The potential of nutraceutical based senolytics in targeting senescent cells and inducing senoptosis in vitro

Lead Research Organisation: University of Leicester
Department Name: Neuroscience, Psychology and Behaviour

Abstract

As the populations grow older, the functioning of cells, tissues and organs begins to decline. Cell cycle arrested, so-called senescent cells, contribute to the aging process. Recent approaches to target these cells has led to the characterisation of so-called senolytics, compounds which can effectively reverse the detrimental cellular phenotype. This project will draw on joint cell culture records to investigate in vitro the use of multiple senolytic compounds, which are available as potential nutraceuticals, in clearing senescent cells by inducing senoptosis - death of sencescent cells. We will use hydroxyurea treatment and multiple population doublings to mimic aging in culture for primary mouse and human cells covering systems which are affected in old age. Potential compounds under investigation will include Quercetin, Giloy and Allicin to determine a novel, potential impact in the field of senescence and the understanding of the aging process.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
1898564 Studentship BB/M01116X/1 02/10/2017 30/09/2021 Amanpreet Kaur
 
Description This award has led to the development and characterization of an in vitro model to study the effects of nutraceuticals on senescence.
Exploitation Route The use of the model created which is transferrable for the use of others in research in similar investigations.
The discovery of any potential senolytics could be further applied in human models and trials.
Sectors Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Giving an interactive poster presentation on the PhD project.
Sparked questions from the conference attendees.
Shaping my thinking and critical analysis of my own work.
Year(s) Of Engagement Activity 2018,2019
 
Description Postgraduate engagement 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Students were invited to attend a presentation on the demands and challenges of a PhD project.
This sparked questions from the audience.
Year(s) Of Engagement Activity 2019
 
Description Research Outreach 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Providing information on the scope of the research portfolio of the university.
This sparked questions about my project.
Year(s) Of Engagement Activity 2019