Soft-Hard Tissue Engineering for Synthetic Bone Manufacturing using Ultrafast Lasers

Lead Research Organisation: University of Leeds
Department Name: Chemical and Process Engineering

Abstract

There is a huge shortage of bio-compatible bone materials in the world for replacing damaged bone tissue. The PhD topic will focus on a novel method for synthetic bone materials engineering using ultrafast lasers and advanced bio-materials. The multidisciplinary research will focus on the sequential deposition of calcium phosphate minerals with collagen, and protein and growth factor gene. The method of bone materials fabrication by engineering hard (mineral)-soft (collagen, protein, growth factor) will also examine micro-mechanics, structure, and bio-compatibility for synthetic bone manufacturing. The manufacturing engineering will also be supplemented by training in cell viability tests. In the project the student will be trained in the core areas of research in laser processing, characterisation, cell viability and micro-mechanics. The PhD student will also gain some experience by working with clinicians.

Publications

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Iqbal N. (2017) CLEO®/Europe-EQEC 2017 chitosan membranes for biodegradable microfluidics in Optics InfoBase Conference Papers

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509681/1 01/10/2016 30/09/2021
1787225 Studentship EP/N509681/1 01/10/2016 31/03/2020 Neelam Iqbal
 
Description The EPSRC project is focused to establish a novel approach, for the development, fabrication and implantation of bone scaffolds, based on the fundamentals of advanced manufacturing using femtosecond lasers. Bone is a complex living tissue with significant metabolic and regenerative activities, which are disrupted when the tissue is damaged. Healing of fractured bone is a complicated process therefore; an ideal bone scaffold should have: i) exceptional osteogenic potential in order to promote new bone formation; ii) load-bearing properties; iii) appropriate microstructure for promoting angiogenesis for the circulation of nutrients and iv) antibacterial resistance to avoid infections that lead to failure of the surgery. Research efforts have been focused on development of the "perfect" biomaterial, targeting to achieve all the aforementioned properties with a single material system; e.g. blocks of calcium phosphates, coated Ti-implants, polymers etc. Micropatterning and microchannels promote guided cellular growth leading eventually to the formation of vasculature. In addition, the increased capillary forces in the channels allows for better circulation of the nutritional components which are necessary for the formation of new blood vessels.
Exploitation Route Further investigation into nanoparticles which are emerging as novel antibacterial agents as they have proven their effectiveness for treating infectious diseases. Factors such as size, shape, surface charge and surface area to volume ratio affect the antibacterial potential of nanoparticles although the exact antibacterial mechanisms are not yet fully clear.
Sectors Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Description Bone & Enamel Tissue Science & Engineering (BETSE 2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I presented a poster regarding chitosan bio-materials prepared, characterized and tested for the soft-hard tissue engineering for synthetic bone manufacturing using ultrafast lasers project at this one-day meeting. This conference/meeting bought together clinicians, practitioners, tissue engineers and laser scientists to discuss emerging regenerative bone, enamel, soft and hard tissue interface reconstruction and surgical technologies.
Year(s) Of Engagement Activity 2017
URL http://www.betse2017.org/
 
Description Postgraduate Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact I assisted during an open day which was directed towards attracting potential postgraduate students where over 300 potential students attended. I was able to answer questions about engineering postgraduate study, application process, funding opportunities but also regarding student life in the vibrant city of Leeds.
Year(s) Of Engagement Activity 2019
URL http://www.leeds.ac.uk/homepage/58/
 
Description Research Event Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I presented a poster at the annual research event day of my results investigating bio-polymers incorporated with bio-active minerals for tissue engineering applications conducted during the first year my PhD studies. This one day research event allowed for all postgraduate students to showcase their work and network, I was awarded the best poster in the Advanced Engineering Materials theme.
Year(s) Of Engagement Activity 2018
URL https://cier.leeds.ac.uk/news/research-event-day/
 
Description Society of Glass Technology Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The SGT Annual Conference at Cambridge provided an opportunity to meet and share insights and enthusiasms about glass.
Year(s) Of Engagement Activity 2017
URL http://www.cambridge2017.sgt.org/Ab-s-NeelamIqbal.htm