages. A collaboration HSV 2 vaccination.
 
Description Building phylodynamic capacity in Botswana 
Organisation Botswana Harvard AIDS Institute Partnership
Country Botswana 
Sector Academic/University 
PI Contribution - Manon Ragonnet spent 3 months at BHP in early 2020, teaching courses in R, phylogenetics and statistics; and organising a multi-day course on Next Generation Sequencing - Manon is supervising two students based in Botswana and has been able to purchase laptops for them through a Research England GCRF grant - One additional student from Botswana has applied for funding from PANGEA (pangea-hiv.org) to spend 12 months at Imperial working with Manon - We have submitted two papers with 3/4 more in preparation
Collaborator Contribution - BHP hosted Manon for 3 months at the lab in Botswana
Impact - NGS course organised (https://www.santheafrica.org/sites/default/files/course-files/course_flyer_ngs_v5.pdf) - One paper submitted to The Journal of Infectious Diseases in January 2021 - One paper summitted to The International Journal of Infectious Diseases in Nov 2020
Start Year 2019
 
Description CDC Outbreak 
Organisation Centers for Disease Control and Prevention (CDC)
Country United States 
Sector Public 
PI Contribution Developing rapid methodologies for analysis of fungal disease outbreaks
Collaborator Contribution Methodological and technological advances
Impact Ongoing manuscript preparation
Start Year 2014
 
Description COVID-19 genomics consortium 
Organisation Government of the UK
Department Department of Health and Social Care
Country United Kingdom 
Sector Public 
PI Contribution Analysis of data collected from the consortium Mathematical modelling expertise
Collaborator Contribution Data provision Dissemination of results Public engagement
Impact Report to SAGE Publication in Cell Report 42 and paper under review Reports to NERVTAG in December 2020 regarding Kent variant - input to policy decisions
Start Year 2020
 
Description COVID-19 genomics consortium 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Analysis of data collected from the consortium Mathematical modelling expertise
Collaborator Contribution Data provision Dissemination of results Public engagement
Impact Report to SAGE Publication in Cell Report 42 and paper under review Reports to NERVTAG in December 2020 regarding Kent variant - input to policy decisions
Start Year 2020
 
Description COVID-19 genomics consortium 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Analysis of data collected from the consortium Mathematical modelling expertise
Collaborator Contribution Data provision Dissemination of results Public engagement
Impact Report to SAGE Publication in Cell Report 42 and paper under review Reports to NERVTAG in December 2020 regarding Kent variant - input to policy decisions
Start Year 2020
 
Description COVID-19 genomics consortium 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of data collected from the consortium Mathematical modelling expertise
Collaborator Contribution Data provision Dissemination of results Public engagement
Impact Report to SAGE Publication in Cell Report 42 and paper under review Reports to NERVTAG in December 2020 regarding Kent variant - input to policy decisions
Start Year 2020
 
Description Capacity building for research in conflict 
Organisation King's College London
Department Fondation Peters, King's College London
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Co-Principle Investigators on the project on capacity building for research in conflict.
Collaborator Contribution Co-Principle Investigators on the project on capacity building for research in conflict.
Impact Papers currently in draft.
Start Year 2018
 
Description Capacity building for research in conflict 
Organisation University of Cambridge
Department Cambridge Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-Principle Investigators on the project on capacity building for research in conflict.
Collaborator Contribution Co-Principle Investigators on the project on capacity building for research in conflict.
Impact Papers currently in draft.
Start Year 2018
 
Description Central TB Division, Ministry of Health, Government of India 
Organisation Indian Ministry of Health
Country India 
Sector Public 
PI Contribution Ongoing work with Central TB Division to develop a modelling framework that can help them prioritise their TB control efforts across the country
Collaborator Contribution Developing the analytical framework in collaboration with national TB programme; coordinating with the programme to ensure that the model is maximally applicable; subcontracting additional analytical support from relevant experts in India
Impact Publications in IJTLD and Lancet Global Health
Start Year 2018
 
Description Centre for Infectious Disease Research Zambia 
Organisation Centre for Infectious Disease Research in Zambia
Country Zambia 
Sector Charity/Non Profit 
PI Contribution Study design and lab support for a rotavirus study
Collaborator Contribution Running a clinical trial of rotavirus vaccine in Zambia
Impact Successful application for "Human infection challenge vaccine (HIC-vac) network" with Roma Chilengi
Start Year 2018
 
