UK Biobank (core renewal)
Lead Research Organisation:
UK Biobank
Department Name: UNLISTED
Abstract
UK Biobank is supported by The Wellcome Trust, The National Institute of Health Research, The Medical Research Council, The British Heart Foundation and Cancer Research UK. The figures presented on this record represent the Medical Research Council funding contribution only with some additional UKRI Infrastructure funds in addition.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
UK Biobank is a prospective study of 500,000 men and women aged 40-69 years at the point of recruitment (2006-10). The study has collected extensive phenotypic and genotypic detail about its participants, including data from questionnaires, physical measures, sample assays, accelerometery, imaging, genome-wide genotyping and long-term longitudinal follow-up for a wide range of health-related outcomes. The resource is regularly augmented with additional data and is available to academic or commercial researchers world-wide to use for any type of health-related research that is in the public interest. It has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. The ongoing identification and adjudication of increasing numbers of incident cases of the commoner conditions in the resource will support extensive and powerful research into their determinants and the range of diseases that can be studied reliably will widen as the numbers of incident events of different types increase during follow-up over the next 5-10 year period. As a result, UK Biobank provides researchers from around the world with greater opportunities to better understand early disease stages and their diagnosis, and can support the development of new treatments for diseases of mid-to-later life.
Technical Summary
The UK Biobank resource has been established primarily for the conduct of prospective studies investigating the relevance of a wide range of exposures to health outcomes that occur during long-term follow-up. There are now sufficient numbers of incident cases of the commoner conditions to support extensive and powerful research into their determinants.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
There is regular augmentation of UK Biobank’s capability for effective use as a prospective resource by the widest possible range of researchers. This activity has included: streamlining resource access management systems; imaging assessments; an agile response to the SARS-2 Covid pandemic; ‘omics; whole genome sequencing and turning biological samples into genotypic and biomarker data to make the resource more accessible to researchers studying a wide range of different conditions.
During the next few years, it is intended to develop UK Biobank as a UK national infrastructure and the resource will move to new premises at the University of Manchester where sample throughput will be accelerated with new robotics and freezer systems, making more large scale studies possible. UK Biobank will make increasing amounts of genotype and biomarker data available. It will seek to extend cohort-wide record linkage to primary care health; develop other linkages relevant to health; complete imaging assessments on close to 100,000 participants, including repeat imaging on a subset; develop and implement further enhancements (such as metabolomics) and introduce changes relating to participant involvement and to address equality diversity and inclusion. Communications will be expanded to a wider audience to help ensure that researchers from around the world are well informed about UK Biobank’s enhanced capabilities in order to maximise suitable use of the resource over the next few years.
Organisations
People |
ORCID iD |
Rory Collins (Principal Investigator) |
Publications
Arathimos R
(2022)
Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts.
in The British journal of psychiatry : the journal of mental science
Arathimos R
(2021)
Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study.
in Translational psychiatry
Ardissino M
(2022)
Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy: a Mendelian randomization study.
in BMC medicine
Ardissino M
(2022)
Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants.
in European heart journal. Cardiovascular Imaging
Argyridou S
(2019)
Relevance of physical function in the association of red and processed meat intake with all-cause, cardiovascular, and cancer mortality.
in Nutrition, metabolism, and cardiovascular diseases : NMCD
Argyridou S
(2020)
Walking pace improves all-cause and cardiovascular mortality risk prediction: A UK Biobank prognostic study.
in European journal of preventive cardiology
Armstrong NJ
(2020)
Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
in Stroke
Arnal Segura M
(2022)
Machine learning methods applied to genotyping data capture interactions between single nucleotide variants in late onset Alzheimer's disease.
in Alzheimer's & dementia (Amsterdam, Netherlands)
Arnau-Soler A
(2019)
Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.
in Translational psychiatry
Arnau-Soler A
(2018)
Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder.
in PloS one
Arthur RS
(2020)
Genetic Factors, Adherence to Healthy Lifestyle Behavior, and Risk of Invasive Breast Cancer Among Women in the UK Biobank.
in Journal of the National Cancer Institute
Arthur RS
(2021)
The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank.
in British journal of cancer
Asaturyan HA
(2022)
Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling.
in PloS one
Ashokumar M
(2022)
261 Hearing impairment after subarachnoid haemorrhage
in Journal of Neurology, Neurosurgery & Psychiatry
Astiazaran-Symonds E
(2022)
A Genome-First Approach to Estimate Prevalence of Germline Pathogenic Variants and Risk of Pancreatic Cancer in Select Cancer Susceptibility Genes.
in Cancers
Astore C
(2022)
Mendelian Randomization Indicates a Causal Role for Omega-3 Fatty Acids in Inflammatory Bowel Disease.
in International journal of molecular sciences
Atkins JL
(2020)
Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy.
in JAMA
Atkins JL
(2021)
A genome-wide association study of the frailty index highlights brain pathways in ageing.
in Aging cell
Atkins JL
(2021)
Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
in Journal of Alzheimer's disease : JAD
Atkins JL
(2019)
Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts.
in The journals of gerontology. Series A, Biological sciences and medical sciences
Atkins JL
(2020)
Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.
