The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019

Lead Research Organisation: The Wellcome Trust Ltd

Abstract

For over 20 years Children of the 90s (or ALSPAC) has charted the health of 14,500 parents and
children. Now in its third decade it has started to study the next generation, the children of the
Children of the 90s. The study is unequalled by other population studies because of the breadth
and depth of information it holds on participants from before birth over 20 years ago through to the
present day. It is internationally renowned and used by researchers worldwide. The data allow
researchers to study key periods of development, how certain conditions develop and change over
time and are passed (or not) from one generation to the next, and how health is affected by the
interplay between genes and other factors like smoking, where people live and the job they do.
Our goals are to ensure the resource remains sustainable and open to researchers to use, and
that participants remain engaged. We will continue to gather information from the original children
through clinical assessments, questionnaires and record linkage, and will be recruiting and
gathering data on the children of the children as well as merging genetic data and enhancing research in the exciting new field of epigenomics.

Technical Summary

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective cohort study with
unprecedented scope and detail of information on thousands of people from before birth through
to early adulthood, on their parents and now on their children. It is an internationally valued
resource at the forefront of population-based research. ALSPAC allows the investigation of
developmental trajectories marking critical periods in human life, the genetic and epigenetic
factors contributing to health and disease and the environmental exposures which form the context
within which these processes act. As ALSPAC participants enter adulthood and start having
children, the study's potential to contribute to scientific discovery is expanding, giving a greater
capacity to explore links between current and future health and the intergenerational components
of health and disease. ALSPAC is unequivocally the richest open-access epidemiological resource
in the world. Our goals are to ensure that ALSPAC (i) is sustained, (ii) has participation maximised
and (iii) is enhanced. These goals will be delivered by follow-up of the original cohort through clinic
assessment, questionnaires and record linkage, data collection on their children, consolidation of
GWAS data on all participants and the development of epigenomics research.

Organisations

Publications

10 25 50
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Colodro-Conde L (2017) Cohort Profile: Nausea and vomiting during pregnancy genetics consortium (NVP Genetics Consortium). in International journal of epidemiology

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Cooper AR (2015) Objectively measured physical activity and sedentary time in youth: the International children's accelerometry database (ICAD). in The international journal of behavioral nutrition and physical activity

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Cooper M (2018) Investigating late-onset ADHD: a population cohort investigation. in Journal of child psychology and psychiatry, and allied disciplines

 
Title Creative Reactions 2018 
Description Creative Reactions is an art exhibition associated with the national Pint of Science festival. Approximately 20 researchers using ALSPAC data were paired with local Bristol artists who produced an artwork based upon their research. The exhibition was held from 11-22 May 2018. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2018 
Impact Artworks were viewed and seen by the general public as well as the scientific community. Local radio, online and print media covered the exhibition. 
URL https://pintofscience.co.uk/event/creative-reactions-bristol-launch
 
Title Creative Reactions- Kayleigh Easey 
Description Collaboration with an artist to produce a piece of artwork that summarises my research on the effects of maternal and paternal drinking in pregnancy on offspring depression. 
Type Of Art Artwork 
Year Produced 2018 
Impact The artwork is to be displayed in an exhibition in Bristol, involved with Pint of Science. There is to be an opening event that is widely advertised to the public. This work will allow scientists to share with the public their research and the implications it may have. 
URL https://pintofscience.co.uk/events/bristol
 
Title Researcher videos for social media & website 
Description A series of video interviews with researchers and collaborators using ALSPAC data. Designed to share the findings and nature of work conducted with a lay audience. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact Widening awareness of research impact among core audiences - public, participants, collaborators and charities/third parties. It also provides an opportunity for researchers to thank participants and engage them in future participation with the study. 
URL http://www.bristol.ac.uk/alspac/media/researcher-interviews/
 
Description "The one-way mirror: public attitudes to commercial access to health data"
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description ALSPAC information used in in 'Your Health Record Saves Lives' information booklet produced by UK Clinical Research Collaboration
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.nhs.uk/Conditions/Clinical-trials/Documents/Research1.pdf
 
Description ALSPAC obesity data cited in government's child obesity strategy
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/childhood-obesity-a-plan-for-action
 
Description ALSPAC research on bullying and maltreatment cited in EHRC race report
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.equalityhumanrights.com/en/race-report-healing-divided-britain
 
Description ALSPAC research on eczema and genes featured in the National Eczema Society's Exchange magazine (159, March 2016)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.eczema.org/products/154
 
Description ALSPAC research on premature babies quoted in Parliament by Stephen Hammond MP
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
URL https://hansard.parliament.uk/commons/2016-10-10/debates/5032D3A8-AA55-4388-BCE2-DE2ACAB8CDCC/School...
 
Description ALSPAC used as example of best practice by Health and Social Care Information Centre
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://systems.hscic.gov.uk/infogov/codes/cop
 
Description Adjournment debate on fetal alcohol spectrum disorder
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://hansard.parliament.uk/Commons/2019-01-17/debates/19011751000002/FoetalAlcoholSpectrumDisorde...
 
