The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019

Lead Research Organisation: Wellcome Trust
Department Name: UNLISTED

Abstract

For over 20 years Children of the 90s (or ALSPAC) has charted the health of 14,500 parents and
children. Now in its third decade it has started to study the next generation, the children of the
Children of the 90s. The study is unequalled by other population studies because of the breadth
and depth of information it holds on participants from before birth over 20 years ago through to the
present day. It is internationally renowned and used by researchers worldwide. The data allow
researchers to study key periods of development, how certain conditions develop and change over
time and are passed (or not) from one generation to the next, and how health is affected by the
interplay between genes and other factors like smoking, where people live and the job they do.
Our goals are to ensure the resource remains sustainable and open to researchers to use, and
that participants remain engaged. We will continue to gather information from the original children
through clinical assessments, questionnaires and record linkage, and will be recruiting and
gathering data on the children of the children as well as merging genetic data and enhancing research in the exciting new field of epigenomics.

Technical Summary

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective cohort study with
unprecedented scope and detail of information on thousands of people from before birth through
to early adulthood, on their parents and now on their children. It is an internationally valued
resource at the forefront of population-based research. ALSPAC allows the investigation of
developmental trajectories marking critical periods in human life, the genetic and epigenetic
factors contributing to health and disease and the environmental exposures which form the context
within which these processes act. As ALSPAC participants enter adulthood and start having
children, the study's potential to contribute to scientific discovery is expanding, giving a greater
capacity to explore links between current and future health and the intergenerational components
of health and disease. ALSPAC is unequivocally the richest open-access epidemiological resource
in the world. Our goals are to ensure that ALSPAC (i) is sustained, (ii) has participation maximised
and (iii) is enhanced. These goals will be delivered by follow-up of the original cohort through clinic
assessment, questionnaires and record linkage, data collection on their children, consolidation of
GWAS data on all participants and the development of epigenomics research.

Organisations

Publications

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Abdulkadir M (2022) Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores. in European eating disorders review : the journal of the Eating Disorders Association

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Abdulkadir M (2023) Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

 
Title Creative Reactions 2018 
Description Creative Reactions is an art exhibition associated with the national Pint of Science festival. Approximately 20 researchers using ALSPAC data were paired with local Bristol artists who produced an artwork based upon their research. The exhibition was held from 11-22 May 2018. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2018 
Impact Artworks were viewed and seen by the general public as well as the scientific community. Local radio, online and print media covered the exhibition. 
URL https://pintofscience.co.uk/event/creative-reactions-bristol-launch
 
Title Creative Reactions- Kayleigh Easey 
Description Collaboration with an artist to produce a piece of artwork that summarises my research on the effects of maternal and paternal drinking in pregnancy on offspring depression. 
Type Of Art Artwork 
Year Produced 2018 
Impact The artwork is to be displayed in an exhibition in Bristol, involved with Pint of Science. There is to be an opening event that is widely advertised to the public. This work will allow scientists to share with the public their research and the implications it may have. 
URL https://pintofscience.co.uk/events/bristol
 
Title Data visualisation images on display at We The Curious's Project 'What If' exhibition 2021 
Description Researchers using ALSPAC data provided imagery for the Open Science lab at We The Curious, Bristol's science centre. Tom Gaunt, Matthew Lee & others provided images to exhibit and create conversations about data collection in ALSPAC. 
Type Of Art Artwork 
Year Produced 2021 
Impact Created opportunities for discussion about population health science in a public space. 
URL https://www.youtube.com/watch?v=TdiOA7Aj3dE
 
Title Researcher videos for social media & website 
Description A series of video interviews with researchers and collaborators using ALSPAC data. Designed to share the findings and nature of work conducted with a lay audience. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact Widening awareness of research impact among core audiences - public, participants, collaborators and charities/third parties. It also provides an opportunity for researchers to thank participants and engage them in future participation with the study. 
URL http://www.bristol.ac.uk/alspac/media/researcher-interviews/
 
Title Short film on health inequality by Nic Timpson 
Description Short film with a talking head by Prof Nic Timpson discussing health inequality to accompany an exhibit 'Bristol Health Map' at We The Curious science centre in Bristol 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2021 
Impact Created an opportunity for discussion around the exhibit Bristol Health Map - showing disparities in health and life expectancies around different wards in Bristol 
URL https://drive.google.com/file/d/1_lv_RUhos9BxJ3H8qT-gfbycFZdAIH-c/view
 
Description "The one-way mirror: public attitudes to commercial access to health data"
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description A longitudinal study of gambling in late adolescence and early adulthood: Follow-up assessment at 24 years
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact This report describes a longitudinal study of young peoples' gambling between 17 and 24 years, using a contemporary UK cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). The aims of the ALSPAC Gambling Study were to describe gambling behaviour in youth aged 17-24 years, investigate the antecedents of regular and problem gambling, and explore the associations with other addictive behaviours and mental health.
URL https://www.begambleaware.org/media/2058/alspac-gambling-study_-report-for-gamble-aware_-july-2019.p...
 
Description ALSPAC Summary for SAGE re: COVID and children/young people
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://hdruk.app.box.com/s/c4p2w3n673js8run56qcbnhtyvjdwyys
 
Description ALSPAC inclusion/reference in the Goldacre review. Exemplar.
Geographic Reach Multiple continents/international 
Policy Influence Type Contribution to a national consultation/review
Impact Developments around the use of data for health and wellbeing research following the pandemic.
URL https://www.goldacrereview.org
 
Description ALSPAC information used in in 'Your Health Record Saves Lives' information booklet produced by UK Clinical Research Collaboration
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.nhs.uk/Conditions/Clinical-trials/Documents/Research1.pdf
 
Description ALSPAC obesity data cited in government's child obesity strategy
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/childhood-obesity-a-plan-for-action
 
Description ALSPAC research on bullying and maltreatment cited in EHRC race report
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.equalityhumanrights.com/en/race-report-healing-divided-britain
 
Description ALSPAC research on eczema and genes featured in the National Eczema Society's Exchange magazine (159, March 2016)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.eczema.org/products/154
 
Description ALSPAC research on premature babies quoted in Parliament by Stephen Hammond MP
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
URL https://hansard.parliament.uk/commons/2016-10-10/debates/5032D3A8-AA55-4388-BCE2-DE2ACAB8CDCC/School...
 
Description ALSPAC used as example of best practice by Health and Social Care Information Centre
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://systems.hscic.gov.uk/infogov/codes/cop
 
Description Adjournment debate on fetal alcohol spectrum disorder
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
URL https://hansard.parliament.uk/Commons/2019-01-17/debates/19011751000002/FoetalAlcoholSpectrumDisorde...
 
Description Better support is needed for young people vulnerable to abuse in intimate relationships
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Guidelines for the training of services for young people, healthcare providers and schools
 
Description Bullying research included in textbook
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies.
URL http://www.independence.co.uk/shop/family-and-relationships/issues/bullying
 
Description Bullying research included in textbook
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies.
URL http://www.independence.co.uk/shop/family-and-relationships/issues/bullying
 
Description COVID-19 Health Data Research 04 August 2020 - Weekly update for SAGE & UKRI/DHS
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.hdruk.ac.uk/wp-content/uploads/2020/08/200804-Health-Data-Research-UK-COVID-19-fortnight...
 
Description COVID-19 Health Data Research 18 August 2020 - Weekly update for SAGE & UKRI/DHSC
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.hdruk.ac.uk/wp-content/uploads/2020/08/200818-Health-Data-Research-UK-COVID-19-fortnight...
 
Description COVID-19 mental health and wellbeing surveillance report (series)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/covid-19-mental-health-and-wellbeing-surveillance-report/...
 
Description COVID-19 mental health and wellbeing surveillance: report
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.gov.uk/government/publications/covid-19-mental-health-and-wellbeing-surveillance-report
 
Description COVID-19 response
Geographic Reach National 
Policy Influence Type Participation in a guidance/advisory committee
Impact Understanding of a broad range of health related factors surrounding the impact of the pandemic. From COVID-19 itself to lockdown.
URL http://www.ucl.ac.uk/covid-19-longitudinal-health-wellbeing/research-outputs
 
Description Change in Information Commissioner's Office code of practice guidance on data protection following the Data Protection Act 2018
Geographic Reach National 
Policy Influence Type Participation in a guidance/advisory committee
Impact CLOSER work on the need for clearer and changed regulatory guidance regarding data retention (see Boyd et al. 2018, available from: https://wellcomeopenresearch.org/articles/3-112/v1) led to a change in official guidance from the Information Commissioner's Office (see https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-regulation-gdpr/principles/storage-limitation/). This has the potential to help safeguard data which could be used as research resources of the future.
URL https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-r...
 
Description Chapter on childhood asthma included in RCPCH air pollution report
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.rcplondon.ac.uk/projects/outputs/every-breath-we-take-lifelong-impact-air-pollution
 
Description Children who fail to meet UK dietary guidelines have worse cardiometabolic health as young adults
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact This research comes as the UK government develops its Major Conditions Strategy, designed to improve the health of the nation, including prevention of heart disease. Our results can help inform future policies in this area and strategies to reduce emergence of CVD risk factors early in life.
URL https://www.gov.uk/government/publications/the-eatwell-guide
 
Description Cohorts knowledge panel - CIHR & Genomes Canada
Geographic Reach North America 
Policy Influence Type Membership of a guideline committee
 
Description Department for Education on grandparental care during COVID-19 pandemic and mitigation.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/quick-findings-on-age-distributions-of-grandparents-and-p...
 
Description Eating disorder symptoms and self-harm are linked to higher levels of depression and anxiety during the COVID-19 pandemic
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.bristol.ac.uk/media-library/sites/policybristol/briefings-and-reports-pdfs/2021/PolicyBr...
 
Description Evidence included in Commons Health Select Committee report
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
URL http://www.publications.parliament.uk/pa/cm201415/cmselect/cmhealth/845/845.pdf
 
Description Evidence that little time outdoors contributes to the development of myopia in middle childhood
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Description Findings of research on dyslexia and vision recommended by Dyslexia Action
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.dyslexiaaction.org.uk/news/%E2%80%98dyslexia-and-sight-wider-view%E2%80%99-research-welco...
 
Description Guidance on iodine cited by Scientific Advisory Committee on Nutrition
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/sacn-statement-on-iodine-and-health-2014
 
Description HDRUK - Lessons from COVID-19: How can we put the UK at the forefront of health data science?
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.hdruk.ac.uk/wp-content/uploads/2020/07/Lessons-from-COVID-19-for-UK-Health-Data-Science....
 
Description HDRUK - regular updates for SAGE, National Core Studies & UKRI/DHSC (ALSPAC have contribute to 7 of these)
Geographic Reach National 
Policy Influence Type Participation in a guidance/advisory committee
URL https://www.hdruk.ac.uk/wp-content/uploads/2021/02/2021-02-23-Health-Data-Research-UK-SAGE-report.pd...
 
Description Health Data Research UK Infrastructure Advisory Group
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://www.hdruk.ac.uk/about-us/who-we-are/our-advisory-groups/
 
Description Impact of voluntary risk-mitigation behaviour on the magnitude of a COVID-19 Omicron variant wave in England, 11 January 2022
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL http://www.gov.uk/government/publications/university-of-bristol-impact-of-voluntary-risk-mitigation-...
 
Description Internet use and suicide
Geographic Reach Multiple continents/international 
Policy Influence Type Contribution to a national consultation/review
Impact Work has highlighted the importance of internet use for understanding the architecture of suicidal behaviour. It has been specifically supported by a Department of Health Policy Research Programme and an ESRC Impact Accelerator Account and has already fed into the All Party Parliamentary Group (APPG) on suicide, the APPG on Social Media and Young People's Mental Health, a report by the House of Commons Health Select Committee on Suicide Prevention https://publications.parliament.uk/pa/cm201617/cmselect/cmhealth/1087/1087.pdf, a Royal College of Psychiatrist Patient Safety report and reviews of industry practice (e.g. advising YouTube).
 
Description Internet use and suicide
Geographic Reach Europe 
Policy Influence Type Participation in a guidance/advisory committee
Impact Description and advice with respect to the improvement of understanding of relationships between online content and mental health/self-harm/suicide.
 
