Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Wootton CA
(2015)
Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry.
in Dalton transactions (Cambridge, England : 2003)
Chen F
(2022)
Effect of cysteine thiols on the catalytic and anticancer activity of Ru(II) sulfonyl-ethylenediamine complexes.
in Dalton transactions (Cambridge, England : 2003)
Sink A
(2022)
Kinetics and mechanism of sequential ring methyl C-H activation in cyclopentadienyl rhodium(III) complexes.
in Dalton transactions (Cambridge, England : 2003)
Carter R
(2014)
Band gap expansion, shear inversion phase change behaviour and low-voltage induced crystal oscillation in low-dimensional tin selenide crystals.
in Dalton transactions (Cambridge, England : 2003)
Shi H
(2019)
Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide.
in Dalton transactions (Cambridge, England : 2003)
Fu Y
(2016)
The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts.
in Dalton transactions (Cambridge, England : 2003)
Liu HK
(2016)
"Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes.
in Dalton transactions (Cambridge, England : 2003)
Pitto-Barry A
(2015)
Synthesis and controlled growth of osmium nanoparticles by electron irradiation.
in Dalton transactions (Cambridge, England : 2003)
Barry NP
(2014)
A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes.
in Dalton transactions (Cambridge, England : 2003)
Li J
(2017)
A novel strategy to construct Janus metallamacrocycles with both a Ru-arene face and an imidazolium face.
in Dalton transactions (Cambridge, England : 2003)
Zou T
(2015)
Speciation of precious metal anti-cancer complexes by NMR spectroscopy.
in Drug discovery today. Technologies
Sargaeva NP
(2011)
Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides.
in Electrophoresis
Zhang P
(2017)
Redox-Active Metal Complexes for Anticancer Therapy
in European Journal of Inorganic Chemistry
Gothe Y
(2018)
Synthesis and Mode of Action Studies on Iridium(I)-NHC Anticancer Drug Candidates
in European Journal of Inorganic Chemistry
Chen P
(2019)
Discovery of novel, potent, isosteviol-based antithrombotic agents.
in European journal of medicinal chemistry
Barry NP
(2014)
Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.
in Faraday discussions
Xue X
(2021)
Photoactivated Osmium Arene Anticancer Complexes.
in Inorganic chemistry
Sriskandakumar T
(2015)
Electrophilic Activation of Oxidized Sulfur Ligands and Implications for the Biological Activity of Ruthenium(II) Arene Anticancer Complexes.
in Inorganic chemistry
Štarha P
(2016)
Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes.
in Inorganic chemistry
Shi H
(2018)
Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.
in Inorganic chemistry
Shi H
(2020)
Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes.
in Inorganic chemistry frontiers
Shi H
(2019)
Diazido platinum( iv ) complexes for photoactivated anticancer chemotherapy
in Inorganic Chemistry Frontiers
Novohradsky V
(2020)
Induction of immunogenic cell death in cancer cells by a photoactivated platinum(IV) prodrug.
in Inorganic chemistry frontiers
Wang Y
(2016)
Nanoparticles of chitosan conjugated to organo-ruthenium complexes
in Inorganic Chemistry Frontiers
Shi H
(2019)
Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands
in Inorganica Chimica Acta
Smith N
(2017)
Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes
in Inorganica Chimica Acta
Bisceglie F
(2022)
Light Triggers the Antiproliferative Activity of Naphthalimide-Conjugated (?6-arene)ruthenium(II) Complexes.
in International journal of molecular sciences
Wang FX
(2022)
Reactions of cisplatin and oxaliplatin with penicillin G: implications for drug inactivation and biological activity.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Bolitho EM
(2020)
X-ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Sanchez-Cano C
(2018)
Microfocus x-ray fluorescence mapping of tumour penetration by an organo-osmium anticancer complex.
in Journal of inorganic biochemistry
Xie MJ
(2017)
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV.
in Journal of inorganic biochemistry
Needham RJ
(2020)
Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents.
in Journal of inorganic biochemistry
Brabec V
(2016)
Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex.
in Journal of inorganic biochemistry
Chellan P
(2021)
Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin.
in Journal of inorganic biochemistry
Gondim ACS
(2017)
The potent anti-cancer activity of Dioclea lasiocarpa lectin.
in Journal of inorganic biochemistry
Wu Q
(2018)
Rigid dinuclear ruthenium-arene complexes showing strong DNA interactions.
in Journal of inorganic biochemistry
Nightingale A
(2013)
Large-scale synthesis of nanocrystals in a multichannel droplet reactor
in Journal of Materials Chemistry A
Chen F
(2018)
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.
in Journal of medicinal chemistry
Coverdale J
(2018)
In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
in Journal of Medicinal Chemistry
Romero-Canelón I
(2015)
Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)
in Journal of Organometallic Chemistry
Zhang P
(2017)
Advances in the design of organometallic anticancer complexes
in Journal of Organometallic Chemistry
Sargaeva NP
(2011)
Unusual fragmentation of ß-linked peptides by ExD tandem mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Qi Y
(2011)
Phase correction of Fourier transform ion cyclotron resonance mass spectra using MatLab.
in Journal of the American Society for Mass Spectrometry
Qi Y
(2013)
Absorption-mode Fourier transform mass spectrometry: the effects of apodization and phasing on modified protein spectra.
in Journal of the American Society for Mass Spectrometry
Li H
(2014)
Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins.
in Journal of the American Society for Mass Spectrometry
Lopez-Clavijo AF
(2014)
Study of an unusual advanced glycation end-product (AGE) derived from glyoxal using mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Li H
(2012)
Electron capture dissociation of disulfide, sulfur-selenium, and diselenide bound peptides.
in Journal of the American Society for Mass Spectrometry
Wills R
(2014)
Insights into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High Resolution Mass Spectrometry
in Journal of the American Society for Mass Spectrometry
Wei J
(2013)
Structural characterization of chlorophyll-a by high resolution tandem mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Lopez-Clavijo AF
(2014)
Unexpected crosslinking and diglycation as advanced glycation end-products from glyoxal.
in Journal of the American Society for Mass Spectrometry