Magnetic Resonance: From the Laboratory to Industrial Practice
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
Magnetic Resonance Imaging is widely used in hospitals to image blood flow and the internal structure of the human body. Our work focuses on extending these magnetic resonance (MR) techniques to study chemical products and processes. Over the past 5 years we have established an internationally respected skill base in developing MR techniques to study transport in porous materials (e.g. oil flow in rocks), transport and reaction in 3-D systems (e.g. chemical conversion occurring inside catalytic reactors) and processing structure-function relationships (e.g. effect of extrusion processing on the structure and texture of food products). We believe that we now have the research base in place to make a step-change in exploiting MR in industrial practice. To achieve this, we wish to extend our research activities by (i) improving signal-to-noise ratios and speeding up data acquisition times such that we will be able to image hydrodynamics and chemical conversion over much shorter timescales than we can now; our target is to reduce data acquisition times by an order of magnitude; and (ii) developing robust methods for mapping pH, oxygen content, temperature and pressure, and constructing realistic process environments (e.g. elevated pressure and temperature) within the MR magnet. As well as being able to make new measurements under realistic process conditions, these data will also enable us to understand the microscopic physical and chemical processes occurring in these complex systems such that we can work with those developing numerical codes of chemical processes to improve and validate the scientific assumptions and models incorporated in their process design tools. Finally, in collaboration with experts in low-field MR hardware (which is cheap, compact and relatively maintenance free compared with high-field technology) we will bring together our advances in reduced data acquisitions times and signal enhancement with their magnet technology to demonstrate MR measurements in the industrial R&D laboratory and eventually on plant.
Organisations
Publications
Tayler AB
(2010)
'Snap-shot' velocity vector mapping using echo-planar imaging.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Somasundram I
(2010)
2-D simulation of wick debinding for ceramic parts in close proximity
in Chemical Engineering Science
Holland DJ
(2011)
A Bayesian approach to characterising multi-phase flows using magnetic resonance: application to bubble flows.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Chandrasekera T
(2012)
A comparison of magnetic resonance imaging and electrical capacitance tomography: An air jet through a bed of particles
in Powder Technology
Mitchell J
(2013)
A General approach to T 2 measurements in the presence of internal gradients
in Microporous and Mesoporous Materials
Thomas JM
(2013)
A new approach to the investigation of nanoparticles: electron tomography with compressed sensing.
in Journal of colloid and interface science
Li R
(2010)
A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acid.
in Physical chemistry chemical physics : PCCP
McGregor J
(2010)
Active coke: Carbonaceous materials as catalysts for alkane dehydrogenation
in Journal of Catalysis
Stevenson R
(2010)
Analysis of partial suspension in stirred mixing cells using both MRI and ERT
in Chemical Engineering Science
Tayler A
(2012)
Applications of ultra-fast MRI to high voidage bubbly flow: Measurement of bubble size distributions, interfacial area and hydrodynamics
in Chemical Engineering Science
Parrott E
(2010)
Atomic charge distribution in sodosilicate glasses from terahertz time-domain spectroscopy
in Physical Review B
Holland D
(2012)
Bubble size measurement using Bayesian magnetic resonance
in Chemical Engineering Science
Graf Von Der Schulenburg D
(2011)
Catalyst effectiveness factor distributions in isothermal packed bed reactors
in Chemical Engineering Science
Robbins D
(2012)
CFD modeling of single-phase flow in a packed bed with MRI validation
in AIChE Journal
Collins J
(2017)
Characterising gas behaviour during gas-liquid co-current up-flow in packed beds using magnetic resonance imaging
in Chemical Engineering Science
Blythe TW
(2015)
Characterising the rheology of non-Newtonian fluids using PFG-NMR and cumulant analysis.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Creber S
(2010)
Chemical cleaning of biofouling in reverse osmosis membranes evaluated using magnetic resonance imaging
in Journal of Membrane Science
Hughes T
(2012)
CO2 sequestration for enhanced gas recovery: New measurements of supercritical CO2-CH4 dispersion in porous media and a review of recent research
in International Journal of Greenhouse Gas Control
Holland DJ
(2013)
Compressed sensing reconstruction improves sensitivity of variable density spiral fMRI.
in Magnetic resonance in medicine
Bostock MJ
(2012)
Compressed sensing reconstruction of undersampled 3D NOESY spectra: application to large membrane proteins.
in Journal of biomolecular NMR
D'Agostino C
(2014)
Deactivation studies of a carbon supported AuPt nanoparticulate catalyst in the liquid-phase aerobic oxidation of 1,2-propanediol
in Catal. Sci. Technol.