in The journals of gerontology. Series A, Biological sciences and medical sciences
Atkins JL
(2022)
Hereditary Hemochromatosis Variant Associations with Incident Nonliver Malignancies: 11-Year Follow-up in UK Biobank.
in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Atla G
(2022)
Genetic regulation of RNA splicing in human pancreatic islets.
in Genome biology
Au Yeung SL
(2018)
The Impact of Glycated Hemoglobin (HbA1c) on Cardiovascular Disease Risk: A Mendelian Randomization Study Using UK Biobank.
in Diabetes care
Au Yeung SL
(2022)
Association of smoking, lung function and COPD in COVID-19 risk: a two-step Mendelian randomization study.
in Addiction (Abingdon, England)
Au Yeung SL
(2020)
The impact of glycated hemoglobin on risk of hypertension: a Mendelian randomization study using UK Biobank.
in Journal of hypertension
Au Yeung SL
(2019)
Impact of glycemic traits, type 2 diabetes and metformin use on breast and prostate cancer risk: a Mendelian randomization study.
in BMJ open diabetes research & care
Auckland K
(2020)
The Human Leukocyte Antigen Locus and Rheumatic Heart Disease Susceptibility in South Asians and Europeans.
in Scientific reports
Aung N
(2022)
Annotation and quality assessment of left ventricular filling and relaxation pattern using one-dimensional convolutional neural network
in European Heart Journal - Cardiovascular Imaging
Aung N
(2020)
Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study
in Frontiers in Genetics
Aung N
(2023)
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy.
in Circulation. Genomic and precision medicine
Aung N
(2023)
Concurrent left ventricular myocardial diffuse fibrosis and left atrial dysfunction strongly predicts incident heart failure and all-cause mortality
in European Heart Journal
Aung N
(2022)
Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function.
in Nature genetics
Aung N
(2020)
The Effect of Blood Lipids on the Left Ventricle: A Mendelian Randomization Study.
in Journal of the American College of Cardiology
Austin-Zimmerman I
(2021)
The Influence of CYP2D6 and CYP2C19 Genetic Variation on Diabetes Mellitus Risk in People Taking Antidepressants and Antipsychotics.
in Genes
Auwerx C
(2022)
The individual and global impact of copy-number variants on complex human traits.
in American journal of human genetics
Avinun R
(2019)
A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation.
in Journal of psychiatric research
Azevedo T
(2022)
A deep graph neural network architecture for modelling spatio-temporal dynamics in resting-state functional MRI data.
in Medical image analysis
Backman JD
(2021)
Exome sequencing and analysis of 454,787 UK Biobank participants.
in Nature
Badini I
(2022)
Depression with atypical neurovegetative symptoms shares genetic predisposition with immuno-metabolic traits and alcohol consumption.
in Psychological medicine
Badji A
(2022)
Relationship Between Arterial Stiffness Index, Pulse Pressure, and Magnetic Resonance Imaging Markers of White Matter Integrity: A UK Biobank Study.
in Frontiers in aging neuroscience
Baecker L
(2021)
Brain age prediction: A comparison between machine learning models using region- and voxel-based morphometric data.
in Human brain mapping
Baek EJ
(2022)
The effect of heteroscedasticity on the prediction efficiency of genome-wide polygenic score for body mass index.
in Frontiers in genetics
Description | Impact of clinically silent atrial fibrillation on cerebrovascular disease and cognitive decline in the UK Biobank Imaging Cohort |
Amount | £2,474,260 (GBP) |
Funding ID | RG/18/6/33576 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2019 |
End | 06/2024 |
Description | UK Biobank - The Repeat Imaging Project |
Amount | £2,500,000 (GBP) |
Funding ID | R39738/CN039 |
Organisation | MRC Dementias Platform UK |
Sector | Academic/University |
Country | United Kingdom |
Start | 04/2019 |
End | 01/2023 |
Description | UK Biobank - Whole genome sequencing of 50,000 UKB participants |
Amount | £30,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2020 |
Description | UK Biobank- Expansion of the UKB imaging to a 4th centre and repeat imaging assessment of 10,000 participants |
Amount | £8,500,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 12/2022 |
Description | UK Biobank Scientific Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The UK Biobank Scientific Symposium included presentations about the successes and future plans of the UK Biobank. It took place on 21 June 2018 in London |
Year(s) Of Engagement Activity | 2018 |
Description | UK Biobank participant imaging event |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UK Biobank for participants of the imaging work |
Year(s) Of Engagement Activity | 2021 |
Description | UKBiobank participant events - 2014 - 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | UKB Biobank participants regularly attend events aimed at informing them about the work being undertaken with their data. Usually, the events last a few hours and include an overview from the chief scientist and two talks from scientists that have used UKB data. From 2014 - 2020 over 4,000 participants have taken part in events in Edinburgh (4), Manchester (4), Nottingham, Leeds, Cardiff (2), Newcastle (5), Glasgow (2), Bristol (2) and Reading(4). They are often over-subscribed and participants leave these events wishing to seek more information and support he programme in new ways (EG in imaging, genome sequencing) |
Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018,2019 |
URL | http://www.ukbiobank.ac.uk |