The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019
Lead Research Organisation:
Wellcome Trust
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- Wellcome Trust (Lead Research Organisation)
- Duke-NUS Graduate Medical School (Collaboration)
- University of Granada (Collaboration)
- The Hospital for Sick Children (SickKids) (Collaboration)
- Lausanne University Hospital (CHUV) (Collaboration)
- Chungnam National University (Collaboration)
- Harvard University (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- University of Vienna (Collaboration)
- McMaster University (Collaboration)
- University of Bradford (Collaboration)
- University of Manitoba (Collaboration)
- Murdoch Children's Research Institute (Collaboration)
- EMIS Group (Collaboration)
- Massachusetts General Hospital (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- Indiana University (Collaboration)
- Norwegian Institute of Public Health (Collaboration)
- European Molecular Biology Laboratory (Collaboration)
- Aarhus University (Collaboration)
- COVENTRY UNIVERSITY (Collaboration)
- Villanova University (Collaboration)
- University of London (Collaboration)
- UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST (Collaboration)
- Erasmus MC (Collaboration)
- Westlake University (Collaboration)
- University of Hull (Collaboration)
- Birkbeck, University of London (Collaboration)
- Cincinnati Children's Hospital Medical Center (Collaboration)
- University of Maryland, College Park (Collaboration)
- University of Waterloo (Collaboration)
- University of Texas at Austin (Collaboration)
- New York State Office of Mental Health (Collaboration)
- Uppsala University (Collaboration)
- University of Tasmania (Collaboration)
- International Agency for Research on Cancer (IARC) (Collaboration)
- Emory University (Collaboration)
- Princeton University (Collaboration)
- Yale University (Collaboration)
- Millennium Cohort Study (MCS) (Collaboration)
- James Cook University (Collaboration)
- Eberhard Karls University of Tübingen (Collaboration)
- Korea University (Collaboration)
- University of Sydney (Collaboration)
- UNIVERSITY OF ABERDEEN (Collaboration)
- Penn State University (Collaboration)
- Sichuan University (Collaboration)
- Our Future Health (Collaboration)
- Boston Children's Hospital (Collaboration)
- University of Adelaide (Collaboration)
- Concordia University (Collaboration)
- University of California, Los Angeles (UCLA) (Collaboration)
- National Institute for Health Research (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- OXFORD BROOKES UNIVERSITY (Collaboration)
- University of Turin (Collaboration)
- Duke University (Collaboration)
- University of Memphis (Collaboration)
- ROSA BIOTECH LIMITED (Collaboration)
- University Hospital Erlangen (Collaboration)
- UNIVERSITY OF YORK (Collaboration)
- QIMR Berghofer Medical Research Institute (Collaboration)
- Hunter Medical Research Institute (Collaboration)
- University of California, San Francisco (Collaboration)
- University of Warwick (Collaboration)
- UNIVERSITY OF STRATHCLYDE (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- University of Amsterdam (Collaboration)
- Leiden University Medical Center (Collaboration)
- The Open University (Collaboration)
- University of Bath (Collaboration)
- University of Pennsylvania (Collaboration)
- University of Otago (Collaboration)
- NHS South, Central and West Commissioning Support Unit (Collaboration)
- University of Pittsburgh (Collaboration)
- University of Leicester (Collaboration)
- Sinai Health System (Collaboration)
- Evolyst (Collaboration)
- Seoul National University (Collaboration)
- MAGIC (The Meta-Analyses of Glucose and Insulin-related traits Consortium) (Collaboration)
- Fudan University (Collaboration)
- UNIVERSITY OF ESSEX (Collaboration)
- University of Wisconsin-Madison (Collaboration)
- National Institute of Health and Medical Research (INSERM) (Collaboration)
- Cambridge Cognition Ltd (Collaboration)
- Columbia University Medical Center (Collaboration)
- University of South Carolina (Collaboration)
- University of Dundee (Collaboration)
- Romanian Academy (Collaboration)
- University of Strasbourg (Collaboration)
- British Geological Survey (Collaboration)
- Hannover Medical School (Collaboration)
- Queen's University Belfast (Collaboration)
- Telethon Kids Institute (Collaboration)
- University of Toronto (Collaboration)
- University of Eastern Finland (Collaboration)
- Vilnius University (Collaboration)
- University of Oslo (Collaboration)
- Massey University (Collaboration)
- University at Buffalo (Collaboration)
- University College Dublin (Collaboration)
- Food and Drug Administration (FDA) (Collaboration)
- Metabolon Inc (Collaboration)
- Utrecht University (Collaboration)
- University of Macau (Collaboration)
- Max Planck Society (Collaboration)
- Barcelona Institute for Global Health (Collaboration)
- Loughborough University (Collaboration)
- University of Auckland (Collaboration)
- University of the Witwatersrand (Collaboration)
- University of Oxford (Collaboration)
- Keele University (Collaboration)
- Chinese University of Hong Kong (Collaboration)
- Drexel University (Collaboration)
- Thames Valley Police (Collaboration)
- University of Iowa (Collaboration)
- University of Arizona (Collaboration)
- University College London (Collaboration)
- Federal University of Bahia (Collaboration)
- State University of New York (Collaboration)
- University of Bergen (Collaboration)
- Virginia Commonwealth University (Collaboration)
- University of Newcastle (Collaboration)
- Delft University of Technology (TU Delft) (Collaboration)
- Maastricht University (UM) (Collaboration)
- University of Rochester (Collaboration)
- University of North Carolina at Chapel Hill (Collaboration)
- Boehringer Ingelheim (Collaboration)
- University of Illinois Urbana-Champaign (Collaboration)
- TrygFonden (Collaboration)
- University of Oulu (Collaboration)
- University of Washington (Collaboration)
- QUEEN MARY UNIVERSITY OF LONDON (Collaboration)
- Stetson University (Collaboration)
- Olink AB (Collaboration)
- Zhejiang University (Collaboration)
- University of Calgary (Collaboration)
- University of Surrey (Collaboration)
- Case Western Reserve University (Collaboration)
- University of Minnesota (Collaboration)
- NORTHUMBRIA UNIVERSITY (Collaboration)
- NHS GRAMPIAN (Collaboration)
- University of Reading (Collaboration)
- University of Santiago, Chile (Collaboration)
- NYU Langone Medical Center (Collaboration)
- NORTH BRISTOL NHS TRUST (Collaboration)
- University of Zurich (Collaboration)
- Vanderbilt University (Collaboration)
- Orygen (Collaboration)
- University College Cork (Collaboration)
- Johns Hopkins University (Collaboration)
- Stanford University (Collaboration)
- Pasteur Institute, Paris (Collaboration)
- Icahn School of Medicine at Mount Sinai (Collaboration)
- Federal University of Rio de Janeiro (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST (Collaboration)
- University of Copenhagen (Collaboration)
- Newcastle University (Collaboration)
- East Tennessee State University (Collaboration)
- University Psychiatric Clinics Basel (Collaboration)
- University of Tilburg (Collaboration)
- University of East Anglia (Collaboration)
- Ottawa Hospital Research Institute (Collaboration)
- UNIVERSITY OF EXETER (Collaboration)
- McGill University (Collaboration)
- Radboud University Nijmegen Medical Center (Collaboration)
- Ipsos MORI (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- Universität Hamburg (Collaboration)
- University of California, San Diego (UCSD) (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- University of Huddersfield (Collaboration)
- University at Albany, State University of New York (Collaboration)
- Hong Kong Polytechnic University (Collaboration)
- Federal University of Pelotas (UFPel) (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- UK Biobank (Collaboration)
- National Information Processing Institute (Collaboration)
- St Thomas' Hospital (Collaboration)
- Nanjing Medical University (Collaboration)
- University of Basel (Collaboration)
- National University of Ireland, Galway (Collaboration)
- National Centre for Social Research (Collaboration)
- Kingston University London (Collaboration)
- Broad Institute (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- EDGE HILL UNIVERSITY (Collaboration)
- University of Göttingen (Collaboration)
- Pompeu Fabra University (Collaboration)
- Isfahan University of Medical Sciences (Collaboration)
- Florida State University (Collaboration)
- University of Montreal (Collaboration)
- UNIVERSITY OF LEEDS (Collaboration)
- Brunel University London (Collaboration)
- University of Bristol (Collaboration)
- QR8 Health (Collaboration)
- University of Lausanne (Collaboration)
- London School of Economics and Political Science (University of London) (Collaboration)
- VU University Medical Center (Collaboration)
- Upstate Medical University (Collaboration)
- University of St Andrews (Collaboration)
- University of Virginia (UVa) (Collaboration)
- Center for Research in Environmental Epidemiology (Collaboration)
- MANCHESTER METROPOLITAN UNIVERSITY (Collaboration)
- Western General Hospital (Collaboration)
- University of Canterbury (Collaboration)
- University of Sussex (Collaboration)
- University of Delaware (Collaboration)
- University of the West of England (Collaboration)
- University of Ulster (Collaboration)
- Teesside University (Collaboration)
- University of Cincinnati (Collaboration)
- University of California, Davis (Collaboration)
- University of Queensland (Collaboration)
- UNIVERSITY OF KENT (Collaboration)
- University Medical Center Gronigen (Collaboration)
- Mount Sinai Hospital (Canada) (Collaboration)
- ASTON UNIVERSITY (Collaboration)
- University of Colorado Boulder (Collaboration)
- Queensland University of Technology (QUT) (Collaboration)
- Northwestern University (Collaboration)
- Ann & Robert H. Lurie Children's Hospital of Chicago (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- University of Ottawa (Collaboration)
- International Neuroinformatics Coordinating Facility (Collaboration)
- Nemours Children's Clinic (Collaboration)
- ST GEORGE'S UNIVERSITY OF LONDON (Collaboration)
- University of Geneva (Collaboration)
- DURHAM UNIVERSITY (Collaboration)
- University of Hong Kong (Collaboration)
- Ludwig Maximilian University of Munich (LMU Munich) (Collaboration)
- Agency for Science, Technology and Research (A*STAR) (Collaboration)
- RTI International (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Buck Institute for Age Research (Collaboration)
- The University of Texas at San Antonio (Collaboration)
- Coventry and Warwickshire Partnership NHS Trust (Collaboration)
- National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) (Collaboration)
- Dartmouth–Hitchcock Medical Center (Collaboration)
- University of Melbourne (Collaboration)
- University of Bern (Collaboration)
- Wessex Academic Health Science Network (Collaboration)
- Monash University (Collaboration)
- Erasmus University Rotterdam (Collaboration)
- University of Technology Sydney (Collaboration)
- MRC Dementias Platform UK (Collaboration)
- Columbia University (Collaboration)
- Swansea University (Collaboration)
- Fatherhood Institute (Collaboration)
- University of Michigan (Collaboration)
- University of Nottingham (Collaboration)
- We The Curious (Collaboration)
- Centre for Applied Education Research (Collaboration)
- China Agricultural University (CAU) (Collaboration)
- Million Women Study (Collaboration)
- National Research Council (Collaboration)
- Bradford Institute for Health Research (BIHR) (Collaboration)
- University of Hasselt (Collaboration)
- UK Centre for Ecology & Hydrology (Collaboration)
- Cardiff University (Collaboration)
- University of Nebraska at Omaha (Collaboration)
- Leiden University (Collaboration)
- Universidade de São Paulo (Collaboration)
- Johns Hopkins Medicine (Collaboration)
- University of Manchester (Collaboration)
- University of Groningen (Collaboration)
- Washington University in St. Louis (Collaboration)
- University of Southampton (Collaboration)
- Royal College of Surgeons in Ireland (Collaboration)
- Peking University (Collaboration)
- South Australian Health and Medical Research Institute (Collaboration)
- Syracuse University (Collaboration)
- Orygen Youth Health (Collaboration)
- University of Cambridge (Collaboration)
- University of Missouri (Collaboration)
- University of the Basque Country (Collaboration)
- Weill Cornell Medical College in Qatar (Collaboration)
- Montreal's Jewish General Hospital (Collaboration)
- Bristol Clinical Commissioning Group (Collaboration)
- Adolfo Ibáñez University (Collaboration)
- King's College London (Collaboration)
- University of Liverpool (Collaboration)
Publications
Abbas H
(2018)
A 3D morphometric perspective for facial gender analysis and classification using geodesic path curvature features
in Computational Visual Media
Abbas H
(2015)
Automatic Classification of Facial Morphology for Medical Applications
in Procedia Computer Science
Abdulkadir M
(2022)
Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children
in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Abdulkadir M
(2022)
Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.
in European eating disorders review : the journal of the Eating Disorders Association
Abdulkadir M
(2019)
Polygenic Risk Scores Derived From a Tourette Syndrome Genome-wide Association Study Predict Presence of Tics in the Avon Longitudinal Study of Parents and Children Cohort.
in Biological psychiatry
Abdulkadir M
(2020)
Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort.
in Journal of clinical medicine
Abdulkadir M
(2022)
The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.
in American journal of human genetics
Abel KM
(2019)
Intelligence in offspring born to women exposed to intimate partner violence: a population-based cohort study.
in Wellcome open research
Abeysekera K
(2020)
Prevalence of steatosis and fibrosis in young adults in the UK: a population-based study
in The Lancet Gastroenterology & Hepatology
Abeysekera KW
(2021)
Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.
