MICA: Dementias Platform UK 2 - Integrated Dementia Experimental Medicine
Lead Research Organisation:
University of Oxford
Department Name: Psychiatry
Abstract
DPUK is a public-private partnership to accelerate the development of new treatments for dementia. Since inception (2014) DPUK has increased the UK capacity for dementia research through infrastructure development and strategic data collection, leveraging a further £74.4m for dementia research.
The second phase of DPUK (DPUK2) focuses on developing UK capacity for dementia experimental medicine. A major challenge in developing new treatments is understanding the mechanisms through which a drug might operate. This involves precision studies where individuals of known vulnerability to specific causes of dementia are recruited to studies of cause-specific mechanistic pathways. These studies are very difficult to do as they require detailed assessment of volunteers before the study begins and standardising all the procedures in centres across the UK. These studies are also high risk in that there is no guarantee of success.
DPUK2 addresses these issues head-on at two levels. First it uses the UK's rich legacy in population cohort studies to identify suitable volunteers by using and enhancing existing cohort data. Second it creates a pre-competitive environment that brings together industry, academic and third-sector entities into partnership. This not only shares the costs and risks of experimental medicine (EM) studies, it also shares the benefits amongst a wider spread of stakeholders, each able to exploit the findings. DPUK2 does this through 3 inter-dependent work-streams.
1. The Data Portal (DP): The DP is a world leading end-to-end dementia focused data management solution. It enables large and complex datasets to be accessed remotely from around the globe without compromising data security. The DP is being developed in partnership with Health Data Research UK (HDR UK) so that we can maximise the data available to dementia research. The DP is used to manage all the data and information systems necessary for conducting precision studies. It brings large and complex datasets together in order to test new ideas; it manages personal information securely to enable recruitment to precision studies; it manages many types of data so that genetics, brain imaging, cognitive performance; and questionnaire data can all be analysed together.
2. The Trials Delivery Framework (TDF): The TDF is the vehicle that enables the DPUK2 experimental medicine programme to be efficient. The TDF organises our Clinical Studies Register (CSR) through which cohort members can volunteer for experimental medicine studies. The CSR allows us to contact members to enrich their data in terms of background information, cognitive testing, and where necessary genetics. As part of the CSR, and in partnership with the Alzheimer's Society, we have a PPI programme to understand what best practice is in terms if recruitment to experimental medicine studies. The TDF also enables us to identify centres of excellence across the UK for conducting experimental studies rigorously. This not only assures data quality, but also means that volunteers do not have to travel too far to participate.
3. The EM Incubator: The incubator is where our partners meet to plan and execute the experimental medicine programme. It has three themes; the first is Vascular Health. This is important because so many factors that affect the heart also affect the brain. If any area is likely to have drugs that already exist and could be re-purposed for dementia, this is it.The second theme is Synaptic Health. Here we investigate factors that affect the loss of neuron synapses. This is important because unlike neurons, synapses (the connections between neurons), can be generated, which is critical to learning and maintaining memory. The third area is Neuroimmunology. This is important as inflammation is a systemic problem that is known to affect the brain and might have systemic solutions, and so represents a promising area for new treatments.
The second phase of DPUK (DPUK2) focuses on developing UK capacity for dementia experimental medicine. A major challenge in developing new treatments is understanding the mechanisms through which a drug might operate. This involves precision studies where individuals of known vulnerability to specific causes of dementia are recruited to studies of cause-specific mechanistic pathways. These studies are very difficult to do as they require detailed assessment of volunteers before the study begins and standardising all the procedures in centres across the UK. These studies are also high risk in that there is no guarantee of success.
DPUK2 addresses these issues head-on at two levels. First it uses the UK's rich legacy in population cohort studies to identify suitable volunteers by using and enhancing existing cohort data. Second it creates a pre-competitive environment that brings together industry, academic and third-sector entities into partnership. This not only shares the costs and risks of experimental medicine (EM) studies, it also shares the benefits amongst a wider spread of stakeholders, each able to exploit the findings. DPUK2 does this through 3 inter-dependent work-streams.
1. The Data Portal (DP): The DP is a world leading end-to-end dementia focused data management solution. It enables large and complex datasets to be accessed remotely from around the globe without compromising data security. The DP is being developed in partnership with Health Data Research UK (HDR UK) so that we can maximise the data available to dementia research. The DP is used to manage all the data and information systems necessary for conducting precision studies. It brings large and complex datasets together in order to test new ideas; it manages personal information securely to enable recruitment to precision studies; it manages many types of data so that genetics, brain imaging, cognitive performance; and questionnaire data can all be analysed together.
2. The Trials Delivery Framework (TDF): The TDF is the vehicle that enables the DPUK2 experimental medicine programme to be efficient. The TDF organises our Clinical Studies Register (CSR) through which cohort members can volunteer for experimental medicine studies. The CSR allows us to contact members to enrich their data in terms of background information, cognitive testing, and where necessary genetics. As part of the CSR, and in partnership with the Alzheimer's Society, we have a PPI programme to understand what best practice is in terms if recruitment to experimental medicine studies. The TDF also enables us to identify centres of excellence across the UK for conducting experimental studies rigorously. This not only assures data quality, but also means that volunteers do not have to travel too far to participate.
3. The EM Incubator: The incubator is where our partners meet to plan and execute the experimental medicine programme. It has three themes; the first is Vascular Health. This is important because so many factors that affect the heart also affect the brain. If any area is likely to have drugs that already exist and could be re-purposed for dementia, this is it.The second theme is Synaptic Health. Here we investigate factors that affect the loss of neuron synapses. This is important because unlike neurons, synapses (the connections between neurons), can be generated, which is critical to learning and maintaining memory. The third area is Neuroimmunology. This is important as inflammation is a systemic problem that is known to affect the brain and might have systemic solutions, and so represents a promising area for new treatments.
Technical Summary
The objectives of the Dementias Platform UK renewal (DPUK2) are to:
1. Increase the precision of experimental medicine (EM) through precision phenotyping according to genetic risk
2. Increase the capacity of EM through streamlined systems and integrated informatics
3. Increase the opportunity for EM through agile and adaptive global partnerships
These will be achieved through three inter-dependent workstreams comprising:
1. Workstream A The Data Portal: The Data Portal will be enhanced to provide secure and auditable data management with an on-premise cloud, and hybrid solutions for :
- Observational and EM multi-modal data discovery
- In silico experiments including multi-modal and machine learning analysis
- Enriched phenotyping for the Clinical Studies Register
- Knowledge development and preservation
2. Workstream B The Trials Delivery Framework (TDF): The TDF will provide a recruitment and study delivery mechanisms for dementia experimental medicine:
- Pre-clinical recruitment via the Clinical Studies Register
- Early disease recruitment via existing NIHR and NHS investments (Join Dementia Research, BRCs, memory clinics)
- Trial delivery centre network drawn from existing structures including the DPUK imaging network, EPAD and NIHR TRC-D and BRCs.
3. Workstream C The EM Incubator: The EM incubator nurtures academic-industry partnerships for precision mechanistic EM studies, demonstrating the value of this approach through a series of pump-prime funded experiments on:
WP 5- Vascular Health
WP 6- Synaptic Health
WP 7- Neuroimmunology
DPUK2 aims to develop its EM portfolio according to scientific interest and further funding.
1. Increase the precision of experimental medicine (EM) through precision phenotyping according to genetic risk
2. Increase the capacity of EM through streamlined systems and integrated informatics
3. Increase the opportunity for EM through agile and adaptive global partnerships
These will be achieved through three inter-dependent workstreams comprising:
1. Workstream A The Data Portal: The Data Portal will be enhanced to provide secure and auditable data management with an on-premise cloud, and hybrid solutions for :
- Observational and EM multi-modal data discovery
- In silico experiments including multi-modal and machine learning analysis
- Enriched phenotyping for the Clinical Studies Register
- Knowledge development and preservation
2. Workstream B The Trials Delivery Framework (TDF): The TDF will provide a recruitment and study delivery mechanisms for dementia experimental medicine:
- Pre-clinical recruitment via the Clinical Studies Register
- Early disease recruitment via existing NIHR and NHS investments (Join Dementia Research, BRCs, memory clinics)
- Trial delivery centre network drawn from existing structures including the DPUK imaging network, EPAD and NIHR TRC-D and BRCs.
3. Workstream C The EM Incubator: The EM incubator nurtures academic-industry partnerships for precision mechanistic EM studies, demonstrating the value of this approach through a series of pump-prime funded experiments on:
WP 5- Vascular Health
WP 6- Synaptic Health
WP 7- Neuroimmunology
DPUK2 aims to develop its EM portfolio according to scientific interest and further funding.
Planned Impact
The main aim of DPUK2 is to use precision experimental medicine (EM) to reduce the mechanistic uncertainty surrounding the discovery of new treatments for dementia. To achieve this we will bring together the essential stages of EM workstreams - vascular, synaptic health and neuroinflammation. With a clear focus on identifying appropriate biomarkers for treatment stratification, there will be many beneficiaries, including dementia patients, their families and the wider population upon which much of the economic burden falls. We outline the immediate areas of academic and non-academic impact for DPUK2:
Academic sector
The Data Portal is a key development in the open science agenda, offering increased opportunity and economies of scale and efficiency. Scientists around the world can access an exceptional breadth of data for rapid data discovery and hypothesis testing. Additionally the implementation of a single common data model across datasets offers researchers unprecedented resource savings in data preparation, and enhanced access for cross-cohort data analysis.
The trials delivery framework addresses the fragmented nature of dementia-related trials in the UK. By providing precision risk stratification and targeted recruitment to multi-centre studies, using a network of clinical research centres, the UK becomes more attractive for conducting rigorous, relevant, cutting-edge science. The EM Incubator offers an agile pre-competitive model for developing partnerships with industry. Benefits to academics include access to developing technologies and commercially strategic research questions.
Commercial and private sector
Precision EM, leading to the de-risking of trials, is of profound interest to molecular, cellular and systems neuroscientists working in industry to identify disease mechanisms and drug targets. DPUK2 will develop its existing profile of industry engagement and collaboration, and has appointed a lead (Declan Jones) for industry. Our strategy is based around active interaction and collaborative funding of proof of concept studies leading to larger programmes of work. Such direct engagement is necessary for meaningful translation of basic research findings. Our list of partners demonstrates the interest of industry in this model.
Public sector, policy and practice
We will continue working with other agencies in spearheading contemporary debate about neurodegenerative disease and dementia. We have appointed a lead (Carol Routledge) for the charity and philanthropy sector who has in-depth contact with UK dementia policy makers, and our partnerships include ARUK and the Alzheimer's Society (the two main UK dementia research charities). More widely we contribute to the NIHR Dementia Progress Group, setting the Dementia 2025 priorities, and to UKRI cohort data management policy discussions - the Data Portal being a key demonstration of the challenges and benefits of policy development in this area.
Public engagement
Engagement and consultation with the public, patients and carers is central to our mission. This shapes how we communicate our research findings and also how we address such issues as stigma, research relevance and the research culture within the NHS in relation to dementia. We are committed to this because neurodegeneration should be regarded as increasingly tractable to research in genetics, neuroscience, and epidemiology, and that EM is key to future progress. We will therefore promote dementia research focusing on the understanding of pathogenesis and pathophysiology, and developing new approaches to treatment.
Skills and training
We will continue to recruit and train staff and students from a wide variety of backgrounds in inter-disciplinary skills that will be widely relevant outside academia. Moreover, through our multi-disciplinary approach we will be training a new cadre of early career researchers who will be attracted to, and equipped for, careers in dementia research
Academic sector
The Data Portal is a key development in the open science agenda, offering increased opportunity and economies of scale and efficiency. Scientists around the world can access an exceptional breadth of data for rapid data discovery and hypothesis testing. Additionally the implementation of a single common data model across datasets offers researchers unprecedented resource savings in data preparation, and enhanced access for cross-cohort data analysis.
The trials delivery framework addresses the fragmented nature of dementia-related trials in the UK. By providing precision risk stratification and targeted recruitment to multi-centre studies, using a network of clinical research centres, the UK becomes more attractive for conducting rigorous, relevant, cutting-edge science. The EM Incubator offers an agile pre-competitive model for developing partnerships with industry. Benefits to academics include access to developing technologies and commercially strategic research questions.
Commercial and private sector
Precision EM, leading to the de-risking of trials, is of profound interest to molecular, cellular and systems neuroscientists working in industry to identify disease mechanisms and drug targets. DPUK2 will develop its existing profile of industry engagement and collaboration, and has appointed a lead (Declan Jones) for industry. Our strategy is based around active interaction and collaborative funding of proof of concept studies leading to larger programmes of work. Such direct engagement is necessary for meaningful translation of basic research findings. Our list of partners demonstrates the interest of industry in this model.
Public sector, policy and practice
We will continue working with other agencies in spearheading contemporary debate about neurodegenerative disease and dementia. We have appointed a lead (Carol Routledge) for the charity and philanthropy sector who has in-depth contact with UK dementia policy makers, and our partnerships include ARUK and the Alzheimer's Society (the two main UK dementia research charities). More widely we contribute to the NIHR Dementia Progress Group, setting the Dementia 2025 priorities, and to UKRI cohort data management policy discussions - the Data Portal being a key demonstration of the challenges and benefits of policy development in this area.
Public engagement
Engagement and consultation with the public, patients and carers is central to our mission. This shapes how we communicate our research findings and also how we address such issues as stigma, research relevance and the research culture within the NHS in relation to dementia. We are committed to this because neurodegeneration should be regarded as increasingly tractable to research in genetics, neuroscience, and epidemiology, and that EM is key to future progress. We will therefore promote dementia research focusing on the understanding of pathogenesis and pathophysiology, and developing new approaches to treatment.
Skills and training
We will continue to recruit and train staff and students from a wide variety of backgrounds in inter-disciplinary skills that will be widely relevant outside academia. Moreover, through our multi-disciplinary approach we will be training a new cadre of early career researchers who will be attracted to, and equipped for, careers in dementia research
Organisations
- University of Oxford (Lead Research Organisation)
- European Bank for induced pluripotent Stem Cells (Collaboration)
- Catalan Health Institute (ICS) (Collaboration)
- University of California, San Francisco (Collaboration)
- Global Alzheimer's Platform Foundation (Collaboration)
- University of Liege (Collaboration)
- Eisai Ltd (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- University of San Francisco (Collaboration)
- Cardiff University (Collaboration)
- The Hong Kong University of Science and Technology (Collaboration)
- Stanford University (Collaboration)
- Ludwig Maximilian University of Munich (LMU Munich) (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- University of Bristol (Collaboration)
- HARVARD UNIVERSITY (Collaboration)
- University College London (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- University of Gothenburg (Collaboration)
- National Institute for Health Research (Collaboration)
- IMI Europe Limited (Collaboration)
- Syracuse University (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- University of California, Irvine (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- University of Lille (Collaboration)
- Apellis Pharmaceutical (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- University of Leuven (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- GlaxoSmithKline (United Kingdom) (Project Partner)
- BrainDTech SpA (Project Partner)
- Autifony Therapeutics (United Kingdom) (Project Partner)
- Eli Lilly (United Kingdom) (Project Partner)
- Alzheimer's Society (Project Partner)
- Cambridge Cognition (United Kingdom) (Project Partner)
- Gates Ventures, LLC. (Project Partner)
- Cognetivity Ltd (Project Partner)
- CytOx Limited (Project Partner)
- Alzheimer’s Research UK (Project Partner)
- AstraZeneca (United Kingdom) (Project Partner)
- IXICO Technologies Ltd (Project Partner)
- Janssen (United States) (Project Partner)
- UCB Pharma (Belgium) (Project Partner)
- Rodin Therapeutics (United States) (Project Partner)
Publications
Venkataraman A
(2021)
Imaging synaptic microstructure and synaptic loss in vivo in early Alzheimer's Disease
Malpetti M
(2023)
Imaging Neuroinflammation
Baker E
(2022)
What does heritability of Alzheimer's disease represent?