Fridjonsson EO
(2012)
Determination of mean droplet sizes of water-in-oil emulsions using an Earth's field NMR instrument.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Fabich H
(2016)
Development of ultrafast UTE imaging for granular systems
Fabich H
(2016)
Development of ultrafast UTE imaging for granular systems
in Journal of Magnetic Resonance
Chen C
(2014)
Direct visualization of in vitro drug mobilization from Lescol XL tablets using two-dimensional (19)F and (1)H magnetic resonance imaging.
in Molecular pharmaceutics
Lingwood IA
(2012)
Emulsion droplet sizing using low-field NMR with chemical shift resolution and the block gradient pulse method.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Mitchell J
(2013)
Exploring Surface Interactions in Catalysts Using Low-Field Nuclear Magnetic Resonance
in The Journal of Physical Chemistry C
Tayler AB
(2012)
Exploring the origins of turbulence in multiphase flow using compressed sensing MRI.
in Physical review letters
Ross JG
(2012)
Extending the use of Earth's Field NMR using Bayesian methodology: application to particle sizing.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Parrott E
(2009)
Extracting accurate optical parameters from glasses usingterahertz time-domain spectroscopy
in Journal of Non-Crystalline Solids
Holland DJ
(2011)
Fast multidimensional NMR spectroscopy using compressed sensing.
in Angewandte Chemie (International ed. in English)
Müller C
(2009)
Geometrical and hydrodynamical study of gas jets in packed and fluidized beds using magnetic resonance
in The Canadian Journal of Chemical Engineering
Abbott A
(2011)
Glycerol eutectics as sustainable solvent systems
in Green Chem.
Holland D
(2013)
Grain Sizing in Porous Media using Bayesian Magnetic Resonance
in Physical Review Letters
D'Agostino C
(2012)
Hydrogen Bonding Network Disruption in Mesoporous Catalyst Supports Probed by PFG-NMR Diffusometry and NMR Relaxometry
in The Journal of Physical Chemistry C
Fridjonsson E
(2011)
Imaging the effects of peptide bio-surfactants on droplet deformation in a Taylor-Couette shear cell
in Soft Matter
Griffith J
(2009)
In situ monitoring of the microstructure of detergent drops during drying using a rapid nuclear magnetic resonance diffusion measurement
in Journal of Materials Science
Wu Y
(2014)
In situ study of reaction kinetics using compressed sensing NMR.
in Chemical communications (Cambridge, England)
Zhang Q
(2011)
In vitro quantitative ((1))H and ((19))F nuclear magnetic resonance spectroscopy and imaging studies of fluvastatin™ in Lescol® XL tablets in a USP-IV dissolution cell.
in Journal of controlled release : official journal of the Controlled Release Society
Youngs T
(2009)
Liquid Structure and Dynamics of Aqueous Isopropanol over ?-Alumina
in The Journal of Physical Chemistry C
Xiaoxia Yin
(2010)
Local Computed Tomography Using a THz Quantum Cascade Laser
in IEEE Sensors Journal
Mitchell J
(2014)
Low-field permanent magnets for industrial process and quality control.
in Progress in nuclear magnetic resonance spectroscopy
Creber S
(2010)
Magnetic resonance imaging and 3D simulation studies of biofilm accumulation and cleaning on reverse osmosis membranes
in Food and Bioproducts Processing
Laity P
(2010)
Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation
in European Journal of Pharmaceutics and Biopharmaceutics
Mitchell J
(2013)
Magnetic resonance imaging in laboratory petrophysical core analysis
in Physics Reports
Song K
(2011)
Magnetic resonance imaging studies of spontaneous capillary water imbibition in aerated gypsum
in Journal of Physics D: Applied Physics
Gladden L
(2013)
Magnetic resonance in reaction engineering: beyond spectroscopy
in Current Opinion in Chemical Engineering
| Description | This was a Platform Grant and therefore covered a wide range of method development in magnetic resonance in application to chemical engineering and the process industries. A large number of the projects initiated within this grant are now supported by industrial funding. Research methods which have been continued in such projects include undersampling methods in NMR such as compressed sensing and Bayesian methods; in situ/operando studies of catalysis; and new measurements capabilities at low field. Industrial collaborators include: Johnson Matthey, Shell, Schlumberger, BP and AstraZeneca. |
| First Year Of Impact | 2013 |
| Sector | Chemicals,Energy,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Title | Research data supporting "Retaining both discrete and smooth features in 1D and 2D NMR relaxation and diffusion experiments" |
| Description | data used in associated publication |
| Type Of Material | Database/Collection of data |
| Provided To Others? | Yes |
| Title | Research data supporting "Study of bubble dynamics in gas-solid fluidized beds using ultrashort echo time (UTE) magnetic resonance imaging (MRI)" |
| Description | data associated with paper |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |