Cambridge CiC 2018: Converting innovative science into human health benefit
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
People |
ORCID iD |
| Patrick Maxwell (Principal Investigator) |
Publications
Stasiak J
(2020)
Biomaterials Science
in GD Design, development, testing at ISO standards and in vivofeasibility study of a novel polymeric heart valve prosthesis
Sienko A
(2024)
An Initial Validation of Community-Based Air-Conduction Audiometry in Adults With Simulated Hearing Impairment Using a New Web App, DigiBel: Validation Study
in JMIR Formative Research
Burn AM
(2022)
Developing a Web-Based App to Assess Mental Health Difficulties in Secondary School Pupils: Qualitative User-Centered Design Study.
in JMIR formative research
Soneson E
(2020)
Feasibility of School-Based Identification of Children and Adolescents Experiencing, or At-risk of Developing, Mental Health Difficulties: a Systematic Review.
in Prevention science : the official journal of the Society for Prevention Research
Anderson, J. K.
(2019)
A systematic review of effectiveness and cost-effectiveness of school-based identification of children and young people at risk of, or currently experiencing mental health difficulties
in Psychological medicine
Woodington BJ
(2021)
Electronics with shape actuation for minimally invasive spinal cord stimulation.
in Science advances
Stochl J
(2021)
Modernising measurement in psychiatry: item banks and computerised adaptive testing.
in The lancet. Psychiatry
| Description | ): Access to Expertise for Cambridge Adaptive Testing - Mental health screening platforms - data governance considerations |
| Amount | £15,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2023 |
| End | 12/2023 |
| Description | A novel transcatheter valve for younger patients with aortic stenosis |
| Amount | £248,018 (GBP) |
| Funding ID | TG/15/4/31891 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| Description | ACT Emergency appeal |
| Amount | £24,956 (GBP) |
| Funding ID | 900250 |
| Organisation | ACT Alliance |
| Sector | Charity/Non Profit |
| Country | Switzerland |
| Start | |
| Description | Access to Expertise for Cambridge Adaptive Testing - Mental health screening platforms - medical device considerations |
| Amount | £6,144 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 03/2023 |
| Description | Cambridge Cardiology: Developing Catheter-based Treatments for Valvular Heart Disease |
| Amount | £60,000 (GBP) |
| Organisation | Royal Academy of Engineering |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 02/2018 |
| Description | Cambridge Enterprise Post-doctoral business plan competition |
| Amount | £5,000 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Cell surface biomarkers to predict outcome of COVID-19 upon hospital admission |
| Amount | £50,000 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2020 |
| End | 09/2022 |
| Description | Development of a Transcatheter Mitral Repair System for patients with Mitral Regurgitation |
| Amount | £69,978 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Development of a novel polymeric trans-catheter aortic valve to improve durability in high-risk patients: proof of concept study |
| Amount | £65,641 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | EPSRC Impact Acceleration Account Follow-on Fund University of Cambridge |
| Amount | £50,000 (GBP) |
| Organisation | ESRC Impact Acceleration Account Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 07/2019 |
| Description | Medical device certification |
| Amount | £20,000 (GBP) |
| Organisation | University of Cambridge |
| Department | Cambridge Enterprise |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2023 |
| End | 04/2024 |
| Description | Minimally invasive Spinal Cord Stimulator (MI-SCS):validation experiments in human spine cadaveric model |
| Amount | £40,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| Description | NIHR i4i Connect CYPMH theme |
| Amount | £150,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2023 |
| Description | NIHR, I4I PDA |
| Amount | £1,600,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR i4i Invention for Innovation (i4i) Programme |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2021 |
| Description | NeWTS: Neonatal Wireless Transmission System for Delivery Unit and Inter-Hospital Transport |
| Amount | £20,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| Description | Preliminary whole cell lysate analysis experiments |
| Amount | £50,000 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2020 |
| End | 09/2022 |
| Description | R9.5 Development of a novel audiology computer application and modified headphone system for the DigiScreener sensory screening platform |
| Amount | £70,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Confidence in Concept Scheme |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 05/2020 |
| Description | Social - Emotional Screener for Neurodiverse Children |
| Amount | £414,918 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2024 |
| Description | Targeting cell death by ferroptosis in Parkinson's disease |
| Amount | £20,039 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Confidence in Concept Scheme |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | i4i Connect CYPMH |