| Title | Sound and Vision |
| Description | The study is in two parts. The first part consists of interviews between local artists (Visiting Researchers) and service users with a study team member (graduate student) in attendance. Each local artist will be paired with two service users, one recruited from the CPFT clozapine clinic and one recruited from the CUH memory clinic with interviews will take place at the CPFT Tennison Road clinical and at the Herchel Smith Building, respectively. There will be two interviews with each service user, each lasting around an hour. The second part is the attendance of the study team at Science Festivals to display materials and engage the general public to complete on-line questionnaires. Completed artworks will be the centrepiece for an exhibition at UK science festivals and a digital (on-line) presentation. |
| Type Of Art | Artistic/Creative Exhibition |
| Year Produced | 2022 |
| Impact | Website for project detailing output now live following COVID related delays. |
| URL | https://soundandvision.org.uk/ |
| Description | Alzheimer Disease and APOE genotyping |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Contribution to UK Government's Neurodegeneration Initiative discussions - December 2021 and January 2022 |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://www.gov.uk/government/news/government-to-invest-375-million-in-neurodegenerative-disease-res... |
| Description | Dr M Malpetti - Invited contribution to the World Alzheimer Report 2021 |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Publication to serve as reference for students and practitioners. |
| URL | https://www.alzint.org/u/World-Alzheimer-Report-2021.pdf |
| Description | Dr M Perquin (Rowe Group) Member Society for Mathematical Psychology |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Dr M Perquin (Rowe Group) Member Society for Mathematical Psychology |
| Description | Dr M Perquin (Rowe Group) Member Women of Mathematical Psychology |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | • Became member of the professional organisation Women of Math Psych. |
| Description | Invited abstract reviewing board member at Tau2022 conference - Dr M Malpetti |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Served as subject specific reviewer. |
| Description | Invited abstract reviewing board member at the European Molecular Imaging Meeting - Dr M Malpetti |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Served as subject specific reviewer. |
| Description | Invited co-authorship for a systematic review - Dr M Malpetti |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to new or Improved professional practice |
| Impact | Publication in a major journal. |
| Description | Invited contribution to hot-topic series for the Journal of Nuclear Medicine - Dr M Malpetti |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to new or Improved professional practice |
| Description | Organising committee member AAIC Neurosciences Next - Dr M Malpetti |
| Geographic Reach | North America |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Postgraduate training |
| Description | Sceintific Advisory Board Meber for AI-MIND |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.ai-mind.eu/partners/ |
| Description | "UK DRI IPSC platform to model Alzheimer's disease risk (IPMAR) " |
| Amount | £1,866,149 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 07/2023 |
| Description | ARUK East Network Travel Grant - Dr M Malpetti |
| Amount | £1,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2022 |
| Description | ARUK Thames Valley Illustration Award 2023 |
| Amount | £250 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 02/2023 |
| Description | Addenbrooke's Charitable Trust |
| Amount | £59,172 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2024 |
| Description | Addenbrooke's Charitable Trust |
| Amount | £59,172 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| Description | Altered Microglia States and Microglia-Endothelial Cell Axis in Relation to White Matter Disease Progression in VCID (vascular theme - Karen Horsburgh, Raj Kalaria, Catherine Hall) |
| Amount | £2,400,000 (GBP) |
| Funding ID | R01NS134015 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 08/2023 |
| End | 09/2028 |
| Description | Alzheimer's Research UK East Network Grant |
| Amount | £913 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2023 |
| End | 07/2023 |
| Description | Bioinformatics and Functional Genomics |
| Amount | £1,250,000 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2028 |
| Description | Biopsychosocial determinants of cognitive and biomarker trajectories in preclinical Alzheimer's disease: Proposing a risk profiling tool for brain health |
| Amount | £100,360 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2027 |
| Description | Blood-based fingerprints of neuroinflammation in people with PSP and CBD - Dr M Malpetti (Rowe Group) |
| Amount | $98,735 (USD) |
| Funding ID | Research Grant 689-2024-01-Pipeline |
| Organisation | CurePSP, Inc. |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2024 |
| End | 05/2026 |
| Description | Centre for Ageing and Dementia Research (CADR) |
| Amount | £386,341 (GBP) |
| Organisation | Welsh Assembly |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Description | Department of Psychiatry Travel Grant |
| Amount | £1,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 10/2023 |
| Description | Development of a digital behavioural intervention to reduce dementia risk in ageing adults |
| Amount | £117,546 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 07/2027 |
| Description | Early-onset depression: Characterising development and identifying risks |
| Amount | £763,680 (GBP) |
| Funding ID | MR/R004609/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 11/2020 |
| Description | Genetics collaboration with Prof Bart De Strooper UK DRI programme |
| Amount | £50,000 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2021 |
| End | 04/2022 |
| Description | Genetics collaboration with Prof Bart De Strooper UK DRI programme |
| Amount | £50,000 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2021 |
| End | 04/2022 |
| Description | Global Mental Health Impact of the Covid-19 Pandemic |
| Amount | $150,000 (USD) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 10/2021 |
| Description | Global Mental Health Impact of the Covid-19 Pandemic - LMIC focus |
| Amount | $42,900 (USD) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 06/2023 |
| End | 06/2024 |
| Description | Harnessing the power of advanced imaging for dementia diagnosis |
| Amount | $137,461 (USD) |
| Funding ID | AARF-21-846366 |
| Organisation | Alzheimer's Association |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2022 |
| End | 12/2023 |
| Description | Hearing aid use and dementia: Reviewing difficulties and barriers for users and non-users. |
| Amount | £4,963 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 12/2022 |
| Description | Identifying genetic biomarkers of survival for bowel cancer to aid patient management |
| Amount | £90,000 (GBP) |
| Organisation | Tenovus Cancer Care |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2022 |
| Description | Inflammation in frontotemporal lobar degeneration - from diagnosis and prognosis to clinical trials - Dr M Malpetti |
| Amount | £495,687 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 02/2027 |
| Description | Kellogg College Travel Grant |
| Amount | £381 (GBP) |
| Organisation | University of Oxford |
| Department | Kellogg College |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 04/2023 |
| Description | Knowledge Exchange (KE) Seed Fund 2022 |
| Amount | £4,825 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 09/2022 |
| Description | Leveraging human genetics to identify target populations for dementia therapeutics (Eisai/DRI), project grant |
| Amount | £200,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 02/2023 |
| Description | NIHR Oxford Senior Research Fellowship |
| Amount | £10,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2024 |
| End | 12/2025 |
| Description | Old Members' Trust Graduate Conference and Academic Travel Fund |
| Amount | £500 (GBP) |
| Organisation | University College Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2024 |
| End | 08/2024 |
| Description | Pilot study to develop an instrument to capture broad-ranging neurodevelopmental problems in children with a genetic diagnosis of intellectual disability |
| Amount | £48,502 (GBP) |
| Organisation | Baily Thomas Charitable Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 10/2020 |
| Description | Pilot study to develop an instrument to capture broad-ranging neurodevelopmental problems in children with a genetic diagnosis of intellectual disability |
| Amount | £48,502 (GBP) |
| Organisation | Baily Thomas Charitable Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 10/2020 |
| Description | Pippa Watson, Clarendon Fund & Dept of Psychiatry Studentship. Project title: An investigation into the role of lifestyle factors in early, mid, and later life in SuperAgers |
| Amount | £90,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2026 |
| Description | Polygenic risk scores for neurodegeneration and Alzheimer's pathophysiology |
| Amount | £951 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 11/2021 |
| Description | Profiling post-translational modifications of histone proteins as a determinant of Parkinson's susceptibility |
| Amount | £232,404 (GBP) |
| Funding ID | G-1502 |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 07/2018 |
| Description | Progressive Supranuclear Palsy Association Small Research Grant |
| Amount | £9,279 (GBP) |
| Organisation | Progressive Supranuclear Palsy Association (PSPA) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2022 |
| Description | Proinflammatory cytokines as Parkinson's biomarkers |
| Amount | $184,247 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 06/2023 |
| End | 12/2024 |
| Description | READOUT Real world dementia outcomes |
| Amount | £4,497,000 (GBP) |
| Funding ID | tbc |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2024 |
| End | 06/2029 |
| Description | Race Against Dementia Data Challenge |
| Amount | £130,000 (GBP) |
| Organisation | Race Against Dementia |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 03/2025 |
| Description | Scottish funding council Brain Health Alliance for Research Challenges |
| Amount | £600,000 (GBP) |
| Organisation | Government of Scotland |
| Department | Scottish Funding Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 06/2027 |
| Description | Software Sustainability Institute Fellowship (awardee: Dr Gaurav V Bhalerao) |
| Amount | £3,000 (GBP) |
| Organisation | Software Sustainability Institute |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2023 |
| Description | Stratification of bipolar disorder: Harnessing clinical heterogeneity and genetics shared with other disorders |
| Amount | £310,234 (GBP) |
| Funding ID | Judith Allardyce |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2021 |
| Description | Stratification of bipolar disorder: Harnessing clinical heterogeneity and genetics shared with other disorders |
| Amount | £310,234 (GBP) |
| Funding ID | 209176 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 06/2022 |
| Description | TRanslating Individual Alzheimer GEnetic risk into disease phenotypes [TRIAGE] |
| Amount | € 420,000 (EUR) |
| Organisation | JPND Research |
| Sector | Academic/University |
| Country | Global |
| Start | 04/2020 |
| End | 04/2023 |
| Description | The development and implementation of polygenic risk algorithms for stratifying individuals for future cognitive decline due to Alzheimer's disease in non-symptomatic and early cognitive impaired subjects |
| Amount | £288,555 (GBP) |
| Funding ID | 104210 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 02/2020 |
| Description | University of Cambridge/Montreal Neurological Institute-Hospital Neuroscience Collaboration - Dr M Malpetti (Rowe Group) |
| Amount | $50,000 (CAD) |
| Organisation | University of Montreal |
| Department | Montreal Neurological Institute |
| Sector | Hospitals |
| Country | Canada |
| Start | 11/2023 |
| End | 02/2025 |
| Description | University of Oxford Medical and Life Sciences Translational Fund (MLSTF) |
| Amount | £74,412 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2023 |
| End | 08/2024 |
| Description | Validating prognostic biomarkers for colorectal cancer and determining their clinical utility |
| Amount | £155,801 (GBP) |
| Organisation | Cancer Research Wales |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 10/2021 |
| Description | WIN Seed Grant |
| Amount | £15,000 (GBP) |
| Organisation | Wellcome Centre for Integrative Neuroimaging |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 10/2024 |
| Description | Your Beautiful Brain: Empowering Afro-Caribbean communities to support dementia research |
| Amount | £22,646 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 04/2023 |
| Description | Your Beautiful Brain: Empowering Afro-Caribbean communities to support dementia research (Inspire Fund, ARUK) - Bauermeister et al. |
| Amount | £22,646 (GBP) |
| Funding ID | ARUK-IF2021-017 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2022 |
| Title | APPLE study data added to DPUK data portal |
| Description | The APPLE (Assessing Post stroke Psychology Longitudinal Evaluation) is a cohort of 350 stroke survivors with frequent cognitive, mood and other assessments. Making this dataset available through the DPUK data portal adds to the 'vascular' data in this resource. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Making this dataset available through the DPUK data portal adds to the 'vascular' data in the DPUK data portal resource. |
| Title | Alzhemer's Disease Polygenic Risk Profiling |
| Description | This model used data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained from the International Genomics of Alzheimer's Project (IGAP). Alzheimer's disease (AD) Polygenic risk scores were generated for 3177 cases and 7277 controls (GERAD data) and tested whether the alleles identified to associate with disease in IGAP sample are significantly enriched in the cases relative to the controls in the GERAD sample. The disease prediction accuracy was investigated in a sample of 3049 cases and 1554 controls (for whom APOE genotype data was available) by means of sensitivity, specificity, area under the receiver operating characteristic curve (AUC) and positive and negative predictive values. The best prediction accuracy AUC = 78.2% (95% confidence interval 77-80%) was achieved by a logistic regression model with APOE, the polygenic score, sex and age as predictors. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | This approach is used to create SNP arrays for AD prediction (for research only so far). |
| Title | a github repository |
| Description | This pipeline takes a published mouse gene list for astrocytes, converts to human, and creates a file for grch38 with and without the APOE region. |
| Type Of Material | Data analysis technique |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | This tool will used for a publication which is currently in preparation. |
| URL | https://github.com/seafloor/escott-price-lab-pipelines/tree/main |
| Description | BRACE |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | advice and training on genomic data analysis |
| Collaborator Contribution | Investigating the genetic overlap between AD and other diseases or traits using polygenic risk scores in Avon Longitudinal Study of Parents and Children (ALSPAC) |
| Impact | 1. Application of newly developed methodology (MR-Base), which hallows to do rapid high-throughput analysis of potentially interesting traits and environmental exposures. 2. Test for shared genetic susceptibility between AD and early life lipid levels, glycaemic, anthropometric, behavioral and cognitive traits in ALSPAC children |
| Start Year | 2016 |
| Description | Cambridge Centre for Ageing and Neuroscience |
| Organisation | University of Cambridge |
| Department | Cambridge Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team has received the permission and access to the genetic data of the CamCan cohort with the aim to analyse the genetic data and calculate dementia related PRS for this cohort. |
| Collaborator Contribution | The partners have provided us with the data |
| Impact | not yet |
| Start Year | 2022 |
| Description | Cardiovascular drugs and dementia |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Advice on statistical data analyses |
| Collaborator Contribution | Collaboration with clinicians to assess a variety of medications and validity of the 'dementia' diagnosis |
| Impact | Collaboration between clinicians and data analysts |
| Start Year | 2024 |
| Description | Collaboration with Dr Ece Kocagoncu for NTAD (Dr A Jafarian) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on data analysis of test-retest data from NTAD. |
| Collaborator Contribution | Availability of NTAD data. |
| Impact | Title: Test-reTest reliability of dynamic casual modelling of resting states MEG data of Alzheimer patients. |
| Start Year | 2022 |
| Description | Collaboration with Dr Nicholas Ashton at the University of Gothenburg |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | "Synaptic fluid markers in dementia", sharing expertise in field. |
| Collaborator Contribution | "Synaptic fluid markers in dementia", sharing expertise in field. |
| Impact | Advancing biomarker discovery projects. |
| Start Year | 2022 |
| Description | Collaboration with Dr. Gil Rabinovici at the Memory and Aging Center, Department of Neurology, University California San Francisco |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaboration on project "Tau-PET and domain-specific cognitive decline in Alzheimer's disease", cross fertilization of research expertise. |
| Collaborator Contribution | Hosted Post-Doc Dr M. malpetti for 4 month fellowship at UCSF. |
| Impact | Reasearch paper: Malpetti M, La Joie R, Rabinovici GD. Tau beats amyloid in predicting brain atrophy in Alzheimer's disease: implications for prognosis and clinical trials. 2022, Journal of Nuclear Medicine - doi: 10.2967/jnumed.121.263694 |
| Start Year | 2022 |
| Description | Collaboration with Dr. Gil Rabinovici, Dr. Rik Ossenkoppele, Dr. Victoria Pelak, Dr. Keir Yong and ISTAART PIA for Atypical AD |
| Organisation | University of San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaboration on project "Clinicopathological Correlates in Posterior Cortical Atrophy" |
| Collaborator Contribution | Hosted Dr M Malpetti (Post-Doc Rowe Group) for 4 month fellowship at UCSF. |
| Impact | Papers in draft & ongoing research activity |
| Start Year | 2022 |
| Description | Collaboration with Dr. Matthias Brendel at the Ludwig Maximilian University of Munich (Germany) and Prof. Pedro Rosa-Neto at the McGill University (Canada) |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | TSPO PET in tauopathies project, sharing of expertise |
| Collaborator Contribution | TSPO PET in tauopathies project, sharing of expertise |
| Impact | Research advancement |
| Start Year | 2022 |
| Description | Collaboration with Eisai AiM Institute |
| Organisation | Eisai Ltd |
| Department | Eisai Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | Consultancy on Polygenic risk score for clinical trials |
| Collaborator Contribution | We are in the process of negotiations |
| Impact | potentially this collaboration will pay for a time of a postdoctoral researcher |
| Start Year | 2018 |
| Description | Collaboration with European Bioinformatics institute |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We plan to provide a software for polygenic risk score calculation and prosess the GWAS summary statistics for all current GWASes available in EBI GWAS catalogue |
| Collaborator Contribution | provide data access to the GWAS catalogue |
| Impact | This collaboration will provide the GWAS processed data to the research community for quick and efficient calculation of polygenic risk score for any disorder (stored in the EBI GWAS catalogue) |
| Start Year | 2019 |
| Description | Collaboration with Ludwig Maximillian University |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Department | University Clinic of Munich |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Overlap with group research interests and activiity. Collaboration focuses on ageing and dementia. |
| Collaborator Contribution | Academic expertise. |
| Impact | In progress. |
| Start Year | 2022 |
| Description | Confidentiality & Material Transfer Agreements with Apellies Pharmaceuticals, Inc. |
| Organisation | Apellis Pharmaceutical |
| Country | United States |
| Sector | Private |
| PI Contribution | Focussed on the areas of synaptic health and fnction in dementia and neurodegeneration. |
| Collaborator Contribution | As per agreement. |
| Impact | Partnership ongoing, impacts expected in due course. |
| Start Year | 2022 |
| Description | DPUK |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Steering Group member, DPUK work package lead. |
| Collaborator Contribution | Creating Dementia Platform UK Data Portal |
| Impact | In the process of creating on-line database with dementia cohorts, available in the UK and pipelines for data analyses. Multidisceplinary: genetics, bioinfirmatics, IT. |
| Start Year | 2014 |
| Description | DPUK-2 (2020 - 2025) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Calculation of pathway specific PRS, relevant to the Neuroinflammation work package. |
| Collaborator Contribution | Access to the DPUK cohorts |
| Impact | data access to DPUK cohorts |
| Start Year | 2020 |
| Description | EISAI |
| Organisation | Eisai Ltd |
| Department | Eisai Europe Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | we provide expertise and data analysis of pathways and gene networks related to neurodegeneration |
| Collaborator Contribution | The partner provide expertise the the biological definition of neurodegenerative gene networks |
| Impact | NA |
| Start Year | 2019 |
| Description | Electronic health records |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | Discussion of data analyses and results using Electronic Health records in the UK databases |
| Collaborator Contribution | Discussion of data analyses and results using Electronic Health records in international databases, replication |
| Impact | Two papers have been submitted. |
| Start Year | 2023 |
| Description | European Alzheimer's disease databank |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Machine learning based data analysis |
| Collaborator Contribution | Provided access to the data and HPC facilities |
| Impact | Paper in preparation |
| Start Year | 2022 |
| Description | GR@CE |
| Organisation | Catalan Health Institute (ICS) |
| Country | Spain |
| Sector | Public |
| PI Contribution | we analyse the genome-wide data |
| Collaborator Contribution | the collaborators provided the data to us |
| Impact | it is a multidisciplinary collaboration, involve clinicians, biologists and bioinformaticians |
| Start Year | 2020 |
| Description | GWAIS |
| Organisation | University of Liege |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | We bring our expertise in AI and ML |
| Collaborator Contribution | Collaborators bring their expertise in genetic interaction analyses. |
| Impact | It is a multidisciplinary collaboration involving mathematicians, software developers and bioinformaticians |
| Start Year | 2021 |
| Description | Global Alzheimer's Platform (GAP) |
| Organisation | Global Alzheimer's Platform Foundation |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Development of processes to enable incorporation of the DPUK Trial Delivery Framework into a GAP European network |
| Collaborator Contribution | Development of a GAP European network |
| Impact | None |
| Start Year | 2021 |
| Description | Harvard University |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | generation of polygenic risk scores |
| Collaborator Contribution | provision of tissue samples and genotyped data |
| Impact | none yet |
| Start Year | 2019 |
| Description | Hong Kong University of Science and Technology |
| Organisation | The Hong Kong University of Science and Technology |
| Country | Hong Kong |
| Sector | Academic/University |
| PI Contribution | Then HKUST will provide the summary statistics from the previous publication work (DOI: 10.1073/pnas.1715554115) to Cardiff to test if models derived from the Chinese population data can be used for disease classification in the European-descent population. |
| Collaborator Contribution | The Cardiff will provide the models derived from the European population, and HKUST will help to examine if those models can classify AD in the Chinese population. |
| Impact | NA |
| Start Year | 2022 |
| Description | Innovate UK |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Consultancy |