Description Internet use and the impact of this on mental health and well-being
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
 
Description Involvement of ALSPAC in the formation of Joint Strategic Needs Assessment - Chlamydia prevalence
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
 
Guideline Title European Association for the Study of the Liver guidelines on use of non-invasive tests.
Description Liver health and disease
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Guidelines on testing and implementing measures to improve liver health.
 
Description Maternal depression increases generation on generation.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Pearson RM, et al. Prevalence of Prenatal Depression Symptoms Among 2 Generations of Pregnant Mothers. JAMA Network Open 2018, 1:e180725 KEY IMPACT - The findings have had global media attention including live tv and radio and the results have been commented on by the Royal College of Midwives and the Maternal Mental Health Alliance. The work is new and has not yet delivered measurable policy change, but highlights the need for increased support for young pregnant women in the current enviro-socio-economic climate. The research has already supported national campaigns to facilitate universal screening for depression (and anxiety) by midwives, for the prioritisation of pregnant women for free psychological therapies and for provision of specialist perinatal mental health community mental health teams across the UK.
 
Description Maternal iodine status and child early and later life health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and child early and later life health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and early child health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and health of the child
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Sarah Bath - University of Surrey- able to look back in time to maternal iodine status in early pregnancy so that we could explore the relationship with child cognition. Using ALSPAC was cost-effective as cognitive measures were available in the child, and samples were available from the mother which we could use for the measurement of maternal iodine status. ALSPAC, unlike many other biobanks had urine samples from very early in pregnancy - which was the time that we were interested in. Iodine and thyroid hormones are required from conception and during the first half of pregnancy the mother is the sole source of thyroid hormone and so adequate iodine is critical; we therefore wanted to measure iodine status as early as possible. ALSPAC also had dietary information, via the food frequency questionnaire completed in pregnancy, which we have been able to use in our follow-on project (EUthyroid - a Horizon 2020 project). Published our research paper in the Lancet in May 2013. Work cited as an example in Medical Research Council document "Outputs, outcomes and impact of MRC research: 2013/14 report". Publication of a fact sheet on iodine for the general public/health practitioners via the British Dietetic Association. Iodine now included in fact sheets for pregnant women by the Infant and Toddler Forum. Work cited in Dairy Council's new publication on iodine. Work cited in iodine review by the Scientific Advisory Committee on Nutrition (gov). Work cited by EFSA in document on Dietary Reference Value for iodine: European Food Safety Authority (2014) Scientific Opinion on Dietary Reference Values for iodine. EFSA Journal 12, 3660. Paper featured in NICE "Eyes on Evidence" February 2014. Further grant funding for follow-on project: European Commission Horizon 2020 EUthyroid: towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe. Grant agreement No 634453
 
Description Maternal iodine status in early pregnancy and child health
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health (2014)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health (2014) (2014)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description New evidence on vitamin D supplementation in pregnancy from research showing that vitamin D status in pregnancy not associated with offspring bone mineral content
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Description New guidance on alcohol in pregnancy endorsed by Dr Simon Newell (RCOP), James Nicholls (Alcohol Research UK) and Professor David Nutt, Imperial.
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
 
Description New guidance on importance of iodine in pregnancy diet backed up by BDA factsheet http://www.bda.uk.com/foodfacts/Iodine.pdf
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.bda.uk.com/foodfacts/Iodine
 
Description Our Future Health Scientific Advisory Board
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://ourfuturehealth.org.uk
 
Description PHE Mental health - Research and analysis 7. Age Spotlight Updated 18 November 2021
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.gov.uk/government/publications/covid-19-mental-health-and-wellbeing-surveillance-spotlig...
 
Description Paediatric incontinence: early identification and treatment needed to prevent mental health problems
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Clinicians need to know that incontinence has a negative impact on mental health, especially if it persists into later childhood and adolescence. Mental health and/or psychological support should be routinely available in paediatric bladder and bowel clinics but is currently lacking due to resource constraints. Parents and carers should be taught what is typical for their child's bladder and bowel health and acquisition of continence. Parents and carers should be encouraged to seek early assessment and intervention for any new or existing childhood incontinence or bladder/bowel issue. Parents, carers, and clinicians should be aware that constipation is often an underlying cause of childhood incontinence and should always be proactively treated as soon as it is recognised. Parents, carers, and clinicians need to know that many children do not simply grow out of incontinence and that problems often become more difficult to treat with increasing age.
 
Description Participation in All Party Parliamentary Group on Autism - building brighter futures for children with autism event (10 July 2018)
Geographic Reach National 
Policy Influence Type Participation in a guidance/advisory committee
 
Description Policy Bristol - briefings
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.bristol.ac.uk/policybristol/policy-briefings/young-adult-relationships/
 
Description Questionnaire, linkage and interview data inform BIS report
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/progression-into-higher-education-for-disadvantaged-and-u...
 
Description Quick findings on age distributions of grandparents and parents of primary school aged children - .gov (asset - Centre for Ageing and Demography)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/8934...
 
Description Research on school outcomes for premature babies endorsed by Professor Sir Al Aynsley Green (first Children's Commissioner for England)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Short Report on Long COVID - Office for National Statistics
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1007...
 
Description Submitted evidence to Commons Health Select committee inquiry into suicide prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Contribution to a national consultation/review
URL http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr...
 
Description Submitted evidence to Commons Health Select committee inquiry into suicide prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Contribution to a national consultation/review
URL http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr...
 
Description Where's the daddy? Fathers and father-figures in UK datasets - The Fatherhood Institute
Geographic Reach National 
Policy Influence Type Citation in systematic reviews
Impact Review aims - Firstly, for funders and providers of large-scale quantitative datasets, a documentation of questions and fieldwork practices which enable researchers to identify specific categories of fathers and collect data directly from fathers. Secondly, for researchers planning secondary analyses to study fathers, an assessment of whether different categories of fathers can be identified in the data. ALSPAC forms a key part of the evidence contained within this review.
 
Description "Improving Understanding Of Weight Stigma With Causal Inference Methods And General Population Survey Data".
Amount £242,921 (GBP)
Funding ID ES/X000486/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2023 
End 03/2025
 
Description (LONGITOOLS) - Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases
Amount € 11,997,449 (EUR)
Funding ID 874739 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2020 
End 12/2024
 
Description 2020 Special Research Awards: Covid-19 scheme
Amount £8,669 (GBP)
Funding ID COV19\200057 
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 07/2020 
End 07/2023
 
Description 37356: Scourfield fellowship: Fathers, social interventions and children's wellbeing
Amount £8,482 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 08/2011 
End 08/2014
 
Description 38361: The determinants of measures of immune function in a wild mammal.
Amount £5,000 (GBP)
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 06/2011 
End 01/2015
 
Description 43249: NICE childhood obesity weight management
Amount £2,250 (GBP)
Funding ID F00003186 
Organisation National Institute for Health and Care Excellence (NICE) 
Sector Public
Country United Kingdom
Start 03/2012 
End 03/2014
 
Description 43992: POPPIE Predictors of Persistence & Psychological Impact of Childhood Eczema
Amount £800 (GBP)
Funding ID F00022685 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2012 
End 11/2012
 
Description 47297: B1227 Biomarker study
Amount £2,593 (GBP)
Organisation Royal College of Surgeons in Ireland 
Sector Academic/University
Country Ireland
Start 03/2013 
End 02/2017
 
Description 59452: C.Williams Senior Research Fellowship
Amount £37,043 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2015 
End 09/2020
 
Description A Recall by Genotype Study to investigate the role of common TRPA1 variants on acute pain perception
Amount £39,813 (GBP)
Funding ID ABL-2019-20-10 
Organisation University Hospitals Bristol NHS Foundation Trust 
Sector Hospitals
Country United Kingdom
Start 12/2019 
End 11/2021
 
Description A Recall by Genotype Study to investigate the role of common TRPA1 variants on acute pain perception
Amount £39,813 (GBP)
Organisation University Hospitals Bristol NHS Foundation Trust 
Department Above and Beyond Grants
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 11/2021
 
Description A UK underpinning platform to study immunology and immunopathology of COVID-19:The UK Coronavirus Immunology Consortium
Amount £6,552,119 (GBP)
Funding ID MR/V028448/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2020 
End 08/2022
 
Description A framework for linking and sharing social media data for high-resolution longitudinal measurement of mental health across CLOSER cohorts
Amount £149,971 (GBP)
Funding ID ES/R011583/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description A life course approach to understanding ADHD among women
Amount £768,160 (GBP)
Funding ID MR/X02220X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2023 
End 07/2026
 
Description ALSPAC Additional Funding from 01/04/2019 to 31/07/2019
Amount £283,265 (GBP)
Funding ID 102215/Z/13/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2019 
End 07/2019
 
Description ALSPAC CRN Funding 22/23
Amount £96,541 (GBP)
Funding ID UoB-ALSPAC22/23 
Organisation UK Clinical Research Network (UKCRN) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2022 
End 03/2023
 
Description ALSPAC Questionnaire - dietary preference
Amount £10,000 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 05/2017 
End 12/2017
 
Description Accumulative processes in health inequalities: the socioeconomic causes and consequences of mental and physical health comorbidity in adolescence
Amount £229,631 (GBP)
Funding ID ES/T013923/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 11/2020 
End 01/2023
 
Description Addressing the adverse impacts of domestic violence during pregnancy
Amount £129,956 (GBP)
Funding ID WF19\190262 
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 03/2022 
End 04/2025
 
Description Adolescent and adult mental health outcomes of autism and autistic traits
Amount £226,152 (GBP)
Funding ID MR/R004889/1 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 05/2019
 
Description Adolescent and adult mental health outcomes of autism and autistic traits
Amount £74,096 (GBP)
Funding ID TRUST/VC/AC/SG/3747-6849 
Organisation Baily Thomas Charitable Fund 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2016 
End 03/2018
 
Description Adult peak circulatory capacity in the Avon Longitudinal Study of Parents and Children (ALSPAC): mechanisms and exposures (ACME)
Amount £441,633 (GBP)
Funding ID SP/F/21/150020 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2021 
End 06/2024
 
Description Adverse life events, inflammation, and trajectories of emotional and behavioural problems in childhood
Amount £161,295 (GBP)
Funding ID ES/P001742/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2017 
End 05/2018
 
Description Alzheimer's Research UK Research Fellowship
Amount £263,088 (GBP)
Funding ID ARUK-RF2021B-006 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2022 
End 03/2025
 
Description An investigation of the causal pathways from childhood conduct problems to poor health outcomes and criminal behaviour in adulthood
Amount £250,000 (GBP)
Funding ID 209138/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 03/2022
 
Description Anxiety and depression in young people: who do they affect, who seeks treatment, and who responds to treatment?
Amount £40,000 (GBP)
Funding ID 226694/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 03/2023
 
Description Anxiety and depression in young people: who do they affect, who seeks treatment, and who responds to treatment?
Amount £40,000 (GBP)
Funding ID 226694/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 03/2023
 
Description Applying causal inference methods to investigate the impact of adverse childhood experiences on mental health
Amount £300,000 (GBP)
Funding ID 215917/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 06/2024
 
Description Are sleep difficulties in ADHD an index of neurodevelopmental severity?
Amount £57,539 (GBP)
Funding ID 918-3021 
Organisation The Waterloo Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 10/2020
 
Description Autism Speaks B954 RX9194 'Genetic Variation and Gene-Environment Influences in Autistic-like traits'
Amount £71,704 (GBP)
Funding ID 7132 
Organisation Autism Speaks 
Sector Charity/Non Profit
Country United States
Start 12/2011 
End 05/2014
 
Description B2390 Internal Locus of Control: Origins, Determinants, and Benefits
Amount £5,000 (GBP)
Funding ID 58223 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 08/2015 
 
Description BIOSHARE Social Core - Qualatative Study
Amount £1,806 (GBP)
Funding ID Health-F4-2010-261433 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 06/2014 
End 01/2015
 
Description Behavioural and neurophysiological effects of schizophrenia risk genes
Amount £789,477 (GBP)
Funding ID MR/K004360/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Biomarkers in Atopic Dermatitis and Psoriasis (BIOMAP)
Amount € 10,499,999 (EUR)
Funding ID 821511 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 03/2019 
End 03/2024
 
Description Biomarkers to investigate Genetics, Environment and Mechanisms in Schizophrenia (Bio-GEMS).
Amount £1,016,445 (GBP)
Funding ID MR/W020238/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2022 
End 12/2025
 