Description Bullying research included in textbook
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies.
URL http://www.independence.co.uk/shop/family-and-relationships/issues/bullying
 
Description Bullying research included in textbook
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies.
URL http://www.independence.co.uk/shop/family-and-relationships/issues/bullying
 
Description Change in Information Commissioner's Office code of practice guidance on data protection following the Data Protection Act 2018
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact CLOSER work on the need for clearer and changed regulatory guidance regarding data retention (see Boyd et al. 2018, available from: https://wellcomeopenresearch.org/articles/3-112/v1) led to a change in official guidance from the Information Commissioner's Office (see https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-regulation-gdpr/principles/storage-limitation/). This has the potential to help safeguard data which could be used as research resources of the future.
URL https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-r...
 
Description Chapter on childhood asthma included in RCPCH air pollution report
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.rcplondon.ac.uk/projects/outputs/every-breath-we-take-lifelong-impact-air-pollution
 
Description Evidence included in Commons Health Select Committee report
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL http://www.publications.parliament.uk/pa/cm201415/cmselect/cmhealth/845/845.pdf
 
Description Evidence that little time outdoors contributes to the development of myopia in middle childhood
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Description Findings of research on dyslexia and vision recommended by Dyslexia Action
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.dyslexiaaction.org.uk/news/%E2%80%98dyslexia-and-sight-wider-view%E2%80%99-research-welco...
 
Description Guidance on iodine cited by Scientific Advisory Committee on Nutrition
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/sacn-statement-on-iodine-and-health-2014
 
Description Internet use and the impact of this on mental health and well-being
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Involvement of ALSPAC in the formation of Joint Strategic Needs Assessment - Chlamydia prevalence
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
 
Description Leading joint academic-NHS review on methods to onward share linked NHS records
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact A joint piece of work between CLOSER (led by Andy Boyd & Alison Park) and NHS Digital (led by Garry Coleman & Estelle Spence) through the NHS Digital Research Advisory Group. The work included conducting a stakeholder needs analysis amongst the longitudinal studies community (two workshops held) and a report generated. The findings are leading to a clearer and more efficient mechanisms to maximise the research value of the secondary use of routine health records in order to develop and more effective and efficient NHS.
URL https://digital.nhs.uk/services/research-advisory-group
 
Description METADAC
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://www.metadac.ac.uk/data-access-committee/application-forms/
 
Description Maternal iodine status and child early and later life health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and child early and later life health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and early child health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and health of the child
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health (2014)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health (2014) (2014)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description New evidence on vitamin D supplementation in pregnancy from research showing that vitamin D status in pregnancy not associated with offspring bone mineral content
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Description New guidance on alcohol in pregnancy endorsed by Dr Simon Newell (RCOP), James Nicholls (Alcohol Research UK) and Professor David Nutt, Imperial.
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
 
Description New guidance on importance of iodine in pregnancy diet backed up by BDA factsheet http://www.bda.uk.com/foodfacts/Iodine.pdf
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.bda.uk.com/foodfacts/Iodine
 
Description Participation in All Party Parliamentary Group on Autism - building brighter futures for children with autism event (10 July 2018)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Questionnaire, linkage and interview data inform BIS report
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/progression-into-higher-education-for-disadvantaged-and-u...
 
Description Research on school outcomes for premature babies endorsed by Professor Sir Al Aynsley Green (first Children's Commissioner for England)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Submitted evidence to Commons Health Select committee inquiry into suicide prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
URL http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr...
 
Description Submitted evidence to Commons Health Select committee inquiry into suicide prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
URL http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr...
 
Description 37356: Scourfield fellowship: Fathers, social interventions and children's wellbeing
Amount £8,482 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2011 
End 08/2014
 
Description 38361: The determinants of measures of immune function in a wild mammal.
Amount £5,000 (GBP)
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 07/2011 
End 01/2015
 
Description 43249: NICE childhood obesity weight management
Amount £2,250 (GBP)
Funding ID F00003186 
Organisation National Institute for Health and Care Excellence (NICE) 
Sector Public
Country United Kingdom
Start 04/2012 
End 03/2014
 
Description 43992: POPPIE Predictors of Persistence & Psychological Impact of Childhood Eczema
Amount £800 (GBP)
Funding ID F00022685 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2012 
End 11/2012
 
Description 47297: B1227 Biomarker study
Amount £2,593 (GBP)
Organisation Royal College of Surgeons in Ireland 
Sector Academic/University
Country Ireland
Start 03/2013 
End 02/2017
 
Description 59452: C.Williams Senior Research Fellowship
Amount £37,043 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2020
 
Description A framework for linking and sharing social media data for high-resolution longitudinal measurement of mental health across CLOSER cohorts
Amount £149,971 (GBP)
Funding ID ES/R011583/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description ALSPAC Additional Funding from 01/04/2019 to 31/07/2019
Amount £283,265 (GBP)
Funding ID 102215/Z/13/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 07/2019
 
Description ALSPAC Questionnaire - dietary preference
Amount £10,000 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 12/2017
 