| Collaborator Contribution | Design of Alzhemer's disease chip |
| Impact | In the process of designing of Alzhemer's disease SNP array. Multidisceplinary: medical genetics, bioinformatics, statistics |
| Start Year | 2015 |
| Description | Join Dementia Research and Great Minds |
| Organisation | National Institute for Health Research |
| Department | NIHR Join Dementia Research |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Developing the processes to incorporate Join Dementia Research volunteers into the Great Minds register, providing information on the Great Minds Register, promoting the use of Join Dementia Research on websites and at public events, updating the Join Dementia Research database for volunteers that have joined the Great Minds register. |
| Collaborator Contribution | Developing the Join Dementia Research platform to enable links to the Great Minds register, promoting Great Minds as a collaborator organisation of Join Dementia Research. |
| Impact | Over 1,500 Join Dementia Research volunteers have joined the Great Minds register |
| Start Year | 2021 |
| Description | Leuven University |
| Organisation | University of Leuven |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | generation of polygenic risk scores |
| Collaborator Contribution | sharing genotyped data and PRS |
| Impact | none yet |
| Start Year | 2018 |
| Description | Lothian birth cohorts |
| Organisation | University of Edinburgh |
| Department | Edinburgh Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team will analyse the genetic and phenotypic data from the Lothian birth cohorts with the primary aim to investigate genetic of cognitive rate of decline in healthy ageing cohort. |
| Collaborator Contribution | Provided the data. |
| Impact | not yet |
| Start Year | 2022 |
| Description | MRC fellowship |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | advice and training on genomic data analysis |
| Collaborator Contribution | A researcher, Dr. Emma Anderson, who is a highly productive junior researcher |
| Impact | 1. To improve causal inference in mendelian randomization studies of dementia 2. To improve understanding of the genetic risk for dementia and trajectories of cognitive capabilities in aging 3. To identify modifiable risk factors that are related to dementia and cognitive decline |
| Start Year | 2016 |
| Description | NEURO Cohort |
| Organisation | IMI Europe Limited |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Development of processes to hold and share data across European sites |
| Collaborator Contribution | Development of technical processes, data model and a synthetic dataset |
| Impact | None |
| Start Year | 2021 |
| Description | Ongoing collaboration between Dr A Jafarain (Rowe Group) and Prof. Karl Firston (UCL) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contributions to the development of Multimodal Dynamic Causal Modelling for projects in translational neuroscience and dementia. |
| Collaborator Contribution | Professional expertise and collaboration sought. |
| Impact | Jafarian, A., Hughes, L.E., Adams, N.E., Lanskey, J., Naessens, M., Rouse, M.A., Murley, A.G., Friston, K.J. and Rowe, J.B., 2022. Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy. bioRxiv, pp.2022-06. |
| Start Year | 2020 |
| Description | Open Network for Frontotemporal dementia Inflammation Research |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration for establishing a national network and collaborative platform for blood marker discovery in FTD; recruiting participants across the whole UK, in diverse healthcare settings. |
| Collaborator Contribution | Discussion of the data collection protocol. |
| Impact | It is a collaboration between clinicians, biologists and bioinformaticians |
| Start Year | 2024 |
| Description | Stanford University |
| Organisation | Stanford University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | generation of polygenic risk scores |
| Collaborator Contribution | sharing genotyped data and PRS |
| Impact | none yet |
| Start Year | 2019 |
| Description | Syracuse University |
| Organisation | Syracuse University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | still under negotiation |
| Collaborator Contribution | data analysis consultancy |
| Impact | none yet |
| Start Year | 2019 |
| Description | Tissue Discovery Platform and EBiSC |
| Organisation | European Bank for induced pluripotent Stem Cells |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Development of processes to enable provision of access to induced pluripotent stem cells and associated phenotypic data |
| Collaborator Contribution | Storage of induced pluripotent stem cells, contribution of phenotypic data, development of polygenic risk scores |
| Impact | None |
| Start Year | 2021 |
| Description | UC Irvine |
| Organisation | University of California, Irvine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | generation of polygenic risk scores |
| Collaborator Contribution | sharing genotyped data and PRS |
| Impact | none yet |
| Start Year | 2019 |
| Description | UK7T Network |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
| Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
| Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
| Start Year | 2021 |
| Description | UK7T Network |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
| Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
| Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
| Start Year | 2021 |
| Description | UK7T Network |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
| Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
| Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
| Start Year | 2021 |
| Description | UK7T Network |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
| Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
| Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
| Start Year | 2021 |
| Description | UK7T Network |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
| Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
| Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
| Start Year | 2021 |
| Description | UK7T Network |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
| Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
| Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
| Start Year | 2021 |
| Title | Application management system |
| Description | The Application management system allows the progress of applications through the application process to be tracked. The creation of the system allows multiple team members to track an application and to action any issues. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2021 |
| Impact | The system allows DPUK to expand the application system across a team of people and creates greater visibility across the administrative team. this will streamline applications and allow DPUK to increase the number of projects that it can administer. |
| Title | EMD toolbox |
| Description | Python tools for the extraction and analysis of non-linear and non-stationary oscillatory signals. |
| Type Of Technology | Software |
| Year Produced | 2023 |
| Open Source License? | Yes |
| Impact | The EMD toolbox is widely adopted by the scientific community, spanning many different fields and having been downloaded thousands of times. It has popularized empirical mode decomposition as an alternative to fourier transforms and enables researchers to answer questions they couldn't before. It has also resulted in multiple publications. |
| URL | https://emd.readthedocs.io/en/stable/#empirical-mode-decomposition-in-python |
| Title | Effective |
| Description | We have developed a novel approach to account for multiple testing in genome-wide association studies as published in (Moskvina and Schmidt, 2008). The software is C++ code, which can be compiled for any computational platform (Windows, Unix, Linux). |
| Type Of Technology | Software |
| Year Produced | 2008 |
| Open Source License? | Yes |
| Impact | The software was requested from the authors more than 10 times since the paper was published. We have made it now publicly available. |
| URL | http://github.com/DRI-Cardiff/Keffective |
| Title | GLM toolbox |
| Description | A python package for General Linear Modelling & a work-in-progress |
| Type Of Technology | Software |
| Year Produced | 2023 |
| Open Source License? | Yes |
| Impact | GLMtools is widely adopted by the scientific community, spanning different fields. It helps researchers to build statistical models with ease and help in research on a daily basis. It has enabled the authors to publish multiple research papers. |
| URL | https://gitlab.com/ajquinn/glmtools |
| Title | OHBA Software Library in Python (OSL) |
| Description | The software is intended for the analysis of electrophysiology data, particularly of magnetoencephalography (MEG) and electroencephalography (EEG) data. Broadly, it includes algorithms for preprocessing, statistical modelling, source modelling, and visualising data. It is largely built on the backbone of the MNE-Python software. |
| Type Of Technology | Software |
| Year Produced | 2023 |
| Open Source License? | Yes |
| Impact | The software firstly allows us to analyse large amounts of data like we could not before, which importantly, is much more reproducible than what was previously available. Secondly, we share the software publicly, and train researchers on how to use it, vastly enhancing the impact of the software but at our own university and at other universities. |
| URL | https://github.com/OHBA-analysis/osl |
| Title | OSL-dynamics Python Toolbox |
| Description | The software contains algorithms for training state of the art generative models on neuroimaging data, particularly MEG and EEG data, but also fMRI. It uses the latest in machine learning to model brain dynamics, e.g. resting state network activity, modelling of population variance, etc. |
| Type Of Technology | Software |
| Year Produced | 2023 |
| Open Source License? | Yes |
| Impact | The software firstly allows us to analyse large amounts of data like we could not before, which importantly, is much more reproducible than what was previously available. Secondly, we share the software publicly, and train researchers on how to use it, vastly enhancing the impact of the software but at our own university and at other universities. |
| URL | https://doi.org/10.7554/eLife.91949.2 |
| Title | POLARIS |
| Description | We developed a novel approach to genetic set-based analysis and polygenic risk scoring, which accounts for linkage disequilibrium between SNPs and informs the analysis with previously reported effect sizes of a SNP's association to disease. We call this method POLARIS: POlygenic Linkage disequilibrium-Adjusted RIsk Score. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Open Source License? | Yes |
| Impact | NA |
| URL | https://github.com/BakerEA/POLARIS |
| Title | Project output tracking system |
| Description | The project outputs system is a webform system that contacts researchers on a regular basis to ask for project outputs update. data entered into the forms populate a database. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2021 |
| Impact | The project outputs system allows DPUK to automate output collection from researchers and to create a database of ouputs. This database will then be used to feed automated dashboards that will allow DPUK to visually track outputs. |
| Description | "The Motor Side of the FTD Spectrum" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered talk to a mixed audience on the motor side of the FTD spectrum. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://wfneurology.org/public/downloads/p9XPX/WCN-2021-Timetable-at-a-glance-Virtual-Congress-26.8.... |
| Description | 'An Overview of Dementia Research: Dementia Platform UK' (John Gallacher, 29/3/23, 14.00) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | John Gallacher gave a keynote talk at the DRC 2023 Zoom conference (Brighton and Sussex Medical School in partnership with NHS Sussex). He broadcast the role of DPUK in the larger UK dementias research landscape to an international audience. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bsms.ac.uk/about/events/2023/03-29-dementia-research-conference-2023.aspx#h2 |
| Description | 'Building massive data platforms: lessons and challenges' (John Gallacher, 19/6/23, 17.30) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher gave this talk at Healthcare Business International 2023. The conference was attended by >550 delegates and >120 speakers from 39 countries. John networked to establish DPUK in the UK and global dementias research landscape. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.healthcarebusinessinternational.com/events/hbi2023-home/ |
| Description | 'Dementias Platform UK Renewal' (John Gallacher, 31/1/24, 11.35) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher gave this talk to the Alzheimer's Society Research Strategy Council. DPUK and AS remain in discussions concerning partnership of the next core grant renewal. |
| Year(s) Of Engagement Activity | 2023 |
| Description | 'Health Cities' (John Gallacher, 1/6/23, 2.10) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | John Gallacher gave this talk at the 'Great Minds live event: Environmental Risk Factors for Dementia'. More than >20 of the Great Minds study participants attended in person, >250 watched live online, and >500 watched later on demand. This drove further engagement with the study. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.greatmindsfordementia.uk/Join-us/great-minds-members-events-june-2023#:~:text=Our%20Grea... |
| Description | 'How can big data platforms contribute to new therapeutics development for dementia' (John Gallacher, 20/5/23, 11.20) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | John Gallacher gave this talk at the 20th Avison Biomedical Symposium (Yonsei College of Medicine, Seoul). In the course of this visit he also networked with the KDRC and KBRI. As a result, DPUK has established further MoUs and plans for collaboration with KBRI and others in the Korean dementia research community. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://sev-rehabil.severance.healthcare/medicine/news/seminar.do?mode=view&articleNo=118186&article... |
| Description | 'Learning from a successful example - DPUK' (John Gallacher, 15/11/23, 12.00) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | John Gallacher gave this talk at a 2-day meeting of the GALENOS group. DPUK continues to work with GALENOS members in the Department of Psychiatry at Oxford University. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://galenos.org.uk/ |
| Description | 'Stress Management 101' (John Gallacher, 22/11/23, 13.00) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | John Gallacher gave this talk at the University of Oxford's Department of Psychiatry as part of Men's Mental Health month. The talk included findings from John's work at DPUK. The talk received positive feedback from the audience. |
| Year(s) Of Engagement Activity | 2023 |
| Description | 21/01/2021 - Data Science and Population Health Research. University of British Columbia, Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Data Science and Population Health Research. University of British Columbia, Canada, 21/01/21. |
| Year(s) Of Engagement Activity | 2021 |
| Description | 23rd National Dementia Conference: Talk on "Frontotemporal Dementia" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | An update on FTD landscape and research output from Rowe group. |
| Year(s) Of Engagement Activity | 2021 |
| Description | A formal working group, expert panel or dialogue - DPUK Annual Conference 2018: The power of cohorts 23 April 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended one-day conference on using DPUK platform. |
| Year(s) Of Engagement Activity | 2018 |
| Description | AAIC pre-conference workshop "Getting Started with Neuroimaging Analysis" August 2022, San Diego , USA (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ludovica Griffanti co-organised the Alzheimer's Association International pre-conference workshop "Getting Started with Neuroimaging Analysis" August 2022 (San Diego, USA) Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) - Imaging Professional Interest Area (PIA). The workshop was well received and approved to be run again in 2023. |
| Year(s) Of Engagement Activity | 2022 |
| Description | AI Risk Evaluation Community Group (John Gallacher, 30/11/23, 10.00) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | John Gallacher was the introductory speaker for this all-day online workshop for the public. Two more workshops on this theme for researchers and for data providers were organised, and the discussion of AI Risk will inform the work of the next DPUK core grant application. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.eventbrite.com/e/ai-risk-evaluation-community-group-public-workshop-online-only-tickets-... |
| Description | AI Risk Evaluation Community Group - Public Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This workshop was to bring together members of the public as part of our AI Risk Evaluation Community Group, to find out what concerns they had with the use of their data within AI models. |
| Year(s) Of Engagement Activity | 2023 |
| Description | AI Risk Evaluation Community Group - Researcher Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a workshop as part of our DARE UK funded project on evaluating privacy concerns in AI models. This workshop was to bring together expert AI researchers to assess privacy-preserving techniques in healthcare data for AI within TRE's. |
| Year(s) Of Engagement Activity | 2024 |
| Description | AI Risk Evaluation Data Provider Workshop (John Gallacher, 7-8/3/24) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | John Gallacher spoke at the last of these three workshops on AI risk. The discussion of AI Risk will inform the work of the next DPUK core grant application. |
| Year(s) Of Engagement Activity | 2023 |
| Description | AI Risk Evaluation Researcher Workshop (John Gallacher, 17/1/24, 10.00) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | John Gallacher was the introductory speaker for this all-day online workshop for researchers. A further workshop on this theme for data providers was organised, and the discussion of AI Risk will inform the work of the next DPUK core grant application. |
| Year(s) Of Engagement Activity | 2023 |
| Description | AI, Neuroscience & Ethics talk on patient privacy in AI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This talk was for the AI, Neuroscience & Ethics Forum hosted by the Applied Neuroscience Association at Kings College London. My talk was on privacy concerns in AI models and how DPUK is enabling the safe development of AI through protecting patient privacy. |
| Year(s) Of Engagement Activity | 2024 |
| Description | ARUK Clinical Conference. talk titled "What's new in Frontotemporal Dementia?" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This conference focussed on the themes of research, innovation, and implementing change in clinical practice. |
| Year(s) Of Engagement Activity | 2021 |
| Description | ARUK Oxford Drug Discovery Institute |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presenter at the ARUK Oxford Drug Discovery Institute (ODDI) Collaborators meeting |
| Year(s) Of Engagement Activity | 2020 |
| Description | ARUK Thames Valley ERC Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | ARUK Thames Valley ERC day was a day of workshops, presentations and posters for ERCs in dementia research across the University of Oxford, Oxford Brookes University and University of Reading. There were approximately 70 attendees. I did a flash talk. |
| Year(s) Of Engagement Activity | 2024 |
| Description | ARUK Thames Valley ERC Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | ARUK Thames Valley ERC day was a day of workshops, presentations and posters for ERCs in dementia research across the University of Oxford, Oxford Brookes University and University of Reading. There were approximately 70 attendees. I presented a poster. |
| Year(s) Of Engagement Activity | 2024 |
| Description | ARUK Thames Valley Network Dementia Research Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Automated QC of T1w scans for clinical datasets: methods comparison & design of a QC classifier |
| Year(s) Of Engagement Activity | 2023 |
| Description | ARUK Thames Valley Network Dementia Research Day presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk on ECR training and conducting multi-cohort research on the DPUK Data Portal |
| Year(s) Of Engagement Activity | 2022 |
| Description | ARUK Thames Valley Network Dementia Research Day, 3rd July 2023 at St Anne's College, Oxford (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled: "Harnessing the power of advanced magnetic resonance imaging and big data to study brain vascular changes" |
| Year(s) Of Engagement Activity | 2023 |
| Description | ARUK Thames Valley Network ECR Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | The ARUK Thames Valley ERC Day was a day filled with workshops, talks, and poster presentations for Early Career Researchers in dementia research from the University of Oxford, Oxford Brookes University, and the University of Reading, with around 70 people attending. I also presented a poster there. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Advisor on tv drama on the theme of dementia |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | TV Soap script editorial advisor on dementia theme |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | African Society Cambridge University Mentorship Programme - Dr Haddy Fye |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Served as a Mentor to African students applying for Postgraduate study at the University of Cambridge. Mentee has since gained acceptance for study within the Sciences. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Alzheimer's Association International Conference San Diego USA poster |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation: ADHD and cognitive change |
| Year(s) Of Engagement Activity | 2022 |
| Description | Alzheimer's Association International Conference San Diego USA presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral Presentation: Facilitating Multi-modal research with the DPUK Data Portal |
| Year(s) Of Engagement Activity | 2022 |
| Description | Alzheimer's Research UK (ARUK) Thames Valley Network Dementia Day (1st July 2022, St Anne's college, Oxford) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ludovica Griffanti co-organised the Alzheimer's Research UK (ARUK) Thames Valley Network Dementia Day and chaired panel discussion session. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Amsterdam meeting at Alzheimer Center Amsterdam |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof John Gallacher was invited to the Alzheimer Center Amsterdam by the Amsterdam University Medical centre. Discussion were made around Biobanking and the fluid biomarker development with the potential to collaborate. |
| Year(s) Of Engagement Activity | 2022 |
| Description | An invited interview at the Alzheimer's Research UK (ARUK) 2019 the Video Journal of Dementia |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An interview for Video Journal of Dementia |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.vjdementia.com |
| Description | An invited interview on issues facing researchers in Brexit for the Cross Party Group on Medical Research for Alzheimer's Society, UK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Have provided an opinion on issues facing researchers in Brexit for the Cross Party Group in the Welsh Assembly looking at Medical Research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Artificial Intelligence for Precision Dementia Medicine Summit at the Royal Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to the round table discussion at the Artificial Intelligence for Precision Dementia Medicine Summit at the Royal Society |
| Year(s) Of Engagement Activity | 2022 |
| Description | Ask a Dr Event - Dr Negin Holland (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited clinician at the PSP Association 'Ask the Dr event' - at least 3 times/year |
| Year(s) Of Engagement Activity | 2023 |
