The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource

Lead Research Organisation: University of Bristol

Abstract

Between April 1991 and December 1992 we enrolled >14000 pregnant women in ALSPAC resulting in 14062 live births. Mothers, fathers, children and now children of the children from this recruitment have been followed up at multiple timepoints and a wide variety of samples, exposure and outcome measures collected.
Our mission is to ensure ALSPAC remains the premier multi-generational birth cohort offering unrivalled access to data and samples. We will look after the existing samples and data, improve visibility and access to the existing resource, maximise the connection of administrative data and continue collecting new data and samples.
Maintaining such a valuable UK resource will enable research uniquely equipped to follow changes in health and well-being across the lifespan, what affects this, how certain factors work across generations, and how changes in society affect the health and well-being of families going through similar events 30 years apart."

Technical Summary

ALSPAC is a multi-generation (G0/G1/G2), prospective cohort based in the UK [1-4] (supplementary information, Figure 1). This proposal seeks support to:
- Maintain the existing samples and data resources.
- Enhance visibility and access to data and samples.
- Maximise linkage opportunities through broad and innovative use of administrative records.
- Expand the resource by maximising recruitment and retention, and collecting new data and
samples on original parents (G0), index participants (G1) and the next generation (G2).
Work will be delivered via an efficient operational and governance infrastructure. We will deploy a combination of face-to-face assessment, biosample collection and analysis, remote data collection and administrative record linkage where the value of this activity is substantially enhanced by existing resources. All proposed work has been designed according to the overarching principles of (i) scientific utility and (ii) engagement/recruitment/retention. Study activities draw on experience from previous ALSPAC activity and consultation with participants and academics through bespoke workshops. Scientific focus reflects ALSPAC strengths and our target science areas, namely: The antecedents of cardiometabolic/cognitive/mental health, cross-generation contributions to health and era specific contributions to health, well-being and society."

Publications

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