Description Biomedical Research Centre (BRC) in Cardiovascular disease, mental health, nutrition, diet and lifestyle (including obesity), reproductive and perinatal health, surgical innovation.
Amount £20,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2017 
End 04/2022
 
Description British Heart Foundation funded PhD programme in cardiovascular science. Interdisciplinary PhD studentship programme in integrative cardiovascular science. 5 students per year for 4 years.
Amount £2,500,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 10/2021
 
Description CLOSER (21/22 Extension)
Amount £55,000 (GBP)
Funding ID ES/K000357/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2021 
End 03/2022
 
Description CLOSER AMENDMENT 4: CLOSER INNOVATION FUND
Amount £112,678 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2017
 
Description CLOSER Amendment 1: Cohort and Longitudinal Studies Enhancement Resources Grant
Amount £327,143 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2019
 
Description CLOSER Amendment 3: Cohort and longitudinal studies enhancement resources grant
Amount £149,136 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2019
 
Description CLOSER Amendment 5: Innovation Fund - Occupational and social class data coding and harmonisation
Amount £9,811 (GBP)
Funding ID ES/K000357/1 
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 08/2017
 
Description CLOSER Ammendment 2: Cohort and longitudinal studies enhancement resources
Amount £95,684 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2017
 
Description COVID-19 Longitudinal Health and Wellbeing - National Core Study (LWH-NCS)
Amount £9,862,000 (GBP)
Funding ID MC_PC_20030 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2020 
End 03/2021
 
Description COVID-19 Questionnaire support
Amount £6,598 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 03/2020 
End 07/2020
 
Description CRN West of England 19/20 ALSPAC Funding
Amount £27,994 (GBP)
Organisation UK Clinical Research Network (UKCRN) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2019 
End 03/2020
 
Description CRN West of England 20/21 ALSPAC Funding
Amount £96,788 (GBP)
Organisation UK Clinical Research Network (UKCRN) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2020 
End 03/2021
 
Description CRN West of England 21/22 ALSPAC Funding
Amount £96,541 (GBP)
Organisation UK Clinical Research Network (UKCRN) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2021 
End 03/2022
 
Description CRN West of England 23/24 ALSPAC Funding
Amount £98,406 (GBP)
Funding ID UoB-ALSPAC23/24 
Organisation UK Clinical Research Network (UKCRN) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2023 
End 03/2024
 
Description Can Hip DXA scans be used to identify genetic determinants of hip shape & osteoarthritis? Proposal for a proof-of-concept study B1372
Amount £11,429 (GBP)
Funding ID 20244 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2013 
End 01/2016
 
Description Cardiac and vascular disease prevention after hypertensive pregnancy: insights from AI-derived, multi-organ, hypertensive disease progression models
Amount £1,981,099 (GBP)
Funding ID MR/W003686/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2022 
End 01/2027
 
Description Characterising brain network differences during scene perception and memory in young adult APOE-e4 carriers: multi-modal imaging in ALSPAC
Amount £1,420,574 (GBP)
Funding ID MR/N01233X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 04/2020
 
Description Childhood adversity, DNA methylation, and risk for depression: A longitudinal study of protective factors and sensitive periods in development
Amount $879,480 (USD)
Funding ID 1R01MH130442-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 04/2023 
End 02/2024
 
Description Childhood predictors of inadequate health literacy in young adults
Amount £28,568 (GBP)
Organisation Sir Halley Stewart Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 02/2019
 
Description Clinical Research Training Fellowship (Simon Haworth)
Amount £167,384 (GBP)
Funding ID 201268/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 05/2019
 
Description Clinical and Genetic Characterization of hEDS using Big Data Analysis
Amount £12,000 (GBP)
Funding ID Project 1257506 
Organisation Ehlers-Danlos Society 
Sector Charity/Non Profit
Country United States
Start 05/2019 
End 05/2020
 
Description Cohorts as Platforms for Mental Health research (CaP:MH)
Amount £1,497,192 (GBP)
Funding ID MC_PC_17210 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2022
 
Description Cohorts as Platforms for Mental Health research (MRC MH Pathfinder)
Amount £1,497,192 (GBP)
Funding ID MC_PC_17210 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Computational Models for the Prediction and Prevention of Child Traumatic Stress
Amount $781,926 (USD)
Funding ID 1R01MH119114-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 08/2019 
End 05/2023
 
Description Consortium Against Pain inEquality (CAPE) - The impact of adverse childhood experiences on chronic pain and responses to treatment
Amount £2,988,176 (GBP)
Funding ID MR/W002566/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2021 
End 06/2025
 
Description Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA)
Amount £1,190,293 (GBP)
Funding ID MR/N000390/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2015 
End 09/2018
 
Description Consortium to Research Individual, Interpersonal, and Social influences in Pain (CRIISP)
Amount £3,824,159 (GBP)
Funding ID MR/W004151/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2021 
End 06/2025
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description Cytoprotective defence mechanisms during tissue maintenance and repair - Helen Weaver
Amount £1,159,829 (GBP)
Funding ID 208762/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2018 
End 07/2023
 
Description Defining 'clinically actionable' genetic mechanisms in atopic eczema risk and resolution
Amount £2,258,810 (GBP)
Funding ID 220875/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2020 
End 10/2025
 
Description Deriving and validating a clinical prediction rule for the diagnosis of asthma in primary care
Amount £207,554 (GBP)
Funding ID CAF/17/01 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 08/2017 
End 06/2021
 
Description Describing habitual levels of physical activity (PA) in older people in terms of impact loads and how this relates to bone and other systems
Amount £58,433 (GBP)
Funding ID MR/K024973/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2013 
End 06/2016
 
Description Development and evaluation of a pathway from 'universal screening' to online intervention for children with anxiety problems
Amount £252,066 (GBP)
Funding ID RP-PG-0218-20010 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2025
 
Description Development of ALSPAC Industry Partner and Participant Portal
Amount £15,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 08/2018
 
Description Development of ALSPAC Industry Partner and Participant Portal (Timpson NJ, Skinner A.)
Amount £15,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 05/2019
 
Description Diagnoptics - AGE readers for field use (Recall by Genotype) in the MRC IEU
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2017 
End 05/2017
 
Description Discovery science to map the common genetic architecture of fine and gross infant motor development in the context of neurodevelopment and autism
Amount $299,486 (USD)
Funding ID 724306 
Organisation Simons Foundation 
Sector Charity/Non Profit
Country United States
Start 03/2021 
End 02/2023
 
Description Discovery science to map the common genetic architecture of fine and gross infant motor development in the context of neurodevelopment and autism
Amount $299,486 (USD)
Funding ID 724306 
Organisation Simons Foundation 
Sector Charity/Non Profit
Country United States
Start 03/2021 
End 02/2023
 
Description Do epigenetic markers contribute to the excess risk of diabetes and coronary heart disease in Indian Asians?
Amount £196,086 (GBP)
Funding ID 082464/Z/07/C 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Does epigenetic methylation explain the gender-switch in adolescent asthma?
Amount $153,747 (USD)
Funding ID 1R01A/121226-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 01/2016 
End 12/2016
 
Description Driven exercise and risk for eating disorders: A combined genetic and longitudinal epidemiological investigation
Amount $185,712 (USD)
Funding ID 1K01MH123914-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 05/2020 
End 05/2024
 
Description Driven exercise and risk for eating disorders: A combined genetic and longitudinal epidemiological investigation
Amount $742,848 (USD)
Funding ID 1K01MH123914-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 05/2020 
End 05/2024
 
Description Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases
Amount £8,327,295 (GBP)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 07/2019 
End 07/2024
 
Description Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases (LONGITOOLS)
Amount € 11,997,449 (EUR)
Funding ID 874739 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 01/2020 
End 12/2024
 
Description EXposome Powered tools for healthy living in urbAN SEttings
Amount € 11,993,907 (EUR)
Funding ID 874627 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2020 
End 12/2024
 
Description Early adulthood education/employment transitions and the development of inequalities in diet quality and cardiovascular health
Amount £1,096,469 (GBP)
Funding ID MR/T010576/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2020 
End 03/2025
 
Description Early life adversity and life course health: an investigation of adversity clustering and associations with health
Amount £232,283 (GBP)
Funding ID ES/P010229/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2020
 
Description Early life adversity: trajectories to mental health and drug use
Amount $60,000 (AUD)
Funding ID 19/10685105 
Organisation Channel 7 Children's Research Foundation 
Sector Charity/Non Profit
Country Australia
Start 03/2019 
End 02/2021
 
Description Eating Behaviour Measurement using the Mandometer - A Pilot Study In ALSPAC B1038
Amount £600 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 01/2012 
End 12/2012
 
Description Effect of different feeding methods and non-nutritive sucking behaviours on child speech development
Amount £52,438 (GBP)
Funding ID ICA-CDRF-2016-02-053 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2017 
End 03/2021
 
Description Efficient and transparent methods for linking and analysing longitudinal population studies and administrative data
Amount £301,055 (GBP)
Funding ID 212953/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 12/2025
 
Description Electronic Longitudinal Alcohol Study in Communities (ELAStiC)
Amount £978,102 (GBP)
Funding ID ES/L015471/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2016 
End 09/2019
 
Description Elizabeth Blackwell Institute Extension Fellowship (Leila Thuma)
Amount £46,467 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 11/2016 
End 08/2017
 
Description Elizabeth Blackwell Institute Postgraduate Extension Scheme (Michelle Taylor)
Amount £32,817 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 09/2016 
End 06/2017
 
Description Emotional dysregulation, self-harm and eating disorders: a mechanistic investigation
Amount £251,713 (GBP)
Funding ID MR/S020292/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2019 
End 09/2022
 
Description Enhancing Environmental data Resources in Cohort Studies: ALSPAC exemplar (ERICA)
Amount £99,899 (GBP)
Funding ID NE/P010830/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 02/2017 
End 01/2018
 
Description Environmental risk factors of health-risk behaviours: Using DNA to strenghten causal inference
Amount £225,000 (GBP)
Organisation MQ Mental Health Research 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description Epidemiological studies of human transgenerational responses (TGR) to paternal and ancestral exposures
Amount $25,000 (USD)
Funding ID 2016-165617 
Organisation Silicon Valley Community Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2017 
End 12/2017
 
Description Epigenetic predictors of time-varying exposures to childhood adversity and depression
Amount $224,448 (USD)
Funding ID R21MH132947-01 
Organisation Department of Health and Human Services 
Sector Public
Country United States
Start 02/2023 
End 01/2024
 
Description Ethical aspects of epidemiological research on young people involving linkage to routine individual data B1089
Amount £860 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2012 
End 10/2012
 
Description Excessive drinking and alcohol related harms in Adulthood: ALSPAC at 24
Amount £1,378,535 (GBP)
Funding ID MR/L022206/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2015 
End 05/2019
 
Description Exome Sequencing of ALSPAC, Born in Bradford and Fenland Cohorts
Amount £3,000,000 (GBP)
Funding ID MC PC 23015 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2023 
End 09/2025
 
Description Exploiting genomic approaches to identify the environmental basis of depression
Amount £2,530,384 (GBP)
Funding ID 220857/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2021 
End 05/2026
 
Description Exploring the role of early-life vascular risk factors linking heart and brain health
Amount £263,088 (GBP)
Funding ID ARUK-RF2021B-006 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2022 
End 03/2025
 
Description Extraordinary COVID-19 questionnaire
Amount £5,650 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 03/2020 
End 03/2021
 
Description Faculty capital bid for portable OCT machine (Alexandra Creavin)
Amount £60,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 09/2015 
 
Description Father involvement and child development in the context of maternal postnatal depression
Amount £301,101 (GBP)
Funding ID 212664/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2019 
End 04/2023
 
Description Fellowship B1088 SSCM.RJ5562 'Molecular and life-course aspects of APOE and TOMM40 in cognition'
Amount £35,305 (GBP)
Funding ID WT096114/Z/11/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 12/2015
 
Description Fellowship Bath B1423 SSCM.RD1832 ' Iodine status in pregnancy & child neurodevelopment'
Amount £11,707 (GBP)
Funding ID MR/K02132X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2013 
End 05/2016
 
Description GW4 BioMed MRC DTP (Bushra Farooq)
Amount £95,056 (GBP)
Organisation GW4 
Sector Academic/University
Country United Kingdom
Start 08/2021 
End 03/2025
 