Description Cervical Cancer Elimination 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Mathematical modelling expertise and systematic reviews of epidemiological studies
Collaborator Contribution WHO - co-ordinating meetings and leading the initiative. Defining guidelines and co-ordinating media response Harvard University - Modelling analysis Laval - Modelling analysis and providing guidance McGill - Modelling analysis and providing guidance
Impact Numerous publications Informing WHO guidelines for cervical cancer elimination globally Media coverage UPDATE 2021: further publications
Start Year 2018
 
Description Cervical Cancer Elimination 
Organisation McGill University
Department Department of Epidemiology, Biostatistics and Occupational Health
Country Canada 
Sector Academic/University 
PI Contribution Mathematical modelling expertise and systematic reviews of epidemiological studies
Collaborator Contribution WHO - co-ordinating meetings and leading the initiative. Defining guidelines and co-ordinating media response Harvard University - Modelling analysis Laval - Modelling analysis and providing guidance McGill - Modelling analysis and providing guidance
Impact Numerous publications Informing WHO guidelines for cervical cancer elimination globally Media coverage UPDATE 2021: further publications
Start Year 2018
 
Description Cervical Cancer Elimination 
Organisation University Hospital of Laval University
Country Canada 
Sector Hospitals 
PI Contribution Mathematical modelling expertise and systematic reviews of epidemiological studies
Collaborator Contribution WHO - co-ordinating meetings and leading the initiative. Defining guidelines and co-ordinating media response Harvard University - Modelling analysis Laval - Modelling analysis and providing guidance McGill - Modelling analysis and providing guidance
Impact Numerous publications Informing WHO guidelines for cervical cancer elimination globally Media coverage UPDATE 2021: further publications
Start Year 2018
 
Description Cervical Cancer Elimination 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Mathematical modelling expertise and systematic reviews of epidemiological studies
Collaborator Contribution WHO - co-ordinating meetings and leading the initiative. Defining guidelines and co-ordinating media response Harvard University - Modelling analysis Laval - Modelling analysis and providing guidance McGill - Modelling analysis and providing guidance
Impact Numerous publications Informing WHO guidelines for cervical cancer elimination globally Media coverage UPDATE 2021: further publications
Start Year 2018
 
Description Collaboration agreement with National Institute of Health, Italy 
Organisation National Institute of Health
Country Italy 
Sector Public 
PI Contribution Writings of confidential reports Epidemiological modelling expertise
Collaborator Contribution Expert advice on local situation in Italy Advice on policy options under consideration
Impact Confidential reports to support COVID-19 response in Italy
Start Year 2020
 
Description Collaboration with HIV model consortium 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Lead on model comparison exercises
Collaborator Contribution Contribution of results
Impact Presented at CROY conference
Start Year 2020
 
Description Collaboration with Natashia Morris, Health GIS Centre, MRC South Africa 
Organisation Medical Research Council of South Africa (MRC)
Country South Africa 
Sector Public 
PI Contribution We have been in discussions with Dr Natashia Morris the Manager Health GIS Centre about how to determine whether a case of malaria identified by routine surveillance was contracted in country or imported from abroad. We have presented our methods and Dr Morris is looking to put into place systems which would allow the probability that a case of malaria was imported to be calculated instead of dichotomous decisions based on personal opinion.
Collaborator Contribution Provided information on data collected by the South African national malaria control programme and other countries in the E8 Partnership.
Impact None as yet.
Start Year 2018
 
Description Collaborations with WHO Global Hepatitis Unit on viral hepatitis elimination strategies 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution We have been collaborating with the WHO, both at headquarter level and at regional WPRO level on viral hepatitis strategies. Our primary work has focus on the use of applied modelling in guiding public health policy, modelling global targets for elimination, country level work in China and elimination of mother-to-child transmission of HBV.
Collaborator Contribution The WHO provided the contacts and the context of the priority policy questions to be addressed.
Impact Our work has been referenced in the Global Health Sector Strategy on Viral Hepatitis and other policy documents (see other sections of form for further details). We have been invited to national consultations in China and Malaysia on the elimination of mother to child transmission of HBV. Participants of this consultative process included academics, representatives of the health ministries and other key policy makers.
Start Year 2014
 