| Description | Attended Barbara Windsor Dementia Mission/Oxford University meeting (John Gallacher, 22/9/23, 12.00) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended this meeting between the chairs of the Dementia Mission and Oxford University dementia researchers. DPUK is in ongoing conversation with the Dementia Mission concerning partnership. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Attended FORUM workshop on the early detection of neurodegenerative diseases in primary care and the community (John Gallacher, 28/2/24, 10.00) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended this event, and networked to establish DPUK in the UK dementias research landscape. He spoke with leadership of the Barbara Windsor Dementia Mission, and discussion of collaboration is ongoing. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Attended GSK/Oxford HZV Vaccine/Dementia Symposium (John Gallacher, 7/12/23, 10.30) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | John Gallacher attended this GlaxoSmithKline-led symposium to discuss work between GSK and Oxford University to explore a link between a HSV vaccine and reduced dementia risk. Discussion around this work is ongoing. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Attended LifeArc/HDR UK/DPUK MND Data Workshop (John Gallacher, 3/4/23) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended a meeting with LifeArc and HDR UK to discuss national MND data strategy. This meeting ultimately led to the ongoing HDR UK-led NIHR funding application for The MND Data Catalyst. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Attended UK DRI/Oxford University meeting (John Gallacher, 1/11/23, 13.30) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended this meeting between the leadership of UK DRI and Oxford University's dementias research community. DPUK continues to discuss collaboration with UK DRI. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Attended World Dementia Council Summit 2023 (John Gallacher, 20/2/23) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended the 2023 WDC summit and networked with key figures in the international dementias research landscape, helping to establish the global role of DPUK and the UK's dementia research community more generally. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.worlddementiacouncil.org/sites/default/files/2023-03/Summit%202023%20agenda_0.pdf |
| Description | Attended a day of meetings with UK DRI's Informatics team in Edinburgh (John Gallacher, 8/12/23) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher met with UK DRI's Informatics team to further discuss potential for collaboration with DPUK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Attended launch of the UK Motor Neuron Disease Research Institute (John Gallacher, 3/11/23, 10.00) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended this launch. He networked with the UK MND research community, which was particularly relevant to DPUK's ongoing administration of the MRC-funded MND Accelerator. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ukmndri.org/ |
| Description | BBC Persian Interview on Dementia Research January 2024 - Dr Negin Holland & Prof. James B Rowe |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviewed by BBC Persian about Dementia research on 25th January 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | BBC Radio Berkshire interview on project 'Your Beautiful Brain' |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview regarding my 'Your Beautiful Brain' art workshops for Black African and Caribbean communities |
| Year(s) Of Engagement Activity | 2023 |
| Description | BBC Radio South interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview regarding my 'Your Beautiful Brain' art workshops for Black African and Caribbean communities |
| Year(s) Of Engagement Activity | 2022 |
| Description | Beautiful Brains Workshops |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | There were 6 workshops in total including an Art workshop, which was funded by ARUK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Benchmarking Alzheimer's Disease polygenic risk scores for disease prediction in diverse samples |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DEMON Network Genetics and Omics group meeting: Benchmarking Alzheimer's Disease polygenic risk scores for disease prediction in diverse samples |
| Year(s) Of Engagement Activity | 2023 |
| Description | Biodiversity, Medicine, and Health workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In this workshop we will explore critically important initiatives - based on botanical-garden and natural-history collections and databases - to build frameworks for extracting knowledge from collections and databases, as building-blocks for future new initiatives. This gives us the background to explore in the following sessions a range of examples in health and medicine. Nature has always been the primary source of novel molecules for drug development and remains the source of primary health care among millions of people worldwide. Much biomedical research relies on plants, animals, and microbes to better understand human physiology and to understand and treat human diseases. Loss of biological diversity of microorganisms, flora and fauna means losing, even before their discovery, many of nature's chemicals and genes of the kind that have already provided humankind with enormous health benefits. Meanwhile, revealing the untapped potential uses of natural products will strengthen the hand of those seeking to better protect the natural world. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Brain Bank Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Regional Brain Bank meeting, chair |
| Year(s) Of Engagement Activity | 2023 |
| Description | Brain Conference, talk given on "Apathy and Impulsivity" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation during cognition and dementia theme of Brain conference 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Brain Health Conference, Edinburgh 2022: "Harnessing the power of big data in the UK Biobank for brain health clinics" (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ludovica Griffanti was invited to present at the Brain Health Conference, Edinburgh 2022: "Harnessing the power of big data in the UK Biobank for brain health clinics" , which sparked conversations and initiated potential collaborations. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Brain Health Conference, Edinburgh 2022: "Oxford Brain Health Clinic and the Translational Research Collaboration for Dementia (TRC-D)" (Prof Clare Mackay) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Clare Mackay was invited to present at the Brain Health Conference, Edinburgh 2022: "Oxford Brain Health Clinic and the Translational Research Collaboration for Dementia (TRC-D)", which sparked discussions and potential collaborations. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Brains for Dementia Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A public engagement event for brain donors, their carriers and the researches who will access the data. |
| Year(s) Of Engagement Activity | 2022 |
| Description | CINECA/H3BioNet Harmonisation Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lecture: Harmonisation and standardisation of large cohort datasets |
| Year(s) Of Engagement Activity | 2022 |
| Description | CUH Memory Clinic Annual Study and Review Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | CUH Memory clinic annual study and review day |
| Year(s) Of Engagement Activity | 2023 |
| Description | Cambridge Imaging Festival - Talk: New directions in dementia imaging |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | This is a meeting of users and experts within the Cambridge NHS and academic community. Results and data are shared as well as new perspectives and applications for novel imaging methods. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.mrc-cbu.cam.ac.uk/wp-content/uploads/2021/05/Programme-Cambridge-Imaging-Festival-2021.p... |
| Description | Chaired 'Artificial Intelligence and Neuroimaging' panel at the 2023 Neuroimaging Symposium (John Gallacher, 24/10/23, 15.30) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher chaired this panel. The Symposium offered the opportunity to showcase DPUK's contribution to the dementias imaging research landscape. DPUK continues to work to produce imaging data pipelines for the Data Portal. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://neuroimagingsymposium2023.com/ |
| Description | Cognitive testing of older adults with ADHD and dyslexia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented at the DPUK conference on 2 March 2023 Authors: Elen Golightly, Emma Squires, Sarah Bauermeister Introduction: Neurodiverse conditions such as Attention Deficit Hyperactivity Disorder (ADHD), Autistic Spectrum Disorder (ASD), and dyslexia may mirror selective symptoms found in dementia and mild cognitive impairment (MCI), including cognitive impairment, memory issues and executive dysfunction. Reaction time variability (RTV) as a measure of a cognitive reaction time variability within a single task is known to be increased for adults with dementia and MCI (Bauermeister & Bunce, 2015). Likewise, neurodiverse conditions, are similarly associated with increased RTV. The aim of this study was to investigate the effect of neurodiverse conditions on cognition (RTV). Methods: We conducted our analysis on the Dementias Platform UK (DPUK) Data Portal using Brain Health Registry (BHR) data, n=38,929 (M=58.76, SD=13.20 years at baseline). We constructed a longitudinal Structural Equation Model investigating the effect of ADHD and dyslexia on cognitive RTV, controlling for baseline age and education. The model included three waves of RTV results as the tasks were repeated over 5 years. The model was repeated for all four cognitive tasks: DET, IDN, OCL and ONB. Approximately 1500 participants have a past and/or current ADHD diagnosis and approximately 1700 have diagnosis of dyslexia or reading disorder. Results: For each task performed at baseline we find RTV increases for people with ADHD (ß=0.004-0.007, p<0.01) and dyslexia, (ß=0.004-0.006, p<0.01). However, when the tasks were repeated, the associations between neurodiversity and RTV were no longer significant after controlling for baseline. Conclusion: While neurodiverse conditions appear to have an initial deleterious effect on RTV, we find little evidence for significant longitudinal increase in RTV from having a neurodiverse condition. We conclude that when conducting cognitive tests on older adults, it is important to take into account the impact neurodiverse conditions may have that might lead to a result similar to what is expected for a patient with dementia or MCI. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Collaborations Workshop (CW23) organised by Software Sustainability Institute, May 2023 (Lightening talk) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Technical development: Dementias Platform UK neuroimaging data portal and remote analysis environment |
| Year(s) Of Engagement Activity | 2023 |
| Description | Comment on the Polygenic Hazard scores for AD study by Tan et al (2019), Brain 142; 460-470 for Alzforum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I have commented on a study which was covered on Alzforum about polygenic hazard scores for AD, and shared my opinion on their availability to the public. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.alzforum.org/news/research-news/multi-gene-score-predicts-cognitive-decline-independentl... |
| Description | Company Visit (Boston) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | ~50 industrial partners attended my talk about blood biomarkers in neurodegeneration |
| Year(s) Of Engagement Activity | 2022 |
| Description | Coordinator FTDUK Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | FTDUK - coordinator and talk London |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ftduk.org/previous-programmes/#1684055574796-923f2281-2b7e |
| Description | DEMON Network - Using the DPUK Remote Data Platform |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | As the Director of Dementias Platform UK, Prof John Gallacher was invited to give a talk introducing DPUK and the Remote Data Platform, demonstration on the DPUK Data Portal including logistics, cohort identification, data discovery and variable selection. |
| Year(s) Of Engagement Activity | 2022 |
| Description | DEMON Network Summit 2022: AI for Precision Dementia Medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The DEMON Network Summit 2022 on AI for Precision Dementia Medicine will be held at the Royal Society in London on the 13th and 14th of June 2022. This invitation-only event is funded by the Alan Turing Institute and Alzheimer's Research UK, and is delivered in partnership with the UK Dementia Research Institute. The Summit, attended by world-leading scientists, clinicians, funders and industry, is based around a series of exciting debates exploring some of the most contentious issues we face. On day two we will run two interactive workshops to discuss what practical changes need to be made to the research landscape to enhance experimental medicine and digital innovation. We would like to invite you to day two of the Summit (14th June) given your role at DPUK, as the focus will be on capacity building and fuelling innovation. We are able to cover your travel and accommodation costs to attend if required, and we are also delighted to invite you to a drinks reception and dinner on the evening of the 13th of June. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://demonsummit2022.com/ |
| Description | DEMON/DPUK workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Co-Organiser and speaker: Using the DPUK Data Portal for cross-cohort research |
| Year(s) Of Engagement Activity | 2022 |
| Description | DPUK Autumn Academy 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | DPUK's Autumn Academy is an annual, week-long series of online presentations, lectures and guided tutorials aimed at helping researchers enhance their data science skillsets. Our next event will be held from Monday 21 to Friday 25 November 2022 and will focus on the theme of longitudinal methods. The Autumn Academy is aimed at experienced data analysts who are seeking to expand their repertoire of cohort analysis techniques. Participants work with cohort data in the DPUK Data Portal to learn new skills and work on real research projects. The Data Portal is a dementia-optimised health research data repository featuring 60 cohorts and over 3.5 million individual participants. Each day of the event involves morning presentations and lectures on themed areas of dementia research and specific longitudinal cohort analysis techniques. Afternoon sessions allow participants to work on research projects using real-world data from cohorts in the DPUK Data Portal. Topics include: Longitudinal logistic and linear modelling, Cox regression and survival analysis, Structural equation modelling, Machine learning |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiasplatform.uk/research-hub/data-analyst-training/dpuk-autumn-academy |
| Description | DPUK C-SURV ontology IP meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | As Director of Dementias Platform UK, Prof John Gallacher was invited to discuss intellectual property surrounding C-SURV. |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK LinkedIn channel |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | The DPUK LinkedIn channel now has 202 followers - more than twice as many as this time last year. We are also supporting a Vascular Health group aimed at engaging with industry. |
| Year(s) Of Engagement Activity | 2021,2022 |
| URL | https://www.linkedin.com/company/dpuk |
| Description | DPUK Neuroimaging Symposium, talk on AI stratification research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on my unsupervised machine learning research on the stratification of major depressive disorder at the DPUK neuroimaging symposium. |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK Neuroimaging symposium, Cardiff, Oct 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Automated QC of T1w scans for clinical datasets: methods comparison & design of a QC classifier |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK Newsletter article: "In conversation: Postdoctoral researcher Gaurav Bhalerao talks about the significance of neuroimaging studies" |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DPUK Newsletter article: "In conversation: Postdoctoral researcher Gaurav Bhalerao talks about the significance of neuroimaging studies" |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiasplatform.uk/news-and-media/blog/in-conversation-postdoctoral-researcher-gaurav-... |
| Description | DPUK Spring Academy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | DPUK's all-new Spring Academy is an annual, week-long series of lectures, presentations and guided tutorials giving researchers an introduction to cohort data analysis techniques. The event ran virtually this year from 7-11 March 2022. Designed for students, researchers and professionals with little experience of analysing health or cohort data, the Spring Academy course provides an introduction to analysis techniques with a particular focus on dementia. Our expert line-up of presenters, lecturers and tutorial leaders explore topics including multi-modal analysis, multi-cohort projects, data standardisation, and linear models. DPUK's Spring Academy complements the Autumn Academy, which is aimed at more advanced analysts and which was held for the first time in 2021, and DPUK's Datathon series, which gives researchers the chance to work in multidisciplinary groups on real research projects in the DPUK Data Portal. Each day involves a morning contextual presentation and statistical lecture, with a guided analysis tutorial in the afternoon. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiasplatform.uk/research-hub/data-analyst-training/dpuk-spring-academy |
| Description | DPUK Translation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Translation 2023 is part of a change to the landscape of dementia research. The conference is now sold out, but you can follow what is said at the conference using the hashtag #TRANSLATION2023. People from academia, industry, the third sector and government will be attending and hearing about the latest research in human experimental medicine for dementia. The challenge for dementia research is translating discoveries in the lab into experimental trials and on to therapies and new drugs quickly, at scale and using all available research channels. There will be discussions about exciting developments in big data, biomarkers and trials delivery - all of which can lead to new disease-modifying treatments for dementia. |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK Translation 2023 Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral Presentation; Big data analytics using the DPUK Data Portal & Oral presentation |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK Translation 2023 Conference Session lead ECRs |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | ECR workshop |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK Twitter channel (@DementiasUK) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | DPUK's Twitter channel has gone from strength to strength, passing 5,500 followers in February 2022 - an increase of over 1,000 on the previous year. The channel achieved an average of 74,500 impressions (people reached) per month throughout 2021. Engagement with the channel is strong, with material about research outputs and awareness days being particularly well received. |
| Year(s) Of Engagement Activity | 2021,2022 |
| URL | https://twitter.com/DementiasUK |
| Description | DPUK Work Package Forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | All leads of the Work Packages under Dementias Platform UK had a meeting to present updates and discuss future strategy for DPUK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK YouTube channel |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The DPUK YouTube channel hosts video content including: DPUK podcasts; our new animation; interviews with event participants; recordings of Great Minds members' events; featured cohorts; monthly research round-up videos. |
| Year(s) Of Engagement Activity | 2021,2022 |
| URL | https://www.youtube.com/channel/UC9OKgZG5Dq0RheCDV3upakw/ |
| Description | DPUK and Deep and Frequent Phenotyping programme (DFP) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | As director of Dementias Platform UK, Prof John Gallacher was invited to a meeting with Deep and Frequent Phenotyping programme (DFP) on potential collaboration and connect to Cartography. |
| Year(s) Of Engagement Activity | 2023 |
| Description | DPUK blog |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The DPUK blog features a range of articles on topics including: different types of dementia; new podcasts; aspects of dementia research; experiences of those in dementia research. The blog is written in a lay-friendly style with the aim of being accessible to wider audiences. Recent blog titles include: --Creutzfeldt-Jakob disease: a rapidly progressing form of dementia --International Day of Women and Girls in Science --Can dance help defend against dementia? --How has modern technology shaped dementia care? |
| Year(s) Of Engagement Activity | 2021,2022 |
| URL | https://www.dementiasplatform.uk/news-and-media/blog |
| Description | DPUK blog post "DPUK researcher picks 'top 5' highlights of AAIC dementia research conference" (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | After attending AAIC 2022, Ludovica Griffanti summarises the highlights of the conference to disseminate the latest news in dementia research through the DPUK blog. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiasplatform.uk/news-and-media/blog/dpuk-researcher-picks-top-5-highlights-of-aaic-... |
| Description | DPUK featured in new Alzheimer Europe report on data sharing - 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | he report, titled 'Data sharing in dementia research - the EU landscape', evaluates the legal and policy landscapes that dementia researchers have had to navigate in recent years, identifying key barriers and enablers for data sharing. In his preface to the document, Jean Georges, Executive Director of Alzheimer Europe, says: 'In our 2019 report, "Estimating the prevalence of dementia in Europe", we showed that the number of people with dementia in Europe is likely to double by 2050, increasing from 9,780,678 to 18,846,286 in the wider European region. However, despite its increasing incidence, and high health and social care cost, research on dementia receives a disproportionately low amount of funding compared to other disease areas. As a result, there is an urgent need to maximise the utility of data from dementia research. 'Data sharing represents an important step towards meeting this need, and could help increase our understanding of the causes, treatment, prevention and care of dementia. However, there is still much to do to improve data sharing in dementia research - in particular, for clinical studies, where data sharing is not yet common practice.' Writing in the report, DPUK's Director, Professor John Gallacher, describes how the DPUK Data Portal is 'democratising science'. He says: 'The DPUK Data Portal was developed in collaboration between the DPUK public-private partnership and research teams leading dementia cohort studies in the UK. As a data repository, the DPUK Data Portal facilitates access to data from over 3 million participants in studies such as Generation Scotland, LBC (Lothian Birth Cohort) 1936 and GERAD (Genetic and Environmental Risk in Alzheimer's Disease). Data from these cohorts cover a broad spectrum of variables, including genetic test results, brain imaging data and neuropsychological assessments of memory and brain function. Once access to data is approved, researchers are able to work with the curated data in a secure, remote-access environment, allowing them to develop new research questions and test or validate novel hypotheses on dementia. 'The DPUK Data Portal was built to democratise science. By providing remote access to data from 42 cohorts (n>3.4m) anyone, from Botwana to Brussels, can access some of the world's best data. All that's required is a good idea, internet connectivity, and an academic or industry email. Our data discovery tools and streamlined access procedures enable rapid access decisions (median time to decision: 23 days), with most datasets and most computational facilities, including analytical software, being free at point of use. Bona fide researchers work on approved projects within a secure and fully auditable multi-modal environment. Findings, but not data, may be exported for publication. 'Integrating imaging, genomic and health data is challenging, even for experts. So our datathon and summer school programme, targeting early-career researchers, is designed to introduce up-and-coming analysts to good data management and rigorous longitudinal analysis. 'In a spirit of collaboration, DPUK is working alongside data platforms around the world, including Dementias Platform Korea, Dementias Platform Australia, EMIF-AD, GAAIN, IALSA, SCAI, Cohen Veterans Bioscience, the Krembil Brain Institute, and ADDI, to create a global data alliance for dementia research.' |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dementiasplatform.uk/news-and-media/latest-news/dpuk-featured-in-new-alzheimer-europe-re... |