Description Gene Environment interactions in Mental health trajectories of Youth
Amount € 8,107,980 (EUR)
Funding ID 101057182 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 05/2022 
End 05/2027
 
Description Gene-Environment Interplay in the Comorbity of PTSD and Disordered Eating
Amount £10,909 (GBP)
Organisation National Institutes of Health Clinical Center 
Sector Hospitals
Country United States
Start 01/2013 
End 12/2016
 
Description Genetic, behavioural and cognitive mechanisms underpinning the association between mother and offspring mental health problems: mental health intergenerational transmission (MHINT)
Amount € 1,499,611 (EUR)
Funding ID 758813 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 12/2017 
End 11/2022
 
Description Genetics of wound healing - BCG scar study
Amount £46,467 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 11/2016 
End 08/2017
 
Description Gill Althia Francis Early Career Fellowship
Amount £138,966 (GBP)
Funding ID ECF-2021-092 
Organisation The Leverhulme Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2021 
End 09/2024
 
Description GlycA as a novel biomarker linking bacterial-mediated inflammation to adverse cardiometabolic and cardiovascular traits in the young
Amount £144,072 (GBP)
Funding ID PG/18/45/33814 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 10/2021
 
Description HDHL-Biomarkers: Early life programming of childhood health: a nutritional and epigenetic investigation (ALPHABET)
Amount £101,222 (GBP)
Funding ID BB/P028187/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 09/2019
 
Description Health, maturity, and the gender gap in education (HEALTH-GAP)
Amount kr 14,794,000 (NOK)
Funding ID 273659 
Organisation Norwegian Institute of Public Health 
Sector Public
Country Norway
Start 04/2018 
End 12/2022
 
Description Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research
Amount $372,900 (USD)
Organisation American Federation for Aging Research 
Sector Charity/Non Profit
Country United States
Start 12/2022 
End 12/2025
 
Description How and why does ADHD lead to depression in young people?
Amount £552,880 (GBP)
Funding ID MR/X021769/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2023 
End 08/2026
 
Description How early stress gets under the skin: The role of DNA methylation in the development of youth conduct problems and comorbid symptoms
Amount £250,543 (GBP)
Funding ID ES/N001273/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Impact of Pediatric Atopic Dermatitis on Neurocognitive Function
Amount $171,860 (USD)
Funding ID 1K23AR077629-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 03/2021 
End 03/2022
 
Description Impact of Pediatric Atopic Dermatitis on Neurocognitive Function
Amount $171,860 (USD)
Funding ID 1K23AR077629-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 03/2021 
End 03/2026
 
Description Improving future treatment options for menopausal symptoms by using genomics to understand aetiology
Amount £808,740 (GBP)
Funding ID MR/Y003780/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2023 
End 10/2026
 
Description Improving mental health outcomes in children born with an orofacial cleft: Identifying children at most risk to target clinical provision
Amount £608,551 (GBP)
Funding ID MR/W020297/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2022 
End 08/2025
 
Description Informing educational interventions using genome-wide data: causal evidence from 573,586 participants of eight cohort studies
Amount £222,571 (GBP)
Funding ID ES/N000757/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Integrative Cancer Epidemiology Programme: Towards improved causal evidence and enhanced prediction of cancer risk and survival
Amount £7,715,113 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2020 
End 05/2025
 
Description Interplay between Peer-based Processes and Alcohol Metabolism Genes on Trajectories of Alcohol Use across Adolescence
Amount $68,657 (USD)
Funding ID 1F31AA025833-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 03/2017 
End 03/2019
 
Description Investigating Sex Differences in Risk for Common Mental Health Problems
Amount $70,000 (USD)
Funding ID 27879 
Organisation Brain & Behaviour Research Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2020 
End 01/2022
 
Description Investigating five large population-based cohort studies to understand for the precursors of multimorbidity risk.
Amount £74,159 (GBP)
Funding ID MR/V004905/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2020 
End 02/2021
 
Description Investigating the Epidemiology of CFS/ME in children using the ALSPAC cohort B1425 RD1805
Amount £21,391 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2013 
End 09/2015
 
Description Investigation of the causal effects of atopic eczema on other health outcomes
Amount £89,968 (GBP)
Organisation British Skin Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 10/2018
 
Description Ipsos Mori: Qualitative research on attitudes around commercial access to health, biomedical and genetic data
Amount £2,195 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 11/2015
 
Description Is exposure to toxic metals contributing to ethnic and social health inequalities in children and young adults in the UK?
Amount £863,011 (GBP)
Funding ID MR/X009777/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2023 
End 03/2026
 
Description Klarman Family Foundation B1190 'Epigentics of Eating Disorders : A Lifespan Approach'
Amount $132,590 (USD)
Organisation The Klarman Family Foundation 
Sector Charity/Non Profit
Country United States
Start 05/2012 
End 05/2014
 
Description LONGITUDINAL ADMINISTRATIVE DATA SPINE SCOPING PROJECT GRANT FOR THE SPF UK POPULATION LAB WAVE I
Amount £236,901 (GBP)
Funding ID ES/S016732/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 12/2018 
End 03/2021
 
Description Life course aetiology of dementia and cognitive decline: improving causal inference
Amount £315,800 (GBP)
Funding ID MR/P014437/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 02/2020
 
Description Lifecourse epidemiology of female reproductive health and its relation to chronic disease
Amount £70,205 (GBP)
Funding ID MR/M009351/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2014 
End 11/2019
 
Description Lipid-modifying therapy in children with familial hypercholesterolemia
Amount £1,491,599 (GBP)
Funding ID NIHR134993 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 02/2023 
End 08/2028
 
Description Long-Term Occupational Implications of Preschool Gender-Related Play Behaviour
Amount HK$1,400,000 (HKD)
Funding ID 17614823 
Organisation University of Hong Kong 
Sector Academic/University
Country Hong Kong
Start 09/2023 
End 09/2026
 
Description Lung Health @30. Understanding the origins of chronic lung disease and the impact of COVID-19
Amount £191,526 (GBP)
Organisation Southmead Hospital Charity 
Sector Public
Country United Kingdom
Start 09/2021 
End 09/2025
 
Description MRC Mental Health Pathfinder Award
Amount £1,400,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 04/2020
 
Description MRC Proximity to Discovery Industry Engagement Fund (Tom Richardson)
Amount £12,225 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2016 
End 05/2017
 
Description MRC Proximity to Discovery Industry Engagement Fund: Development of ALSPAC Industry Partner and Participant Portal
Amount £15,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 09/2018
 
Description MRC Public Engagement Seed Fund- Matthew Lee
Amount £5,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description Mapping Disparities in Childhood Lead Exposure in England
Amount £50,000 (GBP)
Funding ID 0011718 
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 01/2022 
End 05/2022
 
Description Mapping Disparities in Childhood Lead Exposure in England
Amount £49,999 (GBP)
Funding ID ECONCIA21-22-30 
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 01/2022 
End 05/2022
 
Description Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder: ALSPAC-MRI-II
Amount £1,791,731 (GBP)
Funding ID MR/S003436/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 11/2022
 
Description Mapping phenotypic to genetic variability in the High Bone Mass Study
Amount £355,425 (GBP)
Funding ID 20000 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2013 
End 12/2018
 
Description Mental health and educational achievement in UK adolescents
Amount £131,721 (GBP)
Funding ID ES/P00881X/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 06/2017 
End 12/2018
 
Description Mental health and incontinence
Amount £525,115 (GBP)
Funding ID MR/V033581/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2022 
End 11/2024
 
Description Mental health trajectories following pharmacological and psychological treatment
Amount £40,000 (GBP)
Funding ID 226686/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 11/2023
 
Description Mental health trajectories following pharmacological and psychological treatment
Amount £40,000 (GBP)
Funding ID 226686/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 02/2023
 
Description Mitochondrial DNA copy number as a phenotypic trait for human diseases in genetic epidemiological studies
Amount £384,038 (GBP)
Funding ID MR/K002767/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Molecular Genetic and Lifecourse Epidemiology
Amount £5,153,712 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2021 
End 09/2025
 
Description Molecular, Genetic and Lifecourse Epidemiology
Amount £1,350,000 (GBP)
Funding ID 108902/B/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 10/2019
 
Description Molecular, Genetic and Lifecourse Epidemiology - PhD programme (original programme funding and extension - awarded in 2015, extended by one year in 2017)
Amount £1,820,000 (GBP)
Funding ID 108902/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 10/2024
 
Description Molecular, Genetic and Lifecourse Epidemiology. PhD programme to provide 3 PhD students per year (on 4-year PhD programmes) for the intake years 2016/17, 2017/18, 2018/19, 2019/2020. (108902/Z/15/Z).
Amount £1,820,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 01/2016
 
Description Mothers' childhoods and the intergenerational transmission of mental health risk in the context of adversity
Amount $179,981 (USD)
Funding ID 1K01MH117443-01A1 
Organisation National Institute of Mental Health 
Sector Public
Country United States
Start 03/2019 
End 03/2023
 
Description Multidimensional Phenotyping in Eczema
Amount £89,991 (GBP)
Organisation British Skin Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description NIHR Biomedical Research Centre Bristol
Amount £20,858,545 (GBP)
Funding ID BRC-1215-20011 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2017 
End 03/2022
 
Description NMHB Research Grant SSCM.RD1796 'Behavioral & neurophysicological effects of schizophrenia risk genes'
Amount £112,078 (GBP)
Funding ID MR/K004360/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2013 
End 03/2017
 
Description Neurodevelopmental disorders: What happens when children grow up and why?
Amount £893,353 (GBP)
Funding ID 204895/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2021
 
Description Non-genetic inheritance in human development
Amount £995,516 (GBP)
Funding ID ID#60828 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 01/2018 
End 09/2020
 
Description Novel epidemiological methods to infer the causal effects of risk factors on neuropsychiatric and cardiovascular disorders
Amount $358,957 (AUD)
Funding ID APP1079583 
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2015 
End 12/2017
 
Description NutriPROGRAM: Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways
Amount £267,345 (GBP)
Funding ID MR/S036520/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 08/2022
 
Description Nutrition and immunity in pregnancy: maternal responses and consequences for offspring
Amount £904,296 (GBP)
Funding ID MR/W007711/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2023 
End 10/2027
 
Description Our Menopauses: an event for sharing experiences and information about menopause in Bristol
Amount £2,619 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 05/2017 
End 11/2017
 
Description Oxytocin-Related Predictors of Postpartum Maternal Mood and Mothering B1167
Amount £4,628 (GBP)
Organisation National Institutes of Health Clinical Center 
Sector Hospitals
Country United States
Start 03/2012 
End 03/2014
 
Description PAR-13-109 Mechanistic Insights from Birth Cohorts (R01)
Amount £110,613 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 08/2014 
End 08/2019
 
Description Parenting and children's behavioural problems: Micro- and macro-processes at play in the context of intervention
Amount £328,077 (GBP)
Funding ID ES/X001865/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 05/2023 
End 06/2025
 
Description Pathogenic mechanisms in post-bereavement psychopathology: Contributions of gene-environment interplay, psychosocial factors, and cognitive ability in two population-based cohorts
Amount $190,011 (USD)
Funding ID 1K23MH117278-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 03/2019 
End 02/2024
 
Description Pathways to peak lung function: Genetic, Environmental and lifestyle influences on maximally attainable lung function in young adults
Amount £482,295 (GBP)
Funding ID MR/M022501/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2015 
End 08/2018
 
Description Pathways to psychosis: investigating environmental, cognitive and genetic mechanisms underlying development of psychotic experiences in young adults
Amount £455,151 (GBP)
Funding ID MR/M006727/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2014 
End 06/2018
 
Description PhD Studentship - B910 SSCM.RJ5158 'Biological Differences in Smoking Behaviour'
Amount £38,715 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 06/2012
 
Description Physical and mental health multimorbidity across the lifespan (LIfespaN multimorbidity research Collaborative (LINC)).
Amount £3,034,322 (GBP)
Funding ID MR/W014416/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2021 
End 11/2025
 
Description Picky Eating in the ALSPAC cohort: Determinants and related health outcomes
Amount £1,230 (GBP)
Organisation Nestlé (Global) 
Department Société des Produits Nestlé SA
Sector Private
Country Switzerland
Start 04/2014 
End 03/2016
 