Description Comprehensively profiling social mixing patterns in workplace settings to model pandemic influenza transmissions 
Organisation Yale University
Country United States 
Sector Academic/University 
PI Contribution Infectious disease dynamics expertise Developing code Data interpretation Writing of papers
Collaborator Contribution Obtained funding Data collection Project management
Impact Not yet
Start Year 2020
 
Description Consolidated guidelines on HIV testing services for a changing epidemic 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution - Mathematical modelling of new algorithms and strategies for HIV diagnosis.
Collaborator Contribution - Technical leadership and oversight, production of normative guidance.
Impact - Revised 2019 WHO Consolidated Guidelines on HIV Testing Services - Policy brief: Consolidated guidelines on HIV testing services for a changing epidemic - Policy brief: WHO encourages countries to adapt HIV testing strategies in response to changing epidemic
Start Year 2018
 
Description Consultancy to develop guidelines for National Malaria Programmes for stratification, prioritisation and optimised resource allocation within strategic planning 
Organisation World Health Organization (WHO)
Department Global Malaria Programme
Country Switzerland 
Sector Charity/Non Profit 
PI Contribution I am developing a document for National Malaria Programmes for stratification, prioritisation and optimised resource allocation within strategic planning as part of a wider drive to use routine malaria surveillance data for operational action.
Collaborator Contribution WHO is providing consultancy pay as well as general guidance and feedback
Impact No outputs to date.
Start Year 2019
 
Description Coronab 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Mathematical modelling Modelling NPIs and anti-virals
Collaborator Contribution Grant applications Networking and collaborations
Impact Publication in Cell Software outputs: https://github.com/robj411/sequencing_coverage https://github.com/robj411/lineageApp
Start Year 2020
 
Description DAEDALUS project: : integrated economic-epidemiological model for COVID-19 
Organisation Imperial College London
Department Imperial College Business School
Country United Kingdom 
Sector Academic/University 
PI Contribution Project lead and management Integration of epidemiological and economic modelling
Collaborator Contribution Economic modelling
Impact MRC-GIDA report 35
Start Year 2020
 
Description DFID Ebola Situational Reports 
Organisation Government of the UK
Department Department for International Development (DfID)
Country United Kingdom 
Sector Public 
PI Contribution We have continued to share reports of the analysis of the ongoing Ebola outbreak in the Democratic Republic of the Congo. This has included projections of future incidence, bed demand, and vaccine demand estimates.
Collaborator Contribution Context for analysis needs e.g. requirements for vaccine demand.
Impact Reports for internal use at DFID and White Hall.
Start Year 2018
 
Description DeWorm3 
Organisation Natural History Museum
Country United Kingdom 
Sector Public 
PI Contribution Intellectual input, expertise and the training of staff.
Collaborator Contribution Intellectual input, expertise and the training of staff.
Impact Scientific journal publications in PLoS NTDs, Epidemics, Journal of Theoretical Biology, Lancet and Parasites and Vectors
Start Year 2016
 
Description DeWorm3 
Organisation University of Washington
Country United States 
Sector Academic/University 
PI Contribution Intellectual input, expertise and the training of staff.
Collaborator Contribution Intellectual input, expertise and the training of staff.
Impact Scientific journal publications in PLoS NTDs, Epidemics, Journal of Theoretical Biology, Lancet and Parasites and Vectors
Start Year 2016
 
Description Detection and Management of Ivermectin Resistance 
Organisation McGill University
Department Institute of Parasitology
Country Canada 
Sector Academic/University 
PI Contribution Mahematical modelling; preparation of papers; successful preparation of grant proposals
Collaborator Contribution Data on genetic analysis of filarial parasites (lymphatic filariasis, onchocerciasis) for mathematical modelling of the evolution and spread of anthelmintic resistance
Impact Outputs in the form of publications: PubMed ID numbers: 19805362; 19154624; 18382607; 17320006; 16834821. Outcomes in the form of invitations to speak at scientific meetings (Am Soc Trop Med Hyg, December 2008; Royal Society UK-Ghana collaboration, April 2008), and Expert Groups (WHO/World Bank, January 2008). Impacts in the form of invitation to belong to the Disease Reference Group on Helminths, World Health Organization.