| Amount | £150,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2023 |
| Title | Therapeutic targeting of chromosomal instability in cancer |
| Description | • Isolation of intact tumour cells from FFPE using the CellenONE instrument (protocol available on request). • Prototype FFPE single cell isolation protocol complete (available on request). • Prototype fresh frozen single cell isolation (tumour tissue and ascites) protocol complete (available on request). • Prototype library preparation protocol complete (available on request) for different tissue types: FFPE, fresh frozen and cell lines. • Reference dataset generated for single cells at different ploidy and cell cycle states to improve the copy number calling for each cell. |
| Type Of Material | Cell line |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | Milestone 1: genome-wide copy number profiling of gold-standard test samples (completed) Shallow whole genome sequencing of cell lines: CIOV1, PEO1, OVCAR3, NA12787 and tumour FFPE tissue test samples was completed. Milestone 2: comparison of whole-genome amplification and library preparation reagents (completed) 1. Isolation of nuclei and single cells from FFPE material: During the course of this grant we realised that isolation of single cells rather than nuclei was indeed possible from FFPE tissue. Furthermore, we also found that the proportion of ovarian tumour cells with micronuclei were not well characterised with single nucleus preparation, with crucial genomic information being lost. Isolation of the whole intact tumour cells has the advantage of containing all genomic information but also getting more information about the specific cell properties and its morphology (elongation, size, circulation). We successfully established protocol to isolate intact tumour cells from clinical FFPE tissues based on the Bolognesi methodology [PMCID 26864208] and optimise the method for the single cell identification (using nuclear marker - DAPI, tumour positive marker - cytokeratin and non-tumour positive marker - vimentin) and dispensation onto two plates formats: 96 and 384 well plate format using CelleOne instrument. Isolated intact cells from FFPE tissue using CellenOne instrument (channels: transmission, DAPI, cytokeratin and vimentin). 2. Optimisation of the shallow whole genome library prep for single cells isolated form FFPE tumour tissue: During the course of this grant we realised that the whole genome amplification reagents Sigma and Picoplex V1, and associated library kits NEB and Nextera flex, were not optimal and introduced noise compared to the Smarter PicoPlex Gold Single Cell DNAseq kit (Takara). Therefore, we put effort to test and optimise the workflow using Smarter PicoPlex Gold Single Cell DNAseq. Additionally, as ~70% cells from the initial sequencing runs showed poor data quality we also focused on improving the copy number calling for each cell by generating datasets for single cells at different ploidy and cell cycle states. We successfully optimised single cell whole genome library preparation using Smarter PicoPlex Gold Single Cell DNAseq kit (Takara) kit from FFPE tissue. Generated libraries showed no significant allele dropout and good data quality. Absolute copy number comparison between CIOV1 FFPE (A, C) and CIOV1 FF (B, D) and clinical FFPE (E). We successfully optimised sequencing conditions for single cell whole genome library preparation from FFPE tissue. We found that by adding 20% of PhX reference genome to the sequencing reaction significantly improved the data quality. We successfully generated a catalogue of shallow whole genome sequencing datasets from single cells at different ploidy and cell cycle. We selected four cell lines to generate high quality data to train the algorithm to improve single cell data analysis: normal diploid cell line (NA12787), tumour diploid cell line (PEO1), tumour diploid cell line with losses/haploid (CIOV1), triploid cell lin. All cells from cell lines were FACS sorted to obtain three populations: cells at G1, S and G2/M cell cycles. Single cells from all three populations were then isolated using CelleOne instrument and underwent optimised single cell whole genome library preparation using the Smarter PicoPlex Gold Single Cell DNAseq method and sequenced. Milestone 3: observing the effect of DNA repair enzymes (not performed) This was not performed as the current single cell whole genome library prep was optimised for FFPE samples without the need of using the DNA repair system. Milestone 4: reagent dilution and cost reduction (completed) During the experiments outlined under milestone 2 we tested 4x and 5x dilution and achieved accurate results. We successfully optimised the workflow for the single cell whole genome library preparation using Smarter PicoPlex Gold Single Cell DNAseq kit (Takara) kit on Mosquito robot from FFPE tissue. Our current optimised workflow uses 5x dilution reagents on a 384-plate format using automated Mosquito robot. The whole workflow from start to finish takes XX hours: single cell isolation (6hours), cell dispensing (4 hours), library preparation and sequencing (10hours + 16hours) and data analysis XX hours (under development). |
| Description | Artemis with Cambridge Enterprise |
| Organisation | University of Cambridge |