in The Lancet regional health. Europe
| Title | Creative Reactions 2018 |
| Description | Creative Reactions is an art exhibition associated with the national Pint of Science festival. Approximately 20 researchers using ALSPAC data were paired with local Bristol artists who produced an artwork based upon their research. The exhibition was held from 11-22 May 2018. |
| Type Of Art | Artistic/Creative Exhibition |
| Year Produced | 2018 |
| Impact | Artworks were viewed and seen by the general public as well as the scientific community. Local radio, online and print media covered the exhibition. |
| URL | https://pintofscience.co.uk/event/creative-reactions-bristol-launch |
| Title | Data visualisation images on display at We The Curious's Project 'What If' exhibition 2021 |
| Description | Researchers using ALSPAC data provided imagery for the Open Science lab at We The Curious, Bristol's science centre. Tom Gaunt, Matthew Lee & others provided images to exhibit and create conversations about data collection in ALSPAC. |
| Type Of Art | Artwork |
| Year Produced | 2021 |
| Impact | Created opportunities for discussion about population health science in a public space. |
| URL | https://www.youtube.com/watch?v=TdiOA7Aj3dE |
| Title | Researcher videos for social media & website |
| Description | A series of video interviews with researchers and collaborators using ALSPAC data. Designed to share the findings and nature of work conducted with a lay audience. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| Impact | Widening awareness of research impact among core audiences - public, participants, collaborators and charities/third parties. It also provides an opportunity for researchers to thank participants and engage them in future participation with the study. |
| URL | http://www.bristol.ac.uk/alspac/media/researcher-interviews/ |
| Title | Short film on health inequality by Nic Timpson |
| Description | Short film with a talking head by Prof Nic Timpson discussing health inequality to accompany an exhibit 'Bristol Health Map' at We The Curious science centre in Bristol |
| Type Of Art | Artistic/Creative Exhibition |
| Year Produced | 2021 |
| Impact | Created an opportunity for discussion around the exhibit Bristol Health Map - showing disparities in health and life expectancies around different wards in Bristol |
| URL | https://drive.google.com/file/d/1_lv_RUhos9BxJ3H8qT-gfbycFZdAIH-c/view |
| Description | "The one-way mirror: public attitudes to commercial access to health data" |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | A longitudinal study of gambling in late adolescence and early adulthood: Follow-up assessment at 24 years |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Impact | This report describes a longitudinal study of young peoples' gambling between 17 and 24 years, using a contemporary UK cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). The aims of the ALSPAC Gambling Study were to describe gambling behaviour in youth aged 17-24 years, investigate the antecedents of regular and problem gambling, and explore the associations with other addictive behaviours and mental health. |
| URL | https://www.begambleaware.org/media/2058/alspac-gambling-study_-report-for-gamble-aware_-july-2019.p... |
| Description | ALSPAC Summary for SAGE re: COVID and children/young people |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://hdruk.app.box.com/s/c4p2w3n673js8run56qcbnhtyvjdwyys |
| Description | ALSPAC information used in in 'Your Health Record Saves Lives' information booklet produced by UK Clinical Research Collaboration |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | http://www.nhs.uk/Conditions/Clinical-trials/Documents/Research1.pdf |
| Description | ALSPAC obesity data cited in government's child obesity strategy |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.gov.uk/government/publications/childhood-obesity-a-plan-for-action |
| Description | ALSPAC research on bullying and maltreatment cited in EHRC race report |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.equalityhumanrights.com/en/race-report-healing-divided-britain |
| Description | ALSPAC research on eczema and genes featured in the National Eczema Society's Exchange magazine (159, March 2016) |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | http://www.eczema.org/products/154 |
| Description | ALSPAC research on premature babies quoted in Parliament by Stephen Hammond MP |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Citation in other policy documents |
| URL | https://hansard.parliament.uk/commons/2016-10-10/debates/5032D3A8-AA55-4388-BCE2-DE2ACAB8CDCC/School... |
| Description | ALSPAC used as example of best practice by Health and Social Care Information Centre |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | http://systems.hscic.gov.uk/infogov/codes/cop |
| Description | Adjournment debate on fetal alcohol spectrum disorder |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://hansard.parliament.uk/Commons/2019-01-17/debates/19011751000002/FoetalAlcoholSpectrumDisorde... |
| Description | Bullying research included in textbook |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies. |
| URL | http://www.independence.co.uk/shop/family-and-relationships/issues/bullying |
| Description | Bullying research included in textbook |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies. |
| URL | http://www.independence.co.uk/shop/family-and-relationships/issues/bullying |
| Description | COVID-19 Health Data Research 04 August 2020 - Weekly update for SAGE & UKRI/DHS |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.hdruk.ac.uk/wp-content/uploads/2020/08/200804-Health-Data-Research-UK-COVID-19-fortnight... |
| Description | COVID-19 Health Data Research 18 August 2020 - Weekly update for SAGE & UKRI/DHSC |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.hdruk.ac.uk/wp-content/uploads/2020/08/200818-Health-Data-Research-UK-COVID-19-fortnight... |
| Description | COVID-19 mental health and wellbeing surveillance report (series) |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.gov.uk/government/publications/covid-19-mental-health-and-wellbeing-surveillance-report/... |
| Description | COVID-19 mental health and wellbeing surveillance: report |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.gov.uk/government/publications/covid-19-mental-health-and-wellbeing-surveillance-report |
| Description | Change in Information Commissioner's Office code of practice guidance on data protection following the Data Protection Act 2018 |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | CLOSER work on the need for clearer and changed regulatory guidance regarding data retention (see Boyd et al. 2018, available from: https://wellcomeopenresearch.org/articles/3-112/v1) led to a change in official guidance from the Information Commissioner's Office (see https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-regulation-gdpr/principles/storage-limitation/). This has the potential to help safeguard data which could be used as research resources of the future. |
| URL | https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-r... |
| Description | Chapter on childhood asthma included in RCPCH air pollution report |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.rcplondon.ac.uk/projects/outputs/every-breath-we-take-lifelong-impact-air-pollution |
| Description | Cohorts knowledge panel - CIHR & Genomes Canada |
| Geographic Reach | North America |
| Policy Influence Type | Membership of a guideline committee |
| Description | Department for Education on grandparental care during COVID-19 pandemic and mitigation. |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.gov.uk/government/publications/quick-findings-on-age-distributions-of-grandparents-and-p... |
| Description | Eating disorder symptoms and self-harm are linked to higher levels of depression and anxiety during the COVID-19 pandemic |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.bristol.ac.uk/media-library/sites/policybristol/briefings-and-reports-pdfs/2021/PolicyBr... |
| Description | Evidence included in Commons Health Select Committee report |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | http://www.publications.parliament.uk/pa/cm201415/cmselect/cmhealth/845/845.pdf |
| Description | Evidence that little time outdoors contributes to the development of myopia in middle childhood |
| Geographic Reach | National |
| Policy Influence Type | Citation in clinical reviews |
| Description | Findings of research on dyslexia and vision recommended by Dyslexia Action |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | http://www.dyslexiaaction.org.uk/news/%E2%80%98dyslexia-and-sight-wider-view%E2%80%99-research-welco... |
| Description | Guidance on iodine cited by Scientific Advisory Committee on Nutrition |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.gov.uk/government/publications/sacn-statement-on-iodine-and-health-2014 |
| Description | HDRUK - Lessons from COVID-19: How can we put the UK at the forefront of health data science? |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.hdruk.ac.uk/wp-content/uploads/2020/07/Lessons-from-COVID-19-for-UK-Health-Data-Science.... |
| Description | HDRUK - regular updates for SAGE, National Core Studies & UKRI/DHSC (ALSPAC have contribute to 7 of these) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://www.hdruk.ac.uk/wp-content/uploads/2021/02/2021-02-23-Health-Data-Research-UK-SAGE-report.pd... |
| Description | Health Data Research UK Infrastructure Advisory Group |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| URL | https://www.hdruk.ac.uk/about-us/who-we-are/our-advisory-groups/ |
| Description | Impact of voluntary risk-mitigation behaviour on the magnitude of a COVID-19 Omicron variant wave in England, 11 January 2022 |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | http://www.gov.uk/government/publications/university-of-bristol-impact-of-voluntary-risk-mitigation-... |
| Description | Internet use and suicide |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | Work has highlighted the importance of internet use for understanding the architecture of suicidal behaviour. It has been specifically supported by a Department of Health Policy Research Programme and an ESRC Impact Accelerator Account and has already fed into the All Party Parliamentary Group (APPG) on suicide, the APPG on Social Media and Young People's Mental Health, a report by the House of Commons Health Select Committee on Suicide Prevention https://publications.parliament.uk/pa/cm201617/cmselect/cmhealth/1087/1087.pdf, a Royal College of Psychiatrist Patient Safety report and reviews of industry practice (e.g. advising YouTube). |
| Description | Internet use and the impact of this on mental health and well-being |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Involvement of ALSPAC in the formation of Joint Strategic Needs Assessment - Chlamydia prevalence |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Citation in other policy documents |
| Description | Maternal depression increases generation on generation. |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Impact | Pearson RM, et al. Prevalence of Prenatal Depression Symptoms Among 2 Generations of Pregnant Mothers. JAMA Network Open 2018, 1:e180725 KEY IMPACT - The findings have had global media attention including live tv and radio and the results have been commented on by the Royal College of Midwives and the Maternal Mental Health Alliance. The work is new and has not yet delivered measurable policy change, but highlights the need for increased support for young pregnant women in the current enviro-socio-economic climate. The research has already supported national campaigns to facilitate universal screening for depression (and anxiety) by midwives, for the prioritisation of pregnant women for free psychological therapies and for provision of specialist perinatal mental health community mental health teams across the UK. |
| Description | Maternal iodine status and child early and later life health outcomes. |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Maternal iodine status and child early and later life health outcomes. |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Maternal iodine status and early child health outcomes. |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Maternal iodine status and health of the child |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Maternal iodine status in early pregnancy |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | Sarah Bath - University of Surrey- able to look back in time to maternal iodine status in early pregnancy so that we could explore the relationship with child cognition. Using ALSPAC was cost-effective as cognitive measures were available in the child, and samples were available from the mother which we could use for the measurement of maternal iodine status. ALSPAC, unlike many other biobanks had urine samples from very early in pregnancy - which was the time that we were interested in. Iodine and thyroid hormones are required from conception and during the first half of pregnancy the mother is the sole source of thyroid hormone and so adequate iodine is critical; we therefore wanted to measure iodine status as early as possible. ALSPAC also had dietary information, via the food frequency questionnaire completed in pregnancy, which we have been able to use in our follow-on project (EUthyroid - a Horizon 2020 project). Published our research paper in the Lancet in May 2013. Work cited as an example in Medical Research Council document "Outputs, outcomes and impact of MRC research: 2013/14 report". Publication of a fact sheet on iodine for the general public/health practitioners via the British Dietetic Association. Iodine now included in fact sheets for pregnant women by the Infant and Toddler Forum. Work cited in Dairy Council's new publication on iodine. Work cited in iodine review by the Scientific Advisory Committee on Nutrition (gov). Work cited by EFSA in document on Dietary Reference Value for iodine: European Food Safety Authority (2014) Scientific Opinion on Dietary Reference Values for iodine. EFSA Journal 12, 3660. Paper featured in NICE "Eyes on Evidence" February 2014. Further grant funding for follow-on project: European Commission Horizon 2020 EUthyroid: towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe. Grant agreement No 634453 |
| Description | Maternal iodine status in early pregnancy and child health |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Maternal iodine status in early pregnancy and child health (2014) |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Maternal iodine status in early pregnancy and child health (2014) (2014) |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | New evidence on vitamin D supplementation in pregnancy from research showing that vitamin D status in pregnancy not associated with offspring bone mineral content |
| Geographic Reach | National |
| Policy Influence Type | Citation in clinical reviews |
| Description | New guidance on alcohol in pregnancy endorsed by Dr Simon Newell (RCOP), James Nicholls (Alcohol Research UK) and Professor David Nutt, Imperial. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Description | New guidance on importance of iodine in pregnancy diet backed up by BDA factsheet http://www.bda.uk.com/foodfacts/Iodine.pdf |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.bda.uk.com/foodfacts/Iodine |
| Description | Our Future Health Scientific Advisory Board |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| URL | https://ourfuturehealth.org.uk |
| Description | PHE Mental health - Research and analysis 7. Age Spotlight Updated 18 November 2021 |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.gov.uk/government/publications/covid-19-mental-health-and-wellbeing-surveillance-spotlig... |
| Description | Participation in All Party Parliamentary Group on Autism - building brighter futures for children with autism event (10 July 2018) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Questionnaire, linkage and interview data inform BIS report |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.gov.uk/government/publications/progression-into-higher-education-for-disadvantaged-and-u... |
| Description | Quick findings on age distributions of grandparents and parents of primary school aged children - .gov (asset - Centre for Ageing and Demography) |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/8934... |
| Description | Research on school outcomes for premature babies endorsed by Professor Sir Al Aynsley Green (first Children's Commissioner for England) |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Submitted evidence to Commons Health Select committee inquiry into suicide prevention |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr... |
| Description | Submitted evidence to Commons Health Select committee inquiry into suicide prevention |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr... |
| Description | Where's the daddy? Fathers and father-figures in UK datasets - The Fatherhood Institute |
| Geographic Reach | National |
| Policy Influence Type | Citation in systematic reviews |
