Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Vallotto C
(2018)
Photoactivatable platinum anticancer complex can generate tryptophan radicals.
in Chemical communications (Cambridge, England)
Lam YPY
(2018)
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
in Chemical communications (Cambridge, England)
Sanchez-Cano C
(2019)
Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells.
in Chemical communications (Cambridge, England)
Pitto-Barry A
(2017)
Controlled fabrication of osmium nanocrystals by electron, laser and microwave irradiation and characterisation by microfocus X-ray absorption spectroscopy.
in Chemical communications (Cambridge, England)
Barry NP
(2013)
Exploration of the medical periodic table: towards new targets.
in Chemical communications (Cambridge, England)
Gandioso A
(2015)
An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies.
in Chemical communications (Cambridge, England)
Zhang WY
(2020)
Ligand-centred redox activation of inert organoiridium anticancer catalysts.
in Chemical science
Wootton CA
(2018)
Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.
in Chemical science
Smith NA
(2017)
Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.
in Chemical science
Banerjee S
(2018)
New activation mechanism for half-sandwich organometallic anticancer complexes.
in Chemical science
Venkatesh V
(2017)
Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes.
in Chemical science
Chen JS
(2010)
Photochemistry in photonic crystal fiber nanoreactors.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Coverdale JP
(2015)
Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Sanchez-Cano C
(2017)
Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo-Osmium Complex in Human Ovarian Cancer Cells.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Shi H
(2021)
DNA-Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Shaili E
(2015)
A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Chellan P
(2018)
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Chellan P
(2020)
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Pandey P
(2012)
Resolving the Nanoscale Morphology and Crystallographic Structure of Molecular Thin Films: F 16 CuPc on Graphene Oxide
in Chemistry of Materials
Shaili Evyenia
(2015)
A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin
in CHEMISTRY-A EUROPEAN JOURNAL
Soldevila-Barreda JJ
(2015)
Approaches to the design of catalytic metallodrugs.
in Current opinion in chemical biology
Oliveira C
(2020)
Novel tetranuclear Pd II and Pt II anticancer complexes derived from pyrene thiosemicarbazones
in Dalton Transactions
Oliveira CG
(2019)
Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.
in Dalton transactions (Cambridge, England : 2003)
Banerjee S
(2019)
Generation of maghemite nanocrystals from iron-sulfur centres.
in Dalton transactions (Cambridge, England : 2003)
Needham RJ
(2021)
NMR studies of group 8 metallodrugs: 187Os-enriched organo-osmium half-sandwich anticancer complex.
in Dalton transactions (Cambridge, England : 2003)