Identifying cyclic peptide inhibitors of the Myc/Max protein-protein interaction

Lead Research Organisation: University of Southampton
Department Name: Sch of Chemistry


We are going to use a newly developed, microfluidic-based platform to generate and screen libraries of over a hundred million cyclic peptides against the Myc/Max protein-protein interaction. This protein-protein interaction has been heavily implicated in the cancer, however, there are currently no therapeutics that target myc/max. we will use this challenging target to assess the limits of our screening platform. Once a cyclic peptide that inhibits this protein-protein interaction has been identified, we will use a medicinal chemistry approach to improve its potency.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509747/1 30/09/2016 29/09/2021
1990345 Studentship EP/N509747/1 31/01/2018 29/04/2021 Jacob Valentine