Identifying cyclic peptide inhibitors of the Myc/Max protein-protein interaction
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
We are going to use a newly developed, microfluidic-based platform to generate and screen libraries of over a hundred million cyclic peptides against the Myc/Max protein-protein interaction. This protein-protein interaction has been heavily implicated in the cancer, however, there are currently no therapeutics that target myc/max. we will use this challenging target to assess the limits of our screening platform. Once a cyclic peptide that inhibits this protein-protein interaction has been identified, we will use a medicinal chemistry approach to improve its potency.
Organisations
People |
ORCID iD |
Ali Tavassoli (Primary Supervisor) | |
Jacob Valentine (Student) |
Publications
Valentine J
(2018)
Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond.
in Methods in enzymology
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/N509747/1 | 30/09/2016 | 29/09/2021 | |||
1990345 | Studentship | EP/N509747/1 | 31/01/2018 | 29/04/2021 | Jacob Valentine |