| Impact | Review aims - Firstly, for funders and providers of large-scale quantitative datasets, a documentation of questions and fieldwork practices which enable researchers to identify specific categories of fathers and collect data directly from fathers. Secondly, for researchers planning secondary analyses to study fathers, an assessment of whether different categories of fathers can be identified in the data. ALSPAC forms a key part of the evidence contained within this review. |
| Description | 37356: Scourfield fellowship: Fathers, social interventions and children's wellbeing |
| Amount | £8,482 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2011 |
| End | 08/2014 |
| Description | 38361: The determinants of measures of immune function in a wild mammal. |
| Amount | £5,000 (GBP) |
| Organisation | Natural Environment Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2011 |
| End | 01/2015 |
| Description | 43249: NICE childhood obesity weight management |
| Amount | £2,250 (GBP) |
| Funding ID | F00003186 |
| Organisation | National Institute for Health and Care Excellence (NICE) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2012 |
| End | 03/2014 |
| Description | 43992: POPPIE Predictors of Persistence & Psychological Impact of Childhood Eczema |
| Amount | £800 (GBP) |
| Funding ID | F00022685 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2012 |
| End | 11/2012 |
| Description | 47297: B1227 Biomarker study |
| Amount | £2,593 (GBP) |
| Organisation | Royal College of Surgeons in Ireland |
| Sector | Academic/University |
| Country | Ireland |
| Start | 03/2013 |
| End | 02/2017 |
| Description | 59452: C.Williams Senior Research Fellowship |
| Amount | £37,043 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2020 |
| Description | A UK underpinning platform to study immunology and immunopathology of COVID-19:The UK Coronavirus Immunology Consortium |
| Amount | £6,552,119 (GBP) |
| Funding ID | MR/V028448/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 08/2021 |
| Description | A framework for linking and sharing social media data for high-resolution longitudinal measurement of mental health across CLOSER cohorts |
| Amount | £149,971 (GBP) |
| Funding ID | ES/R011583/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 02/2019 |
| Description | ALSPAC Additional Funding from 01/04/2019 to 31/07/2019 |
| Amount | £283,265 (GBP) |
| Funding ID | 102215/Z/13/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 07/2019 |
| Description | ALSPAC Questionnaire - dietary preference |
| Amount | £10,000 (GBP) |
| Organisation | University of Edinburgh |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 12/2017 |
| Description | Accumulative processes in health inequalities: the socioeconomic causes and consequences of mental and physical health comorbidity in adolescence |
| Amount | £229,631 (GBP) |
| Funding ID | ES/T013923/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2020 |
| End | 01/2023 |
| Description | Adolescent and adult mental health outcomes of autism and autistic traits |
| Amount | £74,096 (GBP) |
| Funding ID | TRUST/VC/AC/SG/3747-6849 |
| Organisation | Baily Thomas Charitable Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2016 |
| End | 03/2018 |
| Description | Adolescent and adult mental health outcomes of autism and autistic traits |
| Amount | £226,152 (GBP) |
| Funding ID | MR/R004889/1 |
| Organisation | Medical Research Council (MRC) |
| Department | Medical Research Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 05/2019 |
| Description | Adverse life events, inflammation, and trajectories of emotional and behavioural problems in childhood |
| Amount | £161,295 (GBP) |
| Funding ID | ES/P001742/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 05/2018 |
| Description | An investigation of the causal pathways from childhood conduct problems to poor health outcomes and criminal behaviour in adulthood |
| Amount | £250,000 (GBP) |
| Funding ID | 209138/Z/17/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2022 |
| Description | Are sleep difficulties in ADHD an index of neurodevelopmental severity? |
| Amount | £57,539 (GBP) |
| Funding ID | 918-3021 |
| Organisation | The Waterloo Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 10/2020 |
| Description | Autism Speaks B954 RX9194 'Genetic Variation and Gene-Environment Influences in Autistic-like traits' |
| Amount | £71,704 (GBP) |
| Funding ID | 7132 |
| Organisation | Autism Speaks |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 12/2011 |
| End | 05/2014 |
| Description | B2390 Internal Locus of Control: Origins, Determinants, and Benefits |
| Amount | £5,000 (GBP) |
| Funding ID | 58223 |
| Organisation | The John Templeton Foundation |
| Sector | Academic/University |
| Country | United States |
| Start | 08/2015 |
| Description | BIOSHARE Social Core - Qualatative Study |
| Amount | £1,806 (GBP) |
| Funding ID | Health-F4-2010-261433 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 06/2014 |
| End | 01/2015 |
| Description | Behavioural and neurophysiological effects of schizophrenia risk genes |
| Amount | £789,477 (GBP) |
| Funding ID | MR/K004360/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | CLOSER AMENDMENT 4: CLOSER INNOVATION FUND |
| Amount | £112,678 (GBP) |
| Organisation | Economic and Social Research Council |
| Department | ESRC Seminar Series |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| End | 09/2017 |
| Description | CLOSER Amendment 1: Cohort and Longitudinal Studies Enhancement Resources Grant |
| Amount | £327,143 (GBP) |
| Organisation | Economic and Social Research Council |
| Department | ESRC Seminar Series |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| End | 09/2019 |
| Description | CLOSER Amendment 3: Cohort and longitudinal studies enhancement resources grant |
| Amount | £149,136 (GBP) |
| Organisation | Economic and Social Research Council |
| Department | ESRC Seminar Series |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| End | 09/2019 |
| Description | CLOSER Amendment 5: Innovation Fund - Occupational and social class data coding and harmonisation |
| Amount | £9,811 (GBP) |
| Funding ID | ES/K000357/1 |
| Organisation | Economic and Social Research Council |
| Department | ESRC Seminar Series |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 08/2017 |
| Description | CLOSER Ammendment 2: Cohort and longitudinal studies enhancement resources |
| Amount | £95,684 (GBP) |
| Organisation | Economic and Social Research Council |
| Department | ESRC Seminar Series |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| End | 09/2017 |
| Description | COVID-19 Questionnaire support |
| Amount | £6,598 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 07/2020 |
| Description | Can Hip DXA scans be used to identify genetic determinants of hip shape & osteoarthritis? Proposal for a proof-of-concept study B1372 |
| Amount | £11,429 (GBP) |
| Funding ID | 20244 |
| Organisation | Versus Arthritis |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2013 |
| End | 01/2016 |
| Description | Characterising brain network differences during scene perception and memory in young adult APOE-e4 carriers: multi-modal imaging in ALSPAC |
| Amount | £1,420,574 (GBP) |
| Funding ID | MR/N01233X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 04/2020 |
| Description | Childhood predictors of inadequate health literacy in young adults |
| Amount | £28,568 (GBP) |
| Organisation | Sir Halley Stewart Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 02/2019 |
| Description | Cohorts as Platforms for Mental Health research (CaP:MH) |
| Amount | £1,497,192 (GBP) |
| Funding ID | MC_PC_17210 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Description | Computational Models for the Prediction and Prevention of Child Traumatic Stress |
| Amount | $781,926 (USD) |
| Funding ID | 1R01MH119114-01A1 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 08/2019 |
| End | 05/2023 |
| Description | Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA) |
| Amount | £1,190,293 (GBP) |
| Funding ID | MR/N000390/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | Defining 'clinically actionable' genetic mechanisms in atopic eczema risk and resolution |
| Amount | £2,258,810 (GBP) |
| Funding ID | 220875/Z/20/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2020 |
| End | 10/2025 |
| Description | Deriving and validating a clinical prediction rule for the diagnosis of asthma in primary care |
| Amount | £207,554 (GBP) |
| Funding ID | CAF/17/01 |
| Organisation | Chief Scientist Office |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 06/2021 |
| Description | Describing habitual levels of physical activity (PA) in older people in terms of impact loads and how this relates to bone and other systems |
| Amount | £58,433 (GBP) |
| Funding ID | MR/K024973/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 06/2016 |
| Description | Development of ALSPAC Industry Partner and Participant Portal |
| Amount | £15,000 (GBP) |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 08/2018 |
| Description | Do epigenetic markers contribute to the excess risk of diabetes and coronary heart disease in Indian Asians? |
| Amount | £196,086 (GBP) |
| Funding ID | 082464/Z/07/C |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Does epigenetic methylation explain the gender-switch in adolescent asthma? |
| Amount | $153,747 (USD) |
| Funding ID | 1R01A/121226-01 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 01/2016 |
| End | 12/2016 |
| Description | Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases |
| Amount | £8,327,295 (GBP) |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 07/2019 |
| End | 07/2024 |
| Description | Early adulthood education/employment transitions and the development of inequalities in diet quality and cardiovascular health |
| Amount | £1,096,469 (GBP) |
| Funding ID | MR/T010576/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2025 |
| Description | Early life adversity and life course health: an investigation of adversity clustering and associations with health |
| Amount | £232,283 (GBP) |
| Funding ID | ES/P010229/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2020 |
| Description | Eating Behaviour Measurement using the Mandometer - A Pilot Study In ALSPAC B1038 |
| Amount | £600 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 12/2012 |
| Description | Effect of different feeding methods and non-nutritive sucking behaviours on child speech development |
| Amount | £52,438 (GBP) |
| Funding ID | ICA-CDRF-2016-02-053 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2021 |
| Description | Efficient and transparent methods for linking and analysing longitudinal population studies and administrative data |
| Amount | £301,055 (GBP) |
| Funding ID | 212953/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2021 |
| Description | Electronic Longitudinal Alcohol Study in Communities (ELAStiC) |
| Amount | £978,102 (GBP) |
| Funding ID | ES/L015471/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2019 |
| Description | Emotional dysregulation, self-harm and eating disorders: a mechanistic investigation |
| Amount | £251,713 (GBP) |
| Funding ID | MR/S020292/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 09/2021 |
| Description | Enhancing Environmental data Resources in Cohort Studies: ALSPAC exemplar (ERICA) |
| Amount | £99,899 (GBP) |
| Funding ID | NE/P010830/1 |
| Organisation | Natural Environment Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 01/2018 |
| Description | Environmental risk factors of health-risk behaviours: Using DNA to strenghten causal inference |
| Amount | £225,000 (GBP) |
| Organisation | MQ Mental Health Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 01/2020 |
| Description | Epidemiological studies of human transgenerational responses (TGR) to paternal and ancestral exposures |
| Amount | $25,000 (USD) |
| Funding ID | 2016-165617 |
| Organisation | Silicon Valley Community Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2017 |
| End | 12/2017 |
| Description | Ethical aspects of epidemiological research on young people involving linkage to routine individual data B1089 |
| Amount | £860 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 10/2012 |
| Description | Excessive drinking and alcohol related harms in Adulthood: ALSPAC at 24 |
| Amount | £1,378,535 (GBP) |
| Funding ID | MR/L022206/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 05/2019 |
| Description | Extraordinary COVID-19 questionnaire |
| Amount | £5,650 (GBP) |
| Organisation | University of Bristol |
| Department | Elizabeth Blackwell Institute for Health Research |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2021 |
| Description | Father involvement and child development in the context of maternal postnatal depression |
| Amount | £301,101 (GBP) |
| Funding ID | 212664/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 04/2022 |
| Description | Fellowship B1088 SSCM.RJ5562 'Molecular and life-course aspects of APOE and TOMM40 in cognition' |
| Amount | £35,305 (GBP) |
| Funding ID | WT096114/Z/11/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 12/2015 |
| Description | Fellowship Bath B1423 SSCM.RD1832 ' Iodine status in pregnancy & child neurodevelopment' |
| Amount | £11,707 (GBP) |
| Funding ID | MR/K02132X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2013 |
| End | 05/2016 |
| Description | Gene-Environment Interplay in the Comorbity of PTSD and Disordered Eating |
| Amount | £10,909 (GBP) |
| Organisation | National Institutes of Health Clinical Center |
| Sector | Hospitals |
| Country | United States |
| Start | 01/2013 |
| End | 12/2016 |
| Description | Genetic, behavioural and cognitive mechanisms underpinning the association between mother and offspring mental health problems: mental health intergenerational transmission (MHINT) |
| Amount | € 1,499,611 (EUR) |
| Funding ID | 758813 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 12/2017 |
| End | 11/2022 |
| Description | Genetics of wound healing - BCG scar study |
| Amount | £46,467 (GBP) |
| Organisation | University of Bristol |
| Department | Elizabeth Blackwell Institute for Health Research |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 08/2017 |
| Description | HDHL-Biomarkers: Early life programming of childhood health: a nutritional and epigenetic investigation (ALPHABET) |
| Amount | £101,222 (GBP) |
| Funding ID | BB/P028187/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 09/2019 |
| Description | Health, maturity, and the gender gap in education (HEALTH-GAP) |
| Amount | kr 14,794,000 (NOK) |
| Funding ID | 273659 |
| Organisation | Norwegian Institute of Public Health |
| Sector | Public |
| Country | Norway |
| Start | 04/2018 |
| End | 12/2022 |
| Description | How early stress gets under the skin: The role of DNA methylation in the development of youth conduct problems and comorbid symptoms |
| Amount | £250,543 (GBP) |
| Funding ID | ES/N001273/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2018 |
| Description | Informing educational interventions using genome-wide data: causal evidence from 573,586 participants of eight cohort studies |
| Amount | £222,571 (GBP) |
| Funding ID | ES/N000757/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2018 |
| Description | Integrative Cancer Epidemiology Programme: Towards improved causal evidence and enhanced prediction of cancer risk and survival |
| Amount | £7,715,113 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 05/2025 |
| Description | Interplay between Peer-based Processes and Alcohol Metabolism Genes on Trajectories of Alcohol Use across Adolescence |
| Amount | $68,657 (USD) |
| Funding ID | 1F31AA025833-01 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 03/2017 |
| End | 03/2019 |
| Description | Investigating five large population-based cohort studies to understand for the precursors of multimorbidity risk. |
| Amount | £74,159 (GBP) |
| Funding ID | MR/V004905/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 02/2021 |
| Description | Investigating the Epidemiology of CFS/ME in children using the ALSPAC cohort B1425 RD1805 |
| Amount | £21,391 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 09/2015 |
| Description | Investigation of the causal effects of atopic eczema on other health outcomes |
| Amount | £89,968 (GBP) |
| Organisation | British Skin Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 10/2018 |
| Description | Ipsos Mori: Qualitative research on attitudes around commercial access to health, biomedical and genetic data |
| Amount | £2,195 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 11/2015 |
| Description | Klarman Family Foundation B1190 'Epigentics of Eating Disorders : A Lifespan Approach' |
| Amount | $132,590 (USD) |
| Organisation | The Klarman Family Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 05/2012 |
| End | 05/2014 |
| Description | LONGITUDINAL ADMINISTRATIVE DATA SPINE SCOPING PROJECT GRANT FOR THE SPF UK POPULATION LAB WAVE I |
| Amount | £236,901 (GBP) |
| Funding ID | ES/S016732/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 03/2019 |
| Description | Life course aetiology of dementia and cognitive decline: improving causal inference |
| Amount | £315,800 (GBP) |
| Funding ID | MR/P014437/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2020 |
| Description | Lifecourse epidemiology of female reproductive health and its relation to chronic disease |
| Amount | £70,205 (GBP) |
| Funding ID | MR/M009351/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2014 |
| End | 11/2019 |