| Description | DPUK newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The DPUK newsletter goes out three times a year to a distribution list of around 450 DPUK stakeholders. It provides updates on DPUK developments, research outcomes, funding opportunities etc. it has an average open rate of around 31%, and a click-through rate of around 8%. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | DPUK virtual Datathon (26th June - 30th June) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DPUK Datathon online. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.dementiasplatform.uk/research-hub/data-analyst-training/dpuk-datathons |
| Description | DPUK website news section |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The news section of the DPUK website features articles about new developments in DPUK and outcomes related to the DPUK programme. For example, recent stories have been titled: --People with both type-2 diabetes and high blood pressure have worse brain health than those with just one of these conditions --Study finds hearing aid use is linked to slower decline in thinking skills --New research suggests lowering brain cell excitability could help prevent Alzheimer's disease --DPUK receives funding to run four art workshops to improve diversity in dementia research |
| Year(s) Of Engagement Activity | 2021,2022 |
| URL | https://www.dementiasplatform.uk/news-and-media/latest-news |
| Description | DPUK/ARUK David Cameron Visit (John Gallacher, 5/10/23, 14.30) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | David Cameron, then President of ARUK, visited DPUK in Oxford. A tweet about this event received >57k impressions. ARUK continues to be a key partner for DPUK. John Gallacher remains in talks to guest on a Bloomberg-run podcast with David Cameron should he resume his role in the dementias research community. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://twitter.com/David_Cameron/status/1711674369049534746 |
| Description | Data Science and Population Health : a Team Science Approach |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Data Science and Population Health : a Team Science Approach. Liverpool University MSc in Data Science lecture, 03/11/21. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Data Science and Population Health Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Data Science and Population Health Research. University of British Columbia, Canada, 21/01/21 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dementia Research Oxford - Meeting with Daiichi Sankyo |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | This was a meeting to discuss the potential collaboration between Dementia Research Oxford and Daiichi. Daiichi are undergoing a strategic review of their neuroscience activities that will complete around year end. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dementia Research Oxford - Shionogi meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Prof John Gallacher gave a presentation on DPUK at a joint meeting with Shionogi Inc, a Pharma company from Japan as they are interested in developing collaborations with Oxford in the dementia space. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dementia Research Oxford seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof John Gallacher gave a presentation on Developments in dementia translation research with the Dementias Research Oxford. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dementia Researcher Podcasts and Fundraising events - Dr M Malpetti |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | https://www.dementiaresearcher.nihr.ac.uk/tag/dr-maura-malpetti/ |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiaresearcher.nihr.ac.uk/tag/dr-maura-malpetti/ |
| Description | Dementia biomarker set for UK Biobank |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This meeting was proposed by Prof John Gallacher to convene a small working group to propose dementia/ageing related fluid biomarkers that might be assessed from UK Biobank samples. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dementias Platform UK (DPUK) International Scientific Advisory Board (ISAB) retreat |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International Scientific Advisory Board (ISAB) retreat of Dementias Platform UK (DPUK) has gathered in-person in order to discuss future strategy of the platform. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dementias Platform UK Spring Academy March 2022. Talk: "Multi-modal dementia research" (Prof Clare Mackay) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Clare Mackay contributed to the Dementias Platform UK Spring Academy, a one-week training delivered by DPUK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dementias Platform UK Spring Academy, March 2022. Talk "Large brain imaging datasets: opportunities and challenges" (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ludovica Griffanti contributed to the Dementias Platform UK Spring Academy, a one-week training delivered by DPUK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dept. Psychiatry talk on the DPUK Data Portal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | University of Oxford Dept. Psychiatry BRC Research Ready Schools & Family Hubs Invited oral presentation; Data Discovery and Analysis using the DPUK Portal |
| Year(s) Of Engagement Activity | 2023 |
| Description | DiMe | Collaboration on a patient-centric research in ADRD |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | As the Director of Dementias Platform UK, Prof John Gallacher was invited to discuss potential collaboration between DiMe and Dementias Platform UK. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Discussion on Lecanemab |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Joined an over 1000 person online Dementia Research Initiative led discussion on Lecanemab following publishing of clinical trial results. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiaresearcher.nihr.ac.uk/a-clinical-scientific-perspective-on-lecanemab-ukdri/ |
| Description | Dr M Malpetti - Host of Clinical Neurosciences Seminar & Conversation with Prof. JB Rowe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion on "From mechanisms to treatment, in disorders of frontotemporal lobar degeneration." |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dr M Malpetti Invited career panel speaker at the Biomarker UCL course for PhD students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited career panel speaker at the Biomarker UCL course for PhD students (London, 18/05/2022) |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Maura Malpetti (Rowe Group): Oral Presentation at DPUK Translation 2023 Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation on "Post mortem validation of in vivo PET imaging: test case of inflammation in progressive supranuclear palsy" |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.dementiasplatform.uk/research-hub/translation-2023/early-career-researchers-workshop-and... |
| Description | Dr Maura Malpetti - ROWE GROUP MEMBER Invited speaker at Alzheimer's Association International Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Invited as a speaker on Brain inflammation in frontotemporal dementia. ISTAART conversation with patients and carers. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dr Maura Malpetti - ROWE GROUP MEMBER Invited speaker at Alzheimer's RESEARCH UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | TALK TITLE: Brain imaging in dementia: for better understanding and treatment of human disease |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dr Maura Malpetti - ROWE GROUP MEMBER Organizing committee member "My memory clinic and me" Cambridge Festival 2021 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | My memory clinic and me" at Cambridge Festival 2021 - a session held for those interested in neurodegenerative diseases. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://ftd.neurology.cam.ac.uk/events/201cme-and-my-memory-clinic201d |
| Description | Eisai Ltd webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited presenter at Eisai Ltd webinar |
| Year(s) Of Engagement Activity | 2020 |
| Description | Enabling dementia research using UK Biobank |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Webinar: 'Enabling dementia research using UK Biobank'. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Event - DPUK Autumn Academy - October 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | DPUK's Autumn Academy was an annual, week-long series of presentations, lectures and workshops aimed at helping researchers enhance their data science skillset. The inaugural event (held from 27 September to 1 October 2021) focused on the theme of cohort data analysis. The Autumn Academy was aimed at experienced data analysts who are seeking to expand their repertoire of analysis techniques. Participants worked with cohort data in the DPUK Data Portal to learn new skills and work on real research projects. Each day involved morning presentations and lectures on themed areas of dementia research and specific cohort analysis techniques. Afternoon sessions allowed participants to work on research projects using real-world data from cohorts in the DPUK Data Portal. DPUK's Autumn Academy complements the Spring Academy, which is aimed at beginner analyst. 24 attendees (6 groups of 4 people) from across the globe attended virtually. The event received extremely positive feedback, with some saying 'Thanks to this academy, I have learned a lot about: available databases, multi-cohort and longitudinal analyses, and new research conducted or in progress on dementia and Parkinson's disease. This academy is a great resource for researchers.' 'There were some useful introductory lectures on several techniques that I have not been exposed before, such as machine learning and SEM. That was very informative.' 'A great update including developments in global data initiatives, the latest research on PD and dementia, the basis of different ontologies and projects and a great insight in several very useful new (to me) data analysis models to get to grips with that will bring an advantage to be able to apply in data analysis of DPUK projects. Also need to get on with learning Python! I learnt too how much the DPUK data portal is constantly evolving, building connections internationally with other dementia platforms and with adding training such as this academy, is arming researchers with a wider selection of the latest tools to apply where suitable to aid their dementia research. The questions raised by attendees showed the variety of analysis levels we had but also that we are all working in our various ways towards the same unifying goals.' |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dementiasplatform.uk/research-hub/data-analyst-training/dpuk-autumn-academy |
| Description | Event - DPUK Datathon March 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | DPUK Datathons are a key part of DPUK's data analyst training programme, placing researchers in multidisciplinary teams to generate valuable new findings in dementia research. Attendees attended virtually and used cohort data in the DPUK Data Portal to explore a particular research question relating to dementia risk and progression. Around 15-30 hours of additional work beyond the formal workshops were required for research and collaboration. The event included expert introduction to selected population cohorts; four online cohort analysis workshops; support and guidance during offline periods; and potential for studies to develop into publications. Taking place on 1-12 March 2021, at this event 15 attendees (3 groups of 5 attendees) were asked to develop new studies relating to 'Co-morbidities in Cognitive Decline, including Cardiovascular Disease' . Attendees gained significant understanding on how to use the Data Portal for conducting their analyses. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dementiasplatform.uk/research-hub/data-analyst-training |
| Description | Expert Panel Member on Keynote Programme 'Driving Real World Patient Centricity' - Genesis In-Person Conference - London, 9Dec21 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Astrid Geeraert from Flanders Invest and Trade in London kindly passed me your details after we discussed your possible involvement in the Genesis conference session 'Driving Real World Patient Centricity' at 13.20 GMT on 9 December in London (1 Wimpole street). You can see the programme here. I am conscious you are already involved in the webinar session they organise on the 8 Dec, so just to clarify this panel suggestion would be for the main conference on 9 December in person. To give you some background, Genesis is One Nucleus annual London conference where we discuss the main trends that developed in our industry in the past year including deal activity, therapeutics and technology developments. This particular panel discussion should reflect on how the patient centricity approach claimed by pharma is translated in concrete actions, including more technology and data support, and the various considerations in terms of regulatory, interoperability, data protection it is bringing. I have 3 panelists confirmed who are Mark Avery, Eastern Academic Health Science Network (EAHSN) involved in a very interesting programme linking patient engagement and improved data collection and processing: the Gut reaction programme, Philippa Brown from AstraZeneca to provide the pharma perspective and Natalie Wilson from NIHR who works on decentralised trial design and patient engagement. I think that Dementia is very interesting area to discuss these aspects of 'how' engaging with patients who may not be patients yet as pre symptomatic but how crucial the data collection is at this stage and given your engagement in the UK biobank it would be extremely relevant to the conversation. Panelists: Mark Avery, EAHSN Phillippa Brown, AstraZeneca Natalie Wilson, NIHR Paresh Malhotra, Imperial College London John Gallacher, University of Oxford And I am really pleased that Mike Ward, Global Head of Thought Leadership has agreed to chair it as not only he is good in this role but also has a keen interest in the topic 2. Wherever they are situated in the ecosystem, what is the biggest challenge organizations, will face when attempting to establish a patient-centric culture, and how do you win over skeptics? 3. At which points in the medicines discovery, development and delivery timeline can the patient voice have a genuine and productive impact? Can you give real world examples of how the patient voice has made a real difference to plans at your organization? 4. How do you identify the patients who are going to be useful? How do you ensure that they are truly representative of people who matter? What challenges have you faced and how did you overcome them? 5. In this era of network connectivity and increased use of technology, what tools are you using or plan to use to be able to main a patient-centric trajectory? 6. Looking at how organizations can organize themselves are there any particular functions, activities or processes that are must-haves in order to be patient-centric? How can companies incentivise their employees to be patient-centric? 7. What does good patient-centricity look like and what metrics do you use to determine how well you are doing? 8. How easy is to identify the return on investment or other tangible benefits you can achieve by being patient-centric? 9. The development and delivery of medicines requires a whole ecosystem working well. While we have heard of the bilateral efforts of pharma and biotechs working with patients, what is being done to encourage other stakeholders, such as clinicians, regulators and health technology assessment agencies, to embrace patient-centricity? 10. Finally, what piece of advice would you give to others in the industry that might want to either introduce for the first time or enhance their patient-centricity efforts? |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.genesisconference.com/keynote-programme-2021/ |
| Description | Expert attendee at MND Collaborative Partnership workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | The workshop will start the application process for a new funding initiative called the MND Collaborative Partnership, which has been established by a £4M commitment from the Funders. The Partnership aims to bring the research community together to tackle a major block to the translation of MND research. This is a unique and exciting opportunity for researchers to participate in an initiative that will drive MND research towards translation and lead to new treatments for MND. With significant advances in recent years delivering a better understanding of the MND disease aetiology, it is timely to address the blocks to translation. This is seen as a first step in advancing the research field toward the delivery of new treatments for patients with MND. The Funders aim to support one substantive collaborative application involving multiple institutions that brings together the strengths of the UK MND research field and leverages multidisciplinary expertise and resources in the wider research landscape (e.g. DPUK , UK DRI, HDRUK etc). The applicants will be required to work together to agree a cohesive set of work packages to be delivered and who will lead/deliver each of those. Further details of the call will be made available ahead of the workshop. The Aim of the Workshop • To launch the call and for the Funders to explain what they would like to achieve. • To describe the application process and post award requirements. • To discuss the MND research landscape and agree on the blocks to translation that could be feasibly addressed through a collaborative research effort supported by the Partnership. • Present the resources (e.g. skills, infrastructure etc) available to the Partnership - discuss and agree any gaps. • Discuss the process of development of the application, agree who will do what and begin assigning tasks |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.lifearc.org/funding/rare-disease-research-funding/mnd-collaborative-partnership/ |
| Description | Expert panel member on data sharing at World Dementia Council summit - December 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The meeting will have a combination of plenary and parallel sessions on research and care and feature international dementia leaders from across the globe sharing their thinking and work. It will be hybrid although almost all people speaking in each session will be in person. It would be great if you were willing to share your thinking on data sharing. The session will focus on this theme and address questions and themes such as how do we maximise the benefits of big data developing global cohorts, the comparability and sharing of data, and overcoming regulatory barriers? Each speaker will have 7-8 minutes to present and offer introductory remarks. Outcome: Organisers wanted to get in touch with a draft transcript of your contributions to the data sharing session we held at the virtual summit in December. Said it was a great session and we're keen to publish a transcript of this to share with our network. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://worlddementiacouncil.org/sites/default/files/2021-12/Programme%20%5Brevised%5D%20-%20WDC%20S... |
| Description | Festival of Genomics and Biodata |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented at he Festival of Genomics and Biodata |
| Year(s) Of Engagement Activity | 2022 |
| Description | Filmed Charity Broadcast for PSP Association |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | PSPA broadcast. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Five Lives Health Oxford Industry meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation on multi-modal multi-cohort studies using the DPUK Data Portal |
| Year(s) Of Engagement Activity | 2022 |
| Description | Flash talk at the ARUK Thames Valley Network Early Career Researcher Day, 19 January, 2024 (Dr. Benjamin Tari) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A flash talk defining a proposed study investigating the utility of passive exercise as a treatment for traumatic brain injury. Talk generated discussion which continued at a poster presentation |
| Year(s) Of Engagement Activity | 2024 |
| Description | Frontotemporal Dementia Support Group National Annual Seminar |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Gave a talk titled "Frontotemporal Dementia: introduction and pathways to progress" with the Rare Dementia Support Group. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=xP_yFWzb40g |
| Description | Fundacio Ace - Barcelona |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | As the director of Dementias Platform UK, Prof John Gallacher was invited to have a meeting with Fundacio Alzheimers Centre Barcelona and DPUK to discuss potential collaboration. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Genesis Innovation workshop - virtual - 8 Dec 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Join a panel discussion on access to patient data and translational medicine and the divergence between the EU and the UK's pathways. He thought that you might be better placed to join the discussion as head of DPUK. Following on the conversations with Jan, we have summarized the topics/questions that will be used during the panel discussion on Wednesday 8 December. Please find them below. • Set the stage: o Thanks to new technologies and infrastructures, new frontiers can set using well-organized large patient data systems - have we entered a new era? Are we ready to combine data silos from all over the world into a global data system? o When we talk e.g. about cancer research, inflammation and neurological diseases, how can access to large patient data sets accelerate research in these domains and ultimately improve care? See e.g. single-cell genomics or spatial transcriptomics technologies • Driven by uses/applications: • We hear a lot about patient data, health records, for uses in hospitals, remote monitoring etc o What are the main drivers behind this surge in patient data? Which uses/applications will likely shape the roll out of well-organized patient data systems? o In what way has the current pandemic an effect on this? Did it bring up new innovative ways, did it show a painful shortage in adequate systems? • The current pandemic: o Did it change the access to health records and will it drive the way we handle future health challenges o Did it change or will it change the business model? • Towards a national and international system? o Can we foresee a national (or European) data records system? Is it feasible? Can it be scaled from local to national? o What are the challenges on the level of governance (consent by patients e.g.)? o Can we foresee an optimalization of patient treatments based on patient data outcomes (e.g. best practices, which hospital has the best care for a certain treatment)? • A new business model? o What is the commercial value of data and how is it perceived? o Does this change the balance between payers-care givers-patients? Who pays for these national/international systems and data use? o How can companies jump on the bandwagon and become successful in this new exciting and fast growing domain? |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.genesisconference.com/ |
| Description | Great Minds Public Event May 21 - Healthy Aging |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | On line members event with speakers and question time |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.greatmindsfordementia.uk/Join-us/great-minds-member-event-2021 |
| Description | Great Minds Public Event Nov 21 - Frontotemporal dementia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 18 November 2021 we brought together leading experts on frontotemporal dementia to explain what the condition is, how it's diagnosed and managed, and how researchers are working towards better treatments. The speakers were Dr Siân Thompson (Consultant Neurologist, John Radcliffe Hospital, Oxford) and Professor James Rowe (Professor of Cognitive Neurology, University of Cambridge). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.greatmindsfordementia.uk/Join-us/great-minds-members-event-nov-2021 |