Description Placental contributions to disparities in offspring cardiovascular health across the life course
Amount $130,632 (USD)
Funding ID 1K01HL165038-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 05/2023 
End 05/2028
 
Description Population Research Committee - Programme Award Reducing the burden of cancer: causal risk factors, mechanistic targets and predictive biomarkers
Amount £4,100,000 (GBP)
Funding ID 19169 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 05/2020
 
Description Population Research Committee - Project Award B911 SSCM.RJ5681'Breast tissue composition in young women and its pre-natal and early life determinant: a study nested within the ALSPAC'
Amount £90,345 (GBP)
Funding ID C405/A12730 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2011 
End 12/2012
 
Description Postdoctoral Research Associate/Fellow
Amount £178,493 (GBP)
Organisation Society for the Study of Addiction 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2021 
End 09/2024
 
Description Predictors and consequences of being a Child in Need or Looked After: data linkage study based on ALSPAC
Amount £50,931 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 09/2016 
End 09/2018
 
Description Prenatal influences on childhood health: what role for mums and dads?
Amount £541,891 (GBP)
Funding ID MR/S009310/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2019 
End 07/2022
 
Description Prevention of persistent high levels of depression across adolescence and young adulthood: the role of active ingredients
Amount £40,000 (GBP)
Funding ID 226698/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 02/2023
 
Description Prevention of persistent high levels of depression across adolescence and young adulthood: the role of active ingredients
Amount £40,000 (GBP)
Funding ID 226698/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 03/2023
 
Description Programme B798 SSCM.RJ5447 'The relationship of the menopausal transition to healthy aging and chronic disease risk'
Amount £774,825 (GBP)
Funding ID 092830/Z/10/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2011 
End 06/2016
 
Description Psychosocial factors and cancer incidence: a pre-planned meta-analysis of the Psychosocial factors and Cancer
Amount € 1,328,435 (EUR)
Funding ID VU 20l7-8288 
Organisation Dutch Cancer Society (KWF) 
Sector Charity/Non Profit
Country Netherlands
Start 03/2018 
End 09/2021
 
Description Psychosocial resilience in children of mothers with depression B1112
Amount £702 (GBP)
Funding ID ES/J011657/1 
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start 09/2012 
End 09/2014
 
Description Publication Metadata Augmentation
Amount £112,678 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 11/2017
 
Description Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?
Amount £2,560,571 (GBP)
Funding ID 108818/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2016 
End 12/2018
 
Description Religious belief, health and disease: a family perspective
Amount £7,986,970 (GBP)
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 08/2021 
End 08/2026
 
Description Religious belief, health and disease: a family perspective.
Amount $234,800 (USD)
Funding ID 61356 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 07/2019 
End 07/2021
 
Description Religious belief, health and disease: a family perspective.
Amount £7,986,970 (GBP)
Funding ID 61917 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 08/2021 
End 05/2026
 
Description Research - B1173 SSCM.RD1795 'Study Team for early life Asthma Research (STELAR)
Amount £38,406 (GBP)
Funding ID MR/K002449/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2013 
End 12/2016
 
Description Research B998 SSCM.RD1782Cussens 'A graphical model approach to pedigree construction using constrained optimisation'
Amount £4,602 (GBP)
Funding ID G1002312 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2011 
End 10/2014
 
Description Research Grant - B836 SSCM.RK7212 'Maternal thyroid status and offspring development'.
Amount £14,529 (GBP)
Funding ID ETM/97 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 03/2011 
End 03/2013
 
Description Research Grant BBR Scheme (BBSRC)- B1074 SSCM.RA0543 'A multigenerational prospective resource for integrating genetic, epigenetic and dense phenotypic measures from birth to 18.'
Amount £1,186,455 (GBP)
Funding ID BB/I025751/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2011 
End 08/2013
 
Description Research into the longer term effects of COVID-19 in non-hospitalised individuals
Amount £9,593,946 (GBP)
Funding ID COV-LT-0009 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2021 
End 04/2024
 
Description Risky business: Understanding intergenerational persistence in entrepreneurship
Amount £548,327 (GBP)
Funding ID ES/V016660/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2022 
End 09/2022
 
Description RoSPA: Evaluation of Lifeskills using the ALSPAC Cohort - LASER Safety Education Schemes
Amount £19,733 (GBP)
Organisation Royal Society for the Prevention of Accidents 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2014 
End 10/2014
 
Description S1P1R genetic profiles in endothelial function and disease
Amount € 204,537 (EUR)
Funding ID 166002 - CW388001 
Organisation Sanofi 
Department Sanofi Research Division
Sector Private
Country France
Start 03/2016 
End 07/2019
 
Description Seeing is believing in ALSPAC
Amount £199,387 (GBP)
Funding ID 102215/Z/13/B 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2016 
End 10/2016
 
Description Selection Bias and Mental Health: Towards an Integrated Understanding of Risk Factors for Suicide and Poor Self-rated Mental Health
Amount £183,553 (GBP)
Funding ID MQF22\22 
Organisation MQ Mental Health Research 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2023 
End 08/2026
 
Description Sensitive Periods for the Effects of Depression on Suicide Risk: A longitudinal Study of Gene-Environment Interactions and Epigenetic Mechanisms
Amount £224,966 (GBP)
Funding ID MQF22\9 
Organisation MQ Mental Health Research 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2023 
End 10/2026
 
Description Sensitive periods for prenatal alcohol exposure: a longitudinal study of DNA methylation and subsequent mental health
Amount $199,500 (USD)
Funding ID 1R21AA030640-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 03/2023 
End 02/2024
 
Description Seventh Framework Programme - B1301 SSCM.RQ8840 'Collaborative Projects & Networks of Excellence EXPOsOMICS'
Amount € 56,704 (EUR)
Funding ID 308610 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 09/2012 
End 09/2016
 
Description Smoking and Vaping Transitions in Early Adulthood: investigating predictors with longitudinal data
Amount £354,821 (GBP)
Funding ID PRCPJT-May21\100007 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2022 
End 01/2024
 
Description Smoking and Vaping Transitions in Early Adulthood: investigating predictors with longitudinal data
Amount £354,822 (GBP)
Funding ID PRCPJT-May21\100007 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2022 
End 01/2025
 
Description Solving the 'time puzzle' of epigenetic effects on child mental health (TEMPO)
Amount € 1,500,000 (EUR)
Funding ID 101039672 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 05/2022 
End 05/2027
 
Description Study of Emerging Adulthood and Cardiomatic Health in ALSPAC: The Influence and of growth and other exposures
Amount £999,049 (GBP)
Funding ID CS/15/6/31468 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2015 
End 06/2020
 
Description Synthetic Health Data for Research Support - an exemplar from a birth cohort
Amount £4,518 (GBP)
Funding ID WorkTribe no: 2374474 
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 11/2023 
End 06/2024
 
Description TEMPO
Amount € 1,500,000 (EUR)
Funding ID 101044076 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 05/2022 
End 05/2027
 
Description TENOVUS - Da Silva Focus Group
Amount £804 (GBP)
Organisation University of Dundee 
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 11/2015
 
Description Taking the long view: understanding the precursors and consequences of poor reading comprehension identified in mid-childhood
Amount £237,581 (GBP)
Funding ID ES/S016333/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2020 
End 02/2023
 
Description Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular health
Amount $140,054 (USD)
Funding ID 1K01HL143159-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 06/2019 
End 06/2024
 
Description Testing evolutionary hypotheses of social development in the ALSPAC cohort
Amount £1,559 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 09/2015
 
Description Testing the feasibility and user acceptability of integrating wearable air pollution monitors into population based studies
Amount £24,769 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 08/2017
 
Description The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019
Amount £7,903,667 (GBP)
Funding ID 102215/Z/13/Z 
Organisation Wellcome Trust 
Department Wellcome - MRC Cambridge Stem Cell Institute
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 03/2019
 
Description The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being.
Amount £8,327,295 (GBP)
Funding ID 217065/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
End 08/2024
 
Description The Biosocial Lives of Birth Cohorts
Amount £1,009,755 (GBP)
Funding ID 219844/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2021 
End 03/2025
 
Description The CIVIC Project: A Sustainable Platform for COVID-19 syndromic-surveillance via Health, Deprivation and Mass Loyalty-Card Datasets
Amount £233,965 (GBP)
Funding ID EP/V053922/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 02/2021 
End 01/2022
 
Description The Genetic Basis of Urinary Incontinence in Women B956
Amount £44,664 (GBP)
Organisation International Urogynecological Association (IUGA) 
Sector Academic/University
Country Global
Start 09/2011 
End 09/2014
 
Description The Millennium Cohort Study Sweep 6 (Age 14) Survey (GWAS data collection).
Amount £1,000,000 (GBP)
Organisation ESRC Impact Acceleration Account Cambridge 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 02/2019
 
Description The Millennium Cohort Study Sweep 6 (Age 14) Survey - extension (GWAS data collection and analysis)
Amount £1,052,503 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2017 
End 03/2018
 
Description The causal map of the human phenome
Amount £809,240 (GBP)
Funding ID 208806 
Organisation Sir Henry Dale Fellowships 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 03/2023
 
Description The development of genetically-based pathways underlying problematic alcohol use
Amount $170,638 (USD)
Funding ID 1K01AA027757-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 05/2020 
End 05/2025
 
Description The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways
Amount £215,430 (GBP)
Funding ID MR/R004803/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2017 
End 09/2020
 
Description The emergence of self-harm in the first decades of life: a biopsychosocial perspective on developmental dynamics, risk and protective factors
Amount SFr. 1,797,424 (CHF)
Funding ID 211709 
Organisation Swiss National Science Foundation 
Sector Public
Country Switzerland
Start 11/2023 
End 10/2028
 
Description The genetic epidemiology of High Bone Mass: skeletal geometry, turnover and fat metabolism, and implications for the wider population
Amount £3,322 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2013 
End 01/2018
 
Description The long term impact of COVID-19 on mental health: comparisons between health record linkage and observed longitudinal data
Amount £11,020 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 08/2020 
End 08/2021
 
Description The long term impact of COVID-19 on mental health: comparisons between health record linkage and observed longitudinal data
Amount £11,020 (GBP)
Funding ID R105121-249 
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 08/2020 
End 08/2021
 
Description The relationship between diet quality in childhood and cardiometabolic health and low-grade chronic inflammation in adolescence and early adulthood
Amount £172,563 (GBP)
Funding ID FS/19/3/34255 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 09/2023
 
Description The role of neighbourhood conditions in mental health responses to the Covid-19 lockdown
Amount £8,669 (GBP)
Funding ID COV19\200057 
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 07/2020 
End 09/2024
 
Description Transaction data for population health
Amount £1,114,169 (GBP)
Funding ID MR/T043520/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2021 
End 01/2025
 
Description TwinsUK (2019-2023) - An Epidemiological and Genomic Resource
Amount £3,000,000 (GBP)
Funding ID 212904/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 06/2024
 
Description Type 1 Diabetes Risk in Adults (T1DRA) - A general population study
Amount $1,198,616 (USD)
Organisation The Leona M. and Harry B. Helmsley Charitable Trust 
Sector Charity/Non Profit
Country United States
Start 12/2022 
End 11/2025
 
Description Type 2 Diabetes and Cancer: RD Lawrence Fellowship - Emma Vincent
Amount £587,237 (GBP)
Funding ID 17/0005587 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 09/2022
 
Description UK Department for Business Innovation & Skills (BIS) B931 RK7220 'Further education data linkage projects'
Amount £55,000 (GBP)
Funding ID BIS/RBU/008/2011 
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 02/2011 
End 12/2012
 
Description UK Dept for Business Innovation and Skills B2057 SSCM.RK 'Data Linkage Proposal 2013'
Amount £30,000 (GBP)
Funding ID BIS/RBU/011/2013 
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 09/2013 
End 09/2015
 
Description UK MenCar4
Amount £4,483 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2015 
End 09/2015
 
Description UNICORN (Unified Cohorts Research Network): Disaggregating asthma
Amount £2,428,677 (GBP)
Funding ID MR/S025340/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2020 
End 03/2022
 
Description UNRAVEL-CAUSALITY
Amount € 1,500,000 (EUR)
Funding ID 101076686 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 03/2023 
End 03/2028
 