| Description | MRC Proximity to Discovery Industry Engagement Fund: Development of ALSPAC Industry Partner and Participant Portal |
| Amount | £15,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 09/2018 |
| Description | Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder: ALSPAC-MRI-II |
| Amount | £1,791,731 (GBP) |
| Funding ID | MR/S003436/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 11/2022 |
| Description | Mapping phenotypic to genetic variability in the High Bone Mass Study |
| Amount | £355,425 (GBP) |
| Funding ID | 20000 |
| Organisation | Versus Arthritis |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2018 |
| Description | Mental health and educational achievement in UK adolescents |
| Amount | £131,721 (GBP) |
| Funding ID | ES/P00881X/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 12/2018 |
| Description | Mitochondrial DNA copy number as a phenotypic trait for human diseases in genetic epidemiological studies |
| Amount | £384,038 (GBP) |
| Funding ID | MR/K002767/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Molecular Genetic and Lifecourse Epidemiology |
| Amount | £5,153,712 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 09/2025 |
| Description | Multidimensional Phenotyping in Eczema |
| Amount | £89,991 (GBP) |
| Organisation | British Skin Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | NMHB Research Grant SSCM.RD1796 'Behavioral & neurophysicological effects of schizophrenia risk genes' |
| Amount | £112,078 (GBP) |
| Funding ID | MR/K004360/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 03/2017 |
| Description | Neurodevelopmental disorders: What happens when children grow up and why? |
| Amount | £893,353 (GBP) |
| Funding ID | 204895/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 01/2021 |
| Description | Non-genetic inheritance in human development |
| Amount | £995,516 (GBP) |
| Funding ID | ID#60828 |
| Organisation | The John Templeton Foundation |
| Sector | Academic/University |
| Country | United States |
| Start | 01/2018 |
| End | 09/2020 |
| Description | Novel epidemiological methods to infer the causal effects of risk factors on neuropsychiatric and cardiovascular disorders |
| Amount | $358,957 (AUD) |
| Funding ID | APP1079583 |
| Organisation | National Health and Medical Research Council |
| Sector | Public |
| Country | Australia |
| Start | 01/2015 |
| End | 12/2017 |
| Description | Our Menopauses: an event for sharing experiences and information about menopause in Bristol |
| Amount | £2,619 (GBP) |
| Organisation | University of Bristol |
| Department | Elizabeth Blackwell Institute for Health Research |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 11/2017 |
| Description | Oxytocin-Related Predictors of Postpartum Maternal Mood and Mothering B1167 |
| Amount | £4,628 (GBP) |
| Organisation | National Institutes of Health Clinical Center |
| Sector | Hospitals |
| Country | United States |
| Start | 03/2012 |
| End | 03/2014 |
| Description | PAR-13-109 Mechanistic Insights from Birth Cohorts (R01) |
| Amount | £110,613 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 08/2014 |
| End | 08/2019 |
| Description | Pathogenic mechanisms in post-bereavement psychopathology: Contributions of gene-environment interplay, psychosocial factors, and cognitive ability in two population-based cohorts |
| Amount | $190,011 (USD) |
| Funding ID | 1K23MH117278-01A1 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 03/2019 |
| End | 02/2024 |
| Description | Pathways to peak lung function: Genetic, Environmental and lifestyle influences on maximally attainable lung function in young adults |
| Amount | £482,295 (GBP) |
| Funding ID | MR/M022501/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 08/2018 |
| Description | Pathways to psychosis: investigating environmental, cognitive and genetic mechanisms underlying development of psychotic experiences in young adults |
| Amount | £455,151 (GBP) |
| Funding ID | MR/M006727/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 06/2018 |
| Description | PhD Studentship - B910 SSCM.RJ5158 'Biological Differences in Smoking Behaviour' |
| Amount | £38,715 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 06/2012 |
| Description | Picky Eating in the ALSPAC cohort: Determinants and related health outcomes |
| Amount | £1,230 (GBP) |
| Organisation | Nestlé (Global) |
| Department | Société des Produits Nestlé SA |
| Sector | Private |
| Country | Switzerland |
| Start | 04/2014 |
| End | 03/2016 |
| Description | Population Research Committee - Project Award B911 SSCM.RJ5681'Breast tissue composition in young women and its pre-natal and early life determinant: a study nested within the ALSPAC' |
| Amount | £90,345 (GBP) |
| Funding ID | C405/A12730 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2011 |
| End | 12/2012 |
| Description | Predictors and consequences of being a Child in Need or Looked After: data linkage study based on ALSPAC |
| Amount | £50,931 (GBP) |
| Organisation | University of Bristol |
| Department | Elizabeth Blackwell Institute for Health Research |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2018 |
| Description | Programme B798 SSCM.RJ5447 'The relationship of the menopausal transition to healthy aging and chronic disease risk' |
| Amount | £774,825 (GBP) |
| Funding ID | 092830/Z/10/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2011 |
| End | 06/2016 |
| Description | Psychosocial factors and cancer incidence: a pre-planned meta-analysis of the Psychosocial factors and Cancer |
| Amount | € 1,328,435 (EUR) |
| Funding ID | VU 20l7-8288 |
| Organisation | Dutch Cancer Society (KWF) |
| Sector | Charity/Non Profit |
| Country | Netherlands |
| Start | 03/2018 |
| End | 09/2021 |
| Description | Psychosocial resilience in children of mothers with depression B1112 |
| Amount | £702 (GBP) |
| Funding ID | ES/J011657/1 |
| Organisation | Economic and Social Research Council |
| Department | ESRC Seminar Series |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 09/2014 |
| Description | Publication Metadata Augmentation |
| Amount | £112,678 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 11/2017 |
| Description | Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? |
| Amount | £2,560,571 (GBP) |
| Funding ID | 108818/Z/15/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 12/2018 |
| Description | Religious belief, health and disease: a family perspective. |
| Amount | $234,800 (USD) |
| Funding ID | 61356 |
| Organisation | The John Templeton Foundation |
| Sector | Academic/University |
| Country | United States |
| Start | 07/2019 |
| End | 07/2021 |
| Description | Research - B1173 SSCM.RD1795 'Study Team for early life Asthma Research (STELAR) |
| Amount | £38,406 (GBP) |
| Funding ID | MR/K002449/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2016 |
| Description | Research B998 SSCM.RD1782Cussens 'A graphical model approach to pedigree construction using constrained optimisation' |
| Amount | £4,602 (GBP) |
| Funding ID | G1002312 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2011 |
| End | 10/2014 |
| Description | Research Grant - B836 SSCM.RK7212 'Maternal thyroid status and offspring development'. |
| Amount | £14,529 (GBP) |
| Funding ID | ETM/97 |
| Organisation | Chief Scientist Office |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2011 |
| End | 03/2013 |
| Description | Research Grant BBR Scheme (BBSRC)- B1074 SSCM.RA0543 'A multigenerational prospective resource for integrating genetic, epigenetic and dense phenotypic measures from birth to 18.' |
| Amount | £1,186,455 (GBP) |
| Funding ID | BB/I025751/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2011 |
| End | 08/2013 |
| Description | RoSPA: Evaluation of Lifeskills using the ALSPAC Cohort - LASER Safety Education Schemes |
| Amount | £19,733 (GBP) |
| Organisation | Royal Society for the Prevention of Accidents |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 10/2014 |
| Description | S1P1R genetic profiles in endothelial function and disease |
| Amount | € 204,537 (EUR) |
| Funding ID | 166002 - CW388001 |
| Organisation | Sanofi |
| Department | Sanofi Research Division |
| Sector | Private |
| Country | France |
| Start | 03/2016 |
| End | 07/2019 |
| Description | Seeing is believing in ALSPAC |
| Amount | £199,387 (GBP) |
| Funding ID | 102215/Z/13/B |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 10/2016 |
| Description | Seventh Framework Programme - B1301 SSCM.RQ8840 'Collaborative Projects & Networks of Excellence EXPOsOMICS' |
| Amount | € 56,704 (EUR) |
| Funding ID | 308610 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2012 |
| End | 09/2016 |
| Description | Study of Emerging Adulthood and Cardiomatic Health in ALSPAC: The Influence and of growth and other exposures |
| Amount | £999,049 (GBP) |
| Funding ID | CS/15/6/31468 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2015 |
| End | 06/2020 |
| Description | TENOVUS - Da Silva Focus Group |
| Amount | £804 (GBP) |
| Organisation | University of Dundee |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 11/2015 |
| Description | Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular health |
| Amount | $140,054 (USD) |
| Funding ID | 1K01HL143159-01A1 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 06/2019 |
| End | 06/2024 |
| Description | Testing evolutionary hypotheses of social development in the ALSPAC cohort |
| Amount | £1,559 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2015 |
| Description | Testing the feasibility and user acceptability of integrating wearable air pollution monitors into population based studies |
| Amount | £24,769 (GBP) |
| Organisation | University of Bristol |
| Department | Elizabeth Blackwell Institute for Health Research |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 08/2017 |
| Description | The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019 |
| Amount | £7,903,667 (GBP) |
| Funding ID | 102215/Z/13/Z |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 03/2019 |
| Description | The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being. |
| Amount | £8,327,295 (GBP) |
| Funding ID | 217065/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 08/2024 |
| Description | The Genetic Basis of Urinary Incontinence in Women B956 |
| Amount | £44,664 (GBP) |
| Organisation | International Urogynecological Association (IUGA) |
| Sector | Academic/University |
| Country | Global |
| Start | 09/2011 |
| End | 09/2014 |
| Description | The causal map of the human phenome |
| Amount | £809,240 (GBP) |
| Funding ID | 208806 |
| Organisation | Sir Henry Dale Fellowships |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2023 |
| Description | The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways |
| Amount | £215,430 (GBP) |
| Funding ID | MR/R004803/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 09/2020 |
| Description | The genetic epidemiology of High Bone Mass: skeletal geometry, turnover and fat metabolism, and implications for the wider population |
| Amount | £3,322 (GBP) |
| Organisation | Versus Arthritis |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 01/2018 |
| Description | The long term impact of COVID-19 on mental health: comparisons between health record linkage and observed longitudinal data |
| Amount | £11,020 (GBP) |
| Funding ID | R105121-249 |
| Organisation | University of Bristol |
| Department | Elizabeth Blackwell Institute for Health Research |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 08/2021 |
| Description | TwinsUK (2019-2023) - An Epidemiological and Genomic Resource |
| Amount | £3,000,000 (GBP) |
| Funding ID | 212904/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 06/2022 |
| Description | UK Department for Business Innovation & Skills (BIS) B931 RK7220 'Further education data linkage projects' |
| Amount | £55,000 (GBP) |
| Funding ID | BIS/RBU/008/2011 |
| Organisation | Department for Business, Energy & Industrial Strategy |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2011 |
| End | 12/2012 |
| Description | UK Dept for Business Innovation and Skills B2057 SSCM.RK 'Data Linkage Proposal 2013' |
| Amount | £30,000 (GBP) |
| Funding ID | BIS/RBU/011/2013 |
| Organisation | Department for Business, Energy & Industrial Strategy |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 09/2015 |
| Description | UK MenCar4 |
| Amount | £4,483 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 09/2015 |
| Description | Understanding Asthma Phenotypes |
| Amount | £181,852 (GBP) |
| Funding ID | 668954 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 01/2016 |
| End | 12/2020 |
| Description | Understanding successful progression to higher education for the white working class and minority ethnic groups (B2215) |
| Amount | £14,081 (GBP) |
| Organisation | Department for Business, Energy & Industrial Strategy |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2014 |
| End | 07/2015 |
| Description | Understanding the Antecedents and Outcomes of Frequent Adolescent Cannabis Use |
| Amount | £250,000 (GBP) |
| Funding ID | 209158 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 05/2022 |
| Description | Understanding the mechanisms linking cities to psychotic experiences across the lifespan |
| Amount | £300,000 (GBP) |
| Funding ID | 218632/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 04/2024 |
| Description | Unique research opportunities in the genetics and epidemiology of disordered gambling |
| Amount | $396,559 (USD) |
| Organisation | National Center for Responsible Gaming |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 06/2017 |
| End | 06/2020 |
| Description | Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression |
| Amount | £110,594 (GBP) |
| Funding ID | MR/J01351X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Using birth cohorts to understand the impact of urban green space on child health and wellbeing |
| Amount | £79,929 (GBP) |
| Funding ID | 2081026 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 03/2022 |
| Description | Using genetic and environmental risks to understand variation in social emotional, and educational outcomes in individuals with language impairments |
| Amount | £161,348 (GBP) |
| Funding ID | ES/P001955/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 09/2019 |
| Description | Using linked electronic health data to improve eczema diagnosis and outcomes |
| Amount | £1,305,851 (GBP) |
| Funding ID | 205039/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2019 |
| Description | WT Biomedical Resource - B1234 SSCM.RD1793 'The 1958 Birth Cohort Biomedical Resource - facilitating access to data and samples and enhancing future utility' |
| Amount | £668,124 (GBP) |
| Funding ID | G1001799 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2011 |
| End | 12/2014 |
| Description | WT Project award - B1118 'Dopamine Function, Cognitive Flexibility and Emotion Regulation' |
| Amount | £4,816 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2011 |
| End | 01/2012 |
| Title | A Privacy-Preserving Data Management system for MRI and other Large Image Data |
| Description | ALSPAC are collecting large volumes of image data through scanning individuals at assessment clinics and also work underway as part of ALSPAC's MRC MH Pathfinder award, through linkage to images held in social media accounts. These images are individually relatively small size, but are being accessed in huge volumes - e.g. a single participants MRI scan can comprise ~12,000 separate image files. Furthermore, many images have embedded identifier values (e.g. NHS ID or name embedded in an MRI scan) or have inherently identifiable components (e.g. an individuals MRI head scan can be used to show a 3D topographic map of a persons face). This leaves study databanks with a challenge to archive large volumes of data, efficiently process them for reuse, and to de-identify them in complex ways. Through MRC MH Pathfinder, the ALSPAC Data Team and Data Linkage Team have developed an image management server with capabilities for archiving, processing and de-identification. This is built on a suite of 'open source' software packages and tuned to the needs of a longitudinal study. This new infrastructure is now operational and facilitating new research in ALSPAC. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The tool has enabled ALSPAC to lower the charges for the processing of data for reuse from £750 per project to £300 per project. The use of the tool is supporting multiple grant applications, both in the UK and USA. The tool reduces the cost of the grant compared to previous approaches as it impacts on collection and archiving as well as reuse. E.g. Elanor Hinton application to support assessment of the impact of parenthood on maternal and paternal neurobiology and subsequent child development (ALSPAC Reference: B3386, https://proposals.epi.bristol.ac.uk/?q=node/129988). The tool is supporting the MRC funded grant led by Professor Anthony David (UCL) (ALSPAC Reference: B3035, https://proposals.epi.bristol.ac.uk/?q=node/127353). |
| Title | ALSPAC Biosamples and DNA resources |
| Description | Over 1.2 million aliquots biosamples taken at various timepoints from ALSPAC participants. The bioresource is available to the scientific community for research. Although the resource was initiated in 1991 it is an active collection with new samples being collected and made available constantly. |
