Reprogramming the epigenome for stem cells and in ageing

Lead Research Organisation: University of Cambridge
Department Name: Plant Sciences

Abstract

Epigenetic information in the genome is important for normal development and its deregulation can be associated with various diseases. Epigenetic information is generally stable in differentiated cells in the adult organism, though it degrades during ageing. However in germ cells, early embryos, naïve embryonic stem cells and iPS cells genome-wide reprogramming of epigenetic information takes place. Epigenetic reprogramming is associated with the return of the genome to pluripotency or potentially totipotency, the erasure of epimutations, resetting parental imprints, and possibly the repression of retrotransposons in the germline. Epigenetic reprogramming is also critical for experimental reprogramming such as cloning by nuclear transfer, cell fusion, and iPS cell generation. Erasure of epigenetic information in the germ line is incomplete however and this may result in transgenerational epigenetic inheritance. Single cell DNA methylation sequencing has also revealed substantial epigenetic heterogeneity between cells, which may be associated with transcriptional and functional diversification of cells during development or ageing. Predictable epigenetic changes occur during the ageing process raising the question of whether there is an epigenetic programme that might underlie aspects of ageing and functional decline.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011194/1 01/10/2015 30/09/2023
1645504 Studentship BB/M011194/1 01/10/2015 30/09/2019 Celia Alda Catalinas
 
Description School's day Babraham Institute 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Public engagement activities prepared for GCSE and A level students, including hands-on activities, bioinformatic analysis and career dicussions and advice.
Year(s) Of Engagement Activity 2016,2017