Description Understanding Asthma Phenotypes
Amount £181,852 (GBP)
Funding ID 668954 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 01/2016 
End 12/2020
 
Description Understanding Pathways from Environmental Risk to Internalising Problems for Autistic Young People
Amount £566,642 (GBP)
Funding ID ES/X014207/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 12/2023 
End 11/2026
 
Description Understanding social transitions in emerging adulthood and pathways to later health outcomes
Amount £300,000 (GBP)
Funding ID 224114/Z/21/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2022 
End 08/2026
 
Description Understanding successful progression to higher education for the white working class and minority ethnic groups (B2215)
Amount £14,081 (GBP)
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 02/2014 
End 07/2015
 
Description Understanding the Antecedents and Outcomes of Frequent Adolescent Cannabis Use
Amount £250,000 (GBP)
Funding ID 209158 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 05/2022
 
Description Understanding the Role of Adolescent Dysmenorrhoea as a risk factor for the transition to chronic Pain (RoAdPain)
Amount £976,107 (GBP)
Funding ID MR/W02697X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2022 
End 03/2025
 
Description Understanding the downstream effects of early sleep for education and mental health
Amount £240,726 (GBP)
Funding ID ES/W005972/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 08/2022 
End 09/2024
 
Description Understanding the mechanisms linking cities to psychotic experiences across the lifespan
Amount £300,000 (GBP)
Funding ID 218632/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2020 
End 04/2025
 
Description Unique research opportunities in the genetics and epidemiology of disordered gambling
Amount $396,559 (USD)
Organisation National Center for Responsible Gaming 
Sector Charity/Non Profit
Country United States
Start 06/2017 
End 06/2020
 
Description University of Bristol Widening Participation Grant- Matthew Lee
Amount £1,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 12/2018
 
Description Unravelling patterns in social connection for the prevention of depression and anxiety in adolescents and young adults
Amount £40,000 (GBP)
Funding ID 226701/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 02/2023
 
Description Unravelling the role of social connection in the prevention of depression and anxiety in young people
Amount £40,000 (GBP)
Funding ID 226701/Z/22/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2022 
End 03/2023
 
Description Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression
Amount £110,594 (GBP)
Funding ID MR/J01351X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Using genetic and environmental risks to understand variation in social emotional, and educational outcomes in individuals with language impairments
Amount £161,348 (GBP)
Funding ID ES/P001955/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2017 
End 09/2019
 
Description Using genetics to understand causal mechanisms underlying adverse outcomes of obese pregnancies
Amount £1,391,495 (GBP)
Funding ID 220390/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2020 
End 09/2026
 
Description Using large cohort studies to identify genetic variants for mechanistic testing in mouse and zebrafish models of wound healing.
Amount £788,000 (GBP)
Organisation Scar Free Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2020 
End 05/2025
 
Description Using linked electronic health data to improve eczema diagnosis and outcomes
Amount £1,305,851 (GBP)
Funding ID 205039/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 02/2019
 
Description WT Biomedical Resource - B1234 SSCM.RD1793 'The 1958 Birth Cohort Biomedical Resource - facilitating access to data and samples and enhancing future utility'
Amount £668,124 (GBP)
Funding ID G1001799 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2011 
End 12/2014
 
Description WT Project award - B1118 'Dopamine Function, Cognitive Flexibility and Emotion Regulation'
Amount £4,816 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2011 
End 01/2012
 
Description Wellcome Longitudinal Population Study COVID-19 Steering Group and Secretariat
Amount £120,585 (GBP)
Funding ID 221574/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2020 
End 07/2021
 
Description Wellcome Trust Helen Weavers Sir Henry Dale Wellcome: Cytoprotective defence mechanisms during tissue maintenance and repair.
Amount £150,829 (GBP)
Funding ID 208762 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 01/2023
 
Description Wellcome Trust Research Training Fellowship (Tom Dudding)
Amount £187,327 (GBP)
Funding ID 201237/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 09/2019
 
Description What Influences Vaping Harm Perceptions Among Young Adults And How Can They Be Modified?
Amount £178,493 (GBP)
Organisation Society for the Study of Addiction 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2021 
End 09/2024
 
Description What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping.
Amount £1,850,000 (GBP)
Funding ID 202802/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 08/2022
 
Description What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping.
Amount £1,850,393 (GBP)
Funding ID 202802/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 08/2023
 
Description Working memory and its relation to key outcomes in the real world
Amount £248,739 (GBP)
Funding ID ES/X011135/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2023 
End 09/2025
 
Description Young people's barriers to access mental health services
Amount £246,423 (GBP)
Funding ID ES/W004682/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 08/2022 
End 09/2024
 
Description Young peoples barriers to access mental health services
Amount £246,423 (GBP)
Funding ID ES/W004682/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 08/2022 
End 09/2024
 
Description Youth-GEMs
Amount € 8,107,980 (EUR)
Funding ID 101057182 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2022 
End 05/2027
 
Title A Privacy-Preserving Data Management system for MRI and other Large Image Data 
Description ALSPAC are collecting large volumes of image data through scanning individuals at assessment clinics and also work underway as part of ALSPAC's MRC MH Pathfinder award, through linkage to images held in social media accounts. These images are individually relatively small size, but are being accessed in huge volumes - e.g. a single participants MRI scan can comprise ~12,000 separate image files. Furthermore, many images have embedded identifier values (e.g. NHS ID or name embedded in an MRI scan) or have inherently identifiable components (e.g. an individuals MRI head scan can be used to show a 3D topographic map of a persons face). This leaves study databanks with a challenge to archive large volumes of data, efficiently process them for reuse, and to de-identify them in complex ways. Through MRC MH Pathfinder, the ALSPAC Data Team and Data Linkage Team have developed an image management server with capabilities for archiving, processing and de-identification. This is built on a suite of 'open source' software packages and tuned to the needs of a longitudinal study. This new infrastructure is now operational and facilitating new research in ALSPAC. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact The tool has enabled ALSPAC to lower the charges for the processing of data for reuse from £750 per project to £300 per project. The use of the tool is supporting multiple grant applications, both in the UK and USA. The tool reduces the cost of the grant compared to previous approaches as it impacts on collection and archiving as well as reuse. E.g. Elanor Hinton application to support assessment of the impact of parenthood on maternal and paternal neurobiology and subsequent child development (ALSPAC Reference: B3386, https://proposals.epi.bristol.ac.uk/?q=node/129988). The tool is supporting the MRC funded grant led by Professor Anthony David (UCL) (ALSPAC Reference: B3035, https://proposals.epi.bristol.ac.uk/?q=node/127353). 
 
Title ALSPAC Biosamples and DNA resources 
Description Over 1.2 million aliquots biosamples taken at various timepoints from ALSPAC participants. The bioresource is available to the scientific community for research. Although the resource was initiated in 1991 it is an active collection with new samples being collected and made available constantly. 
Type Of Material Biological samples 
Provided To Others? Yes  
Impact Samples have been made available for numerous ALSPAC projects. The resource received the UK Biobank of the Year award in 2018 reflecting the impact of studies utalising the samples. 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/biological-resources/
 
Title Checklist for synthetic data production 
Description In order to encourage the use of synthetic data, we have developed a checklist (similar to our publications checklist) for resarchers use to adhere to certain rules for data development. A data note has been published to accompany this: https://wellcomeopenresearch.org/articles/9-57 
Type Of Material Improvements to research infrastructure 
Year Produced 2023 
Provided To Others? Yes  
Impact not yet 
URL https://www.bristol.ac.uk/media-library/sites/alspac/documents/ALSPAC-syntheticdata-checklist.pdf
 
Title Data Access Agreement (DAA) data sharing contract 
Description The data access agreement is a new data sharing contract which is compatible with contemporary legislative (e.g. General Data Protection Regulations) and research governance expectations. It aligns with ALSPAC's Online Proposal System for efficient generation of specified and controlled data requests. Importantly, the DAA enables the replication of third-party data owner requirements and the addition of particular governance controls for specific datasets (e.g. geo-spatial datasets), and as such is an important element in ALSPAC's process to allow onward sharing of linked health, geo-spatial and social records. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact The DAA is a central component in ALSPAC's negotiations with NHS Digital to enable onward sharing of linked records. 
URL http://www.bristol.ac.uk/alspac/researchers/access/
 
Title Data Privacy Impact Assessment Process 
Description A new privacy assessment tool for ALSPAC which enables the assessment of data flows (i.e. new record linkages or new data sharing with research users) in line with EU General Data Protection Regulation requirements. The tool allows the assessment of diverse risks and particular research scenarios (e.g. the use of geocoded data in the research process, the additional sensitivities of using mental or sexual health records in research investigations. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact Ensuring ALSPAC data sharing is legally compliant. 
 
Title Deep freeze of ALSPAC datasets 
Description A regular snapshot of our current data is now backed up annually off site. This is in addition to central IT regular back up systems 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? No  
Impact Imperative for disaster recovery 
 
Title Deep freeze of ALSPAC datasets 
Description A regular snapshot of our current data is now backed up annually off site. This is in addition to central IT regular back up systems. The last deep freeze was completed in the Spring of 2023 
Type Of Material Improvements to research infrastructure 
Year Produced 2023 
Provided To Others? No  
Impact Imperative for disaster recovery 
 
Title Development of ALSPAC Explore 
Description ALSPAC Explore is our public facing data catalogue. This is a component of the Obiba Open Source project suite and is hosted by University of Bristol IT services. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact Ultimately this tool will improve the discoverability and accessibility of ALSPAC data. The tool has been launched internally and is undergoing testing for external researchers to use as their primary tool for identifying ALSPAC variables. 
URL https://alspac-explore.bristol.ac.uk/mica-web/
 
Title Development of a rapid online survey regarding plans at Christmas 2021 in light of 'Plan B' 
Description ALSPAC was approach by Dr Ellen Brooks-Pollock, UOB and member of SPI-M to rapidly question our participants about their plans over th festive period and determine whether they might change following the Government's announcement of Plan B mitigation emausres 
Type Of Material Improvements to research infrastructure 
Year Produced 2022 
Provided To Others? Yes  
Impact Published on the Government website: https://www.gov.uk/government/publications/university-of-bristol-impact-of-voluntary-risk-mitigation-behaviour-on-the-magnitude-of-a-covid-19-omicron-variant-wave-in-england-11-january-2022 Pre-print and peer reviewed paper to follow alongside a DOI for the data,. 
URL https://www.gov.uk/government/publications/university-of-bristol-impact-of-voluntary-risk-mitigation...
 
Title Development of online consent procedures 
Description In order to facilitate virtual clinics the systems team have successfully tested and implemented the collection of online consent for remote measures. 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? No  
Impact Consent is vital for all 'face to face' measures we would normally collect. As we have moved to remote data collection the method for obtaining consent has had to change. 
 
Title Development of virtual online visits 
Description To replace face to face visits in the times of pandemic and to provide an alternative offering to participants who do not want to or cannot attend a clinic visit in person. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? No  
Impact Will minimise attrition. 
 