| Description | Great Minds event: the outlook for new dementia treatments |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dementias Platform UK - Great Minds is delighted to invite you to its first in-person live event. We've brought together leading figures in dementia diagnosis and treatment to offer a rare, expert-led insight into the latest developments in the field. Topics will include recent advances in our understanding of dementia, emerging treatment options, how new drugs make it to the NHS, and the role technology can play in diagnosis and condition management. Attendees will also have the opportunity to put questions to our experts. The event is aimed at anyone with an interest in dementia and dementia research - no specialist scientific knowledge is required. Prof John Gallacher was invited to give an introduction at the event as an expert in dementias research. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.eventbrite.co.uk/e/great-minds-event-in-person-the-outlook-for-new-dementia-treatments-t... |
| Description | Great Minds live event: dementia screening and risk factors |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This is the sixth event for members of DPUK's Great Minds (GM) research volunteer registry - and the second to be held in person. GM members are recruited from cohort studies and via Join Dementia Research, and volunteer to participate in dementia research studies and trials. The aim of the event is to give GM participants added value, and to remind them of the difference volunteers make to medical research and of their commitment to supporting new studies through GM.As Director of DPUK, Prof John Gallacher gave a welcome speech to the event and recent updates on DPUK. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Great Minds newsletter: April 2021 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Newsletter |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.greatmindsfordementia.uk/blog/great-minds-newsletter-april-2021?ref=image |
| Description | Great Minds newsletter: January 2022 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Newsletter |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.greatmindsfordementia.uk/blog/great-minds-newsletter-january-2022 |
| Description | Great Minds newsletter: September 2021 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Our newsletter |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.greatmindsfordementia.uk/blog/great-minds-autumn-newsletter-2021 |
| Description | Guest speaker IEEE Engineering in Medicine & Biology Society Manipal Chapter and the Dept of Biomedical Engineering, Manipal Institute of Technology , India |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 50 students attended this presentation |
| Year(s) Of Engagement Activity | 2022 |
| Description | Guest speaker in an online training course on mental health care and biostatics arranged by IIT Guwahati on the topic "Computational Psychiatry" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 50 professionals attended computational psychiatry presentation |
| Year(s) Of Engagement Activity | 2022 |
| Description | HDR UK Scientific Conference 2022: Creating trustworthy research environments that enable the greatest benefits for global health and society |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | The conference showcased how health data science can be harnessed to transform global health and society, with a focus on making sure no groups are excluded from these data-driven improvements. Researchers shared learnings from the rapid progress made in health science and data infrastructure as a result of COVID19, to shape the post-pandemic health data science landscape. It brought members of the scientific community, industry and patients and the public together to provide opportunities for collaboration and knowledge sharing. As a Director of Dementias Platform UK, Prof John Gallacher was invited to speak at the conference to set the scene and discuss what are the key ingredients to creating trustworthy research environments that enable the greatest benefits for global health and society. |
| Year(s) Of Engagement Activity | 2022 |
| Description | HDRUK QQR2 Public Health Research Vision |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | HDRUK QQR2 Public Health Research Vision. HDRUK national meeting, 26/04/21 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Hosted DPUK/KBRI MoU Signing (23/11/23, 10.00) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Third sector organisations |
| Results and Impact | DPUK hosted a delegation from the Korea Brain Research Institute for the signing of a Memorandum of Understanding. DPUK continues to work toward ongoing collaborative research projects with KBRI, and KBRI will speak at DPUK's Translation 2024 conference. There is ongoing discussion of a joint seminar or conference hosted by KBRI. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.kbri.re.kr/new/pages_eng/main/ |
| Description | Hosted the LifeArc/HDR UK/DPUK MND meeting (John Gallacher, 14/11/23, 14.00) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher hosted this meeting to discuss the MND Data Catalyst. This final in-person whole-team meeting precipitated the ongoing series of online meetings in the run up to application for the NIHR-funded grant for the Catalyst. |
| Year(s) Of Engagement Activity | 2023 |
| Description | House of Lords, The potential of AI in healthcare |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | This was an event to discuss the benefits of AI in healthcare, and what can be done to release this potential in the UK. Data sharing was seen as imperative to being able to enable this and also to ensure privacy and fairness in AI models. |
| Year(s) Of Engagement Activity | 2023 |
| Description | In Conversation at Christmas - Broadcast on Dementia |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | In conversation at Christmas is a stimulating discussion, covering some of the progress made in research in 2022, and looking ahead to 2023. Hear from our Chief Scientific Officer, Prof James Rowe and Head of Research, Dr Rosa Sancho and ambassador for Alzheimer's Research UK, Scott Mitchell. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=Vwp8QNIJSZ4 |
| Description | International HundredK+ Consortium (IHCC) Sumit meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral presentation: Global Mental Health Impact of Covid-19 project overview |
| Year(s) Of Engagement Activity | 2023 |
| Description | International HundredK+ Consortium (IHCC) Webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk on large multi-modal multi-cohort studies on harmonisation in mental health |
| Year(s) Of Engagement Activity | 2023 |
| Description | International Society FTD Conference - "Magnetoencephalography (MEG) and frontotemporal dementia' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The International Conference on Frontotemporal Dementias (ICFTD) is l recognized as the primary venue for the synthesis, exchange, and dissemination of research evidence related to FTD, where experts from diverse backgrounds share recent discoveries, insights, and opinions. The talk presented hilighted our groups experiences with applying MEG methods to FTD patients in early research trials. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Interview for UKDRI news and events |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Spotlight on Prof Valentina Escott-Price |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://ukdri.ac.uk/news-and-events/spotlight-on-prof-valentina-escott-price |
| Description | Invited Lecturer at Statistical Parametric Mapping Course, London - Dr A Jafarian (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dynamic causal modelling |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited delegate World Dementia Council Summit |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Expert panel on current state of dementia research and impact, globally. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited guest lecture for Oxford Global, 25 January, 2024 (Dr. Benjamin Tari) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | A guest lecture for Chinese medical undergraduate and undergraduate students as part of Oxford Global. Topics included the state of dementia research, clinical trials, exercise neuroscience and novel studies. Students asked questions which sparked discussions about research. I was invited to return to lecture in future. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Invited member of Polygenic Risk Scoring Expert Panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited member of Polygenic Risk Scoring Expert Panel for Illumina company, Batimore, USA |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited seminar at Icahn School of Medicine at Mount Sinai |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at Icahn School of Medicine at Mount Sinai, NY, USA |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited seminar talk: Multi-modal cross-cohort research using DPUK Data Portal Geneva University Switzerland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar talk: Multi-modal cross-cohort research using DPUK Data Portal |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited session chair at Alzheimer's Association International Conference 2021, USA - Dr M Malpetti |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session on "Neuroimaging: Molecular Imaging of Novel Biomarkers for Neurodegeneration and ADRD" session at AAIC 2021 (07/2021 - Denver USA) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker at 7TMRI group University of Cambridge- Dr Amirhossein Jafarian |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Title: Prior in DCM and MRS informed dynamic causal modelling. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker at Alzheimer's Research UK conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Alzheimer's Research UK conference, Harrogate UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited speaker at DPUK Neuroimaging Symposium, Cardiff, Oct 2023. (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Title: "Harmonisation of imaging data" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited speaker at the Oxford Autumn School in Neuroscience 2023 (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk title: "Translating big data brain imaging to dementia clinical setting: from UK Biobank to the Oxford Brain Health Clinic". The talk sparked questions afterwards and interest in future research projects and lab visits |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://talks.ox.ac.uk/talks/id/b59b575c-5388-4355-b659-d1014c4b35af/ |
| Description | Invited speaker to FBRI Alzheimer's Disease Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker to FBRI Alzheimer's Disease Workshop, Boston, USA |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk "Integrating neuroimaging datasets: approaches for the harmonisation of white matter hyperintensity measurements", ADNI MRI Core meeting 21st December 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk "Integrating neuroimaging datasets: approaches for the harmonisation of white matter hyperintensity measurements", Alzheimer's Disease Neuroimaging Initiative (ADNI) MRI Core meeting 21st December 2021. In the main focus of the presentation was the harmonisation approaches used in our recent Neuroimage paper (https://www.sciencedirect.com/science/article/pii/S1053811921004663?via%3Dihub). It also mentioned newer approaches under development at the Wellcome Centre for Integrative Neuroimaging (WIN), Oxford. The presentation sparked very useful discussions about the harmonisation needs and challenges of ADNI, to guide future directions of harmonisation techniques. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited talk "Structural MRI analysis with FSL", part of the educational webinar "Software for image analysis" organised by the NeuroImaging Professional Interest Area from the Alzheimer's Association ISTAART |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The webinar "Software for Image Analysis" on Thursday May 27, 10am-12pm US ET and was organised by the NeuroImaging Professional Interest Area from the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) It included five speakers from the software tools SPM (J. Ashburner), FSL (L. Griffanti), FreeSurfer (J.E. Iglesias) and Nipy (A.Rana, S. Gosh) providing an introduction to their specific software. The event registered 177 viewers from 28 countries over 5 continents. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.alz.org/research/for_researchers/grants/research-webinars |
| Description | Invitee to roundtable - UK DRI's the impact of Aducanumab approval, implications and opportunities - June 2020 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The recent approval of Aducanumab by the FDA as the first therapeutic for Alzheimer's disease in 20 years through accelerated pathway is challenging the field. We will need to rethink the importance of early diagnosis, the role of biomarkers in dementia, patient stratification. It will affect patients' expectations and raises questions on cost/benefit issues for health systems. The UK DRI in collaboration with ARUK is gathering the Dementia UK Ecosystem representatives and other key stakeholders for a virtual roundtable discussion to reflect on the impact of the FDA decision and its implications for the AD field. Outputs: Position paper on opportunities and priorities for the future of AD drug discovery. Depending on the outcome of this initial event we may follow up with other roundtables focussed on specific aspects raised during the discussion. We will keep you informed about these follow-up events. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Jack FM radio interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview regarding my 'Your Beautiful Brain' art workshops for Black African and Caribbean communities |
| Year(s) Of Engagement Activity | 2022 |
| Description | Janssen Protocol Development |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a meeting to discuss potential collaboration with Janssen Neuroscience as they are preparing for a new phase 2 trial - AD indication/prevention and would like to explore whether we could collaborate/bring the trial to the UK. As this population will be quite challenging to recruit, connecting with existing research cohorts, registries, and global initiatives thinking of UK biobank & DPUK will be key. |
| Year(s) Of Engagement Activity | 2022 |
| Description | John Gallacher as Chair - A4D conference Arts 4 Brain Health: Social Prescribing as Peri-Diagnostic Practice for Dementia event - May 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | An opportunity for GPs, social prescribers, museums, dance studios, music, drama, arts and health organisations, educationalists and funders, innovative and creative ageing specialists, local authorities and policy makers to come together and revolutionise the world of social prescribing for brain health. Organisers said to John: Thank you for so generously giving your time on Friday and your superb chairing of A4D conference to help advance social prescribing to empower people at the onset of dementia to engage in arts to preserve brain health. Your wisdom and expertise gave the sessions gloriously informed flow. Your guidance was tremendous and it felt as if all were working together on a wave to drive this forward. I am inviting chairs and speakers whom it would interest to sign a group letter to generate interest along these lines: to propose an amendment to the NICE guideline 97 (Published 20 June 2018 www.nice.org.uk/guidance/ng97 1.2 Diagnosis : Initial assessment in non-specialist settings, page 15: It would be of real value if after 1.26 a recommendation could be inserted, advising referral to social prescribing for patient choice of a range of weekly activities to preserve brain health. It would be great if social prescribing, recognised for its transformational effect on the mental health and wellbeing of the nation, were to help reduce loneliness and fear at the onset of dementia, through an adaptation woven into the NICE Diagnosis Guideline at the onset - in line with NICE guidelines for Mental Wellbeing and Independence for Older People? |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://arts4dementia.org.uk/spconference2021/ |
| Description | John Gallacher expert comment - RECON management committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | RECON is a research project - Reducing and preventing Cognitive impairment iN older age groups (the RECON programme). It aims to develop and test efficient internet-supported healthy behaviour/cognitive exercises to reduce cognitive decline among older age adults. John Gallacher (as Director of DPUK) provides expert comment to the management committee of the research project. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.southampton.ac.uk/medicine/academic_units/projects/recon.page |
| Description | John Gallacher expert comment in Medical News Today article - Dec 2021 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | John provided a key voice amongst other leading experts on a recent study showing that 'Even light-intensity exercise might reduce dementia risk'. NT also spoke with Prof. John Gallacher, director of Dementias Platform UK, at the University of Oxford in the U.K., who was not involved in the study. He agreed with Prof. Matthews, explaining that the findings were significant, but the question of causation was key. "The idea that physical activity reduces the risk of dementia is entirely plausible, and these findings add to a growing body of evidence supporting this idea. The problem is reverse causation - that is, that people with dementia exercise less." Paper: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787226?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121621 - Prof. John Gallacher "This study goes some way to addressing this by looking at incident events and dropping subjects with incident dementia in the first 2 years of follow-up. The dose-response curves are impressive," he continued. Prof. Gallacher said that "[p]ossible mechanisms [for the association] include improved vascular health and improved immunological function. These mechanisms are likely to be interrelated and not independent of each other." |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.medicalnewstoday.com/articles/even-light-intensity-exercise-might-reduce-dementia-risk |
| Description | John Gallacher speaker - Challenging times, Changing culture - Oxford, November 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Building on the experience of Oxford researchers during SARS-CoV-2, this lunchtime seminar will consider the structural context of scientific activity, the strategic impact of collaboration and the lived experience of scientists. John presented on DPUK's collaborative ethos. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/365773e5-76e1-4d49-ac24-21dee988d961/ |
| Description | John as Chair - Launch of Arts 4 Dementia report 'A.R.T.S. for Brain Health - Social Prescribing as Diagnostic Practice for Dementia, Zoom, World Alzheimer's Day - Sept 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | On World Alzheimer's Day, our 'A.R.T.S. for Brain Health' launch coincides the review of Arts 4 Dementia's 2021 social prescribing conference in The Lancet Neurology this month, by Professors John Gallacher and Alistair Burns. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://arts4dementia.org.uk/2021/09/a4d-launches-social-prescribing-report-arts-to-preserve-brain-h... |
| Description | John presentation - 'Linkages to metrics of the built environment' UK BIOBANK HEALTH-RELATED LINKAGES WORKSHOP - May 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The aim of the workshop was to assess the scientific value and feasibility of linking to health related (but non-medical) data for the purposes of extending research into social sciences and environmental health. 16.40 - 16.55 Linkages to metrics of the built environment John Gallacher |
| Year(s) Of Engagement Activity | 2021 |
| Description | John presentation - Rosetrees Interdisciplinary Workshop on neurodegenerative diseases of the brain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Neurodegenerative diseases in the brain represent a wide range of different underlying pathologies with different clinical sequelae. Therapeutic interventions are currently relatively limited, reflecting the complexity of the diseases. Imaging with different, often combined, modalities (including CT, MRI, PET and SPECT) is a well-established clinical diagnostic tool, whilst imaging at a cellular and molecular level using animal models has also contributed significantly to our understanding of both the detailed anatomical structure and functional behaviour of the brain. Application of advanced statistical techniques and artificial intelligence has accelerated the extraction of detailed and clinically-useful information from images, though combining information from these different techniques across different temporal and spatial scales is challenging. Groups based in physics, mathematics and computational science are increasingly engaged in developing novel tools and techniques which may be applied to the brain and neurodegenerative diseases, including the use of network theory to develop simple models of brain function, applying the understanding of soft matter and polymer physics to the process of protein aggregation, exploring the role of liquid-liquid phase separation in Alzheimer's disease, and developing models of blood flow and mass transport in the brain using computational fluid dynamics. A single workshop in this wide-ranging and developing area will necessarily need to focus on a limited number of particular topics, though it is hoped that in so doing, the value of interdisciplinary approaches to other aspects of the field will be reinforced. The workshop will bring together researchers from the physical, biological and clinical sciences to focus on interdisciplinary approaches to the imaging of neurodegenerative diseases of the brain, including how multiscale imaging information may be combined with other biomarkers in order to better understand and model the extent, nature and impact of neurodegenerative disease. The organiser reported: I just wanted to thank you for making such outstanding contributions to what I hope you will agree was a really stimulating meeting today. The value of working across disciplines was evident with the compelling examples you shared and it was also clear that there are numerous opportunities to build new partnerships in future. I wanted to repeat that we would be very happy to consider applications for follow-on sandpits or w/shops and that the Physics of Life network will also be delighted to signpost the various collaborative platforms and networks. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.physicsoflife.org.uk/neurodegenerative-disease.html |
| Description | KCNI External Scientific Advisory Committee - Fall 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | As a Member of the Krembil Centre for Neuroinformatics External Scientific Advisory Committee, Prof John Gallacher has been invited to participate in this meeting. This meeting is schedule to give updates on Krembil Centre for Neuroinformatics and Brain Canada - Youth Platform. |
| Year(s) Of Engagement Activity | 2022 |
| Description | KCNI External Scientific Advisory Meeting - Spring 2022 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | As the Director of Dementias Platform UK, Prof John Gallacher was invited as an expert on brain health and dementias research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Keynote invited speaker, Genetics and epigenetics of mental disorders international conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote invited speaker, Genetics and epigenetics of mental disorders international conference, St Petersburg 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker at The University of Reading SIAM-IMA student chapter conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Keynote speaker at The University of Reading SIAM-IMA student chapter conference, Reading, UK. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote talk at UK DRI ECR Informatics symposium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at UK DRI ECR Informatics symposium: Learning from Machine Learning in genetics of brain disorders |
| Year(s) Of Engagement Activity | 2024 |
| Description | Lecture on "Introduction to Neuroimaging" at MRC CBU Course - Dr M Malpetti |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture on the "Introduction to Neuroimaging" course at the MRC Cognition and Brain Science Unit, University of Cambridge (Cambridge, 06/02/2023): "PET imaging" |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://imaging.mrc-cbu.cam.ac.uk/methods/IntroductionNeuroimagingLectures |
| Description | Lecture to MPhil Students in Basic and Translational Neuroscience - Dr M Malpetti |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture on the MPhil in Basic and Translational Neuroscience, University of Cambridge (Cambridge, 24/10/2022): "Dementia and neurodegenerative diseases: what have we learned from brain imaging?" |
| Year(s) Of Engagement Activity | 2022 |