| Type Of Material | Biological samples |
| Provided To Others? | Yes |
| Impact | Samples have been made available for numerous ALSPAC projects. The resource received the UK Biobank of the Year award in 2018 reflecting the impact of studies utalising the samples. |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/biological-resources/ |
| Title | Data Access Agreement (DAA) data sharing contract |
| Description | The data access agreement is a new data sharing contract which is compatible with contemporary legislative (e.g. General Data Protection Regulations) and research governance expectations. It aligns with ALSPAC's Online Proposal System for efficient generation of specified and controlled data requests. Importantly, the DAA enables the replication of third-party data owner requirements and the addition of particular governance controls for specific datasets (e.g. geo-spatial datasets), and as such is an important element in ALSPAC's process to allow onward sharing of linked health, geo-spatial and social records. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The DAA is a central component in ALSPAC's negotiations with NHS Digital to enable onward sharing of linked records. |
| URL | http://www.bristol.ac.uk/alspac/researchers/access/ |
| Title | Data Privacy Impact Assessment Process |
| Description | A new privacy assessment tool for ALSPAC which enables the assessment of data flows (i.e. new record linkages or new data sharing with research users) in line with EU General Data Protection Regulation requirements. The tool allows the assessment of diverse risks and particular research scenarios (e.g. the use of geocoded data in the research process, the additional sensitivities of using mental or sexual health records in research investigations. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Ensuring ALSPAC data sharing is legally compliant. |
| Title | Deep freeze of ALSPAC datasets |
| Description | A regular snapshot of our current data is now backed up annually off site. This is in addition to central IT regular back up systems |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | Imperative for disaster recovery |
| Title | Development of ALSPAC Explore |
| Description | ALSPAC Explore is our public facing data catalogue. This is a component of the Obiba Open Source project suite and is hosted by University of Bristol IT services. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Ultimately this tool will improve the discoverability and accessibility of ALSPAC data. The tool has been launched internally and is undergoing testing for external researchers to use as their primary tool for identifying ALSPAC variables. |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/ |
| Title | Development of online consent procedures |
| Description | In order to facilitate virtual clinics the systems team have successfully tested and implemented the collection of online consent for remote measures. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | Consent is vital for all 'face to face' measures we would normally collect. As we have moved to remote data collection the method for obtaining consent has had to change. |
| Title | Handling ethical queries and feedback within studies of genetic sequence data. |
| Description | This work provides a discussion and framework for the handling of incident and pertinent findings in the analysis of sequence data. |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | NA |
| URL | http://www.nature.com/ejhg/journal/v22/n9/full/ejhg2013290a.html |
| Title | Implementation of DataSHIELD for the InterConnect project |
| Description | Prof Paul Burton worked with Professor Nick Wareham's MRC-Epidemiology Unit led, Interconnect Project which is funded by the European Union to implement DataSHIELD on a consortium of eight cohorts/biobanks (seven European, one North American) including ALSPAC. This required a standard implementation of the DataSHIELD structure for remote federated analysis of "horizontally partitioned" data (different sources hold the same variables on different individuals). |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The implementation of DataSHIELD has been successfully led by Tom Bishop who is the lead DataSHIELD development team member based in Cambridge. Prof Burton's team have provided ongoing support of both the technology and statistical methods. This work was successful and a paper is currently under review at the International Journal of Epidemiology: |
| URL | http://www.interconnect-diabetes.eu/ |
| Title | Implementation of new data warehouse and external data catalogue |
| Description | We are in the process of moving all data access to Opal (data warehouse) and to add Mica (public catalogue) as a data discovery option. This will be known externally as ALSPAC Explore. Opal and Mica are both components of the Obiba Open Source project suite and are hosted by University of BRistol IT services. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Mica and Opal talk to each other; a researcher can compile their data list as they search and it can be imported directly into Opal, reducing work for both researchers and data buddies - Realtime frequencies of data in Opal will be displayed in Explore; this drastically reduces the amount of work going into the data dictionary. - Explore much more efficient searching system which should enhance data discoverability - Future developments may include the use of Datashield for federated analyses, networking with other studies using the same software - Enables the use of Ontologies (currently CLOSER topics and Maelstrom classification). |
| URL | https://alspac-data.bristol.ac.uk/mica-web/ |
| Title | Improved access policy |
| Description | A much improved Access Policy has been written and made available via the website |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | Ensures rules regarding data access are clear and transparent |
| URL | http://www.bristol.ac.uk/alspac/researchers/data-access/ |
| Title | Imputed Genome Wide (GWAS) single nucleotide polymorhism (SNP) dataset |
| Description | Imputation of 526,688 SNPs post quality control to the HapMap CEU population, release 22 for subjects in ALSPAC with GWAS data. |
| Type Of Material | Biological samples |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | The data have been used in several high impact publications including: Anttila, V. et al. 2013. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet. 2013 Aug;45(8):912-7 Hinds, D.A. et al. (In press). A meta-analysis of self-reported allergy identifes shared and allergy-specifc susceptibility loci Nat Genet. 2013 Aug;45(8):907-11 Evans, D.M. et al. 2013. Genome-Wide Association Study Identifies Loci Affecting Blood Copper, Selenium and Zinc. Hum Mol Genet. 2013 Oct 1;22(19):3998-4006 |
| Title | Introduction of REDCap as a data collection tool |
| Description | REDCap has been successfuly introduced as the data collection tool used in clinic based data collection. It is also about to be used for the first time for online questionnaire data collection |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | Streamlines data collection; minimising errors |
| URL | http://www.project-redcap.org/ |
| Title | Introduction of cost recovery, replacing data buddy fee |
| Description | At the request of the funders a number of salaries related to data provision are now recovered directly from external researchers who pay a variable amount (depending on the amount and type of data) to access ALSPAC data |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | Cost recovery income is monitored very closely - currently the model is not bringing in sufficient income. It will be reassessed at the end of year 1. |
| Title | MRI images data pipeline |
| Description | Streamlined release of re-indexed MRI images on request. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Data note listed below details the data available through the pipeline. This has resulted in reduced cost recovery charges for this data. |
| URL | https://wellcomeopenresearch.org/articles/5-203 |
| Title | Metadata: Variable catalogue |
| Description | Improved metadata provision - a simple list of variables available so that researchers can simply copy and paste in order to provide lists of variables as part of their data request under cost recovery |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | Improves accessibility/discoverability of data |
| URL | http://www.bristol.ac.uk/alspac/researchers/data-access/data-dictionary/ |
| Title | Online booking system |
| Description | Bespoke software development allowing study participants to book appointments online to attend the clinical assessment |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | Improved participant experience |
| Title | Online proposal for data access system |
| Description | Bespoke software development where researchers can enter details of new proposals to access ALSPAC data, system processes these and logs all relevant supporting information and agreements together (see https://proposals.epi.bristol.ac.uk/) |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | Improved system providing speedier access to ALSPAC data. We have been approached by other research groups interested in using this system and we are exploring options around how we might make this available to others. |
| URL | https://proposals.epi.bristol.ac.uk/ |
| Title | Online questionnaire system |
| Description | Successful development of an effective online questionnaire system used by participants to complete ALSPAC questionnaires via the study website |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | More efficient and cost effective collection of data from research particpants |
| Title | Power calculations for the undertaking of genetic sequence analysis of rare variants. |
| Description | This work provides a framework within which power calculations for the analysis of rare variants from genetic sequence data can be undertaken. |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | NA |
| URL | http://onlinelibrary.wiley.com/doi/10.1002/gepi.21797/abstract |
| Title | Protocol for genetic annotation and characterization |
| Description | We have developed a tool which annotates all genetic variants within a user specified region of the human genome. These annotations are collated from various databases, including information such as (but not limited to) predicted consequence, predicted deleterious impact, trait associations, quantitative trait loci (i.e. expression, methylation, chromatin, metabolomics, proteomics), regulatory information, biological pathways and druggable/trials info. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Provided To Others? | No |
| Impact | As the tool is unreleased there has been no impact yet. However, we intend to share the tool with the French pharmaceutical company Sanofi once it is ready as part of our on-going collaboration. |
| Title | Protocol for recall by genotype study - sleep |
| Description | This work provides a framework within which recall by genotype studies can be undertaken. |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | This description is now published: BMC Med Genet. 2015 Oct 24;16:96. doi: 10.1186/s12881-015-0244-4. Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology. |
| URL | http://www.biomedcentral.com/1471-2350/15/13 |
| Title | Providing a genomic teaching resource |
| Description | Teaching the methods and approaches used in genetic epidemiology is most effective when realistic data is available for students to use. We have scrambled the ALSPAC genetic data in order to preserve the genetic characteristics of the dataset whilst making the data non-disclosive of the participants. |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | This scrambled dataset has been used in at least six short courses on genetic epidemiology to date, and is continually used to teach students. |
| Title | Statistical methods for approaching lifecourse methods |
| Description | A number of groups are working on methods for analysing longitudinal data from the study producing both novel methods and building on existing methods to make best use of the repeat measures ALSPAC has. This area of work has a particular focus on lifecourse models. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | A number of papers have been published including: Smith AD, Hardy R, Heron J, Joinson CJ, Lawlor DA, Macdonald-Wallis C, Tilling K. A structured approach to hypotheses involving continuous exposures over the life course. Int J Epidemiol. 2016 Aug;45(4):1271-1279. Epub 2016 Jul 1. Howe LD, Smith AD, Macdonald-Wallis C, Anderson EL, Galobardes B, Lawlor DA, Ben-Shlomo Y, Hardy R, Cooper R, Tilling K, Fraser A. Relationship between mediation analysis and the structured life course approach. Int J Epidemiol. 2016 Aug;45(4):1280-1294. Epub 2016 Sep 27. Smith AD, Heron J, Mishra G, Gilthorpe MS, |
| Title | Statistical methods for dealing with repeat measures |
| Description | A number of groups are working on methods for analysing longitudinal data from the study producing both novel methods and building on existing methods to make best use of the repeat measures ALSPAC has. This covers a variety of different types of data and areas of research including growth, risky behaviours, diet and health outcomes |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | A number of papers have been published. A few relevant examples are provided below: Anderson EL, Tilling K, Fraser A, Macdonald-Wallis C, Emmett P, Cribb V, Northstone K, Lawlor DA, Howe LD. Estimating Trajectories of Energy Intake Through Childhood and Adolescence Using Linear-Spline Multilevel Models. Epidemiology. Epub 2013 May 21. PMID: 23698751 Howe LD, Tilling K, Galobardes B, Davey Smith G, Gunnell D, Lawlor DA. Socioeconomic differences in childhood growth trajectories: at what age do height inequalities emerge? J Epidemiol Community Health. 2012;66(2):143-8. PMID:20724285. Heron J, Macleod J, Munafo MR, Melotti R, Lewis G, Tilling K, Hickman M. Patterns of Alcohol Use in Early Adolescence Predict Problem Use at Age 16. Alcohol Alcohol. 2012;47(2):169-77. PMID:22215001. Macdonald-Wallis C, Lawlor D, Palmer T, Tilling K. Multivariate multilevel spline models for parallel growth processes: application to weight and mean arterial pressure in pregnancy. Stat Med. 2012;31(26):3147-6. PMID:22733701. |
| Title | Statistical methods for examining missing data/misclassification |
| Description | A number of statisticians are working on methods using linkage data to investigate missing data and/or misclassification of exposures/outcomes. This covers a number of different data sources and areas of research including education, mental health and wellbeing |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | A number of papers have been published including: Cornish R, Tilling K, Boyd A, Macleod J, Van Staa T. Using linkage to electronic primary care records to evaluate recruitment and nonresponse bias in the Avon Longitudinal Study of Parents and Children. Epidemiology. 2015 Jul;26(4):e41-2. doi: 10.1097/EDE.0000000000000288. Cornish RP, Tilling K, Boyd A, Davies A, Macleod J. Using linked educational attainment data to reduce bias due to missing outcome data in estimates of the association between the duration of breastfeeding and IQ at 15 years. Int J Epidemiol. 2015 Jun;44(3):937-45. doi: 10.1093/ije/dyv035. Mars B, Cornish R, Heron J, Boyd A, Crane C, Hawton K, Lewis G, Tilling K, Macleod J, Gunnell D. Using Data Linkage to Investigate Inconsistent Reporting of Self-Harm and Questionnaire Non-Response. Arch Suicide Res. 2016;20(2):113-41. doi: 10.1080/13811118.2015.1033121. Epub 2016 Jan 20. Cornish RP, John A, Boyd A, Tilling K, Macleod J. Defining adolescent common mental disorders using electronic primary care data: a comparison with outcomes measured using the CIS-R. BMJ Open. 2016 Dec 1;6(12):e013167. doi: 10.1136/bmjopen-2016-013167. |
| Title | UK10K Project Dalliance Genome Browser |
| Description | The UK10K Genome Browser is based on the Biodalliance platform (Down et al., Bioinformatics 2011), designed to facilitate the retrieval of genotype-phenotype association results from the UK10K Cohorts Project (Walter et al, Nature 2015), and their visualisation in the context of different annotation features. |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | Allows researchers to easily access key results from the cohort arm of the UK10K and generate new hypothesis based on this dataset |
| URL | http://www.uk10k.org/dalliance.html |
| Title | Variable Search Tool |
| Description | A web application has been developed which performs rapid searching of all variables that are readily accessible in the resource. Using this in conjunction with the detailed data dictionary eases discoverability of the ALSPAC data for potential users. This web based app was formally released in May 2018 |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The release of the tool has facilicated easy searching for variables and is used widely by both internal and external researchers |
| URL | http://variables.alspac.bris.ac.uk/ |
| Title | Web resource for the provision of UK10K sequence data, the display of results, related information and ethical documentation. |