| Department | Cambridge Enterprise |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Cambridge Enterprise (CE) helps with commercialization of our mental healtyh assessment platform. |
| Collaborator Contribution | We have developed platform for online assessment of mental Health. It uses innovative adaptive testing technology and tjhus is way more efficient compared to standard mental health assessment. |
| Impact | IP protection research, proposal for funding (MRC), development of business model |
| Start Year | 2021 |
| Description | Artemis-R |
| Organisation | Effusion LLP |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | this is a small tech company who helped us develop the website and app - we have gone on to work with them in follow on funding (we just got NIHR funding to test Artemis-A in schools on a bigger scale) and Jo Anderson is working with them in a different project |
| Collaborator Contribution | N/A |
| Impact | N/A |
| Start Year | 2021 |
| Description | developing the Artemis-R logo and visual identity |
| Organisation | Effusion LLP |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We are collaborating with Effusion - a digital and design studio. We have been working with Effusion on developing the Artemis-R logo and visual identity, as a part of an ongoing development of the brand's identity. Backend of Artemis-A is developed in collaboration with the Psychometric Centre, Cambridge. |
| Collaborator Contribution | There is a contract in place and once the wok is finalised Effusion will transfer the copyrights for design to the University. |
| Impact | We are working with them in relation to STEP. The website and app - papers to come but nothing yet. And the Artemis-A app itself? |
| Start Year | 2019 |
| Title | Methods and Apparatus for Direct Annuloplasty |
| Description | Detailing the annuloplasty prosthesis and the method of its insertion and adjustment. Now lapsed |
| IP Reference | PCT/GB2017/053326 |
| Protection | Patent application published |
| Year Protection Granted | 2016 |
| Licensed | No |
| Impact | Surgical prototype complete and tested in dead hearts. Trans-catheter prototype designed and parts purchased, awaiting assembly. Some beating heart experiments have been performed in the laboratories of LifeTec Group, Eindhoven under a standard CRO agreement. These demonstrated the viability of the device and its implantability in a beating heart, but not in a living animal. Unfortunately, further funding was not obtained, and so implantation in a living animal has not been tested. Due to funding not being obtained (notably MRC DPFS), the team has dispersed making the project hard to continue. Cambridge Enterprise have now allowed the relevant patent to lapse. Other devices in the mitral space are also now advancing rapidly. These factors mean that translation to the clinic is now unlikely. |
| Title | DigiBel |
| Description | The award was made in August 2019 and the funding available for use from late September, following a successful start to the coding there were major delays (4-5 months) in accessing grant funding following administrative changes in the University finance structure. Subsequently Covid restrictions have delayed clinical validation. Further funding to enable recoding of DigiBel as a web-app was awarded from ACT in addition to funding to undertake CE marking (MDD Class 1). CE marking is now in process using Global Regulatory Services Ltd. A service evaluation study registered at CUH has enables early usability and comparison to standard audiometry. Following CE marking, IRAS application will be made to enable formal clinical validation in the ENT department. Collaboration with Mr James Tysome and Prof Manohar Bance is planned to test DigiBel for conditions such as Meniere's disease in addition to use as a screening device. |
| Type | Products with applications outside of medicine |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2020 |
| Development Status | Under active development/distribution |
| Impact | Louise Allen has formed a start up company Cambridge Medical Innovation Ltd. to commercialise DigiBel following CE marking and clinical validation. The low cost of running Digibel on a standard iPad tablet make it suitable to be used as a standalone hearing testing web-app to be used by patients to monitor their hearing at home and in the community. DigiBel screening test will be teamed up with DigiVis vision screening test as an integrated school screening device which requires no expertise to administer. DigiBel could prove to be a useful tool in screening vision and hearing in LMICs. It runs on standard ipads with relatively cheap headphones. Good internet links which are often available even in rural areas in LMIC countries. |
| Title | DigiBel as a web-app was awarded from ACT in addition to funding to undertake CE marking (MDD Class 1). |
| Description | A pilot service evaluation study (which has been already been registered at CUH to compare measurements and usability of DigiBel to standard audiometry) will be undertaken. The major potential application for DigiBel is its use for screening in primary school age children and in the identification of children who would benefit from bone conduction hearing loss. The low cost of running Digibel on a standard iPad tablet make it suitable to be used as a standalone hearing testing web-app to be used by patients to monitor their hearing at home and in the community. DigiBel screening test will be teamed up with DigiVis vision screening test (now commercialised) as an integrated school screening device which requires no expertise to administer. |