| Description | LifeArc/HDR UK/DPUK MND Data Workshop (John Gallacher, 9/6/23) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended the MND Data Workshop and spoke on DPUK as a current example of an existing data structure. This workshop ultimately led to the ongoing HDR UK-led NIHR funding application The MND Data Catalyst. |
| Year(s) Of Engagement Activity | 2023 |
| Description | MEGUK Oral Presentation by Dr Amirhossein Jafarian (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave an oral presentation titled Multimodal Dynamic causal modelling |
| Year(s) Of Engagement Activity | 2021 |
| Description | MND Association local branch public engagement event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | MND Association visited Cardiff University DRI facilities, had lab tour, overview of MND work, had a Q&A with Cardiff researchers/clinicians. |
| Year(s) Of Engagement Activity | 2024 |
| Description | MRC 10 year Showcase |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | An academic afternoon sharing our latest findings and results of the research undertaken over the last 10 years of the centre. Followed by an evening panel event with Mike, James and Anita chaired by the VC and joined by Robin Buckle of MRC. |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC Integrative Epidemiology Unit Mtg 2: Initial Programmatic Assessment |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | John Gallacher has been invited as a committee member to participate in the quinquennial review (QQR) of the MRC Integrative Epidemiology Unit. |
| Year(s) Of Engagement Activity | 2022 |
| Description | MRC Traumatic Brain Injury platform |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | As the Director of Dementias Platform UK, Prof John Gallacher was invited to a meeting with Traumatic Brain Injury platform to discuss future funding for DPUK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Meeting Hammersmith Medicines Research (HMR) Limited and DPUK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | This was a meeting discuss the potential collaboration betweene Hammersmith Medicines Research (HMR) Limited and DPUK. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Mind over Chatter Podcast: Dementia |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | What causes dementia? And how do we diagnose and treat it? Is there anything we can do to stop ourselves from developing dementia? These are the crucial questions we'll be exploring with clinical neuropsychologist Barbara Sahakian, sociologist Richard Milne, and neurologist James Rowe. In this episode, we'll find out more about what dementia actually is, some surprising factors that increase a person's risk of developing dementia, and computer games that can actually help detect and diagnose dementia. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://podcasts.apple.com/gb/podcast/dementia-risks-diagnosis-and-prevention/id1542332564?i=1000549... |
| Description | Mini Linguistic State Examination (MLSE) Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation at Mini Linguistic State Examination (MLSE) workshop |
| Year(s) Of Engagement Activity | 2023 |
| Description | Mirror Article on Corticobasal Degeneration feat. Prof James B Rowe |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Retired teacher who walks to slow down her dementia eyes trek round coast of Wales.. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.mirror.co.uk/news/health/retired-teacher-who-walks-slow-29620344 |
| Description | Motor Neurone Disease Centre and DPUK potential collaboration |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a meeting on the potential collaboration between Motor Neurone Disease centre and Dementias Platform. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Multi-model analysis for dementia translation' at UK DRI Informatics Scoping Event (John Gallacher, 9/3/23, 10.00) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | A talk to around 100 individuals from UK DRI and its partners on translational analysis, which informed UK DRI's scoping of the UK Dementia informatics landscape. |
| Year(s) Of Engagement Activity | 2023 |
| Description | My Memory Clinic and Me |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented at an event titled My Memory Clinic and Me as part of the Cambridge Festival in March 2021. The Cambridge Memory Clinic provides assessment and management for a wide range of memory and cognitive disorders, for example, due to neurodegeneration (Alzheimer's disease, Mild Cognitive Impairment, Frontotemporal dementia, Dementia with Lewy Bodies) and more. A discussion was help about memory clinics in the context of dementia. How they can help, and what to expect - including their role in leading research that matters to patient care. Short presentations followed by a live Q&A session with consultant neurologists. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://ftd.neurology.cam.ac.uk/events/201cme-and-my-memory-clinic201d |
| Description | NEURONET Final Consortium Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 1 July, representatives of Neuronet's partner organisations and members of its Scientific Coordination Board (SCB) came together in Barcelona (Spain) to compile and evaluate the achievements of Neuronet at a final meeting. This meeting has also served as an opportunity to share and evaluate lessons learned. |
| Year(s) Of Engagement Activity | 2022 |
| Description | NEURONET Summit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | NEURONET has been running since 2019 to provide synergies across the 20+ projects in the current IMI neurodegeneration portfolio (please see www.imi-neuronet.org for more information). The Summit represents a particular ambition: to convene a high-level forum of selected project and opinion leaders to discuss priorities in neurodegeneration research over the next decade. Prof John Gallacher was invited as the Director of Dementias Platform UK and expert in dementias research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | National Advertising Campaign with Alzheimer's Research UK |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | National advertising campaign |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Neuro2024 (PSP/CBS symposium) - Dr Negin Holland (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral Presentation: Neuro2024 (PSP/CBS symposium) - October 2023; attendees over 400 Title: Title: Differential patterns of in vivo synaptic loss in relation to tau accumulation and grey matter atrophy, in amyloid negative vs. positive corticobasal syndrome. Poster Presentation Award received. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Neuroscience R&D Conference, talk on the privacy concerns of AI models in healthcare |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | For this conference, I gave a talk on the privacy risks in AI models trained on sensitive healthcare data and how these concerns can be mitigated. I also discussed ways in which DPUK is enabling the safe development of AI on our data. |
| Year(s) Of Engagement Activity | 2023 |
| Description | New DPUK animation |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | To mark the start of the second phase of DPUK, we commissioned a company called SciAni to produce a new animation outlining DPUK's key activities and how they are contributing to efforts to diagnose, treat and prevent dementia. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://youtu.be/RAKdHSjTVdE |
| Description | New DPUK website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | In 2021 DPUK's communications team lead the redevelopment of its website to ensure it provided a clear overview of DPUK's activities and would be as useful as possible for key audiences (eg study leaders, ECRs, industry representatives, dementia-interested public etc). Early feedback on the revamp has been positive, and further analysis will be undertaken this year. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dementiasplatform.uk/ |
| Description | News article on cognition research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.news-medical.net/news/20220110/Poor-cognition-may-be-part-of-normality-in-older-age-rese... |
| Description | News article on cognition research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.healthline.com/health-news/dementia-can-be-detected-early |
| Description | News article on how cognitive frailty may be part of normal aging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talker.news/2022/01/11/elderly-people-can-show-signs-of-mental-decline-without-getting-demen... |
| Description | News article on how cognitive frailty may be part of normal aging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.thehealthnewsexpress.com/alzheimer_disease_dementia/cognitive-decline-not-always-a-sign-... |
| Description | News article on how cognitive frailty may be part of normal aging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://scitechdaily.com/cognitive-decline-is-not-always-a-sign-of-alzheimers-disease/ |
| Description | News article on how cognitive frailty may be part of normal aging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.medicalnewstoday.com/articles/predicting-alzheimers-risk-why-cognitive-testing-alone-may... |
| Description | News article on how cognitive frailty may be part of normal aging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.medica-tradefair.com/en/News/News_from_the_Editors/Cognitive_decline_not_always_a_sign_o... |
| Description | News article on how cognitive frailty may be part of normal aging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://allmymedicine.com/health-news/predicting-alzheimers-risk-how-useful-are-cognitive-tests/ |
| Description | News article on how cognitive frailty may be part of normal aging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The recent publication titled "Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease" was featured on a health website suggesting that poor cognition may be part of normality in older age. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://en.brinkwire.com/health/alzheimers-disease-isnt-always-caused-by-cognitive-decline/ |
| Description | OLS/UKRI cross sector specialist workshop/committee for new national dementia initiative strategy for 2022 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Meeting with No.10 officials on UK Dementia landscape. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | OSL Analysis Workshop (24-25 April, 2023), OHBA. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | We organised a workshop to teach peers and other researchers about the analysis of MEG and EEG data. This included theoretical lectures on physiology and methods, as well as hands-on practice using the open-source analysis software developed by our group. 30 researchers (including, MSc/PhD students, postdocs and PI's) attended the workshop, and more than 80% expected they were going to use the software in their own work in the future. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://osf.io/zxb6c/ |
| Description | Oral Presentation @ ADPD Barcelona 20222- Dr M Malpetti |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "In vivo PET imaging of inflammation as a prognostic tool in frontotemporal dementia" - ADPD conference (Barcelona, 03/2022) |
| Year(s) Of Engagement Activity | 2022 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Serum cytokines across dementias: fingerprinting inflammation" - Alzheimer's & Parkinson's Diseases Conference (Gothenburg, 03/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Inflammation in dementia: a target for new treatments?" - NIAS Expert Workshop For Women in Science 2023 (Amsterdam, 13/07/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | • "Brain inflammation in dementia: what can we learn from PET imaging and blood markers?" - CUBRIC Seminar Series at the Cardiff University Brain Imaging Center (Cardiff, 09/10/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "From brain scans to blood tests - multidisciplinary progress on inflammation in dementia" - Cambridge Neuroscience Symposium 2023 (Cambridge, 26/09/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Peripheral and central markers of inflammation in frontotemporal dementia and related conditions" - Frontotemporal Dementia UK meeting (London, UK, 12/05/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Inflammation markers in prodrome and prediction of dementia" - Interdisciplinary Dementia and Aging Centre (iDEAC) at University Hospital Southampton NHS Foundation Trust (Southampton, UK, 23/05/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | • "Novel PET Tracers for Dementia" - SINdem4Juniors: 11th Winter Seminar on Dementia and Neurodegenerative Disorders (Brixen, 16/02/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Synaptic biomarkers in FTD: PET imaging in sporadic cases" - Frontotemporal Dementia UK meeting (London, UK, 12/05/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Post mortem validation of in vivo PET imaging: test case of inflammation in progressive supranuclear palsy" - Dementias Platform UK Translation 2023 meeting (London, UK - 03/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation on MEG Data Analysis @ BIOMAG2022 - Dr Amirhossein Jafarain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Jafarain gave a technical talk in the flagship of MEG data analysis conferences BIOMAG2022. The Title of the oral presentation was : Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://biomag2020.org/programme/ |
| Description | Oral Presentation: International Society for FTD Dr Negin Holland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Title: 'Synaptic loss over time is related to worsening symptoms, in people with progressive supranuclear palsy and corticobasal syndrome.' |
| Year(s) Of Engagement Activity | 2022 |
| Description | Oral Presentation: Translational neuropsychiatry @ BIOMAG 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title "Translational neuropsychiatry" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Organisation of training workshop for early career researchers of the DEMON network (International network for data science and AI applied to dementia) "Combining imaging data using machine learning" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The educational workshop 'Combining imaging data using machine learning' was held on 14-15 September 2021 and organised by the early career researchers and imaging working groups of the DEMON (International network for data science and AI applied to dementia) network (https://demondementia.com/). This two-day workshop provided theoretical learning and practical training for over 120 early career researchers on machine learning approaches to combine datasets (Day 1) and modalities (Day 2) in the context of dementia research. The event consisted of two talks each day, followed by practical tutorials (three on Day 1 and two on Day 2) led by skilled facilitators and experts of the field. The main goal of the workshop was to inform early career researchers with experience or interest in using imaging data about innovative machine learning approaches and algorithms that may be used to characterise the structure and function of the nervous system, identify meaningful patterns and support clinical decisions in dementia. The organising committee was also formed by early career researchers: Ludovica Griffanti (University of Oxford), Faeze Heidari (Iran University of Medical Sciences), Luiza Machado (Universidade Federal do Rio Grande do Sul), Maura Malpetti (University of Cambridge) and Henry Musto (Goldsmiths University). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Organization for Human Brain Mapping (OHBM) 29th annual meeting, Jul 2023, Montreal, Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Automated QC of T1w scans for clinical datasets: methods comparison & design of a QC classifier |
| Year(s) Of Engagement Activity | 2023 |
| Description | PPIE Dementia Group Event at Peckover House, Wisbech (Rowe Group) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Peckover House, Wisbech Lucy Bowns, Dr Maura Malpetti, Rebecca Williams Observations/thoughts/comments • Peckover House has been given funding to provide this dementia group. Currently it is the only National Trust property to offer this. It is hoped that it might expand to another five sites, pending ongoing funding. |
| Year(s) Of Engagement Activity | 2023 |
| Description | PROSPECT study and DPUK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a meeting discussing the potential collaboration between PROSPECT study and DPUK regarding metadata and data access. |
| Year(s) Of Engagement Activity | 2022 |
| Description | PSP Association "Ask the Doctor" with Negin Holland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | 'Ask the Dr' event for newly diagnosed patients with PSP and CBD. In this 2 hour long session, Dr Holland spoke with newly diagnosed patients and their carers about what PSP/CBD is, current treatments, and management. A question-and-answer session was also held for this group. |
| Year(s) Of Engagement Activity | 2022 |
| Description | PSP Association's Carers' symposium at Windsor - Dr Negin Holland (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research talk given to the PSP Association's Carers' symposium at Windsor- July 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster at AAIC Conference July 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Emily Baker, PhD Student (Supervisor - Prof Valentina Escott-Price) Poster at AAIC Conference - July 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Poster at ASHG Conference - October 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Emily Baker, PhD Student (Supervisor - Prof Valentina Escott-Price) Poster at ASHG Conference - October 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Poster presentation at Cambridge CNS Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented a poster on the results from one of our public workshops on the risks of AI in healthcare. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at the ARUK Thames Valley Network Early Career Researcher Day, 19 January, 2024 (Dr. Benjamin Tari) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A poster presentation defining a proposed study investigating the utility of passive exercise as a treatment for traumatic brain injury. Questions and discussion may lead to potential collaborations in future. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Poster presentation at the Annual Meeting of the British Association for Cognitive Neuroscience in Cardiff, UK (Dr M Perquin - Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation at the Annual Meeting of the British Association for Cognitive Neuroscience in Cardiff, UK. The target audience of BACN is anyone interested in cognitive neuroscience. Attendence was approx. 200-250. Perquin, M.N., Daghlian, M., Perry, G., Singh, K., & Bompas, A. (2023). Multi-modal predictions of objective RT variability and subjective attentional state ratings. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at the British Neuroscience Association |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This poster presentation presented some results from my unsupervised AI stratification work to identify neuroimaging biomarkers of disease progression in major depressive disorder. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at the Department of Psychiatry Away Day, 13 June, 2023 (Dr. Benjamin Tari) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation describing results of an analysis investigating the influence of education on cognitive decline. Questions and feedback were incorporated into subsequent study designs. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation: DPUK Translation 2023, March 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Automated QC of T1w scans for clinical datasets: methods comparison and design of a quality prediction classifier |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation: MRI together conference 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Comparison of automated and manual quality measures for T1w brain MRI scans from clinical population |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at MRI together conference Global workshop on open, reproducible, and inclusive MR research (Dr Gaurav V Bhalerao) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Gaurav V Bhalerao - Presented abstract as first author, "Comparison of automated and manual quality measures for T1w brain MRI scans from clinical population", MRI together conference Global workshop on open, reproducible, and inclusive MR research - 5th - 8th Dec 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=OKBk4Jhs4bU |
| Description | Presentation to the general public on the DRI program at the DRI launch in Cardiff |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I have presented on my DRI program "Bioinformatics and Functional genomics" to patients, their families, journalists and other invited guests from the general public at the DRI launch in Cardiff, October 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presented at International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders Conference in Gothenburg, Sweden |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | There are three presentations on the following research work: 1. Early adversity 2. Hearing aid use 3. DPUK Data Portal |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://adpd2023.kenes.com/ |
| Description | Presented at International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders Conference in Lisbon, Portugal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | There were 4 presentations/talks delivered at the AP/PD conference in 2024. The titles of all presentations are the following: 1. REJECTION IN CHILDHOOD AND THE LONG-TERM IMPACT ON COGNITION AND DEPRESSION 2. DEMOCRATIZING DATA ACCESS FOR ADPD RESEARCHERS: THE DEMENTIAS PLATFORM UK (DPUK) DATA PORTAL 3. ART WORKSHOPS FOR CULTURAL DIVERSITY IN ADPD RESEARCH AND CARER SUPPORT 4. DEMOCRATISING TRAINING OPPORTUNITIES FOR DEMENTIA RESEARCHERS AND ANALYSTS . |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://adpd.kenes.com/scientific-program/ |
| Description | Press briefing (SMC/ARUK) - Invited on hearing loss and hearing aid use |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Invited press briefing - modifiable risk factors for dementia - 28 global reporters for international press coverage and BBC |
| Year(s) Of Engagement Activity | 2023 |
| Description | Press on hearing aid at ARUK conference |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Press on hearing aid. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Press release - IXICO announcing their committed partnership to DPUK as it enters its second phase - Feb 2022 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | IXICO will be an industry member and stakeholder in the DPUK partner forum, working alongside 13 academic partners with expertise in dementia and big data research such as University of Oxford, Cardiff University, University of Cambridge and University of Edinburgh as well as pharma companies active in dementia research such as AstraZeneca, GlaxoSmithKline, Janssen Pharmaceutica NV and Araclon Biotech. IXICO wanted to show they were dedicated to delivering insights in neuroscience. Their purpose is to advance medicine and human health by turning data into clinically meaningful information, providing valuable new insights in neuroscience and their goal is to be a leading proponent of artificial intelligence in medical image analysis. They will achieve this by developing and deploying breakthrough data analytics, at scale, through our remote access technology platform, to improve the return on investment in drug development and reduce risk and uncertainty in clinical trials for our pharmaceutical clients. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ixico.com/news-and-resources/press-releases/engagement-in-big-data-research-dementia-collabo... |
| Description | Press release on dementia and hearing loss paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A press release on a new paper co-funded by DPUK and involving DPUK scientist Dr Sarah Bauermeister was picked up widely in national and local print, online and broadcast media. Highlights included an article in the Sun newspaper (link below). The paper outlined the links between mild cognitive impairment and hearing aid use. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.thesun.co.uk/health/17747984/how-halve-risk-developing-dementia-hearing-aids/ |
| Description | Professor John Gallacher LinkedIn profile |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Establishing a LinkedIn profile for John has ensured that DPUK's reach goes wider and reinforces John's influence as a expert and leader in the field of dementia. John has over 300 connections, and had posts related to DPUK receive views of over 700. Older contacts of DPUK have gotten in touch with John to reconnect and investigate collaboration again. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.linkedin.com/in/john-gallacher-phd-afbpss-cpsychol-ffph-b86b08210/ |