| Description | This resource provides a collection of material from the UK10K project which involved the sequencing of over 4000 population based human genomes. Resources include: (i) access to raw data (ii) results from association study analysis (rare and common genetic variants) through an integrated browser (iii) ethical documentation (iv) related publications and management information |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | NA |
| URL | http://www.uk10k.org |
| Title | Wellcome LPS COVID Questionnaire bank |
| Description | The ALSPAC team has led the development of the Wellcome funded Longitudinal Population Studies COVID questionnaire bank. This facilitates comparable research across longitudinal studies. Together with Generation Scotland, ALSPAC form the secretariat for the Wellcome LPS COVID group. ALSPAC has provided the questionnaire in REDCap format on demand |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | The questionnaire bank facilitates research across multiple studies about the COVID pandemic. The questions were designed to help researchers explore changes using the same validated questions to the lives of cohort participants the UK and elsewhere. |
| URL | https://www.bristol.ac.uk/alspac/researchers/wellcome-covid-19/ |
| Title | ALSPAC 'GP' dataset of linked primary care records (1991-2018) |
| Description | These data are the coded values - relating to participant symptoms, diagnoses, treatments, care - extracted from GP primary care records of ALSPAC participants receiving care in England. The records are linked from EMIS Ltd (a GP software system company) and are managed by the ALSPAC data linkage team. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The data are being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 4) Professor Dheeraj Rai to study Adolescent and adult mental health outcomes of autism and autistic traits (ALSPAC Reference: B2622, https://proposals.epi.bristol.ac.uk/?q=node/127702) 5) Professor Hilary Pinnock for the derivation of a clinical prediction rule for the diagnosis of asthma (ALSPAC Reference: B2830, https://proposals.epi.bristol.ac.uk/?q=node/127536) 6) Professor Sinead Langan as part of a program to establish efficient methods to understand medical and social outcomes associated with eczema (ALSPAC Reference: B2606, https://proposals.epi.bristol.ac.uk/?q=node/127717). |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/ |
| Title | ALSPAC 'HES' Hospital Episode Statistics records |
| Description | These are minimum returns of Hospital Episode Statistics secondary care records of ALSPAC participants receiving care in England. The records are linked from NHS Digital and accessed under a NHS Digital - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The data are being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/ |
| Title | ALSPAC 'Looked After' and 'Children In Need' linked social care records |
| Description | These are records of children taken into state care and children classifed as 'in Need'. The records are linked from Department for Education National Pupil Database and accessed under a DfE - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). While access is currently restricted to the project team, we are exploring mechanisms to widen access using the new powers of the Digital Economy Act and in partnership with the Administrative Data Research-UK. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The data are being used in a project led by Professor John Macleod and Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). This research has resulted in an academic paper: Teyhan A, Boyd A, Wijedasa D, Macleod J. Early life adversity, contact with children's social care services and educational outcomes at age 16 years: UK birth cohort study with linkage to national administrative records. BMJ open. 2019 Oct 1;9(10):e030213. We have also published a blog article emphasising the value of the novel methodologies in this research: https://www.closer.ac.uk/news-opinion/blog/filling-gaps-boosts-evidence-vulnerable-children/ |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/ |
| Title | ALSPAC 'MHSDS' Data Set of Mental Health & Learning Difficulties Community Care Interactions |
| Description | These are minimum returns of Mental Health community care records of ALSPAC participants receiving care in England. The records are linked from NHS Digital and accessed under a NHS Digital - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The data are being used in a project led by Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/ |
| Title | ALSPAC 'STORK' dataset of linked maternity records (1990-1992) |
| Description | The ALSPAC Data Linkage team have recently (2019-2020) cleaned and documented the STORK dataset of midwifery and birth delivery records for those index participants born in either of the two main maternity hospitals in Bristol (approx. 85% of enrolled participants). These data are available for access to the bona-fide research community via the ALSPAC access mechanism. A 'Data Note' publication is being prepared to contribute documentation and to aid the discoverability of the new dataset. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The data are being used by Dr Katie Harron (UCL) as part of her Wellcome Trust LPS (Aim 2) Award (ALSPAC reference B3002, https://proposals.epi.bristol.ac.uk/?q=node/127384). The data are being used by Dr Alison Teyhan (University of Bristol) as part of the ALSPAC Born-in-Bradford MRC MH Pathfinder award (ALSPAC reference B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/ |
| Title | ALSPAC UK Secure eResearch Platform for the secure analysis of sensitive data |
| Description | The ALSPAC data linkage team have worked with the UK Secure eResearch Platform team (University of Swansea) to establish an 'ALSPAC UKSeRP' secure research server and for the secure analysis of sensitive data, particularly linked routine records accessed under contract. The ALSPAC UKSeRP has been embedded in ALSPAC's linkage ethics and data sharing agreements. It has also been embedded in the study's ISO27001 certified Information Security Management System (ISMS). This is now providing the infrastructure for sharing data with bona fide users, subject to ALSPAC's project approvals process. The management of the system is governed by Standard Operating Procedures and is subject to internal and external audit assessments. We are currently in a 'Beta User' phase, once the mechanisms are fully established the resource will be promoted more widely. |
| Type Of Material | Data handling & control |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The ALSPAC UKSeRP 'Beta User' phase is currently being used for 6 research programmes, 4 based at the University of Bristol, 1 at the University of Edinburgh and 1 at LSHTM. It is the key infrastructure for enabling the ALSPAC Born In Bradford MRC MH Pathfinder deliverables. The infrastructure is being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 4) Professor Dheeraj Rai to study Adolescent and adult mental health outcomes of autism and autistic traits (ALSPAC Reference: B2622, https://proposals.epi.bristol.ac.uk/?q=node/127702) 5) Professor Hilary Pinnock for the derivation of a clinical prediction rule for the diagnosis of asthma (ALSPAC Reference: B2830, https://proposals.epi.bristol.ac.uk/?q=node/127536) 6) Professor Sinead Langan as part of a program to establish efficient methods to understand medical and social outcomes associated with eczema (ALSPAC Reference: B2606, https://proposals.epi.bristol.ac.uk/?q=node/127717). |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/ |
| Title | ALSPAC Whole Exome Sequence Data |
| Description | Whole Exome Sequence (WES)data has been generated on ~ 9,000 ALSPAC G1 individuals and ~ 1,700 of their mothers (G0) and 1,700 of their fathers (G0). The data set will include WES from ~1,700 family trios. Data is now available for researchers in raw format and will be processed and publicised in 2023 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | This data has greatly enhanced ALSPAC's comprehensive omics catalogue and is a valuable resource for genetic epidemiology |
| Title | ARIES-Explorer |
| Description | ARIES-Explorer provides an openly accessible web interface to explore epigenome-wide methylation data from the Accessible Resource for Integrated Epigenomics Studies |
| Type Of Material | Database/Collection of data |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Cited in a key review in the field (Mill et al, Nature Reviews Genetics, VOLUME 14 | AUGUST 2013 | 585). 419 unique visitors to the site in its first month of operation. |
| URL | http://ariesepigenomics.org.uk/ariesexplorer |
| Title | Bristol region NOx modelled Air Pollution Dataset |
| Description | NOx air pollution data was modelled for the ALSPAC catchment area from 1990 to 2018. In conjunction with ALSPAC participant residential and school geocoding database this enables air pollution data exposure to be estimated and linked to participants. Using the ALGAE software ALSPAC can estimate the exposure with critical development periods (e.g. pregnancy trimesters). Directly measured air pollution records have been collected (from local authority deployed air pollution sensors) and these sensor data will be used to calibrate the modelled data. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The data will be used in an ALSPAC based epidemiological assessment of the impact of in utero NOx exposure and lung-function outcomes. It is also being shared with collaborators at Imperial (London) for use in an assessment of the impact of availability of greenspace on mental health outcomes. |
| Title | CLOSER harmonised BMI dataset |
| Description | ALSPAC has contributed to a harmonised dataset through CLOSER which has harmonised data on height, weight and BMI at ages 7, 8, 9, 10, 11 and 17. The data has been lodged with the UK Data Service and can be accessed through a Special License |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Has contributed to our understanding of how rates of obesity have changed over the generations and the impact of social inequalities. See here: https://www.closer.ac.uk/research-fund-2/data-harmonisation/harmonising-measures-body-size-body-composition/ for a summary. |
| URL | http://doi.org/10.5255/UKDA-SN-8208-1 |
| Title | COVID Questionnaire 1 G0 and G1 dataset |
| Description | Dataset containing Q1 results for G1 and G0 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Contribution to our understanding of the impact of the pandemic, particularly mental health |
| URL | https://wellcomeopenresearch.org/articles/5-127 |
| Title | COVID Questionnaire 3 and serology results on G0 and G1 |
| Description | Dataset containing Q3 results and results for home antibody testing for G1 and G0 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Contribution to our understanding of the impact of the pandemic, based for identifying cases for further study on recuperation and longevity of infection. A data note has just been submitted to Wellcome Open |
| Title | COVID questionnaire 2 G0 and G1 dataset |
| Description | Dataset containing Q2 results for G1 and G0 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Contribution to our understanding of the impact of the pandemic, particularly mental health |
| URL | https://wellcomeopenresearch.org/articles/5-210 |
| Title | COVID questionnaire 5 - G0 and G1 |
| Description | Dataset containing Q5 results for G0 and G1 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Contribution to our understanding of the impact of the pandemic, based for identifying cases for further study on recuperation and longevity of infection. A data note is being prepared for Wellcome Open |
| Title | COVID questionnaire 6 - G0 and G1 |
| Description | Dataset containing Q6 results for G0 and G1 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Contribution to our understanding of the impact of the pandemic, based for identifying cases for further study on recuperation and longevity of infection. A data note is being prepared for Wellcome Open |
| Title | Creation of synthetic datasets for the Big Data VR Project |
| Description | Three synthetic datasets were created containing 15,000, 155,000 and 1,555,000 participants. These synthetic datasets retained similar data properties to the original study data they were simulated from. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The data was used in a Wellcome funded project to develop visualisation methods in virtual reality (VR) using big biomedical datasets. As the generated data has no ethical-legal constraints associated with it the synthetic datasets can be used for teaching and training purposes without restriction. |
| URL | https://wellcomeopenresearch.org/articles/2-74/v1 |
| Title | Datasets containing indices of Multiple Deprivation (IMD) and other geocoded measures |
| Description | IMD data has been linked to multiple time points, both on an annual basis (e.g., January 2008, Jan 2009, Jan 2010, etc.), as well as at the time point each child-based ALSPAC questionnaire or clinic was completed/conducted. This has been released all mother and child based data collections |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Data to enable research using geocoded SES measures |
| Title | Derived MRI dataset in G1 |
| Description | This dataset provides data that has been derived from MRI Scans collected by 3 substudies to date (total n=961). the dataset is described in a data note published on Wellcome Open |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | A unique contribution to ALSPAC, offering deep brain phenotyping to researchers |
| URL | https://wellcomeopenresearch.org/articles/5-203 |
| Title | Focus 24+; G1 clinic visit dataset |
| Description | Data collected at from the 24 year clinic. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Substantial datasets enabling ongoing research in the areas of cardiovascular disease, mental health, body composition, physical activity, liver and lung health |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/f24 |
| Title | G0 Partners cohort profile |
| Description | This dataset describes the baseline population of G0 partners and the accompanying cohort profile paper (publication on Wellcome Open is imminent). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | For the first time in the cohort's history, we have provided a detailed description of the G0 partners cohort which will hopefully facilitate futher work in this cohort group. |
| Title | Geocoded School History dataset for ALSPAC index participants |
| Description | We have collated information on the schools ALSPAC participants attended from reception (Age 4-5) through to leaving schooling (Age 16-18). We have addressed issues such as schools changing over time (changing name, moving location etc). We have then geo-coded the school address information and assigned this back into the ALSPAC research database. This now allows ALSPAC staff to map environmental exposure data (e.g. air pollution, proximity to fast-food outlets) to individuals based on which school they attended. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The schools geo-coding was used to assign NO2 exposure to ALSPAC participants in a more accurate manner as the model was then able to weight exposure based on residential geocoding and schools geocoding. This dataset can be used in future for similar purposes with different envrionmental exposures. |
| URL | http://www.bristol.ac.uk/alspac/researchers/our-data/environment-data/ |
| Title | Life@22+; Dataset from questionnaire completed by G1 |
| Description | Data collected at from the 22 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | - Health - Physical activity - Vision Data collected enabling ongoing research into: - Substance use - Moods and feelings - Life events - Being a parent - Childhood experiences - Education and employment - Voting intentions |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypb |
| Title | Life@23+; Dataset from questionnaire completed by G1 |
| Description | Data collected at from the 23 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | - Sexual experiences - Wellbeing - Eating behaviour Data collected enabling ongoing research into: - Being a parent - Brothers and sisters - Smoking and e-cigarette use - Mental health & traumatic experiences - Dental health - Life events - Education and employment |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypc |
| Title | Life@24+; Dataset from questionnaire completed by G1 |
| Description | Data collected at from the 24 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Data collected enabling ongoing research into: - Life events - Being a parent - Communication skills - Monetary choice - behaivour - Deliberate self-harm - Smoking and e-cigarette use - Eating, weight & exercise - Gambling - Social media use |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypd |
| Title | Life@25+; Dataset from questionnaire completed by G1 |
| Description | Data collected at from the 25 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Data enabling ongoing research into mental health, personality, behaviour, life events, Eating behaviours & food preferences |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ype |
| Title | Life@26+; Dataset from questionnaire completed by G1 |
| Description | Data collected at from the 26 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Data to enable research into various aspects of health, wellbeing, physical activity, education, life events and attitudes to data sharing |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypf |
