Identification of regulatory genomic networks underlying skin ageing

Lead Research Organisation: King's College London
Department Name: Genetics and Molecular Medicine

Abstract

Deciphering which mRNA or epigenetic changes with age contribute to ageing rather than are a
consequence of ageing is extremely difficult. However, DNA sequence variants that associate with ageing
traits are likely to be causal, because genetic variants do not change with age. How genetic variants
precisely affect regulation of nearby genes and potential downstream targets needs further study. Hence,
unravelling the complex network of epigenetic and expression pathways associated with ageing-related
genetic variation is useful in determining how causal gene variants influence age-related processes in cells.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/V509656/1 01/02/2021 31/01/2025
2512524 Studentship BB/V509656/1 01/02/2021 31/01/2025 Christopher James Shore