| Type | Therapeutic Intervention - Complementary |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2022 |
| Development Status | Under active development/distribution |
| Impact | The affordable and child-friendly DigiVis and DigiBel apps will enable screening in more children both in the UK and in developing countries. There has already been interest from Unicef regarding the use of both tests in their projects across the world. |
| URL | http://www.digibel.co.uk |
| Title | The Chronic trial intraoperative echo confirming placement and functioning |
| Description | Five animals were implanted in early September 2018, with intraoperative echo confirming placement and functioning. Implantation time was under 1 minute in all cases. Intraoperative imaging showed adequate position and leaflet motion. Blood panels were unremarkable. Unfortunately, 4 out of 5 animals died within 14 days of implantation. Autopsy revealed severe thrombosis covering the proximal and distal surfaces of these valves. It appears that all animals had significant pulmonary insufficiency, leading to acute heart failure in 4 out of 5 cases. There were instances where leaflets failed to open and/or there was not complete coaptation at the centre of the valve. Taken together, the negative outcome was the result of turbulent flow due to poorly manufactured leaflets and not the device frame, materials or procedure. The surviving animal completed the 180-day follow-up period |
| Type | Therapeutic Intervention - Medical Devices |
| Year Development Stage Completed | 2018 |
| Development Status | Actively seeking support |
| Impact | Effective encapsulation of the alloy in a bio-compatible polymer proved more difficult than hoped, which delayed the project. Integration into a trans-catheter system has also been more difficult than hoped, resulting in a trans-apical or surgical approach being required, rather than trans-femoral. |
| Title | There's an app for that!: digitalising childhood vision and hearing screening with DigiVis DVA and DigiBel |
| Description | The World Health Organisation considers school vision and hearing screening essential, since early detection of treatable problems within the period of sensory neuroplasticity, and the provision of therapy and aids (e.g. glasses / hearing aids) optimises educational and social development at this formative time. In the UK, school sensory screening is a recommended but not statutory part of the Health Child Programme. It is being sacrificed as Public Health budgets are increasingly squeezed. As children from deprived backgrounds are more likely to have sensory issues, late detection of treatable conditions may further prejudice their life chances. The NHS Long Term Plan encourages digitalisation of diagnostic testing to improve efficiency, governance and the collection of health information. DigiVis DVA (Distance Visual Acuity) and DigiBel web-apps have been developed for self-testing and home monitoring. Early app development and evaluation was funded by Addenbrooke's Charitable Trust, Cambridge University Health Partners and two MRC Confidence in Concepts grants. Following licensing to Cambridge Medical Innovation Ltd., the DigiVis DVA online app and portal were developed. DigiVis DVA has been validated in two studies involving adults and children from 4 years of age and demonstrated to be as accurate and repeatable as standard clinical testing, with over 86% of users rating the test was good / excellent. (1, 2) The test uses two paired digital devices (e.g. two smartphones), one hand-held and the other at a 2m distance, and mimics a matching letter test (Figure 1a). The technology was recently adopted at Cambridge University Hospitals Trust (CUH), where it has been in clinical use for 3 years. An NIHR i4i Challenge grant funded study (ReVise) is underway to establish the barriers and enablers for remote consultation with self-testing of vision using DigiVis DVA in Ophthalmology (the specialty with the highest out-patient backlog) in three large NHS Trusts. DigiBel is the partner audiometry web-app. Primarily designed as a screening test for childhood hearing impairment, it enables untrained adults to supervise children self testing their hearing in the community, using an iPad with specific air-conduction headphones. (Figure 1b) Validated in adults with simulated hearing loss, DigiBel's unique feature is its potential to identify children who may benefit from the use of cheap, purpose designed bone conduction microphone / headphone kits (Raspberry Pi, Cambridge UK) to assist them while they wait for audiology and ENT services (3, 4). DigiBel's screening accuracy for hearing impairment in young children and its ability to identify bilateral conductive deafness is currently being tested in the paediatric audiology clinic at CUH. Digital technology and the use of child-friendly apps like DigiVis DVA and DigiBel may be part of the solution as we co-design future implementation models to deliver more cost-effective, sustainable and equitable school screening and home monitoring services. |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Refinement. Clinical |