| Title | Major research database re-structure - OPAL interface |
| Description | The whole of ALSPAC data migrated into a mongoDB database fronted by OPAL/mica in order to develop and make more efficient browsing and the formation of new data sets for sharing / research generation. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | This will be tested against existing methods to ensure that ALSPAC resources are visible and can be released more efficiently than before. |
| Title | Parents' Questionnaire 2018 - Your children and grandchildren; Dataset from questionnaire completed by G0 Mothers |
| Description | Data collected from the 'Your children and grandchildren' Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Data collected enabling ongoing research into: child behaviour, personality, communication skills, and attention/activity |
| Title | Synthetic dataset created for MAPS project |
| Description | KN to add more detail |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | KN to add more detail |
| URL | https://osf.io/buqk8/ |
| Title | The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April - June 2021 |
| Description | The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying multiple online questionnaires and a previous home-based antibody test in October 2020. A second antibody test, in collaboration with ten other longitudinal population studies, was completed by 4,622 ALSPAC participants between April and June 2021. Of 4,241 participants with a valid spike protein antibody test result (8.2% were void), indicating antibody response to either COVID-19 vaccination or natural infection, 3,172 were positive (74.8%). Generational differences were substantial, with 2,463/2,555 G0 participants classified positive (96.4%) compared to 709/1,686 G1 participants (42.1%). Of 4,199 participants with a valid nucleocapsid antibody test result (9.2% were void), suggesting potential and recent natural infection, 493 were positive (11.7%); 248/2,526 G0 participants (9.8%) and 245/1,673 G1 participants (14.6%) tested positive, respectively. We also compare results for this round of testing to that undertaken in October 2020. Future work will combine these test results with additional sources of data to identify participants' COVID-19 infection and vaccination status. These ALSPAC COVID-19 serology data are being complemented with linkage to health records and Public Health England pillar testing results as they become available, in addition to four previous questionnaire waves and a prior antibody test. Data have been released as an update to the previous COVID-19 datasets. These comprise: 1) a standard dataset containing all participant responses to all four previous questionnaires with key sociodemographic factors; and 2) individual participant-specific release files enabling bespoke research across all areas supported by the study. This data note describes the second ALSPAC antibody test and the data obtained from it. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Data availability - This is part of a series of cohort serology data sets that were generated as a result of NCS activity. These are described in the publication: https://elifesciences.org/articles/80428 |
| URL | https://wellcomeopenresearch.org/articles/6-283 |
| Title | The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture November 2020 - March 2021 |
| Description | The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study has reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying online questionnaires throughout the pandemic. In November/December 2020, a fourth questionnaire was deployed asking about physical and mental health, lifestyle and behaviours, employment and finances. G0 participants were offered an online questionnaire between 17th November 2020 and 7th February 2021, while G1 participants were offered both online and paper questionnaires between 1st December 2020 and 19th March 2021. Of 15,844 invitations, 8,643 (55%) participants returned the questionnaire (3,101 original mothers [mean age 58.6 years], 1,172 original fathers/partners [mean age 61.5 years] and 4,370 offspring [mean age 28.4 years]). Of these 8,643 participants, 2,012 (23%) had not returned a previous COVID-19 questionnaire, while 3,575 (41%) had returned all three previous questionnaires. In this questionnaire, 300 participants (3.5%) reported a previous positive COVID-19 test, 110 (1.3%) had been told by a doctor they likely had COVID-19, and 759 (8.8%) suspected that they had had COVID-19. Based on self-reported symptoms, between October 2020 and February 2021 359 participants (4.2%) were predicted COVID-19 cases. COVID data is being complemented with linkage to health records and Public Health England pillar testing results as they become available. Data has been released as an update to the previous COVID-19 datasets. It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors; and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. This data note describes the fourth questionnaire and the data obtained from it. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | This a specific questionnaire which was deployed to assess long COVID in LPS and is one of a series of linked cohort collections described here: https://www.nature.com/articles/s41467-022-30836-0 |
| URL | https://wellcomeopenresearch.org/articles/6-155 |
| Title | Training dataset for Mendelian Randomisation |
| Description | Training materials for a Mendelian Randomisation Course using simulated ALSPAC data has been developed by Nic Timpson and Colleagues. The data and all training materials are available for download fro data.bris. The course has been taught around the world |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Enables education and facilitates data use without disclosure risk |
| URL | https://data.bris.ac.uk/data/dataset/2e8d53bcg2yhp26r79zu425cyg |
| Title | UK10K - population based whole genome sequencing |
| Description | This is the collection of raw data and results from the UK10K study. By studying and comparing the DNA of 4,000 people whose physical characteristics are well documented, the project aims to identify those changes that have no discernible effect and those that may be linked to a particular disease; by studying the changes within protein-coding areas of DNA that tell the body how to make proteins of 6,000 people with extreme health problems and comparing them with the first group, it is hoped to find only those changes in DNA that are responsible for the particular health problems observed. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | This work has been published: Nature. 2015 Oct 1;526(7571):82-90. doi: 10.1038/nature14962. Epub 2015 Sep 14. The UK10K project identifies rare variants in health and disease. UK10K Consortium, Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JR, Xu C, Futema M, Lawson D, Iotchkova V, Schiffels S, Hendricks AE,Danecek P, Li R, Floyd J, Wain LV, Barroso I, Humphries SE, Hurles ME, Zeggini E, Barrett JC, Plagnol V, Richards JB, Greenwood CM, Timpson NJ, Durbin R,Soranzo N. |
| URL | http://www.uk10k.org |
| Title | Update to Focusing on You Fathers Questionnaire; Dataset from questionnaire completed by G0 fathers/partners |
| Description | Data collected from the 'Focusing on You Fathers' Questionnaire. Infrastructure funded by this award and supplemented with external funding. Substantial update with the addition of 483 cases to the dataset. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Data collected enabling ongoing research into: - Home life, neighbourhood, friends and family, employment and finances, mental and physical health, physical activity, gambling behaviour, smoking and alcohol consumption |
| Title | Update to Life@25+; Dataset from questionnaire completed by G1 |
| Description | Data collected at from the 25 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Data enabling ongoing research into mental health, personality, behaviour, life events, Eating behaviours & food preferences. Updates: Section B - Strengths and Difficulties; Section C - Anxiety; Question D4 - ADHD medications; Section E - Behaviour; Questions F1 to F7 - Depression and self-harm; Section H - Personality; Section K - Life at Home; and the Friend/Partner Questionnaire |
| URL | https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ype |
| Title | Your life in 2013; Dataset from questionnaire completed by G0 Mothers |
| Description | Data collected at from the 'Your life in 2013' Questionnaire. Infrastructure funded by this award and supplemented with external funding. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Data collected enabling ongoing research into: - Family and home life - Employment - Finances - Physical, sexual and reproductive health - Mental health - Substance Use - Physical activity |
| Title | mQTLdb |
| Description | mQTLdb is a database of methylation QTL, initially set up for methylation QTL from the ALSPAC-ARIES project |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The database is being used by researchers to identify methylation QTL for Mendelian randomization analyses |
| URL | http://www.mqtldb.org/ |
| Description | (Epi)Genetics of Puberty and Risky Sexual Behavior (B3077) |
| Organisation | University at Albany |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | (Epi)Genetics of Puberty and Risky Sexual Behavior (B3077) |
| Organisation | University at Albany |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | 10,000 hours: Children, Childcare and Developmental Opportunity (2335) |
| Organisation | Queensland University of Technology (QUT) |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2014 |
| Description | 2 Sample MR Lung function and Cognition (B3294) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | 2021/22 Continued NIHR Clinical Research Network West of England collaboration with ALSPAC |
| Organisation | National Institute for Health Research |
| Department | NIHR Clinical Research Network (CRN) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Since 2018/19, the CRN has invested in the ALSPAC team via development bids. CRN portfolio recruitment more than quadrupled from 2018/19 to 2019/20 and has increased again in 2020/21 due to addition of Covid-19 studies (see Table 1). In 2019/2020, the CRN nationally supported more than 6,000 studies and recruited over 732,000 participants, of which ALSPAC alone contributed 11 studies and over 18,000 participants. This contribution helped CRN WE recruit the most participants to public health studies nationally. |
| Collaborator Contribution | CRN WE will be rolling over its budget and allocations from 2020/21 to 2021/22. Therefore, ALSPAC will receive the same financial support as 2020/21, allowing them to extend existing CRN-supported posts. Funds will be allocated to supporting activity such as the: • Development and set-up of REDCap/Teleform data collection systems and consent forms. • Day to day response to REDCap/Teleform issues. • Oversight of contact management system and scheduling of invite and reminder correspondence. ALSPAC has contributed significant and consistently increasing levels of recruitment towards West of England CRN targets in 18/19, 19/20, and 20/21. Four suggested posts to be supported by the ALSPAC allocation in 2021/22. |
| Impact | Study recruitment metrics and output (listed here https://www.bristol.ac.uk/alspac/researchers/publications/) reflect contributions made to engagement and recruitment to the ALSPAC study. |
| Start Year | 2018 |
| Description | 24-hour ambulatory measures of blood pressure and their association with cardiac structure and function in adolescents (B2858) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | 3D whole body scans, B3495 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | A Bayesian mixture framework for epigenetics (2441) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | A Consolidator Grant to Study the Developmental Trajectories of Physical and Mental Health Multimorbidity in Genetic High-Risk C (B3439) |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | A GWAS of child's ability to cope as measured by SDQ (B2823) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | A Longitudinal Study on the Impact of Stressful Life Events on Obsessive-Compulsive Disorder Symptomatology (2424) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | A Mendelian Randomisation Study of IL-6, Depression and Psychosis in the ALSPAC Birth Cohort (2323) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None Yet |
| Start Year | 2014 |
| Description | A Mendelian Randomisation study of Skin tone and Vitamin D (2406) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | A Negative Control Analysis Investigating Maternal Smoking, Alcohol consumption and BMI on Molar-Incisor Hypomineralisation, B3679 |
| Organisation | University Hospitals Bristol NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | A Recall by Genotype Study to investigate the role of common TRPA1 variants in acute pain perception. (B3236) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | New Data collection and secondary analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | A UK underpinning platform to study immunology and immunopathology of COVID-19: The UK Coronavirus Immunology Consortium, B3547 |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | A comprehensive literature review of the genetic variants identified in Cleft Lip with/without Palate (continued title) (B2814) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | A deep clinical phenotyping study of a group of participants on a low lung function trajectory, B3947 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | A genetic underpinning of Optimism (2539) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | A hypothesis-free approach to identify DNA sequences regulating gene environment interaction (GxE) in programming adult response (B3203) |
| Organisation | Manchester Metropolitan University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | A latent variable approach to examining the role of maternal RSBB in offspring mental health, B3892 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | A meta-analysis of maternal smoking GFI1-CpGs and cardio-metabolic phenotypes in adults (B3097) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | A methylation-based biomarker for alcohol intake in the general population (B2818) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | A methylation-based biomarker for alcohol intake in the general population (B2818) |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | A molecular genetic study of Theory of Mind (2528) |
| Organisation | McMaster University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | A molecular test of the Nature of Nurture in the psychosis pathway (B3171) |
| Organisation | Icahn School of Medicine at Mount Sinai |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | A multi-cohort GWAS of income using ALSPAC (B3307) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | A multi-omics investigation into the metabolic and epigenetic effects of childhood glycemic profile (2370) |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | A novel genetic instrument for lifetime smoking indicates that smoking is a casual risk factor for depression and schizophrenia (B3094) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | A polygenic approach to understanding resilience to peer victimisation (B3331) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | A prospective examination of the influence of ultra-processed food consumption on measures of adiposity and CVD (B3052) |
| Organisation | Universidade de São Paulo |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | A robust micro-assay to determine the prevalence of COVID-19 antibodies in the general population using capillary sample collect, B3508 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | A study of origins, correlates and determinants of locus of control (2390) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | A summary of pain and related items in ALSPAC, B4029 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2022 |
| Description | ADHD and DNA methylation: a repeated measures EWAS (B2749) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | ALSPAC & DataSHIELD in the InterConnect Project. Subproject1: Physical Activity in Pregnancy & Anthropometric Outcomes (B2660) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | ALSPAC (University of Bristol) - Twins UK (KCL) collaboration on developing linkage methodologies |
| Organisation | St Thomas' Hospital |
| Department | Twins Research Cohorts from St Thomas' Hospital |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ALSPAC are providing strategic support to develop the TwinsUK record linkage programme based on the established and generalisable approaches developed by the 'PEARL' record linkage team. ALSPAC are specifically 1) supporting the development of the TwinsUK governance approvals based on the precedents of ALSPAC approaches; 2) supporting the development of the TwinsUK data access requests based on the precedents of ALSPAC approaches; 3) will lead the programme to secure GP assent to release copies of patients primary care records to the studies & to develop the technical mechanisms by which this will occur with practice software companies. Further to this, ALSPAC and TwinsUK will collaborate on development of aligned data processing and infrastructure and documentation/discovery developments. |