Title Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference 
Description Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. We have described the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We have considered the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner. 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact Recent development. notably described here: https://www.nature.com/articles/s41467-018-03109-y - with related software - see the link below. 
URL http://www.bristol.ac.uk/integrative-epidemiology/faciliitiesresources/software/
 
Title Handling ethical queries and feedback within studies of genetic sequence data. 
Description This work provides a discussion and framework for the handling of incident and pertinent findings in the analysis of sequence data. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact NA 
URL http://www.nature.com/ejhg/journal/v22/n9/full/ejhg2013290a.html
 
Title Implementation of DataSHIELD for the InterConnect project 
Description Prof Paul Burton worked with Professor Nick Wareham's MRC-Epidemiology Unit led, Interconnect Project which is funded by the European Union to implement DataSHIELD on a consortium of eight cohorts/biobanks (seven European, one North American) including ALSPAC. This required a standard implementation of the DataSHIELD structure for remote federated analysis of "horizontally partitioned" data (different sources hold the same variables on different individuals). 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact The implementation of DataSHIELD has been successfully led by Tom Bishop who is the lead DataSHIELD development team member based in Cambridge. Prof Burton's team have provided ongoing support of both the technology and statistical methods. This work was successful and a paper is currently under review at the International Journal of Epidemiology: 
URL http://www.interconnect-diabetes.eu/
 
Title Implementation of new data warehouse and external data catalogue 
Description We are in the process of moving all data access to Opal (data warehouse) and to add Mica (public catalogue) as a data discovery option. This will be known externally as ALSPAC Explore. Opal and Mica are both components of the Obiba Open Source project suite and are hosted by University of BRistol IT services. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact Mica and Opal talk to each other; a researcher can compile their data list as they search and it can be imported directly into Opal, reducing work for both researchers and data buddies - Realtime frequencies of data in Opal will be displayed in Explore; this drastically reduces the amount of work going into the data dictionary. - Explore much more efficient searching system which should enhance data discoverability - Future developments may include the use of Datashield for federated analyses, networking with other studies using the same software - Enables the use of Ontologies (currently CLOSER topics and Maelstrom classification). 
URL https://alspac-data.bristol.ac.uk/mica-web/
 
Title Improved access policy 
Description A much improved Access Policy has been written and made available via the website 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Ensures rules regarding data access are clear and transparent 
URL http://www.bristol.ac.uk/alspac/researchers/data-access/
 
Title Imputed Genome Wide (GWAS) single nucleotide polymorhism (SNP) dataset 
Description Imputation of 526,688 SNPs post quality control to the HapMap CEU population, release 22 for subjects in ALSPAC with GWAS data. 
Type Of Material Biological samples 
Year Produced 2013 
Provided To Others? Yes  
Impact The data have been used in several high impact publications including: Anttila, V. et al. 2013. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet. 2013 Aug;45(8):912-7 Hinds, D.A. et al. (In press). A meta-analysis of self-reported allergy identifes shared and allergy-specifc susceptibility loci Nat Genet. 2013 Aug;45(8):907-11 Evans, D.M. et al. 2013. Genome-Wide Association Study Identifies Loci Affecting Blood Copper, Selenium and Zinc. Hum Mol Genet. 2013 Oct 1;22(19):3998-4006 
 
Title Introduction of REDCap as a data collection tool 
Description REDCap has been successfuly introduced as the data collection tool used in clinic based data collection. It is also about to be used for the first time for online questionnaire data collection 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Streamlines data collection; minimising errors 
URL http://www.project-redcap.org/
 
Title Introduction of cost recovery, replacing data buddy fee 
Description At the request of the funders a number of salaries related to data provision are now recovered directly from external researchers who pay a variable amount (depending on the amount and type of data) to access ALSPAC data 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Cost recovery income is monitored very closely - currently the model is not bringing in sufficient income. It will be reassessed at the end of year 1. 
 
Title Longitudinal Linkage Collaboration 
Description Six National Core Studies have been set up for COVID-19 research, funded by the UK Government. These studies aim to answer pressing COVID-19 questions through accelerating progress in establishing a pioneering health data and research infrastructure for the future. The UK LLC is operated by the University of Bristol and the University of Edinburgh. It is embedded within the COVID-19 Longitudinal Health and Wellbeing National Core Study. This work uses data provided by study participants and patients collected through longitudinal studies, or as part of their care and support. 
Type Of Material Improvements to research infrastructure 
Year Produced 2022 
Provided To Others? Yes  
Impact Coordination of cohorts and record linkage,. 
URL https://ukllc.ac.uk
 
Title MRI images data pipeline 
Description Streamlined release of re-indexed MRI images on request. 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? Yes  
Impact Data note listed below details the data available through the pipeline. This has resulted in reduced cost recovery charges for this data. 
URL https://wellcomeopenresearch.org/articles/5-203
 
Title Management of a whole genome sequencing project and data 
Description This work presents lessons learnt from the management of a whole genome sequence data project. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work has been published: Genome Med. 2013 Nov 15;5(11):100. doi: 10.1186/gm504. eCollection 2013. Implementing a successful data-management framework: the UK10K managed access model. Muddyman D1, Smee C1, Griffin H2, Kaye J2. 
 
Title Management of clinical information within a whole genome sequence project 
Description This work considers and advises on how to handle data which is clinically important within the context of a whole genome sequence project. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work has been published: Eur J Hum Genet. 2014 Sep;22(9):1100-4. doi: 10.1038/ejhg.2013.290. Epub 2014 Jan 15. Managing clinically significant findings in research: the UK10K example. Kaye J1, Hurles M2, Griffin H1, Grewal J3, Bobrow M4, Timpson N5, Smee C2, Bolton P6, Durbin R2, Dyke S2, Fitzpatrick D7, Kennedy K2, Kent A8, Muddyman D2, Muntoni F9, Raymond LF4, Semple R4, Spector T10; UK 10K. 
 
Title Metadata: Variable catalogue 
Description Improved metadata provision - a simple list of variables available so that researchers can simply copy and paste in order to provide lists of variables as part of their data request under cost recovery 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Improves accessibility/discoverability of data 
URL http://www.bristol.ac.uk/alspac/researchers/data-access/data-dictionary/
 
Title Multiple Imputation DOCtor (midoc) R package 
Description Missing data is a common issue in health and social research, often addressed by multiple imputation (MI). MI is a flexible and general approach, with a suite of software packages. However, using MI in practice can be complex. Application of MI involves multiple decisions which are rarely justified or even documented, and for which little guidance is available. The Multiple Imputation DOCtor (midoc) R package is a decision-making system which incorporates expert, up-to-date guidance to help you choose the most appropriate analysis method when there are missing data. IT has been designed by ALSPAC researchers using ALSPAC data as key use-cases. Workships are currently being set up for ALSPAC researchers to demonstrate its use. Funded by MRC 
Type Of Material Improvements to research infrastructure 
Year Produced 2023 
Provided To Others? No  
Impact Still being finalised. 
URL https://github.com/elliecurnow/midoc
 
Title Online booking system 
Description Bespoke software development allowing study participants to book appointments online to attend the clinical assessment 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Improved participant experience 
 
Title Online proposal for data access system 
Description Bespoke software development where researchers can enter details of new proposals to access ALSPAC data, system processes these and logs all relevant supporting information and agreements together (see https://proposals.epi.bristol.ac.uk/) 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Improved system providing speedier access to ALSPAC data. We have been approached by other research groups interested in using this system and we are exploring options around how we might make this available to others. 
URL https://proposals.epi.bristol.ac.uk/
 
Title Online questionnaire system 
Description Successful development of an effective online questionnaire system used by participants to complete ALSPAC questionnaires via the study website 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact More efficient and cost effective collection of data from research particpants 
 
Title Power calculations for the undertaking of genetic sequence analysis of rare variants. 
Description This work provides a framework within which power calculations for the analysis of rare variants from genetic sequence data can be undertaken. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact NA 
URL http://onlinelibrary.wiley.com/doi/10.1002/gepi.21797/abstract
 
Title Protocol for genetic annotation and characterization 
Description We have developed a tool which annotates all genetic variants within a user specified region of the human genome. These annotations are collated from various databases, including information such as (but not limited to) predicted consequence, predicted deleterious impact, trait associations, quantitative trait loci (i.e. expression, methylation, chromatin, metabolomics, proteomics), regulatory information, biological pathways and druggable/trials info. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact As the tool is unreleased there has been no impact yet. However, we intend to share the tool with the French pharmaceutical company Sanofi once it is ready as part of our on-going collaboration. 
 
Title Protocol for recall by genotype study - sleep 
Description This work provides a framework within which recall by genotype studies can be undertaken. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This description is now published: BMC Med Genet. 2015 Oct 24;16:96. doi: 10.1186/s12881-015-0244-4. Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology. 
URL http://www.biomedcentral.com/1471-2350/15/13
 
Title Protocol for recall by genotype study - smoking 
Description This work provides a written protocol for the undertaking of recall by genotype studies. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work is now published: BMC Med Genet. 2014 Jan 22;15:13. doi: 10.1186/1471-2350-15-13. A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol. Ware JJ1, Timpson N, Davey Smith G, Munafò MR. 
 
Title Providing a genomic teaching resource 
Description Teaching the methods and approaches used in genetic epidemiology is most effective when realistic data is available for students to use. We have scrambled the ALSPAC genetic data in order to preserve the genetic characteristics of the dataset whilst making the data non-disclosive of the participants. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This scrambled dataset has been used in at least six short courses on genetic epidemiology to date, and is continually used to teach students. 
 
Title Recall by Genotype Study Planner - app 
Description This is an online "shiny app" which is designed to accompany a position paper describing the principal and application of Recall by Genotype as a research method. It allows the calculation of statistical power and study cost (in comparison to other more conventional designs) in a series of study formats. 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact This research tool will be released in full form with the publication of the Recall by Genotype position paper. 
 
Title Statistical methods for approaching lifecourse methods 
Description A number of groups are working on methods for analysing longitudinal data from the study producing both novel methods and building on existing methods to make best use of the repeat measures ALSPAC has. This area of work has a particular focus on lifecourse models. 
Type Of Material Improvements to research infrastructure 
Year Produced 2015 
Provided To Others? Yes  
Impact A number of papers have been published including: Smith AD, Hardy R, Heron J, Joinson CJ, Lawlor DA, Macdonald-Wallis C, Tilling K. A structured approach to hypotheses involving continuous exposures over the life course. Int J Epidemiol. 2016 Aug;45(4):1271-1279. Epub 2016 Jul 1. Howe LD, Smith AD, Macdonald-Wallis C, Anderson EL, Galobardes B, Lawlor DA, Ben-Shlomo Y, Hardy R, Cooper R, Tilling K, Fraser A. Relationship between mediation analysis and the structured life course approach. Int J Epidemiol. 2016 Aug;45(4):1280-1294. Epub 2016 Sep 27. Smith AD, Heron J, Mishra G, Gilthorpe MS, 
 
Title Statistical methods for dealing with repeat measures 
Description A number of groups are working on methods for analysing longitudinal data from the study producing both novel methods and building on existing methods to make best use of the repeat measures ALSPAC has. This covers a variety of different types of data and areas of research including growth, risky behaviours, diet and health outcomes 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact A number of papers have been published. A few relevant examples are provided below: Anderson EL, Tilling K, Fraser A, Macdonald-Wallis C, Emmett P, Cribb V, Northstone K, Lawlor DA, Howe LD. Estimating Trajectories of Energy Intake Through Childhood and Adolescence Using Linear-Spline Multilevel Models. Epidemiology. Epub 2013 May 21. PMID: 23698751 Howe LD, Tilling K, Galobardes B, Davey Smith G, Gunnell D, Lawlor DA. Socioeconomic differences in childhood growth trajectories: at what age do height inequalities emerge? J Epidemiol Community Health. 2012;66(2):143-8. PMID:20724285. Heron J, Macleod J, Munafo MR, Melotti R, Lewis G, Tilling K, Hickman M. Patterns of Alcohol Use in Early Adolescence Predict Problem Use at Age 16. Alcohol Alcohol. 2012;47(2):169-77. PMID:22215001. Macdonald-Wallis C, Lawlor D, Palmer T, Tilling K. Multivariate multilevel spline models for parallel growth processes: application to weight and mean arterial pressure in pregnancy. Stat Med. 2012;31(26):3147-6. PMID:22733701. 
 
Title Statistical methods for examining missing data/misclassification 
Description A number of statisticians are working on methods using linkage data to investigate missing data and/or misclassification of exposures/outcomes. This covers a number of different data sources and areas of research including education, mental health and wellbeing 
Type Of Material Improvements to research infrastructure 
Year Produced 2015 
Provided To Others? Yes  
Impact A number of papers have been published including: Cornish R, Tilling K, Boyd A, Macleod J, Van Staa T. Using linkage to electronic primary care records to evaluate recruitment and nonresponse bias in the Avon Longitudinal Study of Parents and Children. Epidemiology. 2015 Jul;26(4):e41-2. doi: 10.1097/EDE.0000000000000288. Cornish RP, Tilling K, Boyd A, Davies A, Macleod J. Using linked educational attainment data to reduce bias due to missing outcome data in estimates of the association between the duration of breastfeeding and IQ at 15 years. Int J Epidemiol. 2015 Jun;44(3):937-45. doi: 10.1093/ije/dyv035. Mars B, Cornish R, Heron J, Boyd A, Crane C, Hawton K, Lewis G, Tilling K, Macleod J, Gunnell D. Using Data Linkage to Investigate Inconsistent Reporting of Self-Harm and Questionnaire Non-Response. Arch Suicide Res. 2016;20(2):113-41. doi: 10.1080/13811118.2015.1033121. Epub 2016 Jan 20. Cornish RP, John A, Boyd A, Tilling K, Macleod J. Defining adolescent common mental disorders using electronic primary care data: a comparison with outcomes measured using the CIS-R. BMJ Open. 2016 Dec 1;6(12):e013167. doi: 10.1136/bmjopen-2016-013167. 
 