| Description | Professor John Gallacher Twitter profile - @John_ejg |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Created a social media presence on Twitter for Prof John Gallacher. This has allowed greater reach of DPUK activities and established John as a knowledgeable and respected leader in the field with potential for impact |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://twitter.com/John_ejg |
| Description | Psychiatry Meeting on Drug Treatments in Old Age |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title "Frontotemporal Dementia" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Reinvigorating health registries during COVID for rapid policy analyses. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Reinvigorating health registries during COVID for rapid policy analyses. Norwegian Health Registry Conference, Oslo, 16/11/21. Helse- og Kvalitetsregisterkonferansen 2021 | Keynote presentation. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.registerkonferansen.no/ |
| Description | Report/transcript of discussion - World Dementia Council virtual summit 2021 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Session 1: Data sharing Transcript from the WDC Summit 2021 session looking at data sharing for dementia research, assessing how we can maximise the benefits of big data developing global cohorts, the comparability and sharing of data, and how we can overcome regulatory barriers. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://worlddementiacouncil.org/sites/default/files/2022-02/Summit%202021%20-%20Transcript%20-%20Da... |
| Description | Research proposal presentation at the Department of Psychiatry's Research Meeting Series, 3 December, 2023 (Dr. Benjamin Tari) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | A grant proposal presentation describing an international collaborative effort to define the clinical utility of passive exercise as a treatment for traumatic brain injury. Immediate discussion points were incorporated into the proposal. Subsequent discussions followed with individuals at Oxford University and international colleagues to expand this line of research. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Research proposal presentation at the Department of Psychiatry's Research Meeting Series, 3 May, 2023 (Dr. Benjamin Tari) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | An invited lecture describing proposed fellowship applications. The presentation was primarily focussed on mapping and understanding modifiable risk factors of dementia. Questions and discussions followed, and feedback was incorporated into the subsequent applications. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Roundtable on Motor Neurone Disease (MND) research |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | As the director of Dementias Platform UK, Prof John Gallacher was invited to meet with the Minister of Health on the discussion on Motor Neurone Disease (MND) research. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Rowe Group Member Dr NEGIN HOLLAND gave talk: Synaptic imaging in dementia and neurodegenerative disease @ Cambridge Imaging Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | This is a meeting of users and experts within the Cambridge NHS and academic community. Results and data are shared as well as new perspectives and applications for novel imaging methods. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.mrc-cbu.cam.ac.uk/wp-content/uploads/2021/05/Programme-Cambridge-Imaging-Festival-2021.p... |
| Description | SAIL External Advisory Board meeting and Dinner |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a meeting for the Scientific External Advisory Board to discuss SAIL Update and Into the Future in preparation for the Board report. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Scientific Review of the MRC Integrative Epidemiology Unit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof John Gallacher was asked whether they would be willing to serve as a member of the expert Subcommittee for the MRC Population and Systems Medicine Board (PSMB), which will assess the past progress and future proposals of the MRC Integrative Epidemiology Unit (IEU), University of Bristol. The MRC periodically carries out scientific reviews of its Units in order to be assured of: • the overall quality, impact, and productivity (past and future potential) of the Unit's research programmes and the Unit as a whole; • the distinctive contribution of the Unit to MRC's research portfolio, strategic aims and the wider research effort; • the added value from the Unit structure and that this is the most appropriate future form of support to meet MRC's needs; • the appropriateness of resources for the research to be undertaken. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Scottish Parliament Invited Speaker 'Brain Health' |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited to speak at Scottish Parliament to a cross party group on the subject of Brain Health research in Scotland. Specifically asked to describe the successes of initiatives such as DPUK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Session Chair: Cognition at Brain 2022 Conference |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session on congnition with research presentations on: 1. Transdiagnostic approaches to cognitive disorders and their underlying brain pathology 2. Dissociable brain microstructural diffusivity changes underlying visual short -term memory deficits in Alzheimer's disease. 3. Bayesian Brains and the origin of functional disorders. 4. 'Socioeconomic status impacts cognitive and socioemotional processes in healthy ageing: evidence from Latin American older adults. 5. Noradrenergic treatment of cognitive disorders: big news from the blue spot. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://thebrainconference.co.uk/brain-conference-schedule/ |
| Description | Software Carpentries workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | About 30 students and postgraduates attended the workshop |
| Year(s) Of Engagement Activity | 2024 |
| Description | Specialist PSP Sub-group @ Movement Disorder Society International Conference: UHF 7T Imaging |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Expert panel meeting on imaging and Progressive supranuclear palsy. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk at - Alzheimer's Association International Conference 2021, Dr Maura Malpetti |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia" - Alzheimer's Association International Conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk at Genetic FTD Meeting, Italy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International conference |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk by Dr M Malpetti at (ISTAART) Scientific Meeting: What have we learnt from PET in FTD in the last 10 years? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "What have we learnt from PET in FTD in the last 10 years" - ISTAART FTD and Neuroimaging PIAs webinar: An update on neuroimaging in frontotemporal dementia (virtual event) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk by Dr M Malpetti at Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Scientific Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title: Neuroinflammation in medial temporal regions predicts cognitive decline in dementia with Lewy bodies |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk by Dr M Malpetti at Clinical Neurosciences Away Day, Cambridge University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title: Neuroinflammation in frontotemporal lobar degeneration: a target for treatment? |
| Year(s) Of Engagement Activity | 2021 |
| Description | Telegraph on Florence Pugh visit to University of Cambridge with Race Against Dementia - Rowe Group |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Florence Pugh: 'Ever since I posted about dementia, so many people have reached out to me' When she's not busy with her hectic Hollywood schedule, the star is using her voice - and huge following - to support Race Against Dementia |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.telegraph.co.uk/christmas/2024/01/24/florence-pugh-oppenheimer-race-against-dementia-cha... |
| Description | Temporal structure in sensorimotor variability is a reliable trait, but is unrelated to attentional state measures. (Dr M Perquin - Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • Oral talk at the Annual Meeting of the Society for Mathematical Psychology in Amsterdam, the Netherlands. The target audience of MathPsych is those interested in mathematical and computational theories of human cognition. Attendence was approx. 400-500. |
| Year(s) Of Engagement Activity | 2023 |
| Description | The DPUK Data Portal and big data analytics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral presentation: The DPUK Data Portal and big data analytics |
| Year(s) Of Engagement Activity | 2022 |
| Description | The Dementia UK Ecosystem and Innovations in biomarkers @ Cambridge Memory Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The aim of this Cambridge-wide memory group is to encourage interaction between the many local labs working on the psychology/neuroscience of short- and long-term memory, both human and non-human. The talk given to this audience gave an overview of the key UK institutions and partners involved in dementia research aimed at identifying new biomarkers for plausibale clinical translation. |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.memlab.psychol.cam.ac.uk/CAMM/index.html |
| Description | The Economist Podcast interview - John Gallacher and his reaction to the FDA's approval of aducanumab to treat Alzheimer's disease - 2021 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | John was interviewed by The Economist podcast when the FDA granted conditional approval to a drug for the treatment of Alzheimer's disease, called aducanumab. His podcast, and subsequent DPUK subjects broadcasting the piece, garnered strong reaction. It established John and DPUK further as an expert in the dementia field. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.economist.com/podcasts/2021/06/08/a-flicker-of-light-for-the-treatment-of-alzheimers?utm... |
| Description | Tim Sandhu Talk @ CamBrain Cambridge Neuroscience Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Oral presentation to junior researchers or those interested in neuroscience. Title "Learning under uncertainty in autism and anxiety" |
| Year(s) Of Engagement Activity | 2021 |
| Description | Traumatic Brain Injury platform - Reporter Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | As the Director of \Dementias Platform UK, Prof John Gallacher was invited to join the Traumatic Brain Injury platform Reporter Meeting for the discussion of writing out a grant proposal for DPUK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK Biobank Dementia Group Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor John Gallacher has been invited as an expert of dementias research and discuss how UK Biobank can be more valuable for dementia research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | UK Biobank Dementia Working Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | As Director of Dementias Platform UK, Prof John Gallacher was invited to UK Biobank Dementia Working Group meeting to discuss future Uk Biobank Dementias strategies. |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK Biobank Dementia Working Group (John Gallacher, 16/1/24, 14.00) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher attended this working group. DPUK continues to work closely with UK Biobank and to host its data in the Data Portal. |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK Biobank Dementia Working Group (John Gallacher, 5/9/23) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | John Gallacher attended this meeting of the UK Biobank Dementia Working Group. DPUK continues to work closely with UK Biobank, and host its data on the Data Portal. |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK Biobank Scientific Conference 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | UK Biobank hosted this Scientific Conference as a HYBRID event on Tuesday 21st of June 2022. As the world's most comprehensive biomedical database UK Biobank are incredibly proud of the unique scientific discoveries being generated through use of the resource, with thanks to the ongoing commitment of the participants, funders, and the research community. The day included updates of the latest research findings and future ambitions in the areas of genomics, ageing and environmental health research. Professor John Gallacher has been invited to chair a session at the Conference on Transforming Health in Older Age. Prof John Gallacher was invited as the Director of Dementias Platform UK and expert in dementias research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | UK Biobank Strategic Oversight Committee Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor John Gallacher was invited as a member of the UK Biokbank strategic Oversight Committee and the Director of DPUK. |
| Year(s) Of Engagement Activity | 2022 |
| Description | UK Biobank Winter Scientific Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dementia session at the UK Biobank Winter Scientific Conference |
| Year(s) Of Engagement Activity | 2022 |
| Description | UK Biobank Winter Scientific Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof John Gallacher attended the UK Biobank Winter Scientific Conference as a member of the UK Biobank subcommittee. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ukbiobank.ac.uk/media/sc5fmgvg/copy-of-winter-conference-twitter-banner-facebook-cover-3... |
| Description | UK DRI & DPUK Workshop Experimental models of vascular disease and cognitive impairment |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This workshop, organised jointly by DPUK and UK DRI, assessed the latest developments in animal models, and their relevance and contribution to the understanding of mechanisms of cerebral microvascular disease in humans. Talks and discussions focused on vascular biology, neurovascular coupling, blood-brain barrier function, and neuroinflammation, as well as issues such as translation and reproducibility. The workshop featured keynote talks from Professor Denis Vivien and Professor Claire Gibson, and roundtable discussion with leaders in the field. Other speakers included Dr Paresh Malhotra, Dr Frances Wiseman and Professor Stuart Allan. One particular aim of the workshop was to increase early-career researcher interest in the field. A dedicated ECR morning session on 17 March focused on how well preclinical models recapitulate the clinical phenotypes. Outputs from the event will include a proceedings paper and the establishment of a number of working groups and grant applications. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiasplatform.uk/research-hub/experimental-medicine-incubator/vascular-health/vascul... |
| Description | UK DRI Connectome 2023 (John Gallacher, 2-4/10/23) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | John Gallacher was in attendance at this event. He networked to establish DPUK in the UK dementias research landscape with conference attendees. DPUK continues to discuss collaboration with UK DRI. |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK DRI Dinner at Royal Society |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Dinner at the Royal Society on Wednesday 25thMay 2022, to discuss the institute's innovations with a small group of stakeholders. The evening will include a scientific presentation from the UK DRI's Director, Professor Bart De Strooper. This was a critical time for dementia research. The UK's response to the COVID-19 pandemic has demonstrated the power of our life sciences and health infrastructure, and we have seen extraordinary achievements born of brilliant science and large-scale collaboration. Now is the time to apply this mission-led approach to dementia, which is our greatest - and growing - healthcare challenge. Prof John Gallacher was invited to present on the significant scientific breakthroughs, with the power to transform the dementia research landscape of DPUK. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Video presentation on Youtube |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a video abstract of a recently published paper |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/channel/UClJJHH2xKQk8uZTC7-mJICg |
| Description | Visit from Prof. Inhee Mook-Jung (John Gallacher, 11/3/24) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | John hosted Prof. Inhee Mook-Jung, Director of the KDRC (Seoul), to discuss future collaboration with DPUK following on from the 2021 Memorandum of Understanding. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Voice of Islam - Dementia |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussion on voice of islam broadcast on the theme of dementia to raise public awareness, especially within the Muslim community. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Voice of Islam Radio - Dementia Theme |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Voice of Islam broadcast discussion on dementia. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Wellcome Trust workshop on Sustainability in High Performance Computing |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a workshop to bring together researchers to discuss the environmental impact of high-performance computing research and how this can be improved. During this workshop, I discussed ways that DPUK data portal is helping to create more sustainable use of the HPC. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Wellcome Trust workshop on barriers to the clinical implementation of computational models |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This workshop was to discuss the challenges of implementing computational models into clinical practice. This addressed issues such as data sharing, diversity in data collections and robustness in models. |
| Year(s) Of Engagement Activity | 2023 |
| Description | What's new in Frontotemporal Dementia - Sri Lankan Neurology Association |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to Sri Lanka Neurology association "What's new in Frontotemporal Dementia?" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Within-person reaction time variability as a measure of the underlying mechanisms shared by dementia and ADHD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented at the AAIC conference on August 1 2022 Authors: Elen Golightly, Emma Squires, Sarah Bauermeister There is evidence that selective neurodevelopmental disorders have numerous neurodiverse symptoms that parallel dementia and cognitive decline, such as executive dysfunction, memory problems and cognitive impairment. These are associated with slower reaction time and increased reaction time variability. However, there is a paucity of research into the effects of ageing, and subsequently, cognitive ageing on the neurodiverse population as many studies focus on early development. Our aim is to highlight the importance of focusing on sub-populations within large cohort datasets as well as using sensitive measures to understand the mechanistic pathways underpinning associations where they exist. In this preliminary study we look in particular at the link of increased within-person reaction time variability (WP RTV) and Attention Deficit Hyperactivity Disorder (ADHD). It is well established that children with neurodevelopmental disorders have increased WP RTV, as do older people experiencing cognitive decline and dementia (e.g., Bauermeister & Bunce, 2015). Our objective is to investigate this measure as a sensitive measure of cognitive change, in comparison to the more commonly focused on reaction time. Method: Using data Brain Health Registry (BHR) (M=58.76, SD13.20 years baseline) we conducted our analysis on the Dementias Platform UK (DPUK) Data Portal. In this preliminary work, we investigate neurodiversity and dementia status and association with reaction time and WP RTV on 19,272 participants using multiple regression. Age and education are included as covariates. We assessed three separate measures of reaction extracted from the Identification test (IDN), the Detection test (DET) and the One-Card Learning (OCL) test. Result: For all three tasks, WP RTV was significantly higher (more variable) in those with dementia, and those with a current diagnosis of ADHD (b=.01; and b=.01 ps<.01) whereas reaction time was significantly slower in only the OCL task in those with dementia, and those with a current diagnosis of ADHD. Conclusion: Our conclusions are that the mechanistic pathways underlying WP RTV may be common across dementia and ADHD, and that WP RTV may be a more sensitive measure of underlying shared mechanisms than reaction time. Our future ongoing work will investigate this in further cohorts across additional tasks. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://alz.confex.com/alz/2022/meetingapp.cgi/Paper/67783 |
| Description | World Alzheimer's Month social post |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | For World Alzheimer's Month social posts we aimed to highlight examples of WHAT is being studied - and WHY it might make a difference to our prevention, risk reduction or better understanding of identifying risk around dementia in the theme is 'Risk and Risk reduction'. We developed a post about the Dementias Platform UK Data Portal, which is a data repository bringing together a wide range of cohorts with genetic and phenotypic data. We aggregated and harmonized genetic data from research groups across the UK and internationally, allowing the wider research community to access and process data at scale and pace, ensuring compliance with the permissions and ethics of individual studies. DPUK now provides a platform for comprehensive genetic analyses of the mixed population for both predictive utility and for clinical trials. |
| Year(s) Of Engagement Activity | 2023 |
| Description | oral presentation at DPUK Neuroimaging symposium (October 24th, 2023), Title: MEG activity differences from healthy aging in MCI and AD during rest. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation at DPUK Neuroimaging symposium (October 24th, 2023), Title: MEG activity differences from healthy aging in MCI and AD during rest. ~40 attendees. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://neuroimagingsymposium2023.com/ |
| Description | oral presentation at MEG UKI (October 27-28, 2023), Dublin, Ireland, titled: Large-scale cortical networks are organized in structured cycles |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation given at MEG UKI on October 27, 2023, Dublin, Ireland, titled: Large-scale cortical networks are organized in structured cycles. ~150 attendees conference wide. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://meguk.ac.uk/meg-uki-2023-conference/ |
| Description | poster presentation at MEG UKI (Oct 27-28), Dublin, Ireland, titled: Cyclical evolution of functional brain networks in rest. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presented by Mats Van Es at MEG UKI. ~150 attendees conference wide. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ohbm-schedule-2023.my.canva.site/ |
| Description | poster presentation at OHBM Conference 2023 (July 22-26), Montreal, Canada, titled: Characterizing oscillatory phase in human memory replay. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation given by Mats Van Es at OHBM conference 2023 titled: Characterizing oscillatory phase in human memory replay. ~3000 attendees conference wide. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ohbm-schedule-2023.my.canva.site/ |
| Description | poster presentation at OHBM Conference 2023 (July 22-26), Montreal, Canada, titled: Cyclical evolution of functional brain networks in rest. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presented by Mats Van Es at OHBM conference to conference attendees. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ohbm-schedule-2023.my.canva.site/ |
| Description | poster presentation at the Alzheimer's Association International Conference (AAIC) 2023, Amsterdam, Netherlands, July 2023. (Dr Ludovica Griffanti) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster titled "Who benefits from MRI in memory clinics? A clinical and research perspective from the Oxford Brain Health Clinic." |
| Year(s) Of Engagement Activity | 2023 |
| Description | the UK Pharmacogenetics and Stratified Medicine Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presenter at the UK Pharmacogenetics and Stratified Medicine Network Workshop |
| Year(s) Of Engagement Activity | 2021 |