| Year Development Stage Completed | 2024 |
| Development Status | Under active development/distribution |
| Impact | A further service improvement study will shortly be starting at CUH in the paediatric audiology clinic. In this evaluation we will be screening children using DigiBel when they attend for formal audiology to assess its sensitivity and specificity for detecting conductive hearing loss with both the air-conduction and bone-conduction DigiBel tests. Louise Allen has formed a start up company Cambridge Medical Innovation Ltd. to commercialise DigiBel following CE marking and completion of clinical validation. Once the validation studies are completed CMI Ltd will negotiate a licence agreement with the University of Cambridge. |
| Title | Development of a novel hearing computer application and modified headphone system for the DigiScreener sensory screening platform |
| Description | EG technology Ltd. undertook the initial coding work, developing the screening and threshold hearing test under instruction and following British Society of Audiology standards. This was coded as a windows app to be used on a laptop computer using a specific set of headphones and was completed in January 2020. Covid hit a few months later and we determined the need to have a test which could be undertaken as a web-application on a standard iPAD with a cheaper set of headphones - compatible with home use and monitoring. Although numerous on-line hearing tests and apps exist, these are non-standardised or CE marked, making them inappropriate for clinical decision making. The innovative approach of the new web-app, now called DigiBel includes: 1) web-app use to enable home use and self-testing by patients from 4 year and over 2) initial automated assessment of ambient noise level 3) accurate calibration of ipad system microphone and sound output by Institute of Sound and Vibration research in Southampton University 4) Conditioning pre-test to ensure patient understanding 5) configurable screening and threshold tests (frequency / tone type / screening standard) with child friendly options 6) bone conduction headphone testing facility 7) Feed back regarding test performance - false positive responses to aid clinical evaluation The second prototype was developed following accurate calibration of the system (4 different generations of ipad and the chose air-conduction headphones) at the ISVR as planned |
| Type Of Technology | e-Business Platform |
| Year Produced | 2020 |
| Impact | Covid-19 and the large backlogs in audiology have hampered clinical validation studies. DigiBel v1 is now live at www.digibel.co.uk . Following the validation studies the web-app will be licensed from Cambridge commercialised within the same portfolio as DigiVis (www.digivis.org) by CMI Ltd to give an affordable solution for vision and hearing screening in the UK and internationally. 40% of Local Authorities do not undertake the recommended Reception year school vision screening and 60% do not undertake hearing screening and yet 20% of children suffer from visual disorders such as amblyopia which require early detection to treat and many children are labelled as poor achievers due to hearing impediment which could be mitigated by the use of bone conduction headphones during class. The affordable and child-friendly DigiVis and DigiBel apps will enable screening in more children both in the UK and in developing countries. There has already been interest from Unicef regarding the use of both tests in their projects across the world. |
| URL | http://www.digibel.co.uk |
| Title | The UI/UX design - Artemis-A |
| Description | Procedure: Members of the app development team attended to demonstrate the app and collect feedback about the design and navigation preferences. At the start of each session, participants were given a demonstration of the CAT platform to show how items are selected from the bank of measures. Following this, the app development team presented three visual mock-ups for both mobile and desktop platforms using an interactive prototype and print assets. Participants were prompted to give feedback on the 'look and feel' of the app, select the best design and functionality features, and suggest additional improvements. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2021 |
| Impact | The Artermis family of tools offer a wide range of applications for the identification of poor mental health to the routine monitoring of outcomes of treatment - this could increase access to services for hard to reach groups who might not identify themselves and needing help, such as children, job seekers etc |
| URL | https://www.artemis-a.org/ |
| Description | - CRUK Innovation Summit 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ania Piskorz presented at the summit highlighting her entrepreneurship activities involving our recently created startup Tailor Bio and our support from the MRC through the CiC award. This activity created awareness of Ania's science in a commercial setting and has expanded our network and opportunities to commercialise the output of this study. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.cancerresearchuk.org/funding-for-researchers/research-events-and-conferences/innovation-... |