Description Adolescent and adult mental health outcomes of autism and autistic traits
Amount £74,096 (GBP)
Funding ID TRUST/VC/AC/SG/3747-6849 
Organisation Baily Thomas Charitable Fund 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2016 
End 03/2018
 
Description Adolescent and adult mental health outcomes of autism and autistic traits
Amount £226,152 (GBP)
Funding ID MR/R004889/1 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 06/2017 
End 05/2019
 
Description Adverse life events, inflammation, and trajectories of emotional and behavioural problems in childhood
Amount £161,295 (GBP)
Funding ID ES/P001742/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 04/2017 
End 05/2018
 
Description An investigation of the causal pathways from childhood conduct problems to poor health outcomes and criminal behaviour in adulthood
Amount £250,000 (GBP)
Funding ID 209138/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2022
 
Description Are sleep difficulties in ADHD an index of neurodevelopmental severity?
Amount £57,539 (GBP)
Funding ID 918-3021 
Organisation The Waterloo Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 10/2020
 
Description Autism Speaks B954 RX9194 'Genetic Variation and Gene-Environment Influences in Autistic-like traits'
Amount £71,704 (GBP)
Funding ID 7132 
Organisation Autism Speaks 
Sector Charity/Non Profit
Country United States
Start 12/2011 
End 05/2014
 
Description B2390 Internal Locus of Control: Origins, Determinants, and Benefits
Amount £5,000 (GBP)
Funding ID 58223 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 09/2015 
 
Description BIOSHARE Social Core - Qualatative Study
Amount £1,806 (GBP)
Funding ID Health-F4-2010-261433 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 07/2014 
End 01/2015
 
Description Behavioural and neurophysiological effects of schizophrenia risk genes
Amount £789,477 (GBP)
Funding ID MR/K004360/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Biomedical Research Centre (BRC) in Cardiovascular disease, mental health, nutrition, diet and lifestyle (including obesity), reproductive and perinatal health, surgical innovation.
Amount £20,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 04/2022
 
Description British Heart Foundation funded PhD programme in cardiovascular science. Interdisciplinary PhD studentship programme in integrative cardiovascular science. 5 students per year for 4 years.
Amount £2,500,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 10/2021
 
Description CLOSER AMENDMENT 4: CLOSER INNOVATION FUND
Amount £112,678 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2017
 
Description CLOSER Amendment 1: Cohort and Longitudinal Studies Enhancement Resources Grant
Amount £327,143 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2019
 
Description CLOSER Amendment 3: Cohort and longitudinal studies enhancement resources grant
Amount £149,136 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2019
 
Description CLOSER Amendment 5: Innovation Fund - Occupational and social class data coding and harmonisation
Amount £9,811 (GBP)
Funding ID ES/K000357/1 
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 08/2017
 
Description CLOSER Ammendment 2: Cohort and longitudinal studies enhancement resources
Amount £95,684 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2017
 
Description Can Hip DXA scans be used to identify genetic determinants of hip shape & osteoarthritis? Proposal for a proof-of-concept study B1372
Amount £11,429 (GBP)
Funding ID 20244 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2013 
End 01/2016
 
Description Characterising brain network differences during scene perception and memory in young adult APOE-e4 carriers: multi-modal imaging in ALSPAC
Amount £1,420,574 (GBP)
Funding ID MR/N01233X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 04/2020
 
Description Childhood predictors of inadequate health literacy in young adults
Amount £28,568 (GBP)
Organisation Sir Halley Stewart Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 02/2019
 
Description Clinical Research Training Fellowship (Simon Haworth)
Amount £167,384 (GBP)
Funding ID 201268/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2016 
End 05/2019
 
Description Cohorts as Platforms for Mental Health research (CaP:MH)
Amount £1,497,192 (GBP)
Funding ID MC_PC_17210 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Cohorts as Platforms for Mental Health research (MRC MH Pathfinder)
Amount £1,497,192 (GBP)
Funding ID MC_PC_17210 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Computational Models for the Prediction and Prevention of Child Traumatic Stress
Amount $781,926 (USD)
Funding ID 1R01MH119114-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2019 
End 05/2023
 
Description Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA)
Amount £1,190,293 (GBP)
Funding ID MR/N000390/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description Cytoprotective defence mechanisms during tissue maintenance and repair - Helen Weaver
Amount £1,159,829 (GBP)
Funding ID 208762/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2018 
End 07/2023
 
Description Deriving and validating a clinical prediction rule for the diagnosis of asthma in primary care
Amount £207,554 (GBP)
Funding ID CAF/17/01 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 09/2017 
End 06/2021
 
Description Describing habitual levels of physical activity (PA) in older people in terms of impact loads and how this relates to bone and other systems
Amount £58,433 (GBP)
Funding ID MR/K024973/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2013 
End 06/2016
 
Description Development of ALSPAC Industry Partner and Participant Portal
Amount £15,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 08/2018
 
Description Development of ALSPAC Industry Partner and Participant Portal (Timpson NJ, Skinner A.)
Amount £15,000 (GBP)