| Collaborator Contribution | Regular working meetings to develop policy and materials and to share insights. |
| Impact | In December 2019 TwinsUK received a conditional approval from the HRA Confidentiality Advisory Group to access identifiable patient information without explicit patient consent. This was based on ALSPAC's existing approvals. |
| Start Year | 2019 |
| Description | ALSPAC - Enhancement of Transcriptomic Resources, B3936 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | ALSPAC MRI-II (B3035) |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | New data collection and secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | ALSPAC Proposal - Education and Myopia: A Bi-directional Mendelian Randomisation Study (B2715) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | ALSPAC analysis for ExomeBP consortium (2615) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | none yet |
| Start Year | 2016 |
| Description | ALSPAC and ELSPAC: Pre-birth cohorts with longitudinal data on childhood obesity, respiratory development and neurocognitive abi (B2650) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | New data and secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | ALSPAC cohorts National Chlamydia Screening Programme testing patterns (2594) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analyiss |
| Impact | None yet |
| Start Year | 2015 |
| Description | ALSPAC exome generation (2605) |
| Organisation | Massachusetts General Hospital |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | ALSPAC exome generation (B2680) |
| Organisation | Massachusetts General Hospital |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | ALSPAC families (B3370) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | ALSPAC iPSC bank - (2489) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | ALSPAC in the Digital Age (2588) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | secondary ANALYSIS |
| Impact | None yet |
| Start Year | 2015 |
| Description | ALSPAC linkage team collaboration with Dr Beng Choon-Ho, University of Iowa Carver College of Medicine. |
| Organisation | University of Iowa |
| Department | Carver College of Medicine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | The ALSPAC Data Linkage Team are collaborating with Dr Choon-Ho to develop funding applications to support research investigating the neurobiological mechanisms in Adolescent Marijuana Exposure and subsequent Schizophrenia Risk. This will reuse MRI data collected by ALSPAC and Collaborators Professor David and Professor Linden, it will also utilise new data management infrastructure developed by the ALSPAC MRC MH Pathfinder award. |
| Collaborator Contribution | Contributing expertise to grant applications led by Dr Choo-Ho. |
| Impact | 1) Grant application to NIHR (Not supported) "Adolescent Impulsivity, Reward Brain Networks & Schizophrenia Risk" 2) Grant application to NIHR (in progress) "Neurobiological Mechanisms in Adolescent Marijuana Exposure and Schizophrenia Risk" |
| Start Year | 2019 |
| Description | ALSPAC mGWAS (B2813) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | ALSPAC response to COVID-19 pandemic, B3487 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Abnormal metabolic measures in adolescents with pyschotic experiences (2532) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Acceptability to participants of novel data linkages, ethical issues, and the practicalities of obtaining consent: Evidence from (B3406) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | Accuracy of clinical characteristics, biochemical and ultrasound markers in the prediction of pre-eclampsia: an IPD |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Acetaminophen (paracetamol) use during pregnancy and behaviour problems and autism spectrum symptoms in childhood (B2763) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Acetaminophen Exposure in Utero and Subsequent Impact on Female Reproductive Function (B3225) |
| Organisation | University of Pennsylvania |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Adaptations to Inequality and the Perpetuation of Disadvantages: An Evolutionary Developmental Approach (B3082) |
| Organisation | University of Washington |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Adolescent and adult mental health outcomes of autism and autistic traits (2622) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | none yet |
| Start Year | 2016 |
| Description | Adolescent anxiety and depressive symptoms and subsequent intimate partner violence: the impact of mental health support, B3654 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Adolescent diet and cardiometabolic health (B2798) |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Adolescent insufficient sleep: epigenetic changes and the risk of developing AUD and neuropsychiatric comorbidities, B3641 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Adult Eating Behaviour Questionnaire in ALSPAC (2496) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | New data collection via questionnaire - subject to funding by collaborator |
| Collaborator Contribution | Seeking funding to collect new data |
| Impact | None yet |
| Start Year | 2015 |
| Description | Adult peak Circulatory capacity; Mechanisms and Exposures (ACME), B3502 |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Adverse childhood experiences and body composition in adolescence: a cross-cohort comparison (2598) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Adverse childhood experiences and psychopathology: A genetically informative approach (B3218) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Adverse childhood experiences and psychopathology: A propensity score matching approach (B3219) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Adverse life events, inflammation, and trajectories of emotional and behavioural problems in childhood (B2645) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Prevision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Aetiology of increased birthweight for gestation (2360) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2014 |
| Description | Age at menarche and lung function: A Mendelian randomisation analysis (2461) |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Age specific BMI SNP effects (SNP effect look up) (B2998) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | Ageing Lungs in European Cohorts Project- EWAS on Lung Function (B2909) |
| Organisation | University of Basel |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | Agreement in alcohol reporting (as part of ELAStiC) (B2726) |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Air Pollution Risk and Genetic Liability for Autism and ADHD (2538) |
| Organisation | University of Wisconsin-Madison |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Air pollution and childhood asthma: potential role of common allergies as mediators, B3632 |
| Organisation | Bradford Institute for Health Research (BIHR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Air pollution data in ALSPAC - documentation (2600) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Air pollution exposure and childhood obesity, B3647 |
| Organisation | Barcelona Institute for Global Health |
| Country | Spain |
| Sector | Multiple |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Air pollution exposure during pregnancy and associations with child gene expression at birth, B3777 |
| Organisation | University of Oslo |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Alcohol 18 to 30, B3507 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Alcohol Consumption And Hypertensive Disorders of Pregnancy: A Negative Control Analysis In ALSPAC, B3811 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Alcohol Misuse: Electronic Longitudinal Alcohol Study in Communities (2501) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Alcohol use in the late 20's, B3501 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | New Data and Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Alcohol use, breastfeeding and offspring neurodevelopment (B3248) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | Allostatic load in childhood and the development of mental health disorders, B3847 |
| Organisation | James Cook University |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Almost exact Mendelian randomisation, B3744 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Amendment to STELAR Collaboration - Asthma Trajectories From Childhood to Adulthood (B3149) |
| Organisation | University Hospital Southampton NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | An EWAS of Anti-Mullerian Hormone (2454) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | An adult eating questionnaire to measure disinhibition and restraint (B2872) |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | New data collection and secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | An analysis of the environments which promote the development of early speech and language skills (2465) |
| Organisation | North Bristol NHS Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | An atlas of phenotypic correlations and a correction of multiple testing across human traits and diseases using GWAS summary sta (B2739) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | An ethical and technical framework for linking social media data in UK cohorts (B2934) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | An examination of the association between school engagement at 10-11 yrs and sexual health and behaviours at 21 yrs (2402) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | An exploration into the impact of social contact on the risk of depressive symptoms during COVID-19: findings from a prospective, B3766 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | An exploration into the links between educational attainment, intelligence and wellbeing, B3783 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | An exploration of the relationship of early-life microbiome patterns and susceptibility to future infections, B3704 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | An individual participant data meta-analysis examining the associations between mode of delivery and respiratory outcomes, B3689 |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | An integrative analysis of biological and environmental risks for mental ill-health in young adulthood to precision psychiatry (B3303) |
| Organisation | Royal College of Surgeons in Ireland |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | An investigation into the determinants of fatigue in a population-based cohort of young adults (2408) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | An investigation of maternal risk factors for the development of paediatric obsessive-compulsive disorder (2330) |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2014 |
| Description | An investigation of the association between substance use in adolescence and mental health using linked data (B3112) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | An investigation of the environmental effect of parental genotypes on offspring behavioural problems (B3389) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | Analysing the association between inflammation and scoliosis in a population-based birth cohort's a proof of concept study (B3404) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | Analysis for Global Lipids Genetics / The Genetic Investigation of Anthropometric Traits (GLG/GIANT) consortia (B2861) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | Analysis of 3D body scans: genetics of body morphology, correlation with measure of adiposity and cardiometabolic consequences, B3859 |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Analysis of DNA Methylation for family trios (B2724) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis and new data |
| Impact | None yet |
| Start Year | 2016 |
| Description | Analysis of SNP-heritability and co-heritability of adolescent psychotic experiences (2321) |
| Organisation | Birkbeck, University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2014 |
| Description | Analysis of SNP-heritability and co-heritability of adolescent psychotic experiences (2321) |
| Organisation | Birkbeck, University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2014 |
| Description | Analysis of copy number variation in relation to age at menarche and age at natural menopause (B2978) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | Analysis of developmental relations between co-occurring mental health problems to inform interventions, B3709 |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Analyst and writing group member for the MAGIC 'Trans-ethnic meta-analysis and fine-mapping for fasting glucose, fasting insulin, 2hr glucose and HbA1c using data imputed to the 1000 Genomes reference panel |
| Organisation | MAGIC (The Meta-Analyses of Glucose and Insulin-related traits Consortium) |
| Country | Global |
| Sector | Charity/Non Profit |
| PI Contribution | I have contributed results from the analysis of ALSPAC (Avon Longitudinal Study of Parents and Children) data to the meta-analysis. I have acted as a central analyst which has involved conducting quality control checks and reformatting of data contributed by other analysts. I have a led a side project looking at the variance explained by new markers for glycaemic traits. I have contributed to the drafting of the manuscript that will hopefully be submitted shortly. |
| Collaborator Contribution | The other investigators in the collaboration have also contributed results from analyses run within their own cohorts and similarly although variable contributed to side projects and manuscript writing. |
| Impact | A manuscript is in progress but not yet published. |
| Start Year | 2014 |
| Description | Anorexia and subsequent smoking: cause or correlation (B3355) |
| Organisation | University of Bristol |
| Department | School for Policy Studies |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2019 |
| Description | Antecedents of Trait Psychological Functioning (2514) |
| Organisation | Florida State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Antecedents of obesity in the ALSPAC cohort: the role of early diet (sugar and fibre), antibiotics and gut bacteria (B2753) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Antenatal Selection Gradients (B2915) |
| Organisation | Princeton University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | Antenatal Selection and the Parent-Child Gene Environment: Challenging the Nurture/Nature Dichotomy (B2931) |
| Organisation | Princeton University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2017 |
| Description | Antibodies to Infectious Agents and Psychiatric Disorders (B3033) |
| Organisation | Johns Hopkins Medicine |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Anxiety and depression in young people: who do they affect, who seeks treatment, and who responds to treatment? B4075 |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2022 |
| Description | Anxiety and mood disorders in young people: a multivariate approach using the ALSPAC cohort, B3464 |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2020 |
| Description | Anxiety symptoms and eating patterns during COVID-19 for young UK adults with different eating behaviour traits, B3775 |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Apgar scores and long term growth, health ann development (2495) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2015 |
| Description | Application of co-occurrence networks to the discovery of pre-eclampsia risk, B3786 |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Data Provision |
| Collaborator Contribution | Secondary Analysis |
| Impact | None yet |
| Start Year | 2021 |
| Description | Application of the joint linear mixed effect IOU model:accounting for autocorrelation and informative dropout (B2747) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Applied epidemiology and the human gut microbiome: evidence for causal effects versus confounded companionship (B3043) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Applying Mendelian randomization to predicting the overall effects of interventions targeting sclerostin (B2646) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data Prevision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Applying causal inference methods to investigate the impact of adverse childhood experiences on psychopathology (B3219) |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Applying genetic risk scores for one-carbon micronutrients to Mendelian randomization and epigenome-wide association analyses (B3140) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data provision |
| Collaborator Contribution | Secondary analysis |
| Impact | None yet |
| Start Year | 2018 |
| Description | Appropriate statistical models for multivariate epigenetic data, with focus on prenatal alcohol exposure. (B2745) |
| Organisation | University College Dublin |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Data prevision |
| Collaborator Contribution | Secondary analysis |