| Description | Artemis-A - School visits (e.g Landmark International School, Fulbourn; School visit (Soham Village College, Soham) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | We have presented the Artemis-A and talked about the project in four secondary schools in the area (Cambridge, Ely). These engagement activities were integral to the development of the app but also for informing plans to for how it would successfully be applied within secondary schools for the next stage of the project |
| Year(s) Of Engagement Activity | 2019 |
| Description | Artemis-R |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | this is a network of researchers and practitioners who were interested in supporting mental health in schools. These engagement activities were integral to the development of the app but also for informing plans to for how it would successfully be applied within secondary schools for the next stage of the project. |
| Year(s) Of Engagement Activity | 2020 |
| Description | CRUK Single Cell Workshop in Southampton 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Here we presented some preliminary results on using our protocol to explore ongoing chromosomal instability in ovarian cancer cell lines. The presentation was well received and provided validation of our approach for research use. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.eventbrite.co.uk/e/single-cell-analysis-in-cancer-a-workshop-tickets-64716482742?utm_cam... |
| Description | Cambridge Children's Hospital presentation DigiBel and DigiVis at the University of Cambridge Alumni meeting 24th September 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Due to Covid 19 Restriction DigiBel and DigiVis was an international on-line webinar reaching over 200 University Alumni. DigiBel and DigiVis were presented by Louise Allen This was an introduction to DigiBel as a hearing web-app which enables community screening and testing of children's hearing Its use in Low and Middle income countries as welll as in the UK was discussed. There was a live on-line Q & A session which covered the innovation. The impact of this meeting was to introcue the concept of self-testing to enable early detection of treatable sensory issues in children and highlight innovation within out NHS trust. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Centre33 quarterly staff meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of the project to a CPD session for Centre 33 practitioners. These engagement activities were integral to the development of the app but also for informing plans to for how it would successfully be applied within secondary schools for the next stage of the project |
| Year(s) Of Engagement Activity | 2019 |
| Description | DigiBel and DigiVis - Innovation and technology show July 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DigiBel and DigiVis were presented by Louise Allen at the Institute for Government and Public Policy Healthcare Innovation and technology show July 2021 watched by 450 attendees |
| Year(s) Of Engagement Activity | 2021 |
| Description | DigiBel and DigiVis presentation Eastern Academic Science Network Innovation panel 15th October 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | This was a 20 minute presentation to 20 members of the Innovation panel for EAHSN to determine if they would support adoption of DigiBel . EAHSN decided to support adoption of DigiBel and application to the National Innovation Accelerator. EAHSN decided to support adoption of DigiBel and application to the National Innovation Accelerator. Most significant outcome: support for adoption of DigiBel in the Cambnridgeshitre and Peterborough integrated care system |
| Year(s) Of Engagement Activity | 2021 |
| Description | DigiBel presentation to UNICEF representatives in South America, Africa and the Middle East 17th September 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | This was an hour long presentation to UNICEF leaders in the field of sensory screening from across the world to determine the role that DigiBel might play in school screening. There was much interest about the potential for using the web-app. Following validation UNICEF have demonstrated that they are interested in using the service. Most significant outcome: Potential for UNICEF to adopt the technology for their projects internationally. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FullScope Consortium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussions with Centre 33 - FullScope Consortium senior staff as well as presentations of the work and plans to their practitioners. These engagement activities were integral to the development of the app but also for informing plans to for how it would successfully be applied within secondary schools for the next stage of the project |
| Year(s) Of Engagement Activity | 2014,2020 |
| Description | The NIHR Applied Research Centre (ARC) East of England |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | These engagement activities are integral to the development of the app but also for informing plans to for how it would successfully be applied within secondary schools for the next stage of the project |
| Year(s) Of Engagement Activity | 2021 |