Title Statistical thresholds for the analysis of whole genome sequence data. 
Description This work provides guidelines for the setting of statistical thresholds when analysing whole genome sequence data. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work has been published: Genet Epidemiol. 2014 May;38(4):281-90. doi: 10.1002/gepi.21797. Epub 2014 Feb 14. Estimating genome-wide significance for whole-genome sequencing studies. Xu C1, Tachmazidou I, Walter K, Ciampi A, Zeggini E, Greenwood CM; UK10K Consortium. 
 
Title UK10K Project Dalliance Genome Browser 
Description The UK10K Genome Browser is based on the Biodalliance platform (Down et al., Bioinformatics 2011), designed to facilitate the retrieval of genotype-phenotype association results from the UK10K Cohorts Project (Walter et al, Nature 2015), and their visualisation in the context of different annotation features. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Allows researchers to easily access key results from the cohort arm of the UK10K and generate new hypothesis based on this dataset 
URL http://www.uk10k.org/dalliance.html
 
Title Variable Search Tool 
Description A web application has been developed which performs rapid searching of all variables that are readily accessible in the resource. Using this in conjunction with the detailed data dictionary eases discoverability of the ALSPAC data for potential users. This web based app was formally released in May 2018 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact The release of the tool has facilicated easy searching for variables and is used widely by both internal and external researchers 
URL http://variables.alspac.bris.ac.uk/
 
Title Web resource for the provision of UK10K sequence data, the display of results, related information and ethical documentation. 
Description This resource provides a collection of material from the UK10K project which involved the sequencing of over 4000 population based human genomes. Resources include: (i) access to raw data (ii) results from association study analysis (rare and common genetic variants) through an integrated browser (iii) ethical documentation (iv) related publications and management information 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact NA 
URL http://www.uk10k.org
 
Title Wellcome LPS COVID Questionnaire bank 
Description The ALSPAC team has led the development of the Wellcome funded Longitudinal Population Studies COVID questionnaire bank. This facilitates comparable research across longitudinal studies. Together with Generation Scotland, ALSPAC form the secretariat for the Wellcome LPS COVID group. ALSPAC has provided the questionnaire in REDCap format on demand 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? Yes  
Impact The questionnaire bank facilitates research across multiple studies about the COVID pandemic. The questions were designed to help researchers explore changes using the same validated questions to the lives of cohort participants the UK and elsewhere. 
URL https://www.bristol.ac.uk/alspac/researchers/wellcome-covid-19/
 
Title ALSPAC 'GP' dataset of linked primary care records (1991-2018) 
Description These data are the coded values - relating to participant symptoms, diagnoses, treatments, care - extracted from GP primary care records of ALSPAC participants receiving care in England. The records are linked from EMIS Ltd (a GP software system company) and are managed by the ALSPAC data linkage team. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact The data are being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 4) Professor Dheeraj Rai to study Adolescent and adult mental health outcomes of autism and autistic traits (ALSPAC Reference: B2622, https://proposals.epi.bristol.ac.uk/?q=node/127702) 5) Professor Hilary Pinnock for the derivation of a clinical prediction rule for the diagnosis of asthma (ALSPAC Reference: B2830, https://proposals.epi.bristol.ac.uk/?q=node/127536) 6) Professor Sinead Langan as part of a program to establish efficient methods to understand medical and social outcomes associated with eczema (ALSPAC Reference: B2606, https://proposals.epi.bristol.ac.uk/?q=node/127717). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'HES' Hospital Episode Statistics records 
Description These are minimum returns of Hospital Episode Statistics secondary care records of ALSPAC participants receiving care in England. The records are linked from NHS Digital and accessed under a NHS Digital - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact The data are being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'Looked After' and 'Children In Need' linked social care records 
Description These are records of children taken into state care and children classifed as 'in Need'. The records are linked from Department for Education National Pupil Database and accessed under a DfE - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). While access is currently restricted to the project team, we are exploring mechanisms to widen access using the new powers of the Digital Economy Act and in partnership with the Administrative Data Research-UK. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? No  
Impact The data are being used in a project led by Professor John Macleod and Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). This research has resulted in an academic paper: Teyhan A, Boyd A, Wijedasa D, Macleod J. Early life adversity, contact with children's social care services and educational outcomes at age 16 years: UK birth cohort study with linkage to national administrative records. BMJ open. 2019 Oct 1;9(10):e030213. We have also published a blog article emphasising the value of the novel methodologies in this research: https://www.closer.ac.uk/news-opinion/blog/filling-gaps-boosts-evidence-vulnerable-children/ 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'MHSDS' Data Set of Mental Health & Learning Difficulties Community Care Interactions 
Description These are minimum returns of Mental Health community care records of ALSPAC participants receiving care in England. The records are linked from NHS Digital and accessed under a NHS Digital - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact The data are being used in a project led by Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'STORK' dataset of linked maternity records (1990-1992) 
Description The ALSPAC Data Linkage team have recently (2019-2020) cleaned and documented the STORK dataset of midwifery and birth delivery records for those index participants born in either of the two main maternity hospitals in Bristol (approx. 85% of enrolled participants). These data are available for access to the bona-fide research community via the ALSPAC access mechanism. A 'Data Note' publication is being prepared to contribute documentation and to aid the discoverability of the new dataset. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact The data are being used by Dr Katie Harron (UCL) as part of her Wellcome Trust LPS (Aim 2) Award (ALSPAC reference B3002, https://proposals.epi.bristol.ac.uk/?q=node/127384). The data are being used by Dr Alison Teyhan (University of Bristol) as part of the ALSPAC Born-in-Bradford MRC MH Pathfinder award (ALSPAC reference B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC - genomewide genetic data resources 
Description Currently I am responsible for the delivery of genomewide data from the ALSPAC collection. With over 18000 mother and child samples, this is being increased to include partners/fathers and to make best use of newly available deep imputation panels. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact The resource is fully described online and is available to the academic community. 
URL http://www.bris.ac.uk/alspac/
 
Title ALSPAC UK Secure eResearch Platform for the secure analysis of sensitive data 
Description The ALSPAC data linkage team have worked with the UK Secure eResearch Platform team (University of Swansea) to establish an 'ALSPAC UKSeRP' secure research server and for the secure analysis of sensitive data, particularly linked routine records accessed under contract. The ALSPAC UKSeRP has been embedded in ALSPAC's linkage ethics and data sharing agreements. It has also been embedded in the study's ISO27001 certified Information Security Management System (ISMS). This is now providing the infrastructure for sharing data with bona fide users, subject to ALSPAC's project approvals process. The management of the system is governed by Standard Operating Procedures and is subject to internal and external audit assessments. We are currently in a 'Beta User' phase, once the mechanisms are fully established the resource will be promoted more widely. 
Type Of Material Data handling & control 
Year Produced 2019 
Provided To Others? Yes  
Impact The ALSPAC UKSeRP 'Beta User' phase is currently being used for 6 research programmes, 4 based at the University of Bristol, 1 at the University of Edinburgh and 1 at LSHTM. It is the key infrastructure for enabling the ALSPAC Born In Bradford MRC MH Pathfinder deliverables. The infrastructure is being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 4) Professor Dheeraj Rai to study Adolescent and adult mental health outcomes of autism and autistic traits (ALSPAC Reference: B2622, https://proposals.epi.bristol.ac.uk/?q=node/127702) 5) Professor Hilary Pinnock for the derivation of a clinical prediction rule for the diagnosis of asthma (ALSPAC Reference: B2830, https://proposals.epi.bristol.ac.uk/?q=node/127536) 6) Professor Sinead Langan as part of a program to establish efficient methods to understand medical and social outcomes associated with eczema (ALSPAC Reference: B2606, https://proposals.epi.bristol.ac.uk/?q=node/127717). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC Whole Exome Sequence Data Trios 
Description Whole Exome Sequence (WES)data has been generated on ~ 9,000 ALSPAC G1 individuals and ~ 1,700 of their mothers (G0) and 1,700 of their fathers (G0). The data set will include WES from ~1,700 family trios. Data is now available for researchers in raw format and will be processed and publicised in 2023 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
Impact This data has greatly enhanced ALSPAC's comprehensive omics catalogue and is a valuable resource for genetic epidemiology 
 
Title ARIES-Explorer 
Description ARIES-Explorer provides an openly accessible web interface to explore epigenome-wide methylation data from the Accessible Resource for Integrated Epigenomics Studies 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact Cited in a key review in the field (Mill et al, Nature Reviews Genetics, VOLUME 14 | AUGUST 2013 | 585). 419 unique visitors to the site in its first month of operation. 
URL http://ariesepigenomics.org.uk/ariesexplorer
 
Title Avon & Somerset Regional police records 
Description 1757 G1 participants (14%) linked to at least one police record for a charge, offence 'taken into consideration', caution, or another out of court disposal. 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
Impact Facilitates ressearch into criminal activity without relying on self report. 
URL https://doi.org/10.12688/wellcomeopenres.18720.1
 
Title Bristol region NOx modelled Air Pollution Dataset 
Description NOx air pollution data was modelled for the ALSPAC catchment area from 1990 to 2018. In conjunction with ALSPAC participant residential and school geocoding database this enables air pollution data exposure to be estimated and linked to participants. Using the ALGAE software ALSPAC can estimate the exposure with critical development periods (e.g. pregnancy trimesters). Directly measured air pollution records have been collected (from local authority deployed air pollution sensors) and these sensor data will be used to calibrate the modelled data. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact The data will be used in an ALSPAC based epidemiological assessment of the impact of in utero NOx exposure and lung-function outcomes. It is also being shared with collaborators at Imperial (London) for use in an assessment of the impact of availability of greenspace on mental health outcomes. 
 
Title Broad Whole Exome sequencing 
Description n=3000 to be released in 2024 
Type Of Material Database/Collection of data 
Year Produced 2024 
Provided To Others? No  
Impact none yet 
 
Title Browser for the UK10K whole genome sequencing project 
Description This work represents the need for a way to present both whole genome sequence data and the results obtained from the analysis of those data (for phenotypic associations in principle). This browser is an existing solution to the need to display genomewide results for sequencing data. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact This work has been published: Bioinformatics. 2015 Dec 15;31(24):4029-31. doi: 10.1093/bioinformatics/btv491. Epub 2015 Aug 26. An interactive genome browser of association results from the UK10K cohorts project. Geihs M1, Yan Y1, Walter K1, Huang J1, Memari Y1, Min JL2, Mead D1; UK10K Consortium, Hubbard TJ3, Timpson NJ2, Down TA4, Soranzo N5. 
 
Title CLOSER harmonised BMI dataset 
Description ALSPAC has contributed to a harmonised dataset through CLOSER which has harmonised data on height, weight and BMI at ages 7, 8, 9, 10, 11 and 17. The data has been lodged with the UK Data Service and can be accessed through a Special License 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Has contributed to our understanding of how rates of obesity have changed over the generations and the impact of social inequalities. See here: https://www.closer.ac.uk/research-fund-2/data-harmonisation/harmonising-measures-body-size-body-composition/ for a summary. 
URL http://doi.org/10.5255/UKDA-SN-8208-1
 
Title COVID Questionnaire 1 G0 and G1 dataset 
Description Dataset containing Q1 results for G1 and G0 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Contribution to our understanding of the impact of the pandemic, particularly mental health 
URL https://wellcomeopenresearch.org/articles/5-127
 
Title COVID Questionnaire 3 and serology results on G0 and G1 
Description Dataset containing Q3 results and results for home antibody testing for G1 and G0 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Contribution to our understanding of the impact of the pandemic, based for identifying cases for further study on recuperation and longevity of infection. A data note has just been submitted to Wellcome Open 
 
Title COVID questionnaire 2 G0 and G1 dataset 
Description Dataset containing Q2 results for G1 and G0 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Contribution to our understanding of the impact of the pandemic, particularly mental health 
URL https://wellcomeopenresearch